DK1272488T3 - Tri-aryl-substitueret ethan-PDE4-inhibitorer - Google Patents

Tri-aryl-substitueret ethan-PDE4-inhibitorer

Info

Publication number: DK1272488T3
Authority: DK; Denmark
Prior art keywords: tri; aryl; pde4 inhibitors; substituted ethane; ethane
Prior art date: 2000-03-23

Application number

DK01914905T

Other languages

English (en)

Inventor

Richard Friesen

Yves Ducharme

Bernard Cote

Marc Blouin

Daniel Guay

Pierre Hamel

Mario Girard

Richard Frenette

Evelyn Martins

Sebastien Laliberte

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-23

Filing date

2001-03-19

Publication date

2006-07-17

2001-03-19 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2006-07-17 Application granted granted Critical

2006-07-17 Publication of DK1272488T3 publication Critical patent/DK1272488T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Neurology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Otolaryngology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)

DK01914905T 2000-03-23 2001-03-19 Tri-aryl-substitueret ethan-PDE4-inhibitorer DK1272488T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19166800P	2000-03-23	2000-03-23

Publications (1)

Publication Number	Publication Date
DK1272488T3 true DK1272488T3 (da)	2006-07-17

Family

ID=22706424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01914905T DK1272488T3 (da)	2000-03-23	2001-03-19	Tri-aryl-substitueret ethan-PDE4-inhibitorer

Country Status (16)

Country	Link
US (2)	US6399636B2 (da)
EP (1)	EP1272488B1 (da)
JP (1)	JP4944337B2 (da)
AR (1)	AR029240A1 (da)
AT (1)	ATE321043T1 (da)
AU (2)	AU4217201A (da)
CA (1)	CA2403423C (da)
DE (1)	DE60118165T2 (da)
DK (1)	DK1272488T3 (da)
ES (1)	ES2258521T3 (da)
JO (1)	JO2212B1 (da)
MY (1)	MY123585A (da)
PE (1)	PE20011115A1 (da)
PT (1)	PT1272488E (da)
TW (1)	TW575572B (da)
WO (1)	WO2001070738A2 (da)

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DE4328352A1 (de)	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6639077B2 (en) *	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
US6699890B2 (en)	2000-12-22	2004-03-02	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7205320B2 (en)	2001-01-22	2007-04-17	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7153871B2 (en)	2001-01-22	2006-12-26	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
WO2003000687A1 (en) *	2001-06-22	2003-01-03	Merck & Co., Inc.	Tyrosine kinase inhibitors
CA2460442A1 (en) *	2001-09-19	2003-03-27	Altana Pharma Ag	Combination of a pde inhibitor and a leukotriene receptor antagonist
US20060004056A1 (en) *	2002-07-02	2006-01-05	Bernard Cote	Di-aryl-substituted-ethan pyridone pde4 inhibitors
CN1688545A (zh)	2002-07-19	2005-10-26	记忆药物公司	磷酸二酯酶4抑制剂,包括n－取代的苯胺及二苯胺类似物
CA2492911A1 (en)	2002-07-19	2004-01-29	Memory Pharmaceuticals Corporation	6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
US6872724B2 (en)	2002-07-24	2005-03-29	Merck & Co., Inc.	Polymorphs with tyrosine kinase activity
AU2003288901A1 (en) *	2002-09-06	2004-03-29	Merck And Co., Inc.	Treatment of rheumatoid arthritis by inhibition of pde4
WO2004045508A2 (en) *	2002-11-15	2004-06-03	Merck & Co., Inc.	Use of pde4 inhibitors as adjunct therapy for psychiatric disorders
NZ540138A (en)	2002-11-19	2008-07-31	Memory Pharm Corp	Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors
AU2003286024A1 (en) *	2002-11-22	2004-06-18	Daniel Dube	Use of phosphodiesterase-4 inhibitors as enhancers of cognition
KR20050090435A (ko) *	2002-12-30	2005-09-13	셀진 코포레이션	플루오로알콕시-치환된 1,3-디히드로-이소인돌릴 화합물 및그의 제약학적 용도
US20060173028A1 (en) *	2003-03-17	2006-08-03	Kyowa Hakko Kogyo Co., Ltd.	Therapeutic and/or preventive agent for chronic skin disease
CN1913882A (zh) *	2004-02-06	2007-02-14	Meda制药有限及两合公司	用抗胆碱能药单独或联合抗组胺药、磷酸二酯酶4抑制剂或皮质类固醇来治疗鼻炎
ME01648B (me)	2006-07-05	2014-09-20	Nycomed Gmbh	Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4,kao što je roflumilast, roflumilast-n-oksid za liječenje inflamatornih plućnih oboljenja
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
WO2021237364A1 (en) *	2020-05-28	2021-12-02	Giiant Pharma Inc.	Gut microbiota bioactivated pde4 inhibitor precursors

