Nothing Special   »   [go: up one dir, main page]

DK0494819T3 - New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them - Google Patents

New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them

Info

Publication number
DK0494819T3
DK0494819T3 DK92400038.3T DK92400038T DK0494819T3 DK 0494819 T3 DK0494819 T3 DK 0494819T3 DK 92400038 T DK92400038 T DK 92400038T DK 0494819 T3 DK0494819 T3 DK 0494819T3
Authority
DK
Denmark
Prior art keywords
denotes
preparation
halogen
phenylimidazolidines
pharmaceuticals
Prior art date
Application number
DK92400038.3T
Other languages
Danish (da)
Inventor
Daniel Philibert
Martine Gaillard-Kelly
Francois Goubet
Jean-Georges Teutsch
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of DK0494819T3 publication Critical patent/DK0494819T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Products of formula (I): <IMAGE> in which: R1 denotes cyano, nitro or halogen, R2 denotes trifluoromethyl or halogen; the group -A-B- is chosen from the radicals <IMAGE> in which X denotes oxygen or sulphur and R3 is chosen from: - a hydrogen< - alkyl, alkenyl, alkynyl, aryl or arylalkyl, optionally substituted; Y denotes oxygen or sulphur or NH, with the exception of the products in which: the group -A-B- denotes the radical <IMAGE> in which X denotes oxygen, R3 denotes hydrogen, Y denotes oxygen or NH, R2 denotes halogen or trifluoromethyl and R1 denotes nitro or halogen; the preparation, their application as medications and especially antiandrogens.
DK92400038.3T 1991-01-09 1992-01-08 New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them DK0494819T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9100185A FR2671348B1 (en) 1991-01-09 1991-01-09 NOVEL PHENYLIMIDAZOLIDINES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (1)

