DK1654287T3 - CD20-bindende polypeptidsammensætninger - Google Patents
CD20-bindende polypeptidsammensætningerInfo
- Publication number
- DK1654287T3 DK1654287T3 DK04764037.0T DK04764037T DK1654287T3 DK 1654287 T3 DK1654287 T3 DK 1654287T3 DK 04764037 T DK04764037 T DK 04764037T DK 1654287 T3 DK1654287 T3 DK 1654287T3
- Authority
- DK
- Denmark
- Prior art keywords
- modified
- chain variable
- variable region
- region polypeptide
- seq
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 title abstract 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03018480 | 2003-08-14 | ||
| US52017103P | 2003-11-14 | 2003-11-14 | |
| PCT/EP2004/009033 WO2005016969A2 (en) | 2003-08-14 | 2004-08-16 | Cd20-binding polypeptide compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1654287T3 true DK1654287T3 (da) | 2010-10-25 |
Family
ID=37003287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04764037.0T DK1654287T3 (da) | 2003-08-14 | 2004-08-16 | CD20-bindende polypeptidsammensætninger |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8147832B2 (da) |
| EP (1) | EP1654287B1 (da) |
| JP (1) | JP4787750B2 (da) |
| KR (2) | KR101209541B1 (da) |
| CN (1) | CN1835977B (da) |
| AT (1) | ATE476990T1 (da) |
| AU (1) | AU2004264372B2 (da) |
| BR (1) | BRPI0413489B8 (da) |
| CA (1) | CA2535515C (da) |
| DK (1) | DK1654287T3 (da) |
| ES (1) | ES2349781T3 (da) |
| MX (1) | MXPA06001664A (da) |
| PL (1) | PL1654287T3 (da) |
| PT (1) | PT1654287E (da) |
| RU (1) | RU2396279C2 (da) |
| SI (1) | SI1654287T1 (da) |
| WO (1) | WO2005016969A2 (da) |
| ZA (1) | ZA200602110B (da) |
Families Citing this family (71)
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| EP2960251A1 (en) * | 2003-05-09 | 2015-12-30 | Duke University | CD20-specific antibodies and methods of employing same |
| US8147832B2 (en) * | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| JP2008501712A (ja) | 2004-06-04 | 2008-01-24 | ジェネンテック・インコーポレーテッド | 多発性硬化症を処置するための方法 |
| DOP2005000108A (es) * | 2004-06-04 | 2007-06-15 | Genentech Inc | Method for treating lupus |
| AU2005267028A1 (en) * | 2004-07-22 | 2006-02-02 | Genentech, Inc. | Method of treating Sjogren's syndrome |
| BR122018016031B8 (pt) | 2004-08-04 | 2021-07-27 | Applied Molecular Evolution Inc | processo para produzir um anticorpo monoclonal variante com resposta de adcc realçada |
| US20060110387A1 (en) * | 2004-10-05 | 2006-05-25 | Genentech, Inc. | Method for treating vasculitis |
| AR053579A1 (es) * | 2005-04-15 | 2007-05-09 | Genentech Inc | Tratamiento de la enfermedad inflamatoria intestinal (eii) |
| ES2341484T3 (es) * | 2005-05-20 | 2010-06-21 | Genentech, Inc. | Pretratamiento de una muestra biologica de un sujeto que sufre una enfermedad autoinmune. |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| DK2270050T3 (da) | 2005-12-30 | 2013-08-12 | Merck Patent Gmbh | Anti-CD19-antistoffer med nedsat immunogenicitet |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| US7947813B2 (en) | 2007-01-22 | 2011-05-24 | Genentech, Inc. | Polyelectrolyte precipitation and purification of proteins |
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| HUE030134T2 (en) | 2007-10-16 | 2017-04-28 | Zymogenetics Inc | Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for the treatment of autoimmune diseases |
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| BRPI0823046B1 (pt) | 2008-08-14 | 2021-12-14 | Genentech, Inc | Método para purificar um anticorpo monoclonal de uma composição compreendendo o anticorpo monoclonal e pelo menos uma proteína de ovário de hamster chinês (chop) |
| EP2684570A1 (en) | 2008-09-10 | 2014-01-15 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
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| US9777067B2 (en) | 2012-09-27 | 2017-10-03 | Massachusetts Institute Of Technology | HER2- and VEGF-A-binding proteins with enhanced stability |
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| BR112015026006B1 (pt) | 2013-04-17 | 2022-10-18 | Signal Pharmaceuticals, Llc | Uso de um composto em combinação com um fármaco imunomodulador imid® para tratamento ou prevenção de um câncer, composição farmacêutica e kit compreendendo os referidos compostos |
