DE69214369D1 - Verfahren zur Herstellung von Pyranonen und Pyrandionen - Google Patents
Verfahren zur Herstellung von Pyranonen und PyrandionenInfo
- Publication number
- DE69214369D1 DE69214369D1 DE69214369T DE69214369T DE69214369D1 DE 69214369 D1 DE69214369 D1 DE 69214369D1 DE 69214369 T DE69214369 T DE 69214369T DE 69214369 T DE69214369 T DE 69214369T DE 69214369 D1 DE69214369 D1 DE 69214369D1
- Authority
- DE
- Germany
- Prior art keywords
- chem
- hydrogen
- formula
- substituted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73440891A | 1991-07-23 | 1991-07-23 | |
| US07/849,908 US5274143A (en) | 1991-07-23 | 1992-03-12 | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69214369D1 true DE69214369D1 (de) | 1996-11-14 |
| DE69214369T2 DE69214369T2 (de) | 1997-03-27 |
Family
ID=27112724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69214369T Expired - Lifetime DE69214369T2 (de) | 1991-07-23 | 1992-07-09 | Verfahren zur Herstellung von Pyranonen und Pyrandionen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5274143A (de) |
| EP (1) | EP0524495B1 (de) |
| JP (1) | JP3248760B2 (de) |
| AT (1) | ATE143954T1 (de) |
| DE (1) | DE69214369T2 (de) |
| DK (1) | DK0524495T3 (de) |
| ES (1) | ES2092603T3 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5481008A (en) * | 1993-09-13 | 1996-01-02 | Hoffmann-La Roche Inc. | Process for the preparation of optically active compounds |
| US6545165B1 (en) * | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| CA2416900C (en) | 2000-07-28 | 2007-07-03 | F. Hoffmann-La Roche Ag | The use of a combination of a lipase inhibitor and a pharmaceutically acceptable bile acid sequestrant for the prevention and treatment of diseases associated with high plasma cholesterol levels |
| DK1311260T3 (da) | 2000-08-09 | 2008-06-23 | Hoffmann La Roche | Lipaseinhibitorer til behandling af dyspepsi |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| EP1328515B1 (de) | 2000-10-16 | 2008-08-06 | F. Hoffmann-La Roche AG | Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| AU2002228007B2 (en) | 2000-12-27 | 2007-06-21 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-HT2b and 5-HT2c receptor ligands |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| DE60225274T2 (de) | 2001-05-21 | 2009-03-26 | F. Hoffmann-La Roche Ag | Chinolinderivate als liganden für den neuropeptid-y-rezeptor |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| SE0104274D0 (sv) * | 2001-12-17 | 2001-12-17 | Astrazeneca Ab | Novel process |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| KR100659428B1 (ko) | 2002-02-04 | 2006-12-19 | 에프. 호프만-라 로슈 아게 | Ｎｐｙ 길항제로서의 퀴놀린 유도체 |
| AU2003210305B2 (en) | 2002-02-28 | 2006-07-06 | F. Hoffmann-La Roche Ag | Thiazole derivatives as NPY receptor antagonists |
| CA2489251A1 (en) | 2002-07-05 | 2004-01-15 | F. Hoffmann-La Roche Ag | Quinazoline derivatives |
| WO2004014884A1 (en) | 2002-08-07 | 2004-02-19 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| RU2296759C2 (ru) | 2002-09-12 | 2007-04-10 | Ф.Хоффманн-Ля Рош Аг | N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты) |
| MXPA05005445A (es) | 2002-11-25 | 2005-08-26 | Hoffmann La Roche | Derivados de indolilo. |
| KR100875318B1 (ko) * | 2002-11-26 | 2008-12-22 | 화이자 프로덕츠 인크. | Ｐｐａｒ 활성화 인자로 사용하기 위한 페닐 치환된피페리딘 화합물 |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| BRPI0413500A (pt) | 2003-08-12 | 2006-10-10 | Hoffmann La Roche | compostos, processos para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade |
| CA2533464A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Thiazole derivatives as npy antagonists |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| AU2005308575A1 (en) * | 2004-11-23 | 2006-06-01 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia |
| JP2008540368A (ja) | 2005-05-03 | 2008-11-20 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ２リガンドとしての四環式アザピラジノインドリン |
| EP1912968A1 (de) * | 2005-08-04 | 2008-04-23 | Pfizer Limited | Piperidinoylpyrrolidin- und piperidinoylpiperidin-verbindungen |