Publication Number Publication Date
DK0494819T3 true DK0494819T3 (en) 1996-08-12

Family

ID=9408539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92400038.3T DK0494819T3 (en) 1991-01-09 1992-01-08 New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP0494819B1 (en)
JP (1) JP3383320B2 (en)
KR (1) KR100238385B1 (en)
CN (1) CN1049214C (en)
AT (1) ATE140218T1 (en)
AU (1) AU648376B2 (en)
CA (1) CA2059052C (en)
DE (1) DE69212007T2 (en)
DK (1) DK0494819T3 (en)
ES (1) ES2089425T3 (en)
FR (1) FR2671348B1 (en)
GR (1) GR3020510T3 (en)
HU (1) HU223310B1 (en)
IE (1) IE76143B1 (en)
RU (1) RU2076101C1 (en)
UA (1) UA45299C2 (en)
ZA (1) ZA9290B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693461B1 (en) * 1992-07-08 1994-09-02 Roussel Uclaf New substituted phenylimidazolidines, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them.
US6002016A (en) * 1991-12-20 1999-12-14 Rhone-Poulenc Agrochimie Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
FR2685328B1 (en) * 1991-12-20 1995-12-01 Rhone Poulenc Agrochimie DERIVATIVES OF 2-IMIDAZOLINE-5-ONES AND 2-IMIDAZOLINE-5-THIONES FUNGICIDES.
FR2706456B1 (en) * 1993-06-18 1996-06-28 Rhone Poulenc Agrochimie Optically active derivatives of 2-imidazoline-5-ones and 2-imidazoline-5-thiones fungicides.
FR2694290B1 (en) * 1992-07-08 1994-09-02 Roussel Uclaf New phenylimidazolidines which may be substituted, their preparation process, their use as medicaments and the pharmaceutical compositions containing them.
US6008370A (en) * 1992-11-25 1999-12-28 Rhone-Poulenc Agrochimie Fungicidal-2-alkoxy/haloalkoxy-1-(mono- or disubstituted)amino-4,4-disubstituted-2-imidazolin-5-ones
DE4335438A1 (en) * 1993-10-18 1995-04-20 Bayer Ag 4-cyanophenylimino heterocycles
FR2724169B1 (en) * 1994-09-06 1997-01-03 Roussel Uclaf NOVEL PHENYLIMIDAZOLIDINES WHICH MAY BE SUBSTITUTED, THEIR PROCESS AND PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2715402B1 (en) * 1994-01-05 1996-10-04 Roussel Uclaf New phenylimidazolines optionally substituted, their process and preparation intermediates, their use as medicaments and the pharmaceutical compositions containing them.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2716110B1 (en) * 1994-02-16 1996-04-05 Roussel Uclaf Cosmetic or pharmaceutical compositions comprising liposomes.
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
FR2741342B1 (en) * 1995-11-22 1998-02-06 Roussel Uclaf NOVEL FLUORINATED OR HYDROXYLATED PHENYLIMIDAZOLIDINES, METHOD, PREPARATION MEDIA, APPLICATION AS MEDICAMENTS, NEW USE AND PHARMACEUTICAL COMPOSITIONS
MXPA02012605A (en) * 2000-06-28 2003-05-14 Squibb Bristol Myers Co Selective androgen receptor modulators and methods for their identification, design and use.
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE10322108B4 (en) * 2003-05-09 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Antiandrogenic pyrrolidines with antitumor activity
EP1634874A4 (en) * 2003-06-12 2008-04-02 Chugai Pharmaceutical Co Ltd Imidazolidine derivative
EP1709193B1 (en) 2003-12-19 2011-03-16 The Regents of The University of California Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en) 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
EP1621536A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
KR20070106969A (en) * 2004-09-09 2007-11-06 추가이 세이야쿠 가부시키가이샤 Novel imidazolidine derivative and use thereof
WO2006124447A2 (en) * 2005-05-13 2006-11-23 Eli Lilly And Company Substituted n-arylpyrrolidines as selective androgen receptor modulators
NZ710355A (en) 2005-05-13 2017-01-27 Univ California Diarylhydantoin compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
FR2896504B1 (en) * 2006-01-23 2012-07-13 Aventis Pharma Sa NOVEL CYCLIC UREA DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS INHIBITORS OF KINASES
FI2004181T6 (en) 2006-03-27 2023-09-01 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
JP5350217B2 (en) 2006-03-29 2013-11-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Diarylthiohydantoin compounds
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
WO2008093838A1 (en) * 2007-02-01 2008-08-07 Chugai Seiyaku Kabushiki Kaisha Pyridyl imidazolidine derivative having sulfamoyl group, and pharmaceutical use thereof
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
TW201716385A (en) 2007-10-26 2017-05-16 加州大學董事會 Diarylhydantoin compounds
EP2242745A1 (en) * 2008-02-07 2010-10-27 Sanofi-Aventis Novel phenyl-substituted imidazolidines, method for the production thereof, medicaments containing said compounds and use thereof
FR2944524B1 (en) 2009-04-17 2012-11-30 Ipsen Pharma Sas IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND THEIR USE AS A MEDICINAL PRODUCT
TW201111378A (en) 2009-09-11 2011-04-01 Bayer Schering Pharma Ag Substituted (heteroarylmethyl) thiohydantoins
KR101972719B1 (en) 2010-02-16 2019-04-25 아라곤 파마슈티컬스, 인코포레이티드 Androgen receptor modulators and uses thereof
EP3777845A1 (en) 2012-09-26 2021-02-17 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (en) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc Androgen receptor modulator and uses thereof
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103965112A (en) * 2014-05-13 2014-08-06 上海孚一生物科技有限公司 Compound with antiandrogen activity as well as preparation method and application of compound
TWI726969B (en) 2016-01-11 2021-05-11 比利時商健生藥品公司 Substituted thiohydantoin derivatives as androgen receptor antagonists
CN111479560A (en) 2017-10-16 2020-07-31 阿拉贡药品公司 Antiandrogen for treating non-metastatic castration-resistant prostate cancer
CN113024513A (en) * 2021-03-22 2021-06-25 中国药科大学 Novel androgen receptor degradation agent, preparation method and medical application

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823240A (en) * 1970-10-06 1974-07-09 Rhone Poulenc Sa Fungicidal hydantoin derivatives
FR2329276A1 (en) * 1975-10-29 1977-05-27 Roussel Uclaf NEW SUBSTITUTES IMIDAZOLIDINES, METHOD OF PREPARATION, APPLICATION AS A MEDICINAL PRODUCT AND COMPOSITIONS CONTAINING THEM
IL55774A (en) * 1977-10-28 1982-04-30 Sparamedica Ag Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
MC1220A1 (en) * 1977-10-28 1979-07-20 Hoffmann La Roche NEW DERIVATIVES OF IMIDAZOLIDINE
DE2933917A1 (en) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-IMINO-IMIDAZOLIDIN-2-ONE AND HERBICIDES CONTAINING THEM.
DE3444918A1 (en) * 1984-12-08 1986-06-12 Hoechst Ag, 6230 Frankfurt 1-PHENYL-IMIDAZOLE-5-CARBONIC ACID DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS GROWTH REGULATORS
US4672101A (en) * 1985-09-09 1987-06-09 The Dow Chemical Company Polyepoxy aromatic hydantoins
FR2619381B1 (en) * 1987-08-13 1989-12-08 Roussel Uclaf NOVEL IMIDAZOLIDINES SUBSTITUTED BY A RADICAL HYDROXYMETHYL AND A RADICAL PHENYL SUBSTITUTED, THEIR PREPARATION METHOD, THEIR APPLICATION AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND AN INTERMEDIATE FOR THEIR PREPARATION

