DK0557385T3 - Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin - Google Patents

Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin

Info

Publication number: DK0557385T3
Authority: DK; Denmark
Prior art keywords: transdermal delivery; pct; morphine; topical compositions; prodrug derivatives
Prior art date: 1990-11-16

Application number

DK91920399T

Other languages

Danish (da)

English (en)

Inventor

Hans Bundgaard

Lona Christrup

Joern Drustrup

Ann Fullerton

Martin Nicklasson

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-16

Filing date

1991-11-11

Publication date

1999-04-26

1991-11-11 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

1999-04-26 Application granted granted Critical

1999-04-26 Publication of DK0557385T3 publication Critical patent/DK0557385T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK91920399T 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin DK0557385T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9003665A SE9003665D0 (sv)	1990-11-16	1990-11-16	Morphine prodrugs
PCT/SE1991/000760 WO1992008459A1 (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of produg derivatives of morphine

Publications (1)

Publication Number	Publication Date
DK0557385T3 true DK0557385T3 (da)	1999-04-26

Family

ID=20380936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91920399T DK0557385T3 (da)	1990-11-16	1991-11-11	Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin

Country Status (18)

Country	Link
US (1)	US5908846A (pt)
EP (1)	EP0557385B1 (pt)
JP (1)	JP3493434B2 (pt)
AT (1)	ATE168560T1 (pt)
AU (1)	AU655612B2 (pt)
CA (1)	CA2095223C (pt)
DE (1)	DE69129861T2 (pt)
DK (1)	DK0557385T3 (pt)
ES (1)	ES2121793T3 (pt)
FI (1)	FI932212A (pt)
IE (1)	IE913682A1 (pt)
IL (1)	IL99905A (pt)
NO (1)	NO931766L (pt)
NZ (1)	NZ240349A (pt)
PT (1)	PT99513B (pt)
SE (1)	SE9003665D0 (pt)
WO (1)	WO1992008459A1 (pt)
ZA (1)	ZA918512B (pt)