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GB9212693D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
GB9212673D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
EP0577024B1 (de)	1992-07-01	1996-10-16	Hoechst Aktiengesellschaft	3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9222253D0 (en)	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
US5622977A (en)	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
GB9226830D0 (en)	1992-12-23	1993-02-17	Celltech Ltd	Chemical compounds
DE4306152A1 (de)	1993-02-27	1994-09-01	Hoechst Ag	Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
GB9304919D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
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DE4318756A1 (de)	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE260911T1 (de)	1993-12-22	2004-03-15	Celltech R&D Ltd	Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
GB9326173D0 (en)	1993-12-22	1994-02-23	Celltech Ltd	Chemical compounds and process
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EP0765867A1 (de)	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
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GB9603723D0 (en)	1996-02-22	1996-04-24	Merck & Co Inc	Diphenyl pyridyl derivatives as pde iv inhibitors
GB9526245D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526243D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
DE19622370A1 (de)	1996-06-04	1997-12-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9625184D0 (en)	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
HUP0000475A3 (en)	1996-12-11	2002-11-28	Basf Ag	Ketobenzamides as calpain inhibitors
IL138745A0 (en)	1998-04-01	2001-10-31	Janssen Pharmaceutica Nv	Pde iv inhibiting pyridine derivatives
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.

2001
- 2001-03-13 MY MYPI20011169A patent/MY123585A/en unknown
- 2001-03-16 US US09/810,119 patent/US6399636B2/en not_active Expired - Fee Related
- 2001-03-19 DK DK01914905T patent/DK1272488T3/da active
- 2001-03-19 AU AU4217201A patent/AU4217201A/xx active Pending
- 2001-03-19 AT AT01914905T patent/ATE321043T1/de active
- 2001-03-19 ES ES01914905T patent/ES2258521T3/es not_active Expired - Lifetime
- 2001-03-19 WO PCT/CA2001/000365 patent/WO2001070738A2/en active IP Right Grant
- 2001-03-19 DE DE60118165T patent/DE60118165T2/de not_active Expired - Lifetime
- 2001-03-19 CA CA2403423A patent/CA2403423C/en not_active Expired - Fee Related
- 2001-03-19 JP JP2001568939A patent/JP4944337B2/ja not_active Expired - Fee Related
- 2001-03-19 PT PT01914905T patent/PT1272488E/pt unknown
- 2001-03-19 AU AU2001242172A patent/AU2001242172B2/en not_active Ceased
- 2001-03-19 EP EP01914905A patent/EP1272488B1/en not_active Expired - Lifetime
- 2001-03-20 PE PE2001000258A patent/PE20011115A1/es not_active Application Discontinuation
- 2001-03-21 JO JO200136A patent/JO2212B1/en active
- 2001-03-21 TW TW90106613A patent/TW575572B/zh not_active IP Right Cessation
- 2001-03-22 AR ARP010101343A patent/AR029240A1/es unknown
2002
- 2002-03-20 US US10/102,552 patent/US6841564B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PE20011115A1 (es)	2001-10-29
US6841564B2 (en)	2005-01-11
JP4944337B2 (ja)	2012-05-30
ATE321043T1 (de)	2006-04-15
DE60118165T2 (de)	2006-12-14
MY123585A (en)	2006-05-31
AR029240A1 (es)	2003-06-18
TW575572B (en)	2004-02-11
EP1272488A2 (en)	2003-01-08
CA2403423C (en)	2010-05-25
PT1272488E (pt)	2006-07-31
ES2258521T3 (es)	2006-09-01
WO2001070738A3 (en)	2002-08-01
JO2212B1 (en)	2004-10-07
WO2001070738A2 (en)	2001-09-27
US6399636B2 (en)	2002-06-04
EP1272488B1 (en)	2006-03-22
DE60118165D1 (en)	2006-05-11
JP2003528099A (ja)	2003-09-24
CA2403423A1 (en)	2001-09-27
AU4217201A (en)	2001-10-03
US20020013347A1 (en)	2002-01-31
US20020173661A1 (en)	2002-11-21
AU2001242172B2 (en)	2005-01-27

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