DK1534736T3 - Nogo-receptorantagonister - Google Patents
Nogo-receptorantagonisterInfo
- Publication number
- DK1534736T3 DK1534736T3 DK03785123.5T DK03785123T DK1534736T3 DK 1534736 T3 DK1534736 T3 DK 1534736T3 DK 03785123 T DK03785123 T DK 03785123T DK 1534736 T3 DK1534736 T3 DK 1534736T3
- Authority
- DK
- Denmark
- Prior art keywords
- nogo receptor
- nogo
- receptor antagonists
- antigen
- disclosed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40286602P | 2002-08-10 | 2002-08-10 | |
PCT/US2003/025004 WO2004014311A2 (en) | 2002-08-10 | 2003-08-07 | Nogo receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1534736T3 true DK1534736T3 (da) | 2010-09-20 |
Family
ID=31715907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03785123.5T DK1534736T3 (da) | 2002-08-10 | 2003-08-07 | Nogo-receptorantagonister |
Country Status (21)
Country | Link |
---|---|
US (2) | US7465705B2 (da) |
JP (3) | JP2005535329A (da) |
KR (1) | KR20050062525A (da) |
CN (1) | CN1681838A (da) |
AT (1) | ATE469913T1 (da) |
AU (1) | AU2003264033A1 (da) |
BR (1) | BR0313331A (da) |
CA (1) | CA2495121A1 (da) |
DE (1) | DE60332842D1 (da) |
DK (1) | DK1534736T3 (da) |
EA (1) | EA200500330A1 (da) |
ES (1) | ES2346868T3 (da) |
IL (2) | IL166659A0 (da) |
IS (1) | IS7677A (da) |
MX (1) | MXPA05001615A (da) |
NO (1) | NO20050685L (da) |
PL (1) | PL375301A1 (da) |
PT (1) | PT1534736E (da) |
RS (2) | RS20050129A (da) |
WO (1) | WO2004014311A2 (da) |
ZA (2) | ZA200501135B (da) |
Families Citing this family (40)
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US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
ES2341608T3 (es) * | 2000-10-06 | 2010-06-23 | Yale University | Homologos del receptor de nogo. |
WO2004108069A2 (en) | 2002-05-04 | 2004-12-16 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
DK1534736T3 (da) | 2002-08-10 | 2010-09-20 | Biogen Idec Inc | Nogo-receptorantagonister |
WO2004017044A2 (en) * | 2002-08-15 | 2004-02-26 | Acorda Therapeutics, Inc. | Chimeric protein |
EP1606409B1 (en) | 2003-03-19 | 2010-09-01 | Biogen Idec MA Inc. | Nogo receptor binding protein |
EA009643B1 (ru) * | 2003-04-16 | 2008-02-28 | Йейл Юниверсити | Лечение состояний, включающих амилоидные бляшки |
EP3514238B1 (en) | 2003-05-16 | 2021-05-05 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
US7959914B2 (en) * | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
JP4754492B2 (ja) * | 2003-05-16 | 2011-08-24 | アコーダ セラピューティクス、インク. | 中枢神経系障害を治療するための組成物および方法 |
EA008253B1 (ru) * | 2003-08-07 | 2007-04-27 | Байоджен Айдек Ма Инк. | Антагонисты nogo-рецептора |
US8912144B2 (en) | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
BRPI0507272A (pt) * | 2004-01-30 | 2007-06-26 | Biogen Idec Inc | tratamento de condições que envolvem degeneração neuronal dopaminérgica, usando antagonistas do receptor nogo |
CA2566731C (en) | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
RS52593B (en) | 2004-06-24 | 2013-04-30 | Biogen Idec Ma Inc. | TREATMENT OF THE CONDITIONS CONCERNING DEMYELINIZATION |
CN101014245A (zh) | 2004-08-03 | 2007-08-08 | 比奥根艾迪克Ma公司 | 神经元功能中的taj |
CA2582581A1 (en) * | 2004-10-01 | 2006-05-04 | Yale University | Nogo-a polypeptide fragments, variant nogo receptor-1 polypeptides, and uses thereof |
WO2007008732A2 (en) | 2005-07-07 | 2007-01-18 | Yale University | Compositions and methods for suppressing axonal growth inhibition |
