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DK1608748T3 - Ligeringskodning af små molekyler - Google Patents

Ligeringskodning af små molekyler

Info

Publication number
DK1608748T3
DK1608748T3 DK04722237T DK04722237T DK1608748T3 DK 1608748 T3 DK1608748 T3 DK 1608748T3 DK 04722237 T DK04722237 T DK 04722237T DK 04722237 T DK04722237 T DK 04722237T DK 1608748 T3 DK1608748 T3 DK 1608748T3
Authority
DK
Denmark
Prior art keywords
chemical entities
template
encoded molecule
codon
identifier polynucleotide
Prior art date
Application number
DK04722237T
Other languages
English (en)
Inventor
Soeren Nyboe Jacobsen
Torben Rasmussen
Soeren Neve
Henrik Pedersen
Alex Haahr Gouliaev
Thomas Franch
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of DK1608748T3 publication Critical patent/DK1608748T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK04722237T 2003-03-20 2004-03-22 Ligeringskodning af små molekyler DK1608748T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45585803P 2003-03-20 2003-03-20
DKPA200300430 2003-03-20
PCT/DK2004/000195 WO2004083427A2 (en) 2003-03-20 2004-03-22 Ligational encoding of small molecules

Publications (1)

Publication Number Publication Date
DK1608748T3 true DK1608748T3 (da) 2009-06-29

Family

ID=33031172

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04722237T DK1608748T3 (da) 2003-03-20 2004-03-22 Ligeringskodning af små molekyler
DK09154197.9T DK2236606T3 (da) 2003-03-20 2004-03-22 Kodning af små molekyler ved ligering

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09154197.9T DK2236606T3 (da) 2003-03-20 2004-03-22 Kodning af små molekyler ved ligering

Country Status (6)

Country Link
US (1) US7915201B2 (da)
EP (2) EP2236606B1 (da)
AT (1) ATE424455T1 (da)
DE (1) DE602004019764D1 (da)
DK (2) DK1608748T3 (da)
WO (1) WO2004083427A2 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US7413854B2 (en) 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
EP1545762A2 (en) 2002-09-27 2005-06-29 Carlsberg A/S Spatially encoded polymer matrix
NZ538993A (en) 2002-10-30 2008-04-30 Nuevolution As Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
WO2004083427A2 (en) 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
AU2004299145B2 (en) * 2003-12-17 2011-08-25 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
US7704925B2 (en) 2004-03-22 2010-04-27 Nuevolution A/S Ligational encoding using building block oligonucleotides
US8168381B2 (en) * 2004-11-22 2012-05-01 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
CA2611512C (en) * 2005-06-09 2018-05-22 Praecis Pharmaceuticals, Inc. Methods for synthesis of encoded libraries
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
JP2009513135A (ja) * 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
SI2341140T1 (sl) 2005-12-01 2017-12-29 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
US7727745B2 (en) 2006-08-14 2010-06-01 Bio-Id Diagnostic Inc. Synthesis of single-stranded DNA
WO2009077173A2 (en) * 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
WO2009097673A1 (en) * 2008-02-07 2009-08-13 Bio-Id Diagnostic Inc. Synthesis of single-stranded dna
BRPI1008429A2 (pt) * 2009-02-13 2020-08-25 X-Chem, Inc. métodos de criação e de triagem de bibliotecas de dna codificado.
LT2558577T (lt) 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
EP2405000A1 (en) * 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
MX360438B (es) 2011-09-07 2018-11-01 X Chem Inc Metodos para etiquetar bibliotecas codificadas por adn.
EA034141B1 (ru) 2012-07-13 2020-01-09 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
US9765375B2 (en) 2013-06-28 2017-09-19 General Electric Company Methods for developing binding-elements and uses thereof
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201603789D0 (en) 2016-03-04 2016-04-20 Apta Biosciences Ltd Oligonucleotides and methods for preparing
CN109312492B (zh) 2016-06-16 2022-10-04 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN107802276B (zh) * 2017-09-01 2020-11-27 深圳市菲森科技有限公司 头颅影像的描迹图绘制装置和方法
WO2021072306A1 (en) 2019-10-10 2021-04-15 1859, Inc. Methods and systems for microfluidic screening
CN114729390A (zh) * 2019-11-29 2022-07-08 深圳华大基因科技有限公司 寡核苷酸的酶促合成

