DK0754190T3 - En equilin-dobbeltbindingsisomer fra syreisomeriseringen af equilin - Google Patents

En equilin-dobbeltbindingsisomer fra syreisomeriseringen af equilin

Info

Publication number: DK0754190T3
Authority: DK; Denmark
Prior art keywords: equilin; double bond; bond isomer; acid isomerization; isoestrone
Prior art date: 1994-04-08

Application number

DK95915579T

Other languages

English (en)

Inventor

Frederick Quincy Gemmill Jr

Chester Eugene Orzech

Steven Jay Adelman

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-08

Filing date

1995-04-06

Publication date

1999-09-27

1995-04-06 Application filed by American Home Prod filed Critical American Home Prod

1999-09-27 Application granted granted Critical

1999-09-27 Publication of DK0754190T3 publication Critical patent/DK0754190T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK95915579T 1994-04-08 1995-04-06 En equilin-dobbeltbindingsisomer fra syreisomeriseringen af equilin DK0754190T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/224,849 US5395831A (en)	1994-04-08	1994-04-08	Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
PCT/US1995/004252 WO1995027724A1 (en)	1994-04-08	1995-04-06	An equilin double bond isomer from the acid isomerization of equilin

Publications (1)

Publication Number	Publication Date
DK0754190T3 true DK0754190T3 (da)	1999-09-27

Family

ID=22842497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95915579T DK0754190T3 (da)	1994-04-08	1995-04-06	En equilin-dobbeltbindingsisomer fra syreisomeriseringen af equilin

Country Status (18)

Country	Link
US (3)	US5395831A (da)
EP (1)	EP0754190B1 (da)
JP (1)	JPH09511748A (da)
KR (1)	KR970702291A (da)
CN (1)	CN1149298A (da)
AT (1)	ATE177111T1 (da)
AU (1)	AU688029B2 (da)
CA (1)	CA2186486A1 (da)
DE (1)	DE69508068T2 (da)
DK (1)	DK0754190T3 (da)
ES (1)	ES2128051T3 (da)
GR (1)	GR3030185T3 (da)
HU (1)	HUT76338A (da)
IL (1)	IL113178A (da)
NZ (1)	NZ283951A (da)
TW (1)	TW314468B (da)
WO (1)	WO1995027724A1 (da)
ZA (1)	ZA952771B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5395831A (en) *	1994-04-08	1995-03-07	American Home Products Corporation	Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
EP0761679A1 (en) *	1995-08-30	1997-03-12	Eli Lilly And Company	N-Butylsulfonate esters of estrogens
IL119468A (en) *	1995-11-06	2000-02-29	Akzo Nobel Nv	Method of isomerisation of equilin or derivatives thereof
US5998639A (en) *	1995-11-06	1999-12-07	Akzo Nobel, N.V.	Sulfatation of estrogen mixtures
AU703814B2 (en) *	1995-12-04	1999-04-01	Wyeth	Antioxidant
ID18256A (id) *	1996-09-16	1998-03-19	American Home Prod	Penggunaan dari 8,9-dehidro estron sebagai estrogen dengan hasil netral pada tingkat prolaktin
IL124213A (en) *	1997-05-02	2004-12-15	Akzo Nobel Nv	Sulfation of estrogen mixtures
DE19723794A1 (de) *	1997-06-06	1998-12-10	Jenapharm Gmbh	Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
US5866561A (en) *	1997-08-21	1999-02-02	Scimed Life Systems, Inc.	Local delivery of estrogen for angiogenesis
GB9817623D0 (en) *	1998-08-13	1998-10-07	Glaxo Group Ltd	Pharmaceutical compounds
ATE361310T1 (de)	2000-11-03	2007-05-15	Univ Washington	Östronderivate mit zellschützender wirkung
WO2002040032A2 (en) *	2000-11-17	2002-05-23	Washington University	Cytoprotective estrogen derivatives
US20030158432A1 (en) *	2002-01-08	2003-08-21	Leonard Thomas W.	Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex
US6855735B2 (en)	2002-03-20	2005-02-15	Temple University Of The Commonwealth System Of Higher Education	Ketamine treatment of restless legs syndrome
US7186707B2 (en) *	2002-04-01	2007-03-06	University Of Florida	Prodrugs for use as ophthalmic agents
US7300926B2 (en) *	2002-04-01	2007-11-27	University Of Florida Research Foundation, Inc.	Steroidal quinols and their use for estrogen replacement therapy
PT1490392E (pt) *	2002-04-01	2007-04-30	Univ Florida	Quinóis esteroidais como pró-fármacos de antioxidantes
US20070213310A1 (en) *	2002-04-01	2007-09-13	Laszlo Prokai	Prodrugs for Use as Ophthalmic Agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE205169C (da) *
US3394153A (en) *	1965-08-18	1968-07-23	Merck & Co Inc	Process for the preparation of d, 1-8-dehydroestrone, and intermediates obtained therefrom
US3391170A (en) *	1965-09-21	1968-07-02	Smith	13-alkylogona-1, 3, 5 (10), 9 (11)-tetraenes
US3385872A (en) *	1966-08-29	1968-05-28	Syntex Corp	Process for the preparation of 3-hydroxy-19-nor-delta1, 3, 5(10), 9(11)-tetraene steroids
US3471528A (en) *	1968-02-21	1969-10-07	Lilly Co Eli	Method for producing delta**9(11) unsaturation in estrone and related compound
US3542819A (en) *	1968-06-11	1970-11-24	American Home Prod	Process for preparing 8-isoestrone
US3649621A (en) *	1969-12-19	1972-03-14	American Home Prod	Novel 3-cyclopentyl ethers of 13-alkylgon-poly-enes
US3689512A (en) *	1970-10-06	1972-09-05	American Home Prod	Novel 3-etherified-1,3,5(10)-triene-steroids and process thereof
DE3014120A1 (de) *	1980-04-12	1981-10-29	Hoechst Ag, 6000 Frankfurt	Verfahren zur synthese von oestron bzw. oestronderivaten
DD205169A1 (de) *	1982-05-26	1983-12-21	Adw Ddr	Verfahren zur herstellung von 9(11)-dehydro-oestra-1,3,5(10)-trienen
US5210081A (en) *	1992-02-26	1993-05-11	American Home Products Corporation	Alkali metal 8,9-dehydroestrone sulfate esters
US5395831A (en) *	1994-04-08	1995-03-07	American Home Products Corporation	Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone

1994
- 1994-04-08 US US08/224,849 patent/US5395831A/en not_active Expired - Lifetime
- 1994-12-01 US US08/347,742 patent/US5496814A/en not_active Expired - Lifetime
1995
- 1995-02-20 TW TW084101526A patent/TW314468B/zh active
- 1995-03-29 IL IL11317895A patent/IL113178A/xx not_active IP Right Cessation
- 1995-04-04 ZA ZA952771A patent/ZA952771B/xx unknown
- 1995-04-06 ES ES95915579T patent/ES2128051T3/es not_active Expired - Lifetime
- 1995-04-06 CN CN95193322A patent/CN1149298A/zh active Pending
- 1995-04-06 DE DE69508068T patent/DE69508068T2/de not_active Expired - Fee Related
- 1995-04-06 JP JP7526442A patent/JPH09511748A/ja not_active Withdrawn
- 1995-04-06 DK DK95915579T patent/DK0754190T3/da active
- 1995-04-06 NZ NZ283951A patent/NZ283951A/en unknown
- 1995-04-06 CA CA002186486A patent/CA2186486A1/en not_active Abandoned
- 1995-04-06 AT AT95915579T patent/ATE177111T1/de not_active IP Right Cessation
- 1995-04-06 KR KR1019960705688A patent/KR970702291A/ko not_active Application Discontinuation
- 1995-04-06 EP EP95915579A patent/EP0754190B1/en not_active Expired - Lifetime
- 1995-04-06 HU HU9602755A patent/HUT76338A/hu unknown
- 1995-04-06 WO PCT/US1995/004252 patent/WO1995027724A1/en active IP Right Grant
- 1995-04-06 AU AU22421/95A patent/AU688029B2/en not_active Ceased
- 1995-05-25 US US08/450,960 patent/US5552395A/en not_active Expired - Lifetime
1999
- 1999-05-11 GR GR990401273T patent/GR3030185T3/el unknown