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US5607691A (en) *	1992-06-12	1997-03-04	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
DE4403709A1 (de) *	1994-02-07	1995-08-10	Lohmann Therapie Syst Lts	Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) *	1994-03-29	1995-10-17	Sekisui Chem Co Ltd	経皮吸収貼付剤
DE19508664C2 (de) *	1995-03-14	2001-08-23	Christian Mignat	Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
AU5108596A (en) *	1995-03-14	1996-10-02	Mundipharma Gmbh	Morphine-3-esters
GB9519363D0 (en)	1995-09-22	1995-11-22	Euro Celtique Sa	Pharmaceutical formulation
DE19602969A1 (de) *	1995-12-20	1997-07-31	Nycomed Arzneimittel Gmbh	Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) *	1999-05-21	2000-11-30	Lohmann Therapie Syst Lts	Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
CN107213128A (zh)	1999-10-29	2017-09-29	欧罗赛铁克股份有限公司	控释氢可酮制剂
US20020013331A1 (en)	2000-06-26	2002-01-31	Williams Robert O.	Methods and compositions for treating pain of the mucous membrane
KR100968128B1 (ko)	2000-10-30	2010-07-06	유로-셀티크 소시에떼 아노뉨	서방성 하이드로코돈 제형
US6569449B1 (en) *	2000-11-13	2003-05-27	University Of Kentucky Research Foundation	Transdermal delivery of opioid antagonist prodrugs
BRPI0115953B8 (pt) *	2000-11-14	2021-05-25	Vital Health Sciences Pty Ltd	complexos de derivados de fosfato
AUPR549901A0 (en) *	2001-06-06	2001-07-12	Vital Health Sciences Pty Ltd	Topical formulation containing tocopheryl phosphates
US20110104214A1 (en)	2004-04-15	2011-05-05	Purdue Pharma L.P.	Once-a-day oxycodone formulations
NZ529661A (en) *	2001-06-05	2006-03-31	Control Delivery Systems	Sustained-release analgesic compounds
CA2453823C (en) *	2001-07-27	2010-12-21	Vital Health Sciences Pty Ltd	Dermal therapy using phosphate derivatives of electron transfer agents
EP1460995B1 (en) *	2001-12-13	2010-11-10	Vital Health Sciences Pty Ltd.	Transdermal transport of compounds
AU2002950713A0 (en) *	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
ATE444296T1 (de) *	2002-10-25	2009-10-15	Euro Celtique Sa	Analoga und prodrugs von buprenorphin
WO2004043396A2 (en) *	2002-11-09	2004-05-27	Nobex Corporation	Modified carbamate-containing prodrugs and methods of synthesizing same
ATE534384T1 (de) *	2003-01-17	2011-12-15	Vital Health Sciences Pty Ltd	Verbindungen mit proliferationshemmenden eigenschaften
AU2003901815A0 (en) *	2003-04-15	2003-05-01	Vital Health Sciences Pty Ltd	Phosphate derivatives
ATE382354T1 (de) *	2003-07-25	2008-01-15	Euro Celtique Sa	Präoperative behandlung von postoperativen schmerzen
US8003793B2 (en)	2004-02-06	2011-08-23	Purdue Pharma L.P.	Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
PT2074989E (pt)	2004-02-23	2014-02-06	Euro Celtique Sa	Dispositivo de administração transdérmica de opióides com resistência ao abuso
US20060281716A1 (en) *	2004-03-03	2006-12-14	West Simon M	Alkaloid formulations
EP2548581A3 (en) *	2005-06-17	2013-02-20	Vital Health Sciences Pty Ltd.	A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
JP2009520697A (ja) *	2005-12-23	2009-05-28	バイタルヘルスサイエンシズプロプライアタリーリミティド	サイトカイン調節性を有する化合物
CN101621999B (zh)	2007-03-02	2012-09-26	帝化制药株式会社	经皮吸收医药组合物、医药组合物储存单元以及利用了该储存单元的经皮吸收制剂
US9511016B2 (en) *	2007-06-12	2016-12-06	Epicentrx, Inc.	Topical composition for treating pain
US8354116B2 (en) *	2007-06-18	2013-01-15	Biochemics, Inc.	Bifunctional synthetic molecules
US20090130048A1 (en) *	2007-11-19	2009-05-21	Oronsky Bryan Todd	Topical Composition for Treating Pain
US8784872B2 (en)	2007-11-19	2014-07-22	Comgenrx, Inc.	Formulation for decreasing tobacco, alcohol, drug or food consumption
US20100104614A1 (en) *	2008-06-27	2010-04-29	Oronsky Bryan T	Providone compositions for wound healing
WO2011002995A1 (en) *	2009-07-02	2011-01-06	Kempharm, Inc.	Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
UA102916C2 (uk) *	2009-07-02	2013-08-27	Кемфарм, Інк.	Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en)	2009-07-02	2020-12-01	KemPham, Inc.	Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US10071030B2 (en)	2010-02-05	2018-09-11	Phosphagenics Limited	Carrier comprising non-neutralised tocopheryl phosphate
TWI507193B (zh)	2010-03-30	2015-11-11	Phosphagenics Ltd	經皮輸送貼劑
KR20150036825A (ko)	2010-04-13	2015-04-07	나지브 바불	1-메틸-2''-6''-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법
TWI520732B (zh)	2011-01-18	2016-02-11	輝瑞有限公司	固體分子分散液
US9561243B2 (en)	2011-03-15	2017-02-07	Phosphagenics Limited	Composition comprising non-neutralised tocol phosphate and a vitamin A compound
KR20190049944A (ko)	2014-11-25	2019-05-09	켐팜 인코포레이티드	옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트
WO2017096427A1 (en)	2015-12-09	2017-06-15	Phosphagenics Limited	Pharmaceutical formulation
CN110662733A (zh)	2016-12-21	2020-01-07	埃维科生物技术有限公司	方法

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Publication number	Priority date	Publication date	Assignee	Title
US4626539A (en) *	1984-08-10	1986-12-02	E. I. Dupont De Nemours And Company	Trandermal delivery of opioids
US4673679A (en) *	1986-05-14	1987-06-16	E. I. Du Pont De Nemours And Company	Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) *	1986-08-27	1990-03-13	Warner-Lambert Company	Penetration enhancement system
US4940586A (en) *	1987-02-26	1990-07-10	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4879297A (en) *	1987-06-01	1989-11-07	Warner-Lambert Company	Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) *	1988-12-02	1990-01-02	Board Of Regents Acting For And On Behalf Of University Of Michigan	Transdermal delivery of the narcotic analgesics etorphine and analogs
ES2094809T3 (es) *	1990-03-30	1997-02-01	Yasunori Morimoto	Composicion absorbible por via percutanea del clorhidrato de morfina.
US5069909A (en) *	1990-06-20	1991-12-03	Cygnus Therapeutic Systems	Transdermal administration of buprenorphine

