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DE69133575D1 - Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen - Google Patents

Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen

Info

Publication number
DE69133575D1
DE69133575D1 DE69133575T DE69133575T DE69133575D1 DE 69133575 D1 DE69133575 D1 DE 69133575D1 DE 69133575 T DE69133575 T DE 69133575T DE 69133575 T DE69133575 T DE 69133575T DE 69133575 D1 DE69133575 D1 DE 69133575D1
Authority
DE
Germany
Prior art keywords
nitric oxide
newborn
treatment
pulmonary hypertension
persistent pulmonary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133575T
Other languages
English (en)
Other versions
DE69133575T2 (de
Inventor
Warren M Zapol
Claes Frostell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27089304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133575(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE69133575D1 publication Critical patent/DE69133575D1/de
Application granted granted Critical
Publication of DE69133575T2 publication Critical patent/DE69133575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Glass Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69133575T 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen Expired - Lifetime DE69133575T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62286590A 1990-12-05 1990-12-05
US622865 1990-12-05
US76723491A 1991-09-27 1991-09-27
US767234 1991-09-27

Publications (2)

Publication Number Publication Date
DE69133575D1 true DE69133575D1 (de) 2007-09-06
DE69133575T2 DE69133575T2 (de) 2008-04-17

Family

ID=27089304

Family Applications (9)

Application Number Title Priority Date Filing Date
DE0560928T Pending DE560928T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum behandeln einer lungengefässverengung und von asthma.
DE69133584T Expired - Lifetime DE69133584T4 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE69133575T Expired - Lifetime DE69133575T2 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen
DE200812000012 Active DE122008000012I2 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma.
DE122007000103C Pending DE122007000103I1 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen
DE69127756T Expired - Lifetime DE69127756T2 (de) 1990-12-05 1991-12-05 Verwendung von no zur behandlung oder prävention der bronchokonstriktion
DE69133584A Expired - Lifetime DE69133584D1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE0786264T Pending DE786264T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE2002199002 Pending DE10299002I1 (de) 1990-12-05 1991-12-05 Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE0560928T Pending DE560928T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum behandeln einer lungengefässverengung und von asthma.
DE69133584T Expired - Lifetime DE69133584T4 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma

Family Applications After (6)

Application Number Title Priority Date Filing Date
DE200812000012 Active DE122008000012I2 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma.
DE122007000103C Pending DE122007000103I1 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen
DE69127756T Expired - Lifetime DE69127756T2 (de) 1990-12-05 1991-12-05 Verwendung von no zur behandlung oder prävention der bronchokonstriktion
DE69133584A Expired - Lifetime DE69133584D1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE0786264T Pending DE786264T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE2002199002 Pending DE10299002I1 (de) 1990-12-05 1991-12-05 Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion

Country Status (17)

Country Link
US (2) US5873359A (de)
EP (4) EP0560928B1 (de)
JP (3) JP2701978B2 (de)
AT (3) ATE158509T1 (de)
AU (1) AU657726B2 (de)
CA (1) CA2097823C (de)
DE (9) DE560928T1 (de)
DK (3) DK0786264T3 (de)
EE (1) EE03119B1 (de)
ES (3) ES2132043T3 (de)
GR (3) GR960300032T1 (de)
HK (3) HK1020686A1 (de)
LU (3) LU90886I2 (de)
LV (1) LV12201B (de)
NL (3) NL300081I2 (de)
SG (1) SG47527A1 (de)
WO (1) WO1992010228A1 (de)

Families Citing this family (262)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE560928T1 (de) 1990-12-05 1994-09-22 The General Hospital Corp., Charlestown, Mass. Vorrichtung zum behandeln einer lungengefässverengung und von asthma.
US5570683A (en) * 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
AU651882B2 (en) * 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
FR2695831B1 (fr) * 1992-09-24 1994-11-10 Air Liquide Installation et procédé de fourniture d'un mélange gazeux aux voies respiratoires d'un utilisateur.
EP0692990B1 (de) * 1993-04-06 1998-09-23 Minnesota Mining And Manufacturing Company Vorrichtung zum deagglomerieren für trockenpulverinhalatoren
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation
ATE204491T1 (de) * 1993-04-17 2001-09-15 Messer Griesheim Austria Ges M Gerät zur kontrollierten zudosierung von no zur atemluft von patienten
DK0724723T3 (da) * 1993-07-06 2000-10-23 Kjell Alving System til bestemmelse af NO-Nivveauer i udåndet luft og diagnostiske metoder til forstyrrelser relateret tilunormale NO-ni
SE501074C2 (sv) * 1993-07-22 1994-11-07 Siemens Elema Ab Gasblandning och apparat för att tillföra gasblandningen till lungorna hos ett levande väsen
DE4327732C1 (de) * 1993-08-18 1994-09-01 Messer Griesheim Gmbh NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen
DE4327731C1 (de) * 1993-08-18 1994-11-10 Messer Griesheim Gmbh NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen
GB9320978D0 (en) * 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
US5558083A (en) * 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system
JP3911290B2 (ja) * 1994-05-13 2007-05-09 アラダイム コーポレーション エアゾールを含む麻酔用処方
DE4419860A1 (de) * 1994-06-07 1995-12-14 Hoechst Ag Verfahren und Filter zur Herstellung von NO¶2¶-freiem Stickstoffmonoxid mit schwefelhaltigen Polymeren
US5615669A (en) * 1994-07-22 1997-04-01 Siemens Elema Ab Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject
US6063407A (en) * 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5665077A (en) * 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
SE506208C2 (sv) * 1995-07-05 1997-11-24 Aerocrine Systems Kb Anordning för uppsamling av gas från de övre luftvägarna och leverans av denna gas till inandningsluften i en respirator
RU2072241C1 (ru) * 1995-09-20 1997-01-27 Панина Елена Владимировна Способ формирования дыхательной газовой смеси и аппарат для его осуществления
EP0768095B1 (de) * 1995-10-13 2001-12-19 Siemens-Elema AB Trachealtubus und Vorrichtung für Beatmungssysteme
DE69617719D1 (de) * 1995-10-20 2002-01-17 Air Liquide Pharmazeutische zusammensetzung von stickstoffmonoxid
AU7529796A (en) * 1995-11-13 1997-06-05 Brigham And Women's Hospital S-nitroso-hemoglobin and therapeutic uses thereof
US5699790A (en) * 1996-03-21 1997-12-23 Ohmeda Inc. System for predicting NO2 concentrations
CA2251530C (en) * 1996-04-05 2002-11-19 The General Hospital Corporation Treatment of a hemoglobinopathy
US5765548A (en) * 1996-05-07 1998-06-16 Perry; Bryan J. Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine
US5811437A (en) * 1996-05-21 1998-09-22 Eli Lilly And Company Methods of increasing nitric oxide synthesis
CA2206477A1 (en) 1996-07-10 1998-01-10 Ohmeda Inc. System for correcting no2 monitor
US5732694A (en) * 1996-12-13 1998-03-31 Ohmeda Inc. System for correcting NO2 monitor
CA2260771A1 (en) * 1996-07-17 1998-01-22 The General Hospital Corporation Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene
US6720309B1 (en) * 1996-07-17 2004-04-13 Leuven Research And Development, V.Z.W. Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene
JP3880103B2 (ja) * 1996-07-18 2007-02-14 住友精化株式会社 医療用一酸化窒素混合ガスおよびその製造方法