Also Published As

Publication number	Publication date
TW314468B (da)	1997-09-01
US5395831A (en)	1995-03-07
IL113178A (en)	2000-07-26
KR970702291A (ko)	1997-05-13
AU688029B2 (en)	1998-03-05
AU2242195A (en)	1995-10-30
IL113178A0 (en)	1995-06-29
US5552395A (en)	1996-09-03
CA2186486A1 (en)	1995-10-19
NZ283951A (en)	1998-07-28
ES2128051T3 (es)	1999-05-01
HUT76338A (en)	1997-08-28
EP0754190B1 (en)	1999-03-03
GR3030185T3 (en)	1999-08-31
DE69508068T2 (de)	1999-10-28
DE69508068D1 (de)	1999-04-08
CN1149298A (zh)	1997-05-07
ATE177111T1 (de)	1999-03-15
HU9602755D0 (en)	1996-11-28
JPH09511748A (ja)	1997-11-25
WO1995027724A1 (en)	1995-10-19
EP0754190A1 (en)	1997-01-22
ZA952771B (en)	1996-10-04
US5496814A (en)	1996-03-05

Publication	Publication Date	Title
DK0754190T3 (da)	1999-09-27	En equilin-dobbeltbindingsisomer fra syreisomeriseringen af equilin
RU94027577A (ru)	1996-05-27	Производные 1-бензолсульфонил-1,3-дигидро-2н-бензимидазол-2-она, способ их получения, содержащая их фармацевтическая композиция
IS4695A (is)	1998-03-20	(Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar
ES2018111A6 (es)	1991-03-16	Procedimiento de preparacion de derivados de 4h-1-benzopiran-4-ona o sus sales.
BG104544A (en)	2001-03-30	Novel acylguanadine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
NL980012I1 (nl)	1998-05-06	Mometasonfuroaat-monohydraat, werkwijze om zulks te bereiden en farmaceutische samenstellingen.
EP0911321A3 (en)	2001-01-31	Compounds for the treatment of osteoporosis
AU1280392A (en)	1992-09-17	Urea derivatives
MY115339A (en)	2003-05-31	Compositions containing micronized nebivolol
CA2234642A1 (en)	1997-05-09	3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
ES2128519T3 (es)	1999-05-16	Nuevas pirido-tiadiazinas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
AP9801269A0 (en)	1999-12-18	Prostaglandin agonists.
CA2123232A1 (fr)	1993-06-10	Compositions pharmaceutiques a base d'ebastine ou de ses analogues
PL328225A1 (en)	1999-01-18	Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors
GR3017348T3 (en)	1995-12-31	Novel isoindolinone derivative, preparation thereof, and pharmaceutical compositions containing same.
IL112630A (en)	2003-10-31	Derivatives of (2-(ar)alkyldithioindane-2-carboxamido) tricyclic-oxobenzazepine and similar compouds useful as inhibitors of enkephalinase, their preparation and pharmaceutical compositions containing them
YU51199A (sh)	2002-09-19	Novi 4-halogeni steroidi, postupak i međuproizvodi za njihovo pripremanje, njihova primena kao medikamenata i farmaceutske kompozicije koje ih sadrže
AP9801417A0 (en)	1998-12-31	Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders.
MX9302429A (es)	1994-04-29	Nuevas tetralonas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
DE69614552D1 (de)	2001-09-20	MODIFIZIERTE ALPHA-D-GLCP-(1,2)-ALPHA-D-Glcp-(1,3)-ALPHA-D-Glcp-ANALOGE
IT1265045B1 (it)	1996-10-28	Composizione farmaceutica atta a inibire la sintesi della lipoproteina (a)