DK0969873T3 - Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf - Google Patents

Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf

Info

Publication number: DK0969873T3
Authority: DK; Denmark
Prior art keywords: carbohydrate; multiple carbohydrate; vaccine; glycopeptide antigens; subject
Prior art date: 1997-03-27

Application number

DK98913748T

Other languages

English (en)

Inventor

Claude Leclerc

Sylvie Bay

Daniele Cantacuzene

Richard Lo-Man

Original Assignee

Pasteur Institut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-27

Filing date

1998-03-27

Publication date

2006-10-09

1998-03-27 Application filed by Pasteur Institut filed Critical Pasteur Institut

2006-10-09 Application granted granted Critical

2006-10-09 Publication of DK0969873T3 publication Critical patent/DK0969873T3/da

Links

150000001720 carbohydrates Chemical class 0.000 title abstract 5
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
102000002068 Glycopeptides Human genes 0.000 title 1
108010015899 Glycopeptides Proteins 0.000 title 1
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1
239000000863 peptide conjugate Substances 0.000 abstract 2
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Carbon And Carbon Compounds (AREA)

DK98913748T 1997-03-27 1998-03-27 Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf DK0969873T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4172697P	1997-03-27	1997-03-27

Publications (1)

Publication Number	Publication Date
DK0969873T3 true DK0969873T3 (da)	2006-10-09

Family

ID=21918009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98913748T DK0969873T3 (da)	1997-03-27	1998-03-27	Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf

Country Status (10)

Country	Link
US (1)	US7696326B2 (da)
EP (1)	EP0969873B1 (da)
AT (1)	ATE328611T1 (da)
AU (1)	AU6832398A (da)
CA (1)	CA2285018C (da)
DE (1)	DE69834808T2 (da)
DK (1)	DK0969873T3 (da)
ES (1)	ES2265162T3 (da)
PT (1)	PT969873E (da)
WO (1)	WO1998043677A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6660842B1 (en)	1994-04-28	2003-12-09	Tripep Ab	Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US6933366B2 (en)	1996-12-27	2005-08-23	Tripep Ab	Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US7018637B2 (en)	1998-02-23	2006-03-28	Aventis Pasteur, Inc	Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
GB9808932D0 (en)	1998-04-27	1998-06-24	Chiron Spa	Polyepitope carrier protein
WO2000047229A2 (en) *	1999-02-11	2000-08-17	Genzyme Corporation	Polynucleotide encoding multimers of antigenic peptides in order to enhance presentation of the antigenic peptide by mhc molecules
EP1417965A1 (en) *	2002-11-07	2004-05-12	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	C-type lectin binding molecules, identification and uses thereof
US8133881B2 (en)	2003-01-13	2012-03-13	Shire Llc	Carbohydrate conjugates to prevent abuse of controlled substances
US7335359B2 (en)	2003-02-06	2008-02-26	Tripep Ab	Glycosylated specificity exchangers
KR20050099536A (ko)	2003-02-06	2005-10-13	트리펩 아베	글리코실화된 특이성 교환체
WO2005037190A2 (en) *	2003-09-03	2005-04-28	Dendritherapeutics, Inc.	Multiplex vaccines
EP1793863B1 (en) *	2004-10-01	2017-04-12	Midatech Ltd.	Nanoparticles comprising antigens and adjuvants capable of stimulating t helper cells
GB0428394D0 (en) *	2004-12-24	2005-02-02	Chiron Srl	Saccharide conjugate vaccines
WO2007079448A2 (en)	2006-01-03	2007-07-12	University Of Georgia Research Foundation, Inc.	Three component carbohydrate vaccine
WO2010002478A2 (en)	2008-07-03	2010-01-07	University Of Georgia Research Foundation, Inc.	Glycopeptide and uses thereof
ES2366552T3 (es)	2006-01-13	2011-10-21	Institut Pasteur	Síntesis enzimática a gran escala de glicoconjugados de mucina y sus aplicaciones en inmunología.
ES2834916T3 (es) *	2006-08-11	2021-06-21	Starpharma Pty Ltd	Agente terapéutico dirigido de dendrímero de polilisina
WO2008017122A1 (en)	2006-08-11	2008-02-14	Starpharma Pty Ltd	Polylysine dendrimer contrast agent
EP2413964B1 (en)	2009-04-01	2019-11-13	University of Miami	Vaccine compositions and methods of use thereof
EP2500033A1 (en)	2011-03-17	2012-09-19	Institut Pasteur	Method for preparing muliple antigen glycopeptide carbohydrate conjugates
WO2014053521A2 (en) *	2012-10-02	2014-04-10	Novartis Ag	Nonlinear saccharide conjugates
US9815886B2 (en)	2014-10-28	2017-11-14	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
CN106866793B (zh) *	2015-12-14	2022-04-19	韩苏	一种多肽化合物及其制备方法与应用
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4386026A (en)	1981-04-20	1983-05-31	Merck & Co., Inc.	Cell-specific glycopeptide ligands
US5229490A (en)	1987-05-06	1993-07-20	The Rockefeller University	Multiple antigen peptide system
DE59106279D1 (de) *	1990-05-18	1995-09-21	Genentech Inc	Neue protein-polykation-konjugate.
GB9202219D0 (en) *	1992-02-03	1992-03-18	Connaught Lab	A synthetic heamophilus influenzae conjugate vaccine
IL105503A (en) *	1992-04-28	1999-05-09	Astra Ab	Carbon peptide couplets capable of eliciting an immune response of T cells
US5580563A (en)	1992-05-01	1996-12-03	Tam; James P.	Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof

1998
- 1998-03-27 PT PT98913748T patent/PT969873E/pt unknown
- 1998-03-27 DK DK98913748T patent/DK0969873T3/da active
- 1998-03-27 CA CA2285018A patent/CA2285018C/en not_active Expired - Lifetime
- 1998-03-27 AT AT98913748T patent/ATE328611T1/de active
- 1998-03-27 WO PCT/EP1998/001922 patent/WO1998043677A1/en active IP Right Grant
- 1998-03-27 ES ES98913748T patent/ES2265162T3/es not_active Expired - Lifetime
- 1998-03-27 DE DE69834808T patent/DE69834808T2/de not_active Expired - Lifetime
- 1998-03-27 EP EP98913748A patent/EP0969873B1/en not_active Expired - Lifetime
- 1998-03-27 AU AU68323/98A patent/AU6832398A/en not_active Abandoned
2007
- 2007-01-03 US US11/619,457 patent/US7696326B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0969873A1 (en)	2000-01-12
ES2265162T3 (es)	2007-02-01
DE69834808T2 (de)	2007-06-06
US20070098730A1 (en)	2007-05-03
WO1998043677A1 (en)	1998-10-08
CA2285018A1 (en)	1998-10-08
EP0969873B1 (en)	2006-06-07
PT969873E (pt)	2006-09-29
US7696326B2 (en)	2010-04-13
ATE328611T1 (de)	2006-06-15
AU6832398A (en)	1998-10-22
DE69834808D1 (de)	2006-07-20
CA2285018C (en)	2011-01-04

Publication	Publication Date	Title
DK0969873T3 (da)	2006-10-09	Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf
AR007249A1 (es)	1999-10-27	Preparacion concentrada de anticuerpos
EP0837927A4 (en)	2000-01-05	MONOCLONAL MONKEY ANTIBODIES AGAINST HUMANE B7.1 AND / OR B7.2 ANTIGEN, PRIMATIZED DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS
HUP9802199A1 (hu)	1999-01-28	Poliszacharid antigén-vivőprotein konjugátumot és szabad vivőproteint tartalmazó oltóanyag és alkalmazása
BR9809656A (pt)	2000-07-11	Composição imunopotencializante
IL143797A0 (en)	2002-04-21	Human monoclonal antibodies to cytotoxic t lymphocyte antigen 4
WO1998057994A3 (en)	1999-03-25	Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
CA2290485A1 (en)	1998-11-26	Method for the production of non-immunogenic proteins
DE69129302D1 (de)	1998-05-28	Inhibitoren des tumorwachstums aus geweben, methoden ihrer herstellung und verwendungen
NZ503763A (en)	2003-01-31	Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
ES2093778T3 (es)	1997-01-01	Nuevos anticuerpos y metodos para su uso.
BR9810907A (pt)	2000-08-01	Anticorpos monoclonais e policlonais, peptìdeo suscetìvel de gerar um anticorpo, agente imunogênico, sequência de nucleotìdeos, composição farmacêutica, uso de pelo menos um anticorpo, kit de diagnóstico, e, processo para preparar um agente imunogênico
EP0866133A3 (en)	2001-09-26	A group b streptococcus vaccine
SE9401460D0 (sv)	1994-04-28	Antigen/antibody specificity exhanger
EP1003494A4 (en)	2002-10-16	(d) -METHADONE, NON-OPIOID ANALGESIC
WO1996021734A3 (en)	1996-11-28	P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods
NO986088D0 (no)	1998-12-23	Polypeptider med evnen til Õ danne antigenbindende strukturer med spesifisi
AU2002223462A1 (en)	2002-04-22	Use of cd28-specific monoclonal antibodies for stimulating blood cells that lackcd28
ES2118939T3 (es)	1998-10-01	Peptido para el diagnostico e inmunizacion contra la infeccion con t.cruzi.
DK0810883T3 (da)	2002-11-11	Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler
DE60027905D1 (de)	2006-06-14	Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
BG103872A (en)	2000-07-31	Glycoconjugates of 20(s)-camptotecin
ATE444081T1 (de)	2009-10-15	Proteine-abgabe durch polare epithelzellen schichte
WO2001068677A3 (en)	2002-05-10	Derivatives of breast canacer antigen her-2 for therapeutical use
DE69115104D1 (de)	1996-01-18	Composition comprising at least two different antibodies or fragments thereof.