DE69233536D1 - Kokainrezeptor bindende Liganden - Google Patents
Kokainrezeptor bindende LigandenInfo
- Publication number
- DE69233536D1 DE69233536D1 DE69233536T DE69233536T DE69233536D1 DE 69233536 D1 DE69233536 D1 DE 69233536D1 DE 69233536 T DE69233536 T DE 69233536T DE 69233536 T DE69233536 T DE 69233536T DE 69233536 D1 DE69233536 D1 DE 69233536D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- alkyl
- cycloalkyl
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010063333 cocaine receptor Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 102000006441 Dopamine Plasma Membrane Transport Proteins Human genes 0.000 abstract 1
- 108010044266 Dopamine Plasma Membrane Transport Proteins Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79264891A | 1991-11-15 | 1991-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69233536D1 true DE69233536D1 (de) | 2005-08-25 |
Family
ID=25157598
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69229744T Expired - Lifetime DE69229744T2 (de) | 1991-11-15 | 1992-11-13 | Kokainrezeptor bindende Liganden |
| DE69233536T Expired - Lifetime DE69233536D1 (de) | 1991-11-15 | 1992-11-13 | Kokainrezeptor bindende Liganden |
| DE69233656T Expired - Lifetime DE69233656D1 (de) | 1991-11-15 | 1992-11-13 | Kokain-Rezeptor Bindungsliganden |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69229744T Expired - Lifetime DE69229744T2 (de) | 1991-11-15 | 1992-11-13 | Kokainrezeptor bindende Liganden |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69233656T Expired - Lifetime DE69233656D1 (de) | 1991-11-15 | 1992-11-13 | Kokain-Rezeptor Bindungsliganden |
Country Status (13)
| Country | Link |
|---|---|
| EP (3) | EP0905135B1 (de) |
| JP (1) | JP2852467B2 (de) |
| KR (1) | KR100251339B1 (de) |
| AT (3) | ATE182794T1 (de) |
| AU (1) | AU668371B2 (de) |
| CA (1) | CA2123570C (de) |
| DE (3) | DE69229744T2 (de) |
| DK (1) | DK0644775T3 (de) |
| ES (1) | ES2138601T3 (de) |
| FI (1) | FI942231A (de) |
| GR (1) | GR3031579T3 (de) |
| NO (1) | NO313097B1 (de) |
| WO (1) | WO1993009814A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7011813B2 (en) | 1990-08-09 | 2006-03-14 | Research Triangle Institute | Cocaine receptor binding ligands |
| US5935953A (en) * | 1990-08-09 | 1999-08-10 | Research Triangle Institute | Methods for controlling invertebrate pests using cocaine receptor binding ligands |
| US7189737B2 (en) | 1991-08-09 | 2007-03-13 | Research Triangle Institute | Cocaine receptor binding ligands |
| US6531483B1 (en) | 1990-08-09 | 2003-03-11 | Research Triangle Institute | Cocaine receptor binding ligands |
| US6329520B1 (en) * | 1990-08-09 | 2001-12-11 | Research Triangle Institute | Cocaine receptor binding ligands |
| AU671163B2 (en) | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| FI96603C (fi) * | 1994-12-30 | 1996-07-25 | Joergen Bergman | Uusi radioisotoopilla leimattu yhdiste, yhdistettä sisältävä seos sekä menetelmä niiden valmistamiseksi |
| US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| US6171576B1 (en) | 1995-11-03 | 2001-01-09 | Organix Inc. | Dopamine transporter imaging agent |
| US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
| US7105678B2 (en) | 1995-11-03 | 2006-09-12 | Organix, Inc. | Boat tropanes |
| SG99853A1 (en) * | 1996-02-22 | 2003-11-27 | Neurosearch As | Tropane-derivatives, their preparation and use |
| JP2002501921A (ja) * | 1998-01-28 | 2002-01-22 | ニューロサーチ、アクティーゼルスカブ | 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法 |
