DK0934950T3 - Tetrapeptidderivat - Google Patents

Tetrapeptidderivat

Info

Publication number: DK0934950T3
Authority: DK; Denmark
Prior art keywords: chem; tetrapeptide; dolastatin; salt; useful
Prior art date: 1991-08-09

Application number

DK98115259T

Other languages

English (en)

Inventor

Kyoichi Sakakibara

Masaaki Gondo

Koichi Miyazaki

Original Assignee

Teikoku Hormone Mfg Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-09

Filing date

1992-08-06

Publication date

2002-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0934950(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-08-06 Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd

2002-07-29 Application granted granted Critical

2002-07-29 Publication of DK0934950T3 publication Critical patent/DK0934950T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK98115259T 1991-08-09 1992-08-06 Tetrapeptidderivat DK0934950T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP22353491		1991-08-09
JP22539191		1991-08-12

Publications (1)

Publication Number	Publication Date
DK0934950T3 true DK0934950T3 (da)	2002-07-29

Family

ID=26525532

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK92916961T DK0598129T3 (da)	1991-08-09	1992-08-06	Nye tetrapeptidderivater
DK98115259T DK0934950T3 (da)	1991-08-09	1992-08-06	Tetrapeptidderivat

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK92916961T DK0598129T3 (da)	1991-08-09	1992-08-06	Nye tetrapeptidderivater

Country Status (13)

Country	Link
US (2)	US6004934A (da)
EP (2)	EP0598129B1 (da)
JP (1)	JP2618597B2 (da)
KR (2)	KR0185440B1 (da)
AT (2)	ATE215962T1 (da)
AU (2)	AU662551B2 (da)
CA (1)	CA2115355C (da)
DE (2)	DE69230824T2 (da)
DK (2)	DK0598129T3 (da)
ES (2)	ES2172069T3 (da)
GR (1)	GR3033397T3 (da)
SG (1)	SG87056A1 (da)
WO (1)	WO1993003054A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
RU2116312C1 (ru) *	1992-05-20	1998-07-27	Басф Акциенгезельшафт	Производные пептида или их соли, фармацевтическая композиция
EP0674652B1 (en) *	1992-12-16	2000-09-13	Basf Aktiengesellschaft	Dolastatin analog
WO1995009864A1 (fr) *	1993-10-01	1995-04-13	Teikoku Hormone Mfg. Co., Ltd.	Nouveau derive peptidique
US5599902A (en) *	1994-11-10	1997-02-04	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Cancer inhibitory peptides
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
WO1996033212A1 (fr) *	1995-04-21	1996-10-24	Teikoku Hormone Mfg. Co., Ltd.	Nouveaux derives peptidiques
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
US20010009901A1 (en)	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5939527A (en) *	1996-07-30	1999-08-17	Basf Aktiengesellschaft	Tetrapeptides as antitumor agents
US5741892A (en) *	1996-07-30	1998-04-21	Basf Aktiengesellschaft	Pentapeptides as antitumor agents
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en)	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en)	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6686445B1 (en)	1997-09-24	2004-02-03	Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University	Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
DE69829881T2 (de) *	1997-09-24	2006-03-09	Arizona Board Of Regents, Tempe	Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6323315B1 (en) *	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides
EP2289549A3 (en)	1999-10-01	2011-06-15	Immunogen, Inc.	Immunoconjugates for treating cancer
WO2001041789A1 (fr) *	1999-12-07	2001-06-14	Santen Pharmaceutical Co., Ltd.	Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US6884869B2 (en) *	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
KR20010079252A (ko) *	2001-06-27	2001-08-22	홍진의	주름형 드럼을 갖는 드럼 필터
ES2309233T3 (es) *	2001-09-20	2008-12-16	Aska Pharmaceutical Co., Ltd.	Cristales de derivado tetrapeptidico.
SI1545613T1 (sl)	2002-07-31	2011-11-30	Seattle Genetics Inc	Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
EP2478912B1 (en) *	2003-11-06	2016-08-31	Seattle Genetics, Inc.	Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
EP1817336B1 (en) *	2004-11-12	2019-01-09	Seattle Genetics, Inc.	Auristatins having an aminobenzoic acid unit at the n terminus
EP1883627B1 (en)	2005-05-18	2018-04-18	Pharmascience Inc.	Bir domain binding compounds
ES2585357T3 (es)	2005-07-07	2016-10-05	Seattle Genetics, Inc.	Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
WO2007008848A2 (en) *	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
JP5419685B2 (ja)	2006-05-16	2014-02-19	ファーマサイエンス・インコーポレイテッド	Ｉａｐｂｉｒドメイン結合タンパク質
ES2579323T3 (es)	2007-07-16	2016-08-09	Genentech, Inc.	Anticuerpos anti-CD79B e inmunoconjugados y métodos de uso
CL2008002083A1 (es)	2007-07-16	2008-11-21	Genentech Inc	Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico
US20090035848A1 (en) *	2007-08-03	2009-02-05	Robert Hickey	Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
PE20091318A1 (es)	2008-01-31	2009-09-16	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados y metodos de uso de los mismos
US8609105B2 (en) *	2008-03-18	2013-12-17	Seattle Genetics, Inc.	Auristatin drug linker conjugates
NZ602368A (en)	2010-02-12	2014-10-31	Pharmascience Inc	Iap bir domain binding compounds
MX352738B (es)	2011-11-17	2017-12-06	Pfizer	Peptidos citotoxicos y conjugados de anticuerpo-farmaco de los mismos.
ES2604766T3 (es)	2012-09-20	2017-03-09	Celltrion, Inc.	Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo
AU2012395148B2 (en)	2012-11-24	2016-10-27	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
EP3753578A1 (en)	2013-12-17	2020-12-23	Novartis AG	Cytotoxic peptides and conjugates thereof
CN106414465B (zh)	2014-02-28	2021-11-16	杭州多禧生物科技有限公司	带电荷链接体及其在共轭反应上的应用
WO2015183978A1 (en) *	2014-05-28	2015-12-03	Agensys, Inc.	Derivatives of dolaproine-dolaisoleuine peptides
KR20170016479A (ko)	2014-06-13	2017-02-13	노파르티스 아게	아우리스타틴 유도체 및 그의 접합체
BR112017023576A2 (pt)	2014-09-23	2023-10-03	Genentech Inc	Método para tratar uma disfunção proliferativa de células b
WO2015151081A2 (en)	2015-07-12	2015-10-08	Suzhou M-Conj Biotech Co., Ltd	Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CA2993321A1 (en)	2015-07-24	2017-02-02	George Robert Pettit	Quinstatin compounds
US10722593B2 (en)	2015-10-02	2020-07-28	Sirenas Llc	Anti-cancer compounds and conjugates thereof
ES2948846T3 (es) *	2016-03-29	2023-09-20	Toray Industries	Derivado peptídico y uso del mismo
JP7138350B2 (ja)	2016-11-14	2022-09-16	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．	共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法
US20230000995A1 (en) *	2019-10-28	2023-01-05	Ariel Scientific Innovations Ltd.	Dolastatin 10 analog
CN118119409A (zh)	2021-09-03	2024-05-31	东丽株式会社	癌的治疗和/或预防用药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5017691A (en) *	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4978744A (en) *	1989-01-27	1990-12-18	Arizona Board Of Regents	Synthesis of dolastatin 10
US5635483A (en) *	1992-12-03	1997-06-03	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) *	1992-12-03	2000-03-07	Arizona Board Of Regents	Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

1992
- 1992-08-06 SG SG9905131A patent/SG87056A1/en unknown
- 1992-08-06 DK DK92916961T patent/DK0598129T3/da active
- 1992-08-06 US US08/190,194 patent/US6004934A/en not_active Expired - Fee Related
- 1992-08-06 DE DE69230824T patent/DE69230824T2/de not_active Expired - Lifetime
- 1992-08-06 DK DK98115259T patent/DK0934950T3/da active
- 1992-08-06 CA CA002115355A patent/CA2115355C/en not_active Expired - Fee Related
- 1992-08-06 EP EP92916961A patent/EP0598129B1/en not_active Expired - Lifetime
- 1992-08-06 KR KR1019940700418A patent/KR0185440B1/ko not_active IP Right Cessation
- 1992-08-06 ES ES98115259T patent/ES2172069T3/es not_active Expired - Lifetime
- 1992-08-06 WO PCT/JP1992/001005 patent/WO1993003054A1/ja active IP Right Grant
- 1992-08-06 JP JP5503479A patent/JP2618597B2/ja not_active Expired - Fee Related
- 1992-08-06 AT AT98115259T patent/ATE215962T1/de not_active IP Right Cessation
- 1992-08-06 EP EP98115259A patent/EP0934950B1/en not_active Expired - Lifetime
- 1992-08-06 DE DE69232552T patent/DE69232552T2/de not_active Expired - Fee Related
- 1992-08-06 AT AT92916961T patent/ATE190983T1/de not_active IP Right Cessation
- 1992-08-06 ES ES92916961T patent/ES2144421T3/es not_active Expired - Lifetime
- 1992-08-06 AU AU24152/92A patent/AU662551B2/en not_active Ceased
1995
- 1995-05-12 AU AU20010/95A patent/AU673487B2/en not_active Ceased
- 1995-07-03 US US08/498,688 patent/US5654399A/en not_active Expired - Lifetime
1998
- 1998-09-23 KR KR1019980707541A patent/KR100202474B1/ko not_active IP Right Cessation
2000
- 2000-05-11 GR GR20000401085T patent/GR3033397T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0598129T3 (da)	2000-07-03
AU2001095A (en)	1995-07-20
GR3033397T3 (en)	2000-09-29
DE69232552D1 (de)	2002-05-16
AU2415292A (en)	1993-03-02
KR0185440B1 (ko)	1999-04-01
EP0934950B1 (en)	2002-04-10
DE69230824T2 (de)	2000-07-27
ES2172069T3 (es)	2002-09-16
EP0598129A4 (en)	1995-10-25
JP2618597B2 (ja)	1997-06-11
EP0934950A1 (en)	1999-08-11
WO1993003054A1 (en)	1993-02-18
US6004934A (en)	1999-12-21
ES2144421T3 (es)	2000-06-16
AU673487B2 (en)	1996-11-07
EP0598129A1 (en)	1994-05-25
KR100202474B1 (en)	1999-06-15
AU662551B2 (en)	1995-09-07
CA2115355C (en)	2007-09-11
EP0598129B1 (en)	2000-03-22
DE69232552T2 (de)	2002-10-31
DE69230824D1 (de)	2000-04-27
ATE190983T1 (de)	2000-04-15
US5654399A (en)	1997-08-05
CA2115355A1 (en)	1993-02-18
SG87056A1 (en)	2002-03-19
ATE215962T1 (de)	2002-04-15

Publication	Publication Date	Title
DK0934950T3 (da)	2002-07-29	Tetrapeptidderivat
FI914928A (fi)	1992-04-19	Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
DE69533277D1 (de)	2004-08-26	Dc-89 derivat
NL300374I1 (nl)	2009-04-01	Een pyrrolidylthiocarbapenemderivaat met antibacteriële werkzaamheid
TW269687B (da)	1996-02-01
ES2093037T3 (es)	1996-12-16	Derivados de beta-lactama y su preparacion.
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
DE69312776D1 (de)	1997-09-11	Fungizide 3,4-Diaryl-(5H)-Furan-2-Onederivate
ATE190308T1 (de)	2000-03-15	Epoxycyclohexendionderivat
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
FI963568A (fi)	1996-11-07	Peptidijohdannaisia
ES2064577T3 (es)	1995-02-01	N-azabiciclo(3.3.0)octanoamidas de acidos aromaticos.
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ATE159253T1 (de)	1997-11-15	2-thiazolylpyrroleakrylate mit fungizider wirkung