Nothing Special   »   [go: up one dir, main page]

DE69227750D1 - Neues biologisches Verfahren zur Herstellung von 7-ACA und 7-ADAC - Google Patents

Neues biologisches Verfahren zur Herstellung von 7-ACA und 7-ADAC

Info

Publication number
DE69227750D1
DE69227750D1 DE69227750T DE69227750T DE69227750D1 DE 69227750 D1 DE69227750 D1 DE 69227750D1 DE 69227750 T DE69227750 T DE 69227750T DE 69227750 T DE69227750 T DE 69227750T DE 69227750 D1 DE69227750 D1 DE 69227750D1
Authority
DE
Germany
Prior art keywords
adipoyl
aca
side chain
adac
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69227750T
Other languages
English (en)
Other versions
DE69227750T2 (de
Inventor
Michael J Conder
John A Rambosek
Anthony Michael Stepan
Phyllis C Mcada
Lorilee Crawford
Christopher D Reeves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
Gist Brocades BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades BV filed Critical Gist Brocades BV
Application granted granted Critical
Publication of DE69227750D1 publication Critical patent/DE69227750D1/de
Publication of DE69227750T2 publication Critical patent/DE69227750T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DE69227750T 1991-10-15 1992-10-14 Neues biologisches Verfahren zur Herstellung von 7-ACA und 7-ADAC Expired - Fee Related DE69227750T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06

Publications (2)

Publication Number Publication Date
DE69227750D1 true DE69227750D1 (de) 1999-01-14
DE69227750T2 DE69227750T2 (de) 1999-04-22

Family

ID=27119363

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69232581T Expired - Fee Related DE69232581T2 (de) 1991-10-15 1992-10-14 Adipoyl 7-aminodeacetyl-Cephalosporansäure
DE69227750T Expired - Fee Related DE69227750T2 (de) 1991-10-15 1992-10-14 Neues biologisches Verfahren zur Herstellung von 7-ACA und 7-ADAC

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69232581T Expired - Fee Related DE69232581T2 (de) 1991-10-15 1992-10-14 Adipoyl 7-aminodeacetyl-Cephalosporansäure

Country Status (27)

Country Link
US (4) US5559005A (de)
EP (2) EP0540210B1 (de)
JP (1) JP2655790B2 (de)
KR (1) KR100227711B1 (de)
CN (1) CN1074484A (de)
AT (2) ATE216700T1 (de)
AU (1) AU657800B2 (de)
BG (1) BG62261B1 (de)
CA (1) CA2080573C (de)
CZ (1) CZ288721B6 (de)
DE (2) DE69232581T2 (de)
DK (2) DK0856516T3 (de)
ES (2) ES2127205T3 (de)
FI (1) FI106965B (de)
GR (1) GR3029343T3 (de)
HU (1) HU219370B (de)
IL (3) IL103419A (de)
MX (1) MX9205902A (de)
NO (1) NO315802B1 (de)
NZ (1) NZ244714A (de)
RO (1) RO116648B1 (de)
RU (1) RU2002130702A (de)
SK (1) SK280569B6 (de)
TW (1) TW272233B (de)
UA (1) UA47385C2 (de)
WO (1) WO1993008287A1 (de)
YU (1) YU48930B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233715B1 (de) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen
US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100336174B1 (ko) * 1993-07-30 2002-11-01 디에스엠 기스트 베.파우. 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
ATE234926T1 (de) * 1993-07-30 2003-04-15 Dsm Nv Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca
WO1996010084A1 (en) * 1994-09-28 1996-04-04 Novo Nordisk A/S Process for the production of secondary metabolites
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
KR100421225B1 (ko) * 1995-06-02 2004-06-18 디에스엠 기스트 베.파우. 페니실린g상에서의익스팬다제활성에의한7-adca의제조방법
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
WO1997038107A1 (en) * 1996-04-04 1997-10-16 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
AU4201897A (en) 1996-07-16 1998-02-09 Gist-Brocades B.V. Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
PT918878E (pt) 1997-04-22 2005-05-31 Dsm Ip Assets Bv Processo melhorado para a producao fermentativa de cefalosporina
WO1998048037A1 (en) * 1997-04-22 1998-10-29 Dsm N.V. A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS
AU7648898A (en) * 1997-04-22 1998-11-13 Gist-Brocades B.V. Process for the fermentative production of deacylated cephalosporins
WO1998048035A1 (en) * 1997-04-22 1998-10-29 Gist-Brocades B.V. Process for the fermentative production of deacylated cephalosporins
AU9264598A (en) * 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
EP1066294B1 (de) 1998-03-27 2002-10-30 Dsm N.V. Verfahren zur fermentativen herstellung von cephalosporin
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
KR20010089672A (ko) * 1998-12-22 2001-10-08 윌리암 로엘프 드 보에르 개선된 생체내 세팔로스포린 생산
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
BRPI0110774B8 (pt) 2000-05-13 2021-05-25 Smithkline Beecham Plc processo para purificação de um sal de ácido clavulânico
US6699699B2 (en) * 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
CN1795197B (zh) * 2003-05-28 2010-06-02 帝斯曼知识产权资产管理有限公司 头孢菌素类化合物
WO2007096419A1 (en) * 2006-02-23 2007-08-30 Dsm Ip Assets B.V. Improved cephalosporin production
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
EP2414530A1 (de) 2009-04-03 2012-02-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Fermentationsverfahren
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
CN103003439A (zh) 2010-06-22 2013-03-27 中化帝斯曼制药有限公司荷兰公司 气泡发酵工艺
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101808192B1 (ko) * 2016-08-26 2018-01-18 아미코젠주식회사 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1270852A (fr) * 1960-09-20 1961-09-01 Bayer Ag Procédé d'acylation enzymatique d'acide 6-aminopénicillanique
FR2241557A1 (en) * 1973-08-22 1975-03-21 Aries Robert 7-Amino-desacetoxy cephalosporanic acid prepn - from cephalosporin C, using an amido hydrolase enzyme
JPS5417032B2 (de) * 1974-01-23 1979-06-27
JPS5282791A (en) * 1975-12-27 1977-07-11 Toyo Jozo Co Ltd Preparation of 7-amino compounds
JPS5920360B2 (ja) * 1976-04-19 1984-05-12 萬有製薬株式会社 ７−アミノセフアロスポラン酸および其の誘導体の製造法
JPS5386094A (en) * 1977-01-06 1978-07-29 Banyu Pharmaceut Co Ltd Preparation of 7-amino-cephem derivatives
US4178210A (en) * 1977-03-07 1979-12-11 Massachusetts Institute Of Technology Accellular synthesis of cephalosporins
US4248966A (en) * 1979-05-17 1981-02-03 Massachusetts Institute Of Technology Synthesis of isopenicillin derivatives in the absence of living cells
US4307192A (en) * 1979-05-17 1981-12-22 Massachusetts Institute Of Technology Cell-free synthesis of deacetoxycephalosporin C
US4536476A (en) * 1982-08-23 1985-08-20 Queen's University At Kingston Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
US4510246A (en) * 1982-08-23 1985-04-09 Queen's University At Kingston Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins
JPS60110292A (ja) * 1983-11-22 1985-06-15 Asahi Chem Ind Co Ltd セフアロスポリン・アシラ−ゼ産生遺伝情報を担うｄνａ断片
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
FR2569723B1 (fr) * 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
JPS61152286A (ja) * 1984-12-27 1986-07-10 Asahi Chem Ind Co Ltd セフアロスポリンｃアシラ−ゼ産生遺伝情報を担うｄｎａ断片
EP0233715B1 (de) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen
US4753881A (en) * 1986-09-10 1988-06-28 Eli Lilly And Company Purified enzyme and process therefor
JPH0829114B2 (ja) * 1986-09-18 1996-03-27 旭化成工業株式会社 ７−アミノセフアロスポラン酸およびその誘導体の製造法
IL81555A0 (en) * 1986-11-17 1987-09-16 Baldwin Jack Edward Enzymatic process for 3-substituted cephalosporins
EP0275901B1 (de) * 1987-01-17 1993-06-09 Hoechst Aktiengesellschaft Verwendung von Gamma-Glutamyl-Transpeptidase
CA1327170C (en) * 1987-03-04 1994-02-22 Stephen Wyatt Queener Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase and deacetylcephalosporin c synthetase
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
DE3743323A1 (de) * 1987-12-21 1989-06-29 Hoechst Ag Verfahren zur enzymatischen hydrolyse von (alpha)-aminoadipinyl-monoaminoverbindungen
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5082772A (en) * 1988-10-24 1992-01-21 Eli Lilly And Company Process for preparing deacetylcephalosporin c
JP2928884B2 (ja) * 1989-02-01 1999-08-03 武田薬品工業株式会社 Ｄｎａおよびその用途
JPH04504362A (ja) * 1989-04-04 1992-08-06 バイオピユア・コーポレーシヨン 酵素による７―アミノセフアロスポラン酸の製造
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
IL95766A (en) * 1989-09-27 1996-12-05 Lilly Co Eli Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
ES2133140T3 (es) * 1990-01-12 1999-09-01 Glaxo Group Ltd Secuencia de adn que codifica una enzima de biosintesis de antibioticos.
JPH03254684A (ja) * 1990-03-02 1991-11-13 Asahi Chem Ind Co Ltd 新規ｃＤＮＡ化合物
CA2045951A1 (en) * 1990-07-06 1992-01-07 Steven Kovacevic Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Also Published As

Publication number Publication date
NO315802B1 (no) 2003-10-27
ES2176613T3 (es) 2002-12-01
US6017726A (en) 2000-01-25
US6071713A (en) 2000-06-06
DE69232581T2 (de) 2002-11-14
DE69227750T2 (de) 1999-04-22
US5629171A (en) 1997-05-13
UA47385C2 (uk) 2002-07-15
RU2002130702A (ru) 2004-05-20
HU9401073D0 (en) 1994-07-28
SK280569B6 (sk) 2000-03-13
CN1074484A (zh) 1993-07-21
RO116648B1 (ro) 2001-04-30
EP0856516A1 (de) 1998-08-05
JPH06113884A (ja) 1994-04-26
US5559005A (en) 1996-09-24
ES2127205T3 (es) 1999-04-16
AU2701692A (en) 1993-04-22
IL133733A0 (en) 2001-04-30
IL103419A0 (en) 1993-03-15
ATE216700T1 (de) 2002-05-15
EP0540210B1 (de) 1998-12-02
AU657800B2 (en) 1995-03-23
CZ288721B6 (cs) 2001-08-15
TW272233B (de) 1996-03-11
FI941730A0 (fi) 1994-04-14
ATE174057T1 (de) 1998-12-15
YU92592A (sh) 1995-10-03
DE69232581D1 (de) 2002-05-29
YU48930B (sh) 2002-12-10
BG98714A (bg) 1995-02-28
IL103419A (en) 2003-06-24
WO1993008287A1 (en) 1993-04-29
KR100227711B1 (ko) 1999-12-01
FI941730A (fi) 1994-04-14
NZ244714A (en) 1994-03-25
IL133734A0 (en) 2001-04-30
DK0856516T3 (da) 2002-07-29
EP0856516B1 (de) 2002-04-24
FI106965B (fi) 2001-05-15
JP2655790B2 (ja) 1997-09-24
CZ88494A3 (en) 1995-03-15
CA2080573A1 (en) 1993-04-16
EP0540210A1 (de) 1993-05-05
BG62261B1 (bg) 1999-06-30
GR3029343T3 (en) 1999-05-28
CA2080573C (en) 2004-01-06
SK43194A3 (en) 1996-11-06
DK0540210T3 (da) 1999-06-23
HU219370B (en) 2001-03-28
MX9205902A (es) 1994-06-30
NO941345L (no) 1994-06-15
NO941345D0 (no) 1994-04-14
HUT69783A (en) 1995-09-28

Similar Documents

Publication Publication Date Title
DE69227750D1 (de) Neues biologisches Verfahren zur Herstellung von 7-ACA und 7-ADAC
CA2077921A1 (en) Bioprocess for preparing 7-adca
RU94017674A (ru) Способ получения соединения, вектор, клетка
US6518039B2 (en) Process for the fermentative production of deacylated cephalosporins
US5441874A (en) Method for the acylation of the 7-amino group of the cephalosporanic ring
EP0915988B1 (de) Verfahren für die fermentative produktion von deazylierten cephalosporinen.
IE39462L (en) 7-ß-AMINO-7-Ó-METHOXYCEPHALOSPORANIC ACID ESTERS
Baldaro et al. Phenylacetyloxymethylene, a carboxyl protecting group removable with immobilized penicillin acylase, useful in benzyl penicillin chemistry
HUT45006A (en) Process for producing 4-halogeno-2-/oxy-imino/-3-oxo-butiric acid derivatives
US6319684B1 (en) Process for the fermentative production of cephalosporin
Conder et al. Bioprocess for preparing 7-ACA and 7-ADAC
ATE191932T1 (de) Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor
US20020006642A1 (en) Method for preparing a beta-lactam antibiotic
HUP9801906A2 (hu) Eljárás 7-amino-dezacetoxi-cefalosporánsav (7-ADCA) előállítására G-penicillinre kifejtett expandáz aktivitás útján
EP0638649A2 (de) Neue Anwendung von Alcaligenes faecalis Penicillin G Acylase
GB1512660A (en) Cephalosporin esters
YU48769B (sh) Novi biopostupak za izradu 7-adck
WO1998048037A1 (en) A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS
GB1480850A (en) Enzymatic hydrolysis and synthesis
ITMI960033A1 (it) Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima
RU94022268A (ru) Способы получения промежуточных продуктов для синтеза цефалоспориновых антибиотиков, векторы, клетка

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8339 Ceased/non-payment of the annual fee