| CA2285516C (en) | 1999-05-12 | 2010-12-07 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
| DE20120708U1 (de) | 2001-10-09 | 2002-08-01 | Blundell, Paul, Sommerville, Mass. | Tropan-Analoga zur Inhibierung des Monoamin-Transports |
| EP1727547A1 (de) * | 2004-01-22 | 2006-12-06 | Neurosearch A/S | Verbindungen für die anhaltende verringerung des körpergewichts |
| WO2007006738A2 (en) * | 2005-07-12 | 2007-01-18 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising 2 , 3-disubstituted tropanes for the treatment of disorders of sexual desire |
| EP1779851A1 (de) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Behandlung von Diabetes |
| GB0922304D0 (en) * | 2009-12-22 | 2010-02-03 | Ge Healthcare Ltd | Radioiodinated compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
| US4179567A (en) * | 1978-04-10 | 1979-12-18 | Sterling Drug Inc. | 2-Aryltropane compounds |
| US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
-
1992
- 1992-11-13 WO PCT/US1992/009482 patent/WO1993009814A1/en active IP Right Grant
- 1992-11-13 EP EP98203570A patent/EP0905135B1/de not_active Expired - Lifetime
- 1992-11-13 JP JP5509307A patent/JP2852467B2/ja not_active Expired - Lifetime
- 1992-11-13 DE DE69229744T patent/DE69229744T2/de not_active Expired - Lifetime
- 1992-11-13 ES ES92924277T patent/ES2138601T3/es not_active Expired - Lifetime
- 1992-11-13 DK DK92924277T patent/DK0644775T3/da active
- 1992-11-13 DE DE69233536T patent/DE69233536D1/de not_active Expired - Lifetime
- 1992-11-13 AT AT92924277T patent/ATE182794T1/de active
- 1992-11-13 CA CA002123570A patent/CA2123570C/en not_active Expired - Lifetime
- 1992-11-13 EP EP92924277A patent/EP0644775B1/de not_active Expired - Lifetime
- 1992-11-13 KR KR1019940701635A patent/KR100251339B1/ko not_active IP Right Cessation
- 1992-11-13 DE DE69233656T patent/DE69233656D1/de not_active Expired - Lifetime
- 1992-11-13 EP EP98202861A patent/EP0897922B1/de not_active Expired - Lifetime
- 1992-11-13 AT AT98202861T patent/ATE299879T1/de not_active IP Right Cessation
- 1992-11-13 AT AT98203570T patent/ATE338755T1/de not_active IP Right Cessation
- 1992-11-13 AU AU30645/92A patent/AU668371B2/en not_active Expired
-
1994
- 1994-05-10 NO NO19941753A patent/NO313097B1/no active IP Right Review Request
- 1994-05-13 FI FI942231A patent/FI942231A/fi unknown
-
1999
- 1999-10-21 GR GR990402672T patent/GR3031579T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0905135A3 (de) | 1999-04-14 |
| ES2138601T3 (es) | 2000-01-16 |
| CA2123570A1 (en) | 1993-05-27 |
| DE69229744T2 (de) | 2000-04-27 |
| EP0905135B1 (de) | 2006-09-06 |
| NO941753D0 (no) | 1994-05-10 |
| GR3031579T3 (en) | 2000-01-31 |
| DE69229744D1 (de) | 1999-09-09 |
| AU668371B2 (en) | 1996-05-02 |
| DE69233656D1 (de) | 2006-10-19 |
| KR100251339B1 (ko) | 2000-09-01 |
| ATE299879T1 (de) | 2005-08-15 |
| WO1993009814A1 (en) | 1993-05-27 |
| ATE338755T1 (de) | 2006-09-15 |
| AU3064592A (en) | 1993-06-15 |
| EP0897922B1 (de) | 2005-07-20 |
| EP0644775A1 (de) | 1995-03-29 |
| NO941753L (no) | 1994-05-10 |
| DK0644775T3 (da) | 2000-03-06 |
| EP0644775A4 (de) | 1994-10-19 |
| FI942231A0 (fi) | 1994-05-13 |
| JPH07501074A (ja) | 1995-02-02 |
| FI942231A (fi) | 1994-05-13 |
| ATE182794T1 (de) | 1999-08-15 |
| NO313097B1 (no) | 2002-08-12 |
| CA2123570C (en) | 2003-11-04 |
| EP0905135A2 (de) | 1999-03-31 |
| EP0897922A3 (de) | 1999-04-07 |
| EP0644775B1 (de) | 1999-08-04 |
| JP2852467B2 (ja) | 1999-02-03 |
| EP0897922A2 (de) | 1999-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |