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DE69329461D1 - Verfahren zur extraktion und reinigung von hamoglobin - Google Patents

Verfahren zur extraktion und reinigung von hamoglobin

Info

Publication number
DE69329461D1
DE69329461D1 DE69329461T DE69329461T DE69329461D1 DE 69329461 D1 DE69329461 D1 DE 69329461D1 DE 69329461 T DE69329461 T DE 69329461T DE 69329461 T DE69329461 T DE 69329461T DE 69329461 D1 DE69329461 D1 DE 69329461D1
Authority
DE
Germany
Prior art keywords
hamoglobin
purification
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69329461T
Other languages
English (en)
Other versions
DE69329461T2 (de
Inventor
G Shorr
Kwang Nho
Myung-Ok Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Application granted granted Critical
Publication of DE69329461D1 publication Critical patent/DE69329461D1/de
Publication of DE69329461T2 publication Critical patent/DE69329461T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69329461T 1992-07-14 1993-06-17 Verfahren zur extraktion und reinigung von hamoglobin Expired - Fee Related DE69329461T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/913,138 US5264555A (en) 1992-07-14 1992-07-14 Process for hemoglobin extraction and purification
PCT/US1993/005789 WO1994001452A1 (en) 1992-07-14 1993-06-17 Process for hemoglobin extraction and purification

Publications (2)

Publication Number Publication Date
DE69329461D1 true DE69329461D1 (de) 2000-10-26
DE69329461T2 DE69329461T2 (de) 2001-05-23

Family

ID=25432958

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329461T Expired - Fee Related DE69329461T2 (de) 1992-07-14 1993-06-17 Verfahren zur extraktion und reinigung von hamoglobin

Country Status (5)

Country Link
US (1) US5264555A (de)
EP (1) EP0654039B1 (de)
AU (1) AU4638393A (de)
DE (1) DE69329461T2 (de)
WO (1) WO1994001452A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5312808A (en) * 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5478806A (en) * 1989-11-22 1995-12-26 Enzon, Inc. Enhancement of antitumor therapy with hemoglobin-based conjugates
US5407579A (en) * 1993-07-02 1995-04-18 National Science Council Hemoglobin purification
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5545328A (en) * 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
WO1995027040A1 (en) * 1994-04-01 1995-10-12 Unisyn Technologies, Inc. Culture media additives for hollow fiber bioreactors
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
EP0815138B1 (de) * 1995-03-23 2002-08-28 Biopure Corporation Stabiles polymerisiertes hämoglobin-blutersatzmittel
US5691452A (en) * 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6274103B1 (en) 1999-03-26 2001-08-14 Prismedical Corporation Apparatus and method for preparation of a peritoneal dialysis solution
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
CN100338093C (zh) 2001-04-18 2007-09-19 北方实验室公司 储存稳定的血红蛋白溶液的柔韧性容器系统
AU2002309825A1 (en) * 2001-05-14 2002-11-25 Prismedical Corporation Powered sterile solution device
CN1543440A (zh) * 2001-06-19 2004-11-03 ��������ҽѧ���޹�˾ 医用级水生产系统
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
CN1208346C (zh) * 2003-04-09 2005-06-29 中国科学院过程工程研究所 血红蛋白－人血清白蛋白偶联物制备血液代用品及其制备方法
SI1869065T1 (sl) 2005-03-11 2020-08-31 Wyeth Llc Postopek kromatografije z nizko porazdelitvijo
JP2009524436A (ja) 2006-01-24 2009-07-02 ノースフィールド ラボラトリーズ、インコーポレイテッド 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
CL2008002053A1 (es) * 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
AR067536A1 (es) * 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
AU2010258752B2 (en) 2009-06-09 2015-07-09 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
CN111989568B (zh) * 2018-04-18 2024-05-28 积水医疗株式会社 血红蛋白分析方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
SU940066A1 (ru) * 1979-12-10 1982-06-30 За витель Г. П. Григорьев Способ разделени эритроцитов на строму и гемоглобин
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2548670B1 (fr) * 1983-07-07 1985-10-25 Merieux Inst Procede de preparation des principales proteines du sang hemolyse sous forme non denaturee
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
EP0206448B1 (de) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US4900780A (en) * 1988-05-25 1990-02-13 Masonic Medical Research Laboratory Acellular resuscitative fluid
CA1338244C (en) * 1988-08-17 1996-04-09 Xiang-Fu Wu Purification of hemoglobin and methemoglobin by bioselective elution
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
DK0507870T3 (da) * 1989-12-29 1996-06-10 Univ Texas Tech Polyhæmoglobin stabiliseret med purinderivater af glutathion

Also Published As

Publication number Publication date
EP0654039A4 (de) 1996-09-11
EP0654039B1 (de) 2000-09-20
DE69329461T2 (de) 2001-05-23
AU4638393A (en) 1994-01-31
US5264555A (en) 1993-11-23
WO1994001452A1 (en) 1994-01-20
EP0654039A1 (de) 1995-05-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee