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DK1593690T3 - Fremstilling af ScFv-antistoffragmenter - Google Patents

Fremstilling af ScFv-antistoffragmenter

Info

Publication number
DK1593690T3
DK1593690T3 DK04010702T DK04010702T DK1593690T3 DK 1593690 T3 DK1593690 T3 DK 1593690T3 DK 04010702 T DK04010702 T DK 04010702T DK 04010702 T DK04010702 T DK 04010702T DK 1593690 T3 DK1593690 T3 DK 1593690T3
Authority
DK
Denmark
Prior art keywords
antibody fragments
preparation
scfv antibody
methods
invention further
Prior art date
Application number
DK04010702T
Other languages
English (en)
Inventor
Tobias Raum
Julia Henckel
Eva Krinner
Silke Mittelstrass
Andreas Wolf
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of DK1593690T3 publication Critical patent/DK1593690T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK04010702T 2004-05-05 2004-05-05 Fremstilling af ScFv-antistoffragmenter DK1593690T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010702A EP1593690B1 (en) 2004-05-05 2004-05-05 Preparation of ScFv antibody fragments

Publications (1)

Publication Number Publication Date
DK1593690T3 true DK1593690T3 (da) 2009-11-09

Family

ID=34924877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04010702T DK1593690T3 (da) 2004-05-05 2004-05-05 Fremstilling af ScFv-antistoffragmenter

Country Status (8)

Country Link
US (2) US8247194B2 (da)
EP (2) EP1593690B1 (da)
AT (1) ATE435238T1 (da)
AU (1) AU2005238203B2 (da)
CA (1) CA2562604C (da)
DE (1) DE602004021773D1 (da)
DK (1) DK1593690T3 (da)
WO (1) WO2005105844A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004021773D1 (de) * 2004-05-05 2009-08-13 Micromet Ag Herstellung eines einkettigen fv Antikörperfragments
EP1874819B1 (en) * 2005-04-18 2015-05-27 Amgen Research (Munich) GmbH Antibody neutralizers of human granulocyte macrophage colony stimulating factor
CN101218255B (zh) 2005-05-18 2013-01-09 莫菲西斯公司 抗gm-csf抗体和其用途
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
KR101395515B1 (ko) * 2006-02-08 2014-05-14 모르포테크, 인크. 항원성 ｇｍ-ｃｓｆ 펩티드 및 ｇｍ-ｃｓｆ에 대한 항체
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
BRPI0720271A2 (pt) 2006-12-14 2014-01-28 Schering Corp Anticorpo anti-tslp projetado
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
SI2215119T1 (sl) 2007-11-13 2013-04-30 Evec Inc. Monoklonska protitelesa, ki se veĹľejo na hGM-CSF, in medicinski sestavki, ki jih obsegajo
WO2010056898A2 (en) * 2008-11-12 2010-05-20 University Of Maryland, Baltimore Rapid expression cloning of human monoclonal antibodies from memory b cells
RU2630969C2 (ru) 2008-12-22 2017-09-15 Де Юниверсити Оф Мельбурн Лечение боли
KR101799264B1 (ko) 2008-12-22 2017-11-20 더 유니버시티 오브 멜버른 골관절염 치료
US8637019B2 (en) 2009-11-04 2014-01-28 Merck Sharp & Dohme Corp. Engineered anti-TSLP antibody
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
EP2914289B1 (en) 2012-10-31 2019-05-22 Takeda GmbH Lyophilized formulation comprising gm-csf neutralizing compound
KR20220045064A (ko) 2013-08-30 2022-04-12 다케다 야쿠힌 고교 가부시키가이샤 류마티스성 관절염의 치료에서 또는 진통제로서 사용하기 위한 gm-csf 중화 항체
US9884921B2 (en) 2014-07-01 2018-02-06 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
DE602004021773D1 (de) * 2004-05-05 2009-08-13 Micromet Ag Herstellung eines einkettigen fv Antikörperfragments

Also Published As

Publication number Publication date
WO2005105844A3 (en) 2006-01-26
US20080193978A1 (en) 2008-08-14
EP1593690B1 (en) 2009-07-01
CA2562604A1 (en) 2005-11-10
AU2005238203B2 (en) 2010-09-02
EP1593690A1 (en) 2005-11-09
DE602004021773D1 (de) 2009-08-13
ATE435238T1 (de) 2009-07-15
CA2562604C (en) 2014-02-18
EP1742967A2 (en) 2007-01-17
US9279017B2 (en) 2016-03-08
AU2005238203A1 (en) 2005-11-10
WO2005105844A2 (en) 2005-11-10
US8247194B2 (en) 2012-08-21
US20130171165A1 (en) 2013-07-04

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