| WO2007020213A2 (en) | 2005-08-18 | 2007-02-22 | F. Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as h3 receptor modulators |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| CN101316838B (zh) | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
| BRPI0619233A2 (pt) | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
| CN101316840B (zh) | 2005-11-30 | 2012-08-08 | 霍夫曼-拉罗奇有限公司 | 1,5-取代的吲哚-2-基酰胺衍生物 |
| AU2006324089A1 (en) | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| ES2334580T3 (es) | 2005-12-15 | 2010-03-12 | F. Hoffmann-La Roche Ag | Derivados de pirrolo(2,3-c)piridina. |
| CN101331131A (zh) | 2005-12-16 | 2008-12-24 | 霍夫曼-拉罗奇有限公司 | 用作H3受体调节剂的吡咯并[2,3-b]吡啶衍生物 |
| MEP6808A (xx) * | 2006-02-23 | 2010-02-10 | Lundbeck & Co As H | Priperidinoilpirodolini agonisti receptora menalokortina tipa 4 |
| US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| MX2008014532A (es) | 2006-05-30 | 2008-11-27 | Hoffmann La Roche | Derivados de piperidinil pirimidinas. |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| MX2009004314A (es) | 2006-11-13 | 2009-05-05 | Pfizer Prod Inc | Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos. |
| WO2008062276A2 (en) * | 2006-11-20 | 2008-05-29 | Glenmark Pharmaceuticals S.A. | Acetylene derivatives as stearoyl coa desaturase inhibitors |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| EP2183237A1 (de) * | 2007-07-25 | 2010-05-12 | F. Hoffmann-Roche AG | Benzofuran- und benzo[b]thiophen-2-carbonsäureamidderivate und deren verwendung als modulatoren des histamin-3-rezeptors |
| WO2009037542A2 (en) | 2007-09-20 | 2009-03-26 | Glenmark Pharmaceuticals, S.A. | Spirocyclic compounds as stearoyl coa desaturase inhibitors |
| KR101076680B1 (ko) * | 2007-11-01 | 2011-10-26 | 한미홀딩스 주식회사 | (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체 |
| BRPI0820701A2 (pt) | 2007-12-11 | 2015-06-16 | Cytopathfinder Inc | Composto de carboxamida e seu uso como agonistas do receptor de quimiocina |
| KR101280786B1 (ko) * | 2008-08-06 | 2013-07-05 | 화이자 리미티드 | 멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물 |
| JP2013528172A (ja) | 2010-05-21 | 2013-07-08 | ファイザー・インク | ２−フェニルベンゾイルアミド |
| CA2828343A1 (en) | 2011-03-04 | 2012-09-13 | The Scripps Research Institute | Edn3-like peptides and uses thereof |
| SG11201507496UA (en) | 2013-04-17 | 2015-11-27 | Pfizer | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2542849A (en) * | 1948-10-22 | 1951-02-20 | Gen Aniline & Film Corp | Diazotypes containing pyronones |
| US4206222A (en) * | 1977-06-23 | 1980-06-03 | Societe Civile Particuliere De Brevets Suffren | Method for preparing a substance having properties against collagen diseases and products obtained |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
-
1992
- 1992-03-12 US US07/849,908 patent/US5274143A/en not_active Expired - Lifetime
- 1992-07-09 DK DK92111663.8T patent/DK0524495T3/da active
- 1992-07-09 EP EP92111663A patent/EP0524495B1/de not_active Expired - Lifetime
- 1992-07-09 AT AT92111663T patent/ATE143954T1/de active
- 1992-07-09 DE DE69214369T patent/DE69214369T2/de not_active Expired - Lifetime
- 1992-07-09 ES ES92111663T patent/ES2092603T3/es not_active Expired - Lifetime
- 1992-07-22 JP JP21573492A patent/JP3248760B2/ja not_active Expired - Lifetime
-
1993
- 1993-10-04 US US08/131,843 patent/US5420305A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69214369T2 (de) | 1997-03-27 |
| DK0524495T3 (da) | 1996-11-25 |
| US5420305A (en) | 1995-05-30 |
| ES2092603T3 (es) | 1996-12-01 |
| US5274143A (en) | 1993-12-28 |
| JPH05194471A (ja) | 1993-08-03 |
| JP3248760B2 (ja) | 2002-01-21 |
| EP0524495A1 (de) | 1993-01-27 |
| ATE143954T1 (de) | 1996-10-15 |
| EP0524495B1 (de) | 1996-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH |
|
| 8364 | No opposition during term of opposition | ||
| R071 | Expiry of right |
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