Nothing Special   »   [go: up one dir, main page]

DK0414275T3 - Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter - Google Patents

Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter

Info

Publication number
DK0414275T3
DK0414275T3 DK90116293.3T DK90116293T DK0414275T3 DK 0414275 T3 DK0414275 T3 DK 0414275T3 DK 90116293 T DK90116293 T DK 90116293T DK 0414275 T3 DK0414275 T3 DK 0414275T3
Authority
DK
Denmark
Prior art keywords
preparation
amino acid
acid derivatives
cyclic amino
intermediates
Prior art date
Application number
DK90116293.3T
Other languages
English (en)
Inventor
Wolfgang Dr Herrmann
Klaus Dr Steiner
Guenter Dr Crone
Charles Shepherd Combs
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Application granted granted Critical
Publication of DK0414275T3 publication Critical patent/DK0414275T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D201/00Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/02Preparation of lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
DK90116293.3T 1989-08-25 1990-08-24 Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter DK0414275T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3928184A DE3928184A1 (de) 1989-08-25 1989-08-25 Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte

Publications (1)

Publication Number Publication Date
DK0414275T3 true DK0414275T3 (da) 1994-02-14

Family

ID=6387902

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90116293.3T DK0414275T3 (da) 1989-08-25 1990-08-24 Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter

Country Status (14)

Country Link
US (1) US5068413A (da)
EP (1) EP0414275B1 (da)
JP (1) JP2839344B2 (da)
KR (3) KR0179657B1 (da)
AT (1) ATE98219T1 (da)
DE (2) DE3928184A1 (da)
DK (1) DK0414275T3 (da)
ES (1) ES2059938T3 (da)
FI (1) FI103506B (da)
HU (1) HU208521B (da)
IE (1) IE63922B1 (da)
IL (1) IL95480A (da)
MY (1) MY107319A (da)
PT (1) PT95099B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY106864A (en) * 1989-08-25 1995-08-30 Warner Lambert Co Improved process for cyclic amino acid anticonvulsant compounds.
PT888286E (pt) * 1996-03-14 2002-04-29 Warner Lambert Co Novos amino acidos ciclicos substituidos como agentes farmaceuticos
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6255526B1 (en) 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
IL119890A (en) * 1996-12-24 2002-03-10 Teva Pharma Gabapentin form iii and preparation of gabapentin form ii
AU9318398A (en) 1997-10-07 1999-04-27 Warner-Lambert Company Process for preparing a cyclic amino acid anticonvulsant compound
DK1032555T3 (da) 1997-10-27 2006-07-17 Warner Lambert Co Cykliske aminosyrer og derivater deraf, som er anvendelige som lægemidler
US6984659B2 (en) * 1997-11-18 2006-01-10 Klinikum Der Albert-Ludwigs Universitaet 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level
ES2137137B1 (es) * 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) * 1998-07-03 2000-01-03 Zambon Spa Processo per la preparazione di gabapentina
IT1311984B1 (it) * 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi Procedimento per la preparzione di gabapentin.
TR200302296T4 (tr) 2000-06-16 2004-02-23 Teva Pharmaceutical Industries Ltd. 20 ppm klor iyonundan daha çok ihtiva eden kararlı gabapentin
AU2001266992B8 (en) * 2000-06-16 2005-12-01 Teva Pharmaceutical Industries Ltd. Stable gabapentin having pH within a controlled range
IT1319674B1 (it) * 2000-12-01 2003-10-23 Erregierre Spa Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.
US6800782B2 (en) * 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
ITMI20012750A1 (it) 2001-12-21 2003-06-21 Procos Spa Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura
US20040034248A1 (en) * 2002-04-16 2004-02-19 Taro Pharmaceutical Industries, Ltd. Process for preparing gabapentin
DE60230552D1 (de) * 2002-11-18 2009-02-05 Nicholas Piramal India Ltd Verbessertes verfahren zur herstellung von gabapentin
US7632953B2 (en) * 2002-11-20 2009-12-15 Hikal Limited Process for the preparation of gabalactam
DE602004017166D1 (de) * 2003-03-25 2008-11-27 Kiel Lab Inc Gabapentintannat in flüssigen und/oder halbfesten dosierformen
EP1622603A4 (en) * 2003-03-25 2010-03-24 Kiel Lab Inc GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE
WO2004093866A1 (en) * 2003-03-25 2004-11-04 Kiel Laboratories, Inc. Process for preparing phenolic acid salts of gabapentin
WO2004093780A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii
US20070043236A1 (en) * 2003-05-19 2007-02-22 Chandiran Thakashina M Process for preparation of gabapentin
US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
ITMI20040579A1 (it) * 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
CN100404504C (zh) * 2006-06-12 2008-07-23 浙江手心医药化学品有限公司 3,3-亚戊基丁内酰胺的制备方法
CA2660769C (en) * 2006-06-30 2013-12-03 Zach System S.P.A. Process for preparing gabapentin
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
ITMI20131757A1 (it) 2013-10-22 2015-04-23 Zach System Spa Processo di preparazione di gabapentina
EP2923694B1 (en) 2014-03-27 2018-11-14 Sanovel Ilac Sanayi ve Ticaret A.S. Oral liquid pharmaceutical solution of gabapentin
CN107235850B (zh) * 2017-05-31 2019-07-26 浙江工业大学 利用1-氰基环己基乙酸直接合成加巴喷丁的方法
CN116606216B (zh) * 2023-04-10 2024-06-14 浙江手心制药有限公司 一种加巴喷丁的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4822692B1 (da) * 1963-12-24 1973-07-07
DE2543821C2 (de) * 1974-12-21 1984-10-18 Gödecke AG, 1000 Berlin Bestimmte Salze und Ester von 1-Aminomethyl-1-cycloalkanessigsäuren und diese Verbindungen enthaltende Arzneimittel
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US4894476A (en) * 1988-05-02 1990-01-16 Warner-Lambert Company Gabapentin monohydrate and a process for producing the same
YU162789A (en) * 1988-09-01 1990-12-31 Lonza Ag 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones

Also Published As

Publication number Publication date
EP0414275A2 (de) 1991-02-27
IE903090A1 (en) 1991-02-27
HU905333D0 (en) 1991-02-28
FI904204A0 (fi) 1990-08-24
DE59003771D1 (de) 1994-01-20
ATE98219T1 (de) 1993-12-15
IE63922B1 (en) 1995-06-14
HUT54624A (en) 1991-03-28
JPH0390054A (ja) 1991-04-16
PT95099B (pt) 1997-04-30
EP0414275A3 (en) 1991-05-15
JP2839344B2 (ja) 1998-12-16
FI103506B1 (fi) 1999-07-15
ES2059938T3 (es) 1994-11-16
PT95099A (pt) 1991-04-18
FI103506B (fi) 1999-07-15
DE3928184A1 (de) 1991-02-28
US5068413A (en) 1991-11-26
HU208521B (en) 1993-11-29
IL95480A (en) 1995-06-29
EP0414275B1 (de) 1993-12-08
IL95480A0 (en) 1991-06-30
KR910004542A (ko) 1991-03-28
KR0179946B1 (ko) 1999-05-15
MY107319A (en) 1995-11-30
KR0179657B1 (ko) 1999-05-15
KR100192007B1 (ko) 1999-06-15

Similar Documents

Publication Publication Date Title
DK0414275T3 (da) Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter
MA19753A1 (fr) Procede de preparation de nouveaux derives d'acides amines bicycliques.
DE68919246D1 (de) Verfahren zur Herstellung von Aminosäuren.
DE3852959D1 (de) Verfahren zur Herstellung von N-substituiertes Amin.
DE69014707D1 (de) Verfahren zur Herstellung von CMOS-Feldeffekt-Transistoren.
DE69007800D1 (de) Verfahren zur fermentativen Herstellung von L-Arginin.
DE69020172D1 (de) Verfahren zur Herstellung von epsilon-Caprolactam.
DE69004582D1 (de) Verfahren zur Herstellung von alpha-Hydroxycarbonsäure-Amid.
DE69131376D1 (de) Verfahren zur Herstellung von doppelt-diffundierten integrierten MOSFET-Zellen
DE69022631D1 (de) Verfahren zur Herstellung von L-Tryptophan.
DE69024105D1 (de) Verfahren zur Herstellung von gereinigten Albuminlösungen
MA21122A1 (fr) Procede de preparation de derives d'acides aminocarboxyliques bicycliques .
DE69019788D1 (de) Verfahren zur Herstellung von Organohalogensilanen.
DK516684A (da) Purinderivater
DE69009682D1 (de) Verfahren zur Herstellung von Cyclohexanolderivaten.
DE58907777D1 (de) Verfahren zur Herstellung von Caprolactam.
DE59004490D1 (de) Verfahren zur Herstellung von alpha-Fluoracrylsäurederivaten.
DE68923912D1 (de) Verfahren zur Herstellung von 3-Pyrrolidinol.
DE58907409D1 (de) Verfahren zur Herstellung von Caprolactam.
DE69011758D1 (de) Verfahren zur Herstellung von N-substituierten Maleinimiden.
IT8521428A0 (it) Processo perfezionato di transaminazione per la produzionedi aminoacidi.
DK162048C (da) 4-oxothiazolidin-2-yliden-acetamidderivater, fremgangsmaade til deres fremstilling samt deres anvendelse
DE3884324D1 (de) Verfahren zur Herstellung von menschlichen pro-apolipoprotein-A-I-ähnlichen Proteinen.
DE69014747D1 (de) Verfahren zur Herstellung von Kaliumtitanarsenat-Einkristallen.
DE69019910D1 (de) Verfahren zur Herstellung von 1-Indanonderivaten.