SE9602959L (sv) * 1996-08-12 1998-02-09 Siemens Elema Ab Förfarande vid blandning av gaser och en anordning för blandning av gaser
WO1998007020A1 (en) * 1996-08-13 1998-02-19 University Of Massachusetts Nitric oxide sensor
DE19734279A1 (de) * 1997-08-07 1999-02-11 Messer Griesheim Gmbh Wasserstoffhaltiges Medikament
US5732693A (en) 1996-10-02 1998-03-31 Ohmeda Inc. Pause control of nitric oxide therapy
PT973443E (pt) 1997-01-17 2006-08-31 Ino Therapeutics Gmbh Sistema comandado de fornecimento de gas
US6027713A (en) * 1997-03-06 2000-02-22 Meri Charmyne Russell Composition and method for the treatment of exercise induced pulmonary hemorrhage
SE9700940D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler IV
CA2225013C (en) 1997-04-04 2006-06-06 Institut Du N.O. Inc. Injection system for delivery of a gaseous substance
WO1998046277A2 (en) * 1997-04-16 1998-10-22 Ohmeda, Inc. Humidity compensation for fuel cell zeroing in respiratory gas measurement
US5918596A (en) * 1997-04-22 1999-07-06 Instrumentarium Corp. Special gas dose delivery apparatus for respiration equipment
FR2762992B1 (fr) * 1997-05-07 2000-08-25 Air Liquide Transporteurs de no a base de complexes polyazamacrocycles de fer et de cobalt
US6125846A (en) * 1997-05-16 2000-10-03 Datex-Ohmeda, Inc. Purge system for nitric oxide administration apparatus
US6656452B1 (en) * 1997-10-21 2003-12-02 The General Hospital Corporation Use of inhaled NO as anti-inflammatory agent
US6109260A (en) * 1998-02-18 2000-08-29 Datex-Ohmeda, Inc. Nitric oxide administration device with timed pulse
US6142147A (en) * 1998-03-31 2000-11-07 The General Hospital Corporation Nasal delivery system for inhaled nitric oxide
CA2254645A1 (en) * 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070086954A1 (en) * 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
JP3641151B2 (ja) * 1999-02-04 2005-04-20 帝人株式会社 治療用ガス投入用呼吸マスク
US9486429B2 (en) * 1999-06-01 2016-11-08 Vanderbilt University Therapeutic methods employing nitric oxide precursors
US6346382B1 (en) 1999-06-01 2002-02-12 Vanderbilt University Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
FR2795644B1 (fr) * 1999-07-02 2004-07-30 Air Liquide Sante Int Utilisations therapeutiques d'un melange helium/oxygene, en particulier dans le traitement de l'asthme
US7017573B1 (en) * 1999-07-12 2006-03-28 Capnia, Incorporated Methods and apparatus for relieving headaches, rhinitis and other common ailments
DE60043731D1 (de) * 1999-08-02 2010-03-11 Univ Duke Methode zur bestimmung der physiologischen wirkungen von hämoglobin
US7045152B2 (en) * 1999-09-08 2006-05-16 Duke University Treating pulmonary disorders with gaseous agent causing repletion of GSNO
US6314956B1 (en) * 1999-09-08 2001-11-13 Duke University Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
US6694969B1 (en) 1999-09-22 2004-02-24 Instrumentarium Corp. Method to improve oxygenation in subjects suffering impaired oxygenation
ATE323521T1 (de) 1999-09-22 2006-05-15 Instrumentarium Corp Verbesserung der sauerstoffversorgung in lebewesen mit gestörter sauerstoffversorgung
US6612306B1 (en) 1999-10-13 2003-09-02 Healthetech, Inc. Respiratory nitric oxide meter
RU2259827C2 (ru) 1999-10-29 2005-09-10 Орион Корпорейшн Лечение или предупреждение гипотензии и шока
SE9903985D0 (sv) * 1999-11-03 1999-11-03 Aga Ab Use of nitric oxide
CA2389294A1 (en) * 1999-11-08 2001-05-25 Capnia, Incorporated Method and apparatus for relieving ailments using gases to increase the effectiveness of drugs
US20060172017A1 (en) 1999-11-08 2006-08-03 Capnia, Incorporated Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US20070039615A1 (en) * 1999-11-08 2007-02-22 Capnia, Incorporated Methods and apparatus for treating rhinitis
