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DK0524517T3 - Substituerede 3,4-dihydronaphtalener, lægemidler indeholdende disse forbindelser og fremgangsmåder til fremstilling af forbindelserne - Google Patents

Substituerede 3,4-dihydronaphtalener, lægemidler indeholdende disse forbindelser og fremgangsmåder til fremstilling af forbindelserne

Info

Publication number
DK0524517T3
DK0524517T3 DK92111875.8T DK92111875T DK0524517T3 DK 0524517 T3 DK0524517 T3 DK 0524517T3 DK 92111875 T DK92111875 T DK 92111875T DK 0524517 T3 DK0524517 T3 DK 0524517T3
Authority
DK
Denmark
Prior art keywords
compounds
radical
denotes
image
dihydronaphthalenes
Prior art date
Application number
DK92111875.8T
Other languages
English (en)
Inventor
Johannes Dr Schneider
Oswald Dr Zimmer
Werner Dr Vollenberg
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0524517T3 publication Critical patent/DK0524517T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92111875.8T 1991-07-23 1992-07-13 Substituerede 3,4-dihydronaphtalener, lægemidler indeholdende disse forbindelser og fremgangsmåder til fremstilling af forbindelserne DK0524517T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4124345A DE4124345A1 (de) 1991-07-23 1991-07-23 Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Publications (1)

Publication Number Publication Date
DK0524517T3 true DK0524517T3 (da) 1995-11-06

Family

ID=6436795

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92111875.8T DK0524517T3 (da) 1991-07-23 1992-07-13 Substituerede 3,4-dihydronaphtalener, lægemidler indeholdende disse forbindelser og fremgangsmåder til fremstilling af forbindelserne

Country Status (10)

Country Link
US (1) US5254731A (da)
EP (1) EP0524517B1 (da)
JP (1) JP3163173B2 (da)
AT (1) ATE124035T1 (da)
AU (1) AU650154B2 (da)
CA (1) CA2070495A1 (da)
DE (2) DE4124345A1 (da)
DK (1) DK0524517T3 (da)
ES (1) ES2076623T3 (da)
HK (1) HK1005179A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とn―ヒドロキシ尿素誘導体およびそれらの組成物
WO1995002575A1 (en) * 1993-07-14 1995-01-26 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
DE602004021573D1 (de) 2003-04-07 2009-07-30 Pharmacyclics Inc Hydroxamate als therapeutische mittel
PT2099442E (pt) * 2006-12-26 2015-02-10 Pharmacyclics Inc Métodos de utilização de inibidores de histona desacetilase e monitorização de biomarcadores em terapia de combinação
EP2993473A1 (en) * 2007-01-30 2016-03-09 Pharmacyclics, Inc. Methods for determining cancer resistance to histone deacetylase inhibitors
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
BRPI1014405A2 (pt) 2009-04-29 2016-04-05 Amarin Corp Plc composições farmacêuticas compreendendo epa e um agente cardiovascular e métodos de seu uso
EP2755648B1 (en) 2011-09-13 2017-03-08 Pharmacyclics LLC Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
EP3027192A4 (en) 2013-08-02 2017-03-22 Pharmacyclics, LLC Methods for the treatment of solid tumors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279263B1 (en) * 1987-02-10 1993-08-04 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
DE3888574T2 (de) * 1987-04-24 1994-06-30 Abbott Lab Harnstoff-Derivate mit lipoxygenasehemmender Wirkung.
JPH027494A (ja) * 1988-06-24 1990-01-11 Fujitsu Ltd プリント基板のメッキ装置
AU4717889A (en) * 1988-12-29 1990-07-05 Ciba-Geigy Ag Amino-substituted hydroxamic acids
GB8830427D0 (en) * 1988-12-30 1989-03-01 Fujisawa Pharmaceutical Co New hydroxylamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same
JPH04504261A (ja) * 1989-03-30 1992-07-30 アボツト・ラボラトリーズ 尿素系リポキシゲナーゼ阻害化合物
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 [ジ―tert―ブチル(ヒドロキシ)フェニルチオ]置換ヒドロキサム酸誘導体
WO1991005757A1 (en) * 1989-10-19 1991-05-02 Schering Corporation Lipoxygenase inhibitors
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids

Also Published As

Publication number Publication date
CA2070495A1 (en) 1993-01-24
JPH05194350A (ja) 1993-08-03
ES2076623T3 (es) 1995-11-01
HK1005179A1 (en) 1998-12-24
EP0524517A1 (de) 1993-01-27
ATE124035T1 (de) 1995-07-15
JP3163173B2 (ja) 2001-05-08
AU2031092A (en) 1993-01-28
DE59202599D1 (de) 1995-07-27
DE4124345A1 (de) 1993-01-28
AU650154B2 (en) 1994-06-09
US5254731A (en) 1993-10-19
EP0524517B1 (de) 1995-06-21

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