Also Published As

Publication number Publication date
GR3020510T3 (en) 1996-10-31
FR2671348B1 (en) 1993-03-26
FR2671348A1 (en) 1992-07-10
ZA9290B (en) 1993-03-31
JP3383320B2 (en) 2003-03-04
IE920059A1 (en) 1992-07-15
AU648376B2 (en) 1994-04-21
CN1063102A (en) 1992-07-29
HUT60250A (en) 1992-08-28
CN1049214C (en) 2000-02-09
EP0494819A1 (en) 1992-07-15
AU1010692A (en) 1992-07-16
HU223310B1 (en) 2004-05-28
KR100238385B1 (en) 2000-03-02
CA2059052C (en) 2004-11-23
JPH04308579A (en) 1992-10-30
IE76143B1 (en) 1997-10-08
DE69212007T2 (en) 1997-01-09
KR920014786A (en) 1992-08-25
ATE140218T1 (en) 1996-07-15
DE69212007D1 (en) 1996-08-14
EP0494819B1 (en) 1996-07-10
CA2059052A1 (en) 1992-07-10
ES2089425T3 (en) 1996-10-01
UA45299C2 (en) 2002-04-15
HU9200065D0 (en) 1992-03-30
RU2076101C1 (en) 1997-03-27

Similar Documents

Publication Publication Date Title
DK0494819T3 (en) New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them
DK0580459T3 (en) Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them
HUP0003731A2 (en) 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
ATE303357T1 (en) AMIDE DERIVATIVES
ATE97664T1 (en) ISOXAZOLE AND ISOXAZOLINE DERIVATIVES WITH ANTICONVULSANTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE73776T1 (en) 4-AMINOQUILINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS.
BG104499A (en) Retinoic acid mimetic anilides
IL80437A0 (en) Benzimidazole derivatives and pharmaceutical compositions containing them
DK0404283T3 (en) 11alpha-aryl-4-estrenes, processes for their preparation and their use as pharmaceuticals
DK0675717T3 (en) Use of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) as a drug with antidepressant effect
HUP0002853A2 (en) 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, and pharmaceutical compositions containing them
ATE45734T1 (en) N-SUBSTITUTED 2-AMINOTHIAZOLES, PROCESS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION.
DE69431316D1 (en) Amide derivatives and their therapeutic use
DK527984A (en) 11-SUBSTITUTED 5H, 11H-PYRROLO (2,1-C) (1,4) BENZOXAZEPINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF, THEIR PREPARATION AND INTERMEDIATES THEREOF, AND THEIR USE AS ANTICOTIC ANTIPSY ANTIPSY
ES2103440T3 (en) NEW AMPHASES AND NAPHTHALENIC SULPHONAMIDES, PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ES2057802T3 (en) NEW DERIVATIVES OF 3-AMINO-CHROMAN, PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DK0998471T3 (en) Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them
NZ322227A (en) Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
ATE68494T1 (en) BENZOFURAN DERIVATIVES AND THERAPEUTIC AGENTS CONTAINING THEM.
ES2095431T3 (en) N- (ISOQUINOLEIN-5-IL) -SULFONIL-AZACICLOALCANOS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
PT84161B (en) PROCESS FOR THE PREPARATION OF 3-ACYLAMINOMETHYL-IMIDAZO- (1,2-A) -PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ATE88176T1 (en) 2-HYDROXY-3-ARYLOXY-PROPYLAMINE DERIVATIVES WITH CARDIOVASCULAR ACTIVITIES.
ATE44875T1 (en) 4-AMINO-2-(IMIDAZOLIDIN-2-ON-L-YL)-PYRIMIDIN-5CARBONS|URE-(N-(3-TRIFLUORMETHYL-PHENYL)-AMIDE) FOR ANTITHROMBOTIC PROPHYLAXIS AND TREATMENT AND ITS USE FOR THE PREPARATION OF ANTITHROMBOTIC ACTIVE AGENTS MEDICATIONS.
PT1068200E (en) ANTIFUNGIC 1,3-DIOXOLANE 2,4,4-TIR-SUBSTITUTED