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DE69306908D1 - Verfahren zur Herstellung von Diltiazem - Google Patents

Verfahren zur Herstellung von Diltiazem

Info

Publication number
DE69306908D1
DE69306908D1 DE69306908T DE69306908T DE69306908D1 DE 69306908 D1 DE69306908 D1 DE 69306908D1 DE 69306908 T DE69306908 T DE 69306908T DE 69306908 T DE69306908 T DE 69306908T DE 69306908 D1 DE69306908 D1 DE 69306908D1
Authority
DE
Germany
Prior art keywords
diltiazem
preparation
benzothiazepine
chem
starting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306908T
Other languages
English (en)
Other versions
DE69306908T2 (de
Inventor
Fulvio Leone Piselli
Piermarino Boschi
Claudio Navoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambrex Profarmaco Milano SRL
Original Assignee
Profarmaco SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Profarmaco SRL filed Critical Profarmaco SRL
Application granted granted Critical
Publication of DE69306908D1 publication Critical patent/DE69306908D1/de
Publication of DE69306908T2 publication Critical patent/DE69306908T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
DE69306908T 1992-10-23 1993-10-18 Verfahren zur Herstellung von Diltiazem Expired - Fee Related DE69306908T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922432A IT1255545B (it) 1992-10-23 1992-10-23 Procedimento per la preparazione di diltiazem

Publications (2)

Publication Number Publication Date
DE69306908D1 true DE69306908D1 (de) 1997-02-06
DE69306908T2 DE69306908T2 (de) 1997-05-07

Family

ID=11364158

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306908T Expired - Fee Related DE69306908T2 (de) 1992-10-23 1993-10-18 Verfahren zur Herstellung von Diltiazem

Country Status (8)

Country Link
US (1) US5495013A (de)
EP (1) EP0594101B1 (de)
JP (1) JP3531954B2 (de)
AT (1) ATE146785T1 (de)
CA (1) CA2108950A1 (de)
DE (1) DE69306908T2 (de)
IL (1) IL107246A (de)
IT (1) IT1255545B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2576690B2 (ja) * 1993-03-11 1997-01-29 日本電気株式会社 ディジタル携帯電話機
FI97725C (fi) * 1995-02-17 1997-02-10 Orion Yhtymae Oy Menetelmä diltiatseemin valmistamiseksi
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
CN103305583A (zh) * 2012-03-12 2013-09-18 江苏华荣生物科技有限公司 简便化提取消旋对甲氧苯基缩水甘油酸甲酯

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS5899471A (ja) * 1981-12-07 1983-06-13 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5002942A (en) * 1988-07-25 1991-03-26 Sankyo Company, Limited 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1244878B (it) * 1990-12-11 1994-09-12 Lusochimica Spa Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato

Also Published As

Publication number Publication date
IT1255545B (it) 1995-11-09
JP3531954B2 (ja) 2004-05-31
EP0594101A1 (de) 1994-04-27
CA2108950A1 (en) 1994-04-24
ITMI922432A1 (it) 1994-04-23
DE69306908T2 (de) 1997-05-07
JPH06228117A (ja) 1994-08-16
ATE146785T1 (de) 1997-01-15
ITMI922432A0 (it) 1992-10-23
IL107246A (en) 1999-11-30
IL107246A0 (en) 1994-01-25
US5495013A (en) 1996-02-27
EP0594101B1 (de) 1996-12-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee