DK0977873T3 - Fremgangsmåde til spaltning af fusionsproteiner - Google Patents
Fremgangsmåde til spaltning af fusionsproteinerInfo
- Publication number
- DK0977873T3 DK0977873T3 DK98916746T DK98916746T DK0977873T3 DK 0977873 T3 DK0977873 T3 DK 0977873T3 DK 98916746 T DK98916746 T DK 98916746T DK 98916746 T DK98916746 T DK 98916746T DK 0977873 T3 DK0977873 T3 DK 0977873T3
- Authority
- DK
- Denmark
- Prior art keywords
- cleavage
- fusion proteins
- fusion
- proteins
- Prior art date
Links
- 238000003776 cleavage reaction Methods 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4425497P | 1997-04-25 | 1997-04-25 | |
PCT/CA1998/000398 WO1998049326A1 (en) | 1997-04-25 | 1998-04-23 | Method for cleavage of fusion proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0977873T3 true DK0977873T3 (da) | 2007-02-05 |
Family
ID=21931348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98916746T DK0977873T3 (da) | 1997-04-25 | 1998-04-23 | Fremgangsmåde til spaltning af fusionsproteiner |
Country Status (18)
Country | Link |
---|---|
US (1) | US7501265B1 (es) |
EP (1) | EP0977873B1 (es) |
JP (1) | JP4120972B2 (es) |
KR (2) | KR100635623B1 (es) |
AR (1) | AR012499A1 (es) |
AT (1) | ATE341633T1 (es) |
AU (1) | AU742794B2 (es) |
BR (1) | BR9809416A (es) |
CA (1) | CA2286861A1 (es) |
DE (1) | DE69836075T2 (es) |
DK (1) | DK0977873T3 (es) |
ES (1) | ES2273414T3 (es) |
IL (2) | IL132259A0 (es) |
MX (1) | MX219629B (es) |
NZ (1) | NZ500736A (es) |
TW (1) | TW505697B (es) |
WO (1) | WO1998049326A1 (es) |
ZA (1) | ZA983471B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420157B1 (en) * | 1999-04-30 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
WO2000066709A2 (en) * | 1999-04-30 | 2000-11-09 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
JP4820512B2 (ja) * | 1999-08-09 | 2011-11-24 | サンド・アクチエンゲゼルシヤフト | タンパク質の製造 |
JP5480458B2 (ja) * | 1999-08-09 | 2014-04-23 | サンド・アクチエンゲゼルシヤフト | 自己タンパク質分解切断によるタンパク質の製造 |
US7390936B1 (en) | 1999-08-23 | 2008-06-24 | Sembiosys Genetics Inc. | Commercial production of chymosin in plants |
ATE400661T1 (de) * | 1999-08-23 | 2008-07-15 | Sembiosys Genetics Inc | Kommerzielle herstellung von chymosin in pflanzen |
US6750034B1 (en) | 2000-06-30 | 2004-06-15 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human serine protease D-G |
US6737262B1 (en) | 2000-07-11 | 2004-05-18 | Robert I. Bolla | Animal feed containing polypeptides |
TWI345587B (en) | 2003-06-17 | 2011-07-21 | Sembiosys Genetics Inc | Methods for the production of insulin in plants |
JP5639324B2 (ja) | 2003-08-06 | 2014-12-10 | ユニバーシティー オブ メリーランド,カレッジ パーク | 融合タンパク質のアフィニティ精製およびプロセッシングのための修飾されたプロテアーゼ |
CN102389575B (zh) * | 2011-11-18 | 2013-01-23 | 武汉凯肽来生物科技有限公司 | 一种基因工程口服dna疫苗及制备方法和应用 |
WO2013142859A2 (en) * | 2012-03-23 | 2013-09-26 | Wuhan Peptech Pharmaceutical Co., Ltd. | Fusion proteins of superfolder green fluorescent protein and use thereof |
US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
WO2022072718A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4180559A (en) * | 1978-01-05 | 1979-12-25 | Richardson-Merrell Inc. | Coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine compositions |