SG10201508322SA (en) | 2005-07-08 | 2015-11-27 | Biogen Ma Inc | Sp35 antibodies and uses thereof |
US20090062199A1 (en) * | 2005-08-25 | 2009-03-05 | Biogen Idec Ma Inc. | Nogo Receptor Polypeptides and Polypeptide Fragments and Uses Thereof |
AU2006294755B2 (en) | 2005-09-26 | 2012-04-19 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
JPWO2007074747A1 (ja) * | 2005-12-26 | 2009-06-04 | 株式会社クラレ | 細胞培養用材料 |
PT1981902E (pt) * | 2006-01-27 | 2015-11-02 | Biogen Ma Inc | Antagonistas dos recetores nogo |
JP2009538282A (ja) * | 2006-05-15 | 2009-11-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 乏突起膠細胞の生存を促進させるためのNogo受容体−1(NgR1)アンタゴニストの使用 |
WO2008013782A2 (en) | 2006-07-24 | 2008-01-31 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of sp35 or trka antagonists |
US20120058125A1 (en) * | 2006-08-31 | 2012-03-08 | Biogen Idec Ma Inc. | Methods relating to peripheral administration of nogo receptor polypeptides |
EP2081562B1 (en) | 2006-09-20 | 2016-02-24 | The Board of Regents of The University of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
EP2079835B1 (en) * | 2006-10-10 | 2014-03-26 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
CA2987970A1 (en) | 2006-11-21 | 2008-05-29 | Abbvie Inc. | Neutralizing monoclonal antibodies against the nogo-66 receptor (ngr) and uses thereof |
WO2009070957A1 (fr) * | 2007-12-05 | 2009-06-11 | Institute Of Genetics And Developmental Biology Chinese Academy Of Sciences | Inhibiteur de l'interaction entre blys et ngr et son utilisation |
CN107661293A (zh) | 2008-01-22 | 2018-02-06 | 得克萨斯大学体系董事会 | 用于局部麻醉和/或疼痛缓解的含有萃取溶剂的挥发性麻醉剂组合物 |
EP2276500A4 (en) * | 2008-03-13 | 2015-03-04 | Univ Yale | REACTIVATION OF AXONE GROWTH AND CHRONIC MEDALLIONAL LESIONAL HEALING |
EP2315779A2 (en) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
EP2323691A2 (en) * | 2008-07-11 | 2011-05-25 | Glaxo Group Limited | Treatment of amyotrophic lateral sclerosis by nogo-a-antagonist |
US20110020359A1 (en) * | 2009-07-24 | 2011-01-27 | California Institute Of Technology | Methods and compositions for treating neuronal damage or degeneration |
ES2699658T3 (es) | 2012-04-09 | 2019-02-12 | Univ Case Western Reserve | Composiciones para su uso en el tratamiento de lesión neural inhibiendo la actividad de fosfatasas de la familia LAR |
WO2013173364A2 (en) | 2012-05-14 | 2013-11-21 | Biogen Idec Ma Inc. | Lingo-2 antagonists for treatment of conditions involving motor neurons |
KR101685109B1 (ko) * | 2014-12-22 | 2016-12-09 | 경북대학교 산학협력단 | 근육 분화, 재생, 또는 질환 상태와 관련된 노고-에이의 용도 |
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CN113527462B (zh) * | 2020-04-22 | 2023-05-23 | 北京大学 | 一种具有镇痛作用的小分子肽及其特异性抗体 |
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US7745151B2 (en) * | 2002-08-02 | 2010-06-29 | Children's Medical Center Corporation | Methods of determining binding between Nogo receptor and p75 neurotrophin receptor |
DK1534736T3 (da) | 2002-08-10 | 2010-09-20 | Biogen Idec Inc | Nogo-receptorantagonister |
EA009643B1 (ru) | 2003-04-16 | 2008-02-28 | Йейл Юниверсити | Лечение состояний, включающих амилоидные бляшки |
EA008253B1 (ru) | 2003-08-07 | 2007-04-27 | Байоджен Айдек Ма Инк. | Антагонисты nogo-рецептора |
PL380274A1 (pl) | 2003-08-07 | 2007-01-22 | Biogen Idec Ma Inc. | Antagoniści receptora Nogo |
BRPI0507272A (pt) * | 2004-01-30 | 2007-06-26 | Biogen Idec Inc | tratamento de condições que envolvem degeneração neuronal dopaminérgica, usando antagonistas do receptor nogo |