1990
- 1990-11-16 SE SE9003665A patent/SE9003665D0/xx unknown
1991
- 1991-10-21 IE IE368291A patent/IE913682A1/en not_active IP Right Cessation
- 1991-10-25 NZ NZ240349A patent/NZ240349A/en not_active IP Right Cessation
- 1991-10-25 ZA ZA918512A patent/ZA918512B/xx unknown
- 1991-10-30 IL IL9990591A patent/IL99905A/en not_active IP Right Cessation
- 1991-11-11 CA CA002095223A patent/CA2095223C/en not_active Expired - Fee Related
- 1991-11-11 ES ES91920399T patent/ES2121793T3/es not_active Expired - Lifetime
- 1991-11-11 US US08/050,336 patent/US5908846A/en not_active Expired - Fee Related
- 1991-11-11 DE DE69129861T patent/DE69129861T2/de not_active Expired - Fee Related
- 1991-11-11 AU AU89381/91A patent/AU655612B2/en not_active Ceased
- 1991-11-11 DK DK91920399T patent/DK0557385T3/da active
- 1991-11-11 AT AT91920399T patent/ATE168560T1/de not_active IP Right Cessation
- 1991-11-11 WO PCT/SE1991/000760 patent/WO1992008459A1/en active IP Right Grant
- 1991-11-11 JP JP50056892A patent/JP3493434B2/ja not_active Expired - Fee Related
- 1991-11-11 EP EP91920399A patent/EP0557385B1/en not_active Expired - Lifetime
- 1991-11-14 PT PT99513A patent/PT99513B/pt not_active IP Right Cessation
1993
- 1993-05-14 NO NO93931766A patent/NO931766L/no unknown
- 1993-05-14 FI FI932212A patent/FI932212A/fi unknown

Also Published As

Publication number	Publication date
IE913682A1 (en)	1992-05-20
DE69129861D1 (de)	1998-08-27
EP0557385B1 (en)	1998-07-22
ATE168560T1 (de)	1998-08-15
IL99905A0 (en)	1992-08-18
WO1992008459A1 (en)	1992-05-29
JP3493434B2 (ja)	2004-02-03
PT99513B (pt)	1999-04-30
AU655612B2 (en)	1995-01-05
PT99513A (pt)	1992-09-30
JPH06502422A (ja)	1994-03-17
SE9003665D0 (sv)	1990-11-16
NZ240349A (en)	1993-07-27
ES2121793T3 (es)	1998-12-16
NO931766D0 (no)	1993-05-14
IL99905A (en)	1995-06-29
ZA918512B (en)	1992-08-26
FI932212A0 (fi)	1993-05-14
CA2095223A1 (en)	1992-05-17
EP0557385A1 (en)	1993-09-01
AU8938191A (en)	1992-06-11
FI932212A (fi)	1993-05-14
CA2095223C (en)	2002-12-17
NO931766L (no)	1993-05-14
US5908846A (en)	1999-06-01
DE69129861T2 (de)	1999-04-01

Publication	Publication Date	Title
DK0557385T3 (da)	1999-04-26	Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin
MY107158A (en)	1995-09-30	3-arylcarbonyl; -1h-indoles useful as therapeutic agents.
AU2291097A (en)	1997-10-17	Novel phenanthridines substituted in the 6 position
DK1093819T3 (da)	2006-09-11	Forbindelse og præparat til tilförsel af aktive midler
FI952680A0 (fi)	1995-06-01	Injektoitavia taksaanijohdannaisiin pohjautuvia koostumuksia
BR9707233A (pt)	1999-07-20	Fenantridinas
GB2270075B (en)	1995-01-04	Substituted 2-phenyl-3-methoxypropenoate fungicides
MX9700886A (es)	1998-04-30	Nuevas oxazolidinonas sustituidas.
ES2189235T3 (es)	2003-07-01	6-fenilfenantridinas sustituidas.
TR199800077T1 (xx)	1998-05-21	Kontroll� ��z�len paroksetin terkipleri.
NO924672L (no)	1992-12-03	Metode for fremstilling av interferon alfa-2-krystaller
ATE157536T1 (de)	1997-09-15	Synergistische lichtschutzkombinationen und kosmetische und dermatologische formulierungen, solche kombinationen enthaltend
GEP20032953B (en)	2003-04-25	Antitumor Agents
TR199900951T2 (xx)	1999-07-21	G��s kanserinin engellenmesi i�in y�ntemler.
MD502G2 (ro)	1996-11-30	Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
BR9814495A (pt)	2000-10-10	Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo
SE9504662D0 (sv)	1995-12-22	New compounds
DE69727385D1 (de)	2004-03-04	Benzophenanthridinalkaloid-enthaltende pestizide
DK0588873T3 (da)	1997-09-15	Behandling af levercancer
ATE227122T1 (de)	2002-11-15	Stabilisierte tablettenformulierung
SE9300106L (sv)	1993-07-18	Komposition foer att paaskynda saarlaekning
DK0669826T3 (da)	1999-05-25	(-)-Metrifonatholdigt lægemiddel
ES456280A1 (es)	1978-04-16	Un procedimiento para la obtencion de alfa-2,5,9-trimetil- benzo(b)tieno(2,3-f)morfano.
DK0750502T3 (da)	2001-08-06	Anvendelse af phosphorderivater af alkaloider til behandling af endokrinopatier
MY107387A (en)	1995-11-30	Aromatic steroid 5-(alpha)-reductase inhibitors.