US4774183A (en) * | 1983-06-29 | 1988-09-27 | Kansas State University Research Foundation | Process for producing fructose |
AU3036684A (en) | 1983-07-07 | 1985-01-10 | Genex Corp. | Production of bovine calf chymosin |
US4743679A (en) | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
DK0511978T3 (da) | 1990-01-24 | 1994-08-01 | Upjohn Co | Fremgangsmåde til rensning af rekombinante polypeptider |
US5650554A (en) * | 1991-02-22 | 1997-07-22 | Sembiosys Genetics Inc. | Oil-body proteins as carriers of high-value peptides in plants |
AU675506B2 (en) * | 1993-01-15 | 1997-02-06 | Genetics Institute, Llc | Cloning of enterokinase and method of use |
US6265204B1 (en) * | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
-
1998
- 1998-04-23 DE DE69836075T patent/DE69836075T2/de not_active Expired - Fee Related
- 1998-04-23 DK DK98916746T patent/DK0977873T3/da active
- 1998-04-23 MX MX9909801A patent/MX219629B/es not_active IP Right Cessation
- 1998-04-23 NZ NZ500736A patent/NZ500736A/en unknown
- 1998-04-23 TW TW087106216A patent/TW505697B/zh active
- 1998-04-23 JP JP54643998A patent/JP4120972B2/ja not_active Expired - Fee Related
- 1998-04-23 ES ES98916746T patent/ES2273414T3/es not_active Expired - Lifetime
- 1998-04-23 AU AU70240/98A patent/AU742794B2/en not_active Ceased
- 1998-04-23 EP EP98916746A patent/EP0977873B1/en not_active Expired - Lifetime
- 1998-04-23 BR BR9809416-5A patent/BR9809416A/pt not_active IP Right Cessation
- 1998-04-23 WO PCT/CA1998/000398 patent/WO1998049326A1/en active IP Right Grant
- 1998-04-23 AT AT98916746T patent/ATE341633T1/de not_active IP Right Cessation
- 1998-04-23 CA CA002286861A patent/CA2286861A1/en not_active Abandoned
- 1998-04-23 KR KR1020057018518A patent/KR100635623B1/ko not_active IP Right Cessation
- 1998-04-23 AR ARP980101873A patent/AR012499A1/es active IP Right Grant
- 1998-04-23 IL IL13225998A patent/IL132259A0/xx active IP Right Grant
- 1998-04-23 KR KR1019997009596A patent/KR100609886B1/ko not_active IP Right Cessation
- 1998-04-23 US US09/402,488 patent/US7501265B1/en not_active Expired - Fee Related
- 1998-04-24 ZA ZA983471A patent/ZA983471B/xx unknown
-
1999
- 1999-10-07 IL IL132259A patent/IL132259A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE341633T1 (de) | 2006-10-15 |
IL132259A (en) | 2007-05-15 |
CA2286861A1 (en) | 1998-11-05 |
MX219629B (es) | 2004-03-30 |
JP4120972B2 (ja) | 2008-07-16 |
DE69836075T2 (de) | 2007-06-06 |
TW505697B (en) | 2002-10-11 |
JP2001527400A (ja) | 2001-12-25 |
WO1998049326A1 (en) | 1998-11-05 |
EP0977873B1 (en) | 2006-10-04 |
BR9809416A (pt) | 2000-06-13 |
AU7024098A (en) | 1998-11-24 |
MX9909801A (es) | 2000-03-31 |
AU742794B2 (en) | 2002-01-10 |
US7501265B1 (en) | 2009-03-10 |
DE69836075D1 (de) | 2006-11-16 |
NZ500736A (en) | 2005-01-28 |
KR100635623B1 (ko) | 2006-10-18 |
AR012499A1 (es) | 2000-10-18 |
ZA983471B (en) | 1998-10-27 |
KR20050100712A (ko) | 2005-10-19 |
IL132259A0 (en) | 2001-03-19 |
EP0977873A1 (en) | 2000-02-09 |
ES2273414T3 (es) | 2007-05-01 |
KR20010006506A (ko) | 2001-01-26 |
KR100609886B1 (ko) | 2006-08-18 |
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