DK1692105T3 - Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives - Google Patents

Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives

Info

Publication number: DK1692105T3
Authority: DK; Denmark
Prior art keywords: isoindol; dihydro; oxo; preparation; acetylguanidine
Prior art date: 2003-12-02

Application number

DK04803188T

Other languages

Danish (da)

Inventor

Gerrit Schubert

Joerg Rieke-Zapp

Johannes Keil

Heinz-Werner Kleemann

Reda Hanna

Bao-Guo Huang

Xiao-Dong Wu

Yves Gouraud

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-02

Filing date

2004-11-19

Publication date

2008-08-25

2004-11-19 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-08-25 Application granted granted Critical

2008-08-25 Publication of DK1692105T3 publication Critical patent/DK1692105T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK04803188T 2003-12-02 2004-11-19 Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives DK1692105T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10356717A DE10356717A1 (en)	2003-12-02	2003-12-02	Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives
PCT/EP2004/013153 WO2005054195A1 (en)	2003-12-02	2004-11-19	Method for producing (3-oxo-2,3-dihydro-1h-isoindol-1-yl) acetylguanidine derivatives

Publications (1)

Publication Number	Publication Date
DK1692105T3 true DK1692105T3 (en)	2008-08-25

Family

ID=34638338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04803188T DK1692105T3 (en)	2003-12-02	2004-11-19	Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives

Country Status (38)

Country	Link
EP (1)	EP1692105B1 (en)
JP (1)	JP4809774B2 (en)
KR (1)	KR101202604B1 (en)
CN (1)	CN100526297C (en)
AR (1)	AR046733A1 (en)
AT (1)	ATE395334T1 (en)
AU (1)	AU2004295056B2 (en)
BR (1)	BRPI0417147A (en)
CA (1)	CA2548020C (en)
CR (1)	CR8376A (en)
CY (1)	CY1108187T1 (en)
DE (2)	DE10356717A1 (en)
DK (1)	DK1692105T3 (en)
EC (1)	ECSP066597A (en)
EG (1)	EG25498A (en)
ES (1)	ES2304634T3 (en)
HK (1)	HK1097525A1 (en)
HR (1)	HRP20080253T3 (en)
IL (1)	IL175834A (en)
JO (1)	JO2498B1 (en)
MA (1)	MA28220A1 (en)
MY (1)	MY136467A (en)
NO (1)	NO20063058L (en)
NZ (1)	NZ547625A (en)
OA (1)	OA13293A (en)
PA (1)	PA8618701A1 (en)
PE (1)	PE20051037A1 (en)
PL (1)	PL1692105T3 (en)
PT (1)	PT1692105E (en)
RS (1)	RS50571B (en)
RU (1)	RU2397159C2 (en)
SI (1)	SI1692105T1 (en)
TN (1)	TNSN06167A1 (en)
TW (1)	TWI334348B (en)
UA (1)	UA83883C2 (en)
UY (1)	UY28648A1 (en)
WO (1)	WO2005054195A1 (en)
ZA (1)	ZA200603338B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200812962A (en) *	2006-07-12	2008-03-16	Astrazeneca Ab	New compounds I/418
US8354382B2 (en) *	2008-04-16	2013-01-15	Kissei Pharmaceutical Co., Ltd.	Hemifumarate of a pyrazole derivative
RU2518740C1 (en) *	2013-03-22	2014-06-10	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ"	METHOD, INHIBITING Na+/H+-EXCHANGE, AND DIHYDROCHLORIDE OF 2-(3,4-METHYLENEDIOXYPHENYL)-9-MORPHOLINOETHYLIMIDAZO[1,2-a]BENZIMIDAZOLE
CN107778238B (en) *	2016-08-29	2022-07-22	中山大学	Novel synthesis method of 3, 4-dihydroisoquinoline-1-ketone
CN107286074B (en) *	2017-08-16	2019-08-20	厦门华厦学院	3- hydroxyl iso-indoles -1- ketone derivatives and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU581324B2 (en) *	1985-07-05	1989-02-16	Smith Kline & French Laboratories Limited	Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
DE19737224A1 (en) *	1997-08-27	1999-03-18	Hoechst Marion Roussel De Gmbh	Pharmaceutical preparation for cardiovascular treatment
DE19832429A1 (en) *	1998-07-18	2000-01-20	Hoechst Marion Roussel De Gmbh	New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
ES2278016T3 (en)	2001-04-09	2007-08-01	Novartis Vaccines And Diagnostics, Inc.	GUANIDINE COMPOUNDS AS AGONISTS OF THE RECEIVER OF MELANOCORTINA 4 (MC4-R).
FR2840302B1 (en) *	2002-06-03	2004-07-16	Aventis Pharma Sa	ISOINDOLONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIARY THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