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
WO1990005785A1 (en) 1988-11-18 1990-05-31 The Regents Of The University Of California Method for site-specifically incorporating unnatural amino acids into proteins
DE69032483T2 (de) 1989-10-05 1998-11-26 Optein, Inc., Seattle, Wash. Zellfreie synthese und isolierung von genen und polypeptiden
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
WO1993003172A1 (en) 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
WO1994024143A1 (en) 1993-04-12 1994-10-27 Northwestern University Method of forming oligonucleotides
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
EP0726906A4 (en) 1993-11-02 1998-10-07 Affymax Tech Nv THE SYNTHESIS AND EXAMINATION OF MOLECULAR DIVERSITY
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5739386A (en) 1994-06-23 1998-04-14 Affymax Technologies N.V. Photolabile compounds and methods for their use
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
KR100566859B1 (ko) 1997-01-21 2006-04-03 제너럴 하스피톨 코포레이션 Rna-단백질 융합물을 이용한 단백질의 선별
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
CA2291721C (en) 1997-05-28 2011-08-09 Babraham Institute Ribosome complexes as selection particles for in vitro display and evolution of proteins
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
CA2323638A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US6143503A (en) 1998-04-17 2000-11-07 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
EP1119530A2 (en) 1998-10-09 2001-08-01 Pharmacopeia, Inc. Selecting codes to be used for encoding combinatorial libraries
AU1318400A (en) * 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
EP1137812B1 (en) 1998-12-02 2007-02-21 Adnexus Therapeutics, Inc. Dna-protein fusions and uses thereof
WO2000061775A1 (en) 1999-04-08 2000-10-19 Pavel Sergeev Synthesis of biologically active compounds in cells
AU784040B2 (en) 1999-06-25 2006-01-19 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
KR20020033743A (ko) 1999-07-27 2002-05-07 추후기재 펩티드 수용체 리게이션 방법
WO2001016151A1 (fr) 1999-08-27 2001-03-08 Japan Science And Technology Corporation Acide nucleique a photocouplage reversible et phosphoroamidite
US7070928B2 (en) 2001-03-19 2006-07-04 President And Fellows Of Harvard College Evolving new molecular function
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP2305808B1 (en) 2001-06-20 2016-03-02 Nuevolution A/S Templated molecules and methods for using such molecules
EP1487851A2 (en) 2002-03-15 2004-12-22 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US7413854B2 (en) 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
EP1487850A2 (en) 2002-03-15 2004-12-22 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
EP1487848A2 (en) 2002-03-15 2004-12-22 Nuevolution A/S A building block forming a c=c double bond upon reaction
US7255991B2 (en) 2002-03-22 2007-08-14 Emory University Template-drive processes for synthesizing polymers and components related to such processes
AU2003240436A1 (en) 2002-06-20 2004-01-06 Nuevolution A/S Microarrays displaying encoded molecules
US20060099589A1 (en) 2002-07-23 2006-05-11 Nuevolution A/S Gene shuffling by template switching
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
NZ538993A (en) 2002-10-30 2008-04-30 Nuevolution As Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US20060269920A1 (en) 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
WO2004083427A2 (en) 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
EP1625230A2 (en) 2003-05-09 2006-02-15 Thorleif Möller Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
EP1533385A1 (en) 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
AU2005300886B2 (en) 2004-11-08 2009-11-12 Vipergen Aps Structural nucleic acid guided chemical synthesis
US8168381B2 (en) 2004-11-22 2012-05-01 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries

Also Published As

Publication number Publication date
WO2004083427A2 (en) 2004-09-30
US7915201B2 (en) 2011-03-29
US20060246450A1 (en) 2006-11-02
DK2236606T3 (da) 2014-02-10
DE602004019764D1 (de) 2009-04-16
EP2236606A2 (en) 2010-10-06
WO2004083427A3 (en) 2005-02-17
EP2236606A3 (en) 2010-10-20
ATE424455T1 (de) 2009-03-15
EP1608748B1 (en) 2009-03-04
EP1608748A2 (en) 2005-12-28
EP2236606B1 (en) 2013-11-06

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