DK1140984T3 - Selektive inhibitorer af MMP-12 - Google Patents

Selektive inhibitorer af MMP-12

Info

Publication number: DK1140984T3
Authority: DK; Denmark
Prior art keywords: mmp; selective inhibitors; inhibitors; selective
Prior art date: 1998-12-31

Application number

DK99960295T

Other languages

English (en)

Inventor

Alan M Warshawsky

Michael J Janusz

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-11-12

Publication date

2003-05-26

1999-11-12 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1140984T3 publication Critical patent/DK1140984T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK99960295T 1998-12-31 1999-11-12 Selektive inhibitorer af MMP-12 DK1140984T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22455098A	1998-12-31	1998-12-31
PCT/US1999/026749 WO2000040600A1 (en)	1998-12-31	1999-11-12	Selective inhibitors of mmp-12

Publications (1)

Publication Number	Publication Date
DK1140984T3 true DK1140984T3 (da)	2003-05-26

Family

ID=22841172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99960295T DK1140984T3 (da)	1998-12-31	1999-11-12	Selektive inhibitorer af MMP-12

Country Status (10)

Country	Link
EP (1)	EP1140984B1 (da)
JP (1)	JP2002534435A (da)
AR (1)	AR022170A1 (da)
AT (1)	ATE232544T1 (da)
AU (1)	AU1719700A (da)
CA (1)	CA2356919A1 (da)
DE (1)	DE69905397T2 (da)
DK (1)	DK1140984T3 (da)
ES (1)	ES2188277T3 (da)
WO (1)	WO2000040600A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6777443B2 (en)	2001-05-15	2004-08-17	Novartis Ag	Dipeptide derivatives
EP1394159A1 (fr) *	2002-08-13	2004-03-03	Warner-Lambert Company LLC	Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP2907512A1 (en)	2014-02-14	2015-08-19	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Inhibitors of MMP-12 as antiviral Agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL69795A (en) *	1983-09-23	1987-01-30	Univ Ramot	Ophthalmic preparations containing as active ingredient 2-mercaptoalkanoyl peptides
GB9607120D0 (en) *	1996-04-04	1996-06-12	Chiroscience Ltd	Compounds
GB9615976D0 (en) *	1996-07-30	1996-09-11	Center For Clinical & Basic Re	The use of proteinase inhibitors for the prevention or reduction of bone resorption
EA002971B1 (ru) *	1998-01-09	2002-12-26	Пфайзер Инк.	Ингибиторы металлопротеаз матрикса, способы их получения, фармкомпозиция, применение и способ лечения

1999
- 1999-11-12 ES ES99960295T patent/ES2188277T3/es not_active Expired - Lifetime
- 1999-11-12 CA CA002356919A patent/CA2356919A1/en not_active Abandoned
- 1999-11-12 AU AU17197/00A patent/AU1719700A/en not_active Abandoned
- 1999-11-12 WO PCT/US1999/026749 patent/WO2000040600A1/en active IP Right Grant
- 1999-11-12 JP JP2000592308A patent/JP2002534435A/ja active Pending
- 1999-11-12 DK DK99960295T patent/DK1140984T3/da active
- 1999-11-12 DE DE69905397T patent/DE69905397T2/de not_active Expired - Fee Related
- 1999-11-12 AT AT99960295T patent/ATE232544T1/de not_active IP Right Cessation
- 1999-11-12 EP EP99960295A patent/EP1140984B1/en not_active Expired - Lifetime
- 1999-12-30 AR ARP990106864A patent/AR022170A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE232544T1 (de)	2003-02-15
EP1140984B1 (en)	2003-02-12
AR022170A1 (es)	2002-09-04
EP1140984A1 (en)	2001-10-10
AU1719700A (en)	2000-07-24
CA2356919A1 (en)	2000-07-13
JP2002534435A (ja)	2002-10-15
DE69905397D1 (de)	2003-03-20
DE69905397T2 (de)	2003-12-18
ES2188277T3 (es)	2003-06-16
WO2000040600A1 (en)	2000-07-13

Publication	Publication Date	Title
DK1064298T3 (da)	2009-01-19	Inhibitorer af caspaser
DK1077943T3 (da)	2009-03-16	Heterocykliske inhibitorer af p38
PT1114051E (pt)	2003-07-31	Inibidores de p38
DK1049662T3 (da)	2006-10-23	Inhibitorer af alpha4-medieret celleadhæsion
NO20004550D0 (no)	2000-09-12	Enzyminhibitorer
DK1107980T3 (da)	2003-04-22	Krystallinske former af EtO2C-CH2-(R)Cgl-Aze-Pab-OH
IS5772A (is)	2000-12-15	Þalazín (phthalazine) afleiður af fosfódíesterasa4 lötum
DE69930340D1 (de)	2006-05-11	Reibahle
DK0989543T3 (da)	2007-03-26	Indretning for tilföjelse af lydeffekt
NO20003814D0 (no)	2000-07-25	Trombininhibitorer
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
ID28032A (id)	2001-05-03	TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
DK1155050T3 (da)	2007-06-11	Fremstilling af polyolefin
DE69903319D1 (de)	2002-11-07	Fkbp inhibitoren
NO20010085D0 (no)	2001-01-05	Angiogeneseinhibitorer
IS5155A (is)	2000-02-22	Fjölgervingur af zópólrestat mónóhýdrati
IS5821A (is)	2001-01-23	Kristalluð form af ósanetant
DE59909114D1 (de)	2004-05-13	Armschiene
DK1140984T3 (da)	2003-05-26	Selektive inhibitorer af MMP-12
EE200100017A (et)	2002-06-17	N-tert-butüülhüdroksüülamiini uued soolad
DE59911393D1 (de)	2005-02-10	Ausdrehkopf
DK1088010T3 (da)	2004-07-12	Fremstilling af polyolefiner
NO993161L (no)	2000-01-03	Cyklooksygenaseinhibitor
FI980856A0 (fi)	1998-04-17	Andningsskydd utrustad med en identifierare
ATE303996T1 (de)	2005-09-15	Substituierte acylaminophenyl-uracile