US20120058125A1 (en) | 2006-08-31 | 2012-03-08 | Biogen Idec Ma Inc. | Methods relating to peripheral administration of nogo receptor polypeptides |
-
2003
- 2003-08-07 DK DK03785123.5T patent/DK1534736T3/da active
- 2003-08-07 WO PCT/US2003/025004 patent/WO2004014311A2/en active Application Filing
- 2003-08-07 PL PL03375301A patent/PL375301A1/xx not_active Application Discontinuation
- 2003-08-07 PT PT03785123T patent/PT1534736E/pt unknown
- 2003-08-07 EA EA200500330A patent/EA200500330A1/ru unknown
- 2003-08-07 AT AT03785123T patent/ATE469913T1/de active
- 2003-08-07 JP JP2004527960A patent/JP2005535329A/ja active Pending
- 2003-08-07 CN CNA038214091A patent/CN1681838A/zh active Pending
- 2003-08-07 MX MXPA05001615A patent/MXPA05001615A/es unknown
- 2003-08-07 CA CA002495121A patent/CA2495121A1/en not_active Abandoned
- 2003-08-07 DE DE60332842T patent/DE60332842D1/de not_active Expired - Lifetime
- 2003-08-07 AU AU2003264033A patent/AU2003264033A1/en not_active Abandoned
- 2003-08-07 BR BRPI0313331-1A patent/BR0313331A/pt not_active IP Right Cessation
- 2003-08-07 KR KR1020057002176A patent/KR20050062525A/ko not_active Application Discontinuation
- 2003-08-07 RS YUP-2005/0129A patent/RS20050129A/sr unknown
- 2003-08-07 ES ES03785123T patent/ES2346868T3/es not_active Expired - Lifetime
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2004
- 2004-01-30 RS YUP-2006/0089A patent/RS20060089A/sr unknown
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2005
- 2005-01-28 IS IS7677A patent/IS7677A/is unknown
- 2005-02-02 IL IL16665905A patent/IL166659A0/xx unknown
- 2005-02-08 ZA ZA200501135A patent/ZA200501135B/en unknown
- 2005-02-09 NO NO20050685A patent/NO20050685L/no not_active Application Discontinuation
- 2005-02-10 US US11/055,163 patent/US7465705B2/en not_active Expired - Lifetime
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2006
- 2006-02-06 IL IL173559A patent/IL173559A0/en unknown
- 2006-03-06 ZA ZA200601909A patent/ZA200601909B/en unknown
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2008
- 2008-12-15 US US12/335,328 patent/US8030456B2/en not_active Expired - Lifetime
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2010
- 2010-05-06 JP JP2010106824A patent/JP2010207239A/ja active Pending
-
2011
- 2011-04-07 JP JP2011085613A patent/JP2011173899A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20050062525A (ko) | 2005-06-23 |
ES2346868T3 (es) | 2010-10-21 |
US8030456B2 (en) | 2011-10-04 |
IL173559A0 (en) | 2006-07-05 |
ZA200601909B (en) | 2007-05-30 |
NO20050685L (no) | 2005-05-10 |
RS20060089A (en) | 2008-08-07 |
ZA200501135B (en) | 2006-10-25 |
AU2003264033A1 (en) | 2004-02-25 |
JP2010207239A (ja) | 2010-09-24 |
WO2004014311A3 (en) | 2004-04-29 |
US20050271655A1 (en) | 2005-12-08 |
RS20050129A (en) | 2007-06-04 |
BR0313331A (pt) | 2007-07-24 |
IL166659A0 (en) | 2006-01-15 |
PL375301A1 (en) | 2005-11-28 |
IS7677A (is) | 2005-01-28 |
MXPA05001615A (es) | 2005-08-19 |
US7465705B2 (en) | 2008-12-16 |
DE60332842D1 (de) | 2010-07-15 |
CA2495121A1 (en) | 2004-02-19 |
CN1681838A (zh) | 2005-10-12 |
ATE469913T1 (de) | 2010-06-15 |
PT1534736E (pt) | 2010-09-07 |
JP2011173899A (ja) | 2011-09-08 |
JP2005535329A (ja) | 2005-11-24 |
US20090215691A1 (en) | 2009-08-27 |
WO2004014311A2 (en) | 2004-02-19 |
EA200500330A1 (ru) | 2006-06-30 |
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