| JP2016516818A (ja) | 2013-04-17 | 2016-06-09 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのｔｏｒキナーゼ阻害剤及びｎ−（３−（５−フルオロ−２−（４−（２−メトキシエトキシ）フェニルアミノ）ピリミジン−４−イルアミノ）フェニル）アクリルアミドを含む組合せ療法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6010902A (en) | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
| US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| DK0669836T3 (da) * | 1992-11-13 | 1996-10-14 | Idec Pharma Corp | Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom |
| US6100387A (en) | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
| CZ303155B6 (cs) | 1999-02-12 | 2012-05-09 | The Scripps Research Institute | Terapeutický prostredek pro lécení nádorové bunky v nádoru nebo metastázích nádoru a souprava jej obsahující |
| JP4286483B2 (ja) * | 1999-06-09 | 2009-07-01 | イムノメディクス， インコーポレイテッド | Ｂ細胞をターゲットとする抗体を使用する自己免疫疾患に対する免疫療法 |
| HUP0303171A2 (hu) * | 2001-02-19 | 2003-12-29 | Merck Patent Gmbh | Csökkentett immunogenitású mesterséges fehérjék |
| AU2002256624B2 (en) * | 2001-02-19 | 2007-12-06 | Merck Patent Gmbh | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
| US7132511B2 (en) * | 2001-02-19 | 2006-11-07 | Merck Patent Gmbh | Modified anti-EGFR antibodies with reduced immunogenicity |
| WO2003061694A1 (en) * | 2001-05-10 | 2003-07-31 | Seattle Genetics, Inc. | Immunosuppression of the humoral immune response by anti-cd20 antibodies |
| US7321026B2 (en) * | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| CN1585778A (zh) * | 2001-11-12 | 2005-02-23 | 默克专利有限公司 | 修饰的抗－TNFα抗体 |
| JP2005538034A (ja) * | 2001-12-07 | 2005-12-15 | カイロン コーポレイション | 非ホジキンリンパ腫の治療方法 |
| US8147832B2 (en) * | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
-
2004
- 2004-08-13 US US10/917,599 patent/US8147832B2/en not_active Expired - Fee Related
- 2004-08-16 PL PL04764037T patent/PL1654287T3/pl unknown
- 2004-08-16 CA CA2535515A patent/CA2535515C/en not_active Expired - Fee Related
- 2004-08-16 AT AT04764037T patent/ATE476990T1/de active
- 2004-08-16 PT PT04764037T patent/PT1654287E/pt unknown
- 2004-08-16 ES ES04764037T patent/ES2349781T3/es not_active Expired - Lifetime
- 2004-08-16 AU AU2004264372A patent/AU2004264372B2/en not_active Expired
- 2004-08-16 SI SI200431518T patent/SI1654287T1/sl unknown
- 2004-08-16 KR KR1020067003006A patent/KR101209541B1/ko not_active Expired - Fee Related
- 2004-08-16 MX MXPA06001664A patent/MXPA06001664A/es active IP Right Grant
- 2004-08-16 CN CN2004800233720A patent/CN1835977B/zh not_active Expired - Lifetime
- 2004-08-16 KR KR1020127019703A patent/KR20120101155A/ko not_active Ceased
- 2004-08-16 RU RU2006107453/13A patent/RU2396279C2/ru active
- 2004-08-16 BR BRPI0413489A patent/BRPI0413489B8/pt not_active IP Right Cessation
- 2004-08-16 EP EP04764037A patent/EP1654287B1/en not_active Expired - Lifetime
- 2004-08-16 WO PCT/EP2004/009033 patent/WO2005016969A2/en active Application Filing
- 2004-08-16 DK DK04764037.0T patent/DK1654287T3/da active
- 2004-08-16 JP JP2006522984A patent/JP4787750B2/ja not_active Expired - Fee Related
-
2006
- 2006-03-13 ZA ZA200602110A patent/ZA200602110B/en unknown
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2012
- 2012-03-28 US US13/432,671 patent/US8337844B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120101155A (ko) | 2012-09-12 |
| PL1654287T3 (pl) | 2010-12-31 |
| CN1835977A (zh) | 2006-09-20 |
| ES2349781T3 (es) | 2011-01-11 |
| BRPI0413489A (pt) | 2006-10-17 |
| RU2006107453A (ru) | 2007-09-20 |
| US20120183545A1 (en) | 2012-07-19 |
| WO2005016969A2 (en) | 2005-02-24 |
| MXPA06001664A (es) | 2006-04-28 |
| ZA200602110B (en) | 2007-05-30 |
| US8147832B2 (en) | 2012-04-03 |
| US8337844B2 (en) | 2012-12-25 |
| CA2535515C (en) | 2013-10-29 |
| JP2007525202A (ja) | 2007-09-06 |
| AU2004264372B2 (en) | 2010-07-29 |
| JP4787750B2 (ja) | 2011-10-05 |
| SI1654287T1 (sl) | 2010-11-30 |
| US20050069545A1 (en) | 2005-03-31 |
| BRPI0413489B1 (pt) | 2019-12-03 |
| WO2005016969A3 (en) | 2005-04-21 |
| EP1654287B1 (en) | 2010-08-11 |
| RU2396279C2 (ru) | 2010-08-10 |
| BRPI0413489B8 (pt) | 2021-05-25 |
| PT1654287E (pt) | 2010-11-17 |
| AU2004264372A1 (en) | 2005-02-24 |
| CA2535515A1 (en) | 2005-02-24 |
| KR101209541B1 (ko) | 2012-12-13 |
| KR20060067956A (ko) | 2006-06-20 |
| EP1654287A2 (en) | 2006-05-10 |
| ATE476990T1 (de) | 2010-08-15 |
| CN1835977B (zh) | 2012-10-31 |
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