2003
- 2003-12-02 DE DE10356717A patent/DE10356717A1/en not_active Withdrawn
2004
- 2004-11-04 JO JO2004155A patent/JO2498B1/en active
- 2004-11-19 RU RU2006123410/04A patent/RU2397159C2/en not_active IP Right Cessation
- 2004-11-19 JP JP2006541829A patent/JP4809774B2/en not_active Expired - Fee Related
- 2004-11-19 AU AU2004295056A patent/AU2004295056B2/en not_active Ceased
- 2004-11-19 PT PT04803188T patent/PT1692105E/en unknown
- 2004-11-19 OA OA1200600177A patent/OA13293A/en unknown
- 2004-11-19 BR BRPI0417147-0A patent/BRPI0417147A/en not_active IP Right Cessation
- 2004-11-19 EP EP04803188A patent/EP1692105B1/en active Active
- 2004-11-19 UA UAA200607292A patent/UA83883C2/en unknown
- 2004-11-19 CA CA2548020A patent/CA2548020C/en not_active Expired - Fee Related
- 2004-11-19 KR KR1020067010920A patent/KR101202604B1/en not_active IP Right Cessation
- 2004-11-19 SI SI200430747T patent/SI1692105T1/en unknown
- 2004-11-19 CN CNB2004800348122A patent/CN100526297C/en not_active Expired - Fee Related
- 2004-11-19 ES ES04803188T patent/ES2304634T3/en active Active
- 2004-11-19 WO PCT/EP2004/013153 patent/WO2005054195A1/en active Application Filing
- 2004-11-19 DE DE502004007177T patent/DE502004007177D1/en active Active
- 2004-11-19 AT AT04803188T patent/ATE395334T1/en active
- 2004-11-19 DK DK04803188T patent/DK1692105T3/en active
- 2004-11-19 NZ NZ547625A patent/NZ547625A/en not_active IP Right Cessation
- 2004-11-19 PL PL04803188T patent/PL1692105T3/en unknown
- 2004-11-19 RS RSP-2008/0311A patent/RS50571B/en unknown
- 2004-11-29 PE PE2004001175A patent/PE20051037A1/en not_active Application Discontinuation
- 2004-11-30 TW TW093136804A patent/TWI334348B/en not_active IP Right Cessation
- 2004-11-30 AR ARP040104450A patent/AR046733A1/en not_active Application Discontinuation
- 2004-12-01 MY MYPI20044973A patent/MY136467A/en unknown
- 2004-12-01 PA PA20048618701A patent/PA8618701A1/en unknown
- 2004-12-02 UY UY28648A patent/UY28648A1/en not_active Application Discontinuation
2006
- 2006-04-26 ZA ZA200603338A patent/ZA200603338B/en unknown
- 2006-04-28 CR CR8376A patent/CR8376A/en unknown
- 2006-05-22 IL IL175834A patent/IL175834A/en not_active IP Right Cessation
- 2006-06-01 EC EC2006006597A patent/ECSP066597A/en unknown
- 2006-06-01 TN TNP2006000167A patent/TNSN06167A1/en unknown
- 2006-06-01 EG EGNA2006000508 patent/EG25498A/en active
- 2006-06-02 MA MA29077A patent/MA28220A1/en unknown
- 2006-06-30 NO NO20063058A patent/NO20063058L/en unknown
2007
- 2007-03-09 HK HK07102616.3A patent/HK1097525A1/en not_active IP Right Cessation
2008
- 2008-06-09 HR HR20080253T patent/HRP20080253T3/en unknown
- 2008-07-11 CY CY20081100727T patent/CY1108187T1/en unknown

Also Published As

Publication number	Publication date
EP1692105B1 (en)	2008-05-14
JP4809774B2 (en)	2011-11-09
JO2498B1 (en)	2009-10-05
NZ547625A (en)	2010-01-29
HK1097525A1 (en)	2007-06-29
ES2304634T3 (en)	2008-10-16
AU2004295056B2 (en)	2011-04-14
SI1692105T1 (en)	2008-08-31
AR046733A1 (en)	2005-12-21
TW200526207A (en)	2005-08-16
UA83883C2 (en)	2008-08-26
CN100526297C (en)	2009-08-12
RU2006123410A (en)	2008-01-10
OA13293A (en)	2007-01-31
PT1692105E (en)	2008-07-04
CR8376A (en)	2007-12-04
TNSN06167A1 (en)	2007-11-15
KR20060111558A (en)	2006-10-27
IL175834A (en)	2010-12-30
ECSP066597A (en)	2006-10-25
JP2007516243A (en)	2007-06-21
PL1692105T3 (en)	2008-09-30
HRP20080253T3 (en)	2008-09-30
MA28220A1 (en)	2006-10-02
IL175834A0 (en)	2006-10-05
RU2397159C2 (en)	2010-08-20
CY1108187T1 (en)	2014-02-12
DE502004007177D1 (en)	2008-06-26
EG25498A (en)	2012-01-22
PA8618701A1 (en)	2006-07-03
MY136467A (en)	2008-10-31
DE10356717A1 (en)	2005-07-07
PE20051037A1 (en)	2005-12-29
CN1886374A (en)	2006-12-27
TWI334348B (en)	2010-12-11
UY28648A1 (en)	2005-06-30
EP1692105A1 (en)	2006-08-23
ZA200603338B (en)	2007-06-27
ATE395334T1 (en)	2008-05-15
AU2004295056A1 (en)	2005-06-16
BRPI0417147A (en)	2007-03-06
KR101202604B1 (en)	2012-11-19
WO2005054195A1 (en)	2005-06-16
NO20063058L (en)	2006-06-30
CA2548020C (en)	2013-01-08
CA2548020A1 (en)	2005-06-16
RS50571B (en)	2010-05-07

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