US7516742B2 (en) * 1999-11-24 2009-04-14 Cardinal Health 207, Inc. Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
US6581599B1 (en) 1999-11-24 2003-06-24 Sensormedics Corporation Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients
US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
US20030026766A1 (en) * 2000-04-13 2003-02-06 Mark Sanders Medicaments for treating respiratory disorders comprising formoterol and fluticasone
US6601580B1 (en) * 2000-06-28 2003-08-05 The General Hospital Corporation Enhancing therapeutic effectiveness of nitric oxide inhalation
US6951215B1 (en) * 2000-07-14 2005-10-04 Tufts University Drug delivery device for animals
AU8484901A (en) 2000-08-11 2002-02-25 David R Whitlock Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same
US6620106B2 (en) 2000-09-29 2003-09-16 Healthetech, Inc. Indirect calorimetry system
US6668828B1 (en) 2000-10-16 2003-12-30 Pulmonox Technologies Corporations System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient
SE0004229D0 (sv) * 2000-11-17 2000-11-17 Aga Ab Inhalation of nitric oxide
US7335181B2 (en) * 2000-12-26 2008-02-26 Pulmonox Technologies Corporation Nitric oxide decontamination of the upper respiratory tract
US6432077B1 (en) * 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US7122018B2 (en) * 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
AUPR315401A0 (en) 2001-02-16 2001-03-15 Resmed Limited An apparatus for supplying clean breathable gas
WO2002087673A1 (de) * 2001-04-25 2002-11-07 Messer Austria Gmbh Aerosoldosiergerät
US6749834B2 (en) * 2001-06-19 2004-06-15 World Precision Instruments, Inc. Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies
CA2833997C (en) 2001-09-05 2017-09-26 Geno Llc Method and apparatus for nitric oxide generation
US6575918B2 (en) 2001-09-27 2003-06-10 Charlotte-Mecklenburg Hospital Non-invasive device and method for the diagnosis of pulmonary vascular occlusions
US20030070674A1 (en) * 2001-10-12 2003-04-17 Bryan Perry Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US6472390B1 (en) * 2001-11-13 2002-10-29 Duke University Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
KR20040086267A (ko) * 2002-01-11 2004-10-08 데이비드 알. 휘트록 암모니아 산화 박테리아를 포함하는 조성물 및 그를사용하는 방법
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
CA2487719A1 (en) * 2002-05-29 2003-12-11 Duke University Measuring nitric oxide in blood gases and treatments based thereon
EA200500062A1 (ru) * 2002-06-21 2005-06-30 Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Фармацевтическое применение оксида азота, гемоксигеназы-1 и продуктов деградации гема
ES2651342T3 (es) * 2002-06-28 2018-01-25 The Research Foundation Of The State University Of New York Dispositivo y procedimiento de administración de un agente terapéutico
AU2003259897B2 (en) * 2002-08-20 2008-04-03 Aga Ab Methods and devices for administration of therapeutic gases
US7337776B2 (en) * 2002-08-20 2008-03-04 Aga Ab Methods for easing pain and anxiety from atrial or ventricular defibrillation
US7681572B2 (en) * 2002-08-20 2010-03-23 Aga Ab Method and devices for administration of therapeutic gases
US8001962B2 (en) * 2002-08-23 2011-08-23 Sheiman Ultrasonic Research Foundation Pty Ltd. Nebulizing and drug delivery device
US6869402B2 (en) * 2002-08-27 2005-03-22 Precision Pulsus, Inc. Method and apparatus for measuring pulsus paradoxus
US7828739B2 (en) * 2002-08-27 2010-11-09 Precision Pulsus, Inc. Apnea detection system
US7531133B2 (en) * 2002-09-10 2009-05-12 Pulmonox Technologies Corporation Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
WO2004032964A1 (ja) * 2002-10-10 2004-04-22 Ono Pharmaceutical Co., Ltd. アレルギー性疾患治療剤
CA2413834A1 (en) * 2002-12-10 2004-06-10 1017975 Alberta Limited Nitric oxide gas generator
US9138707B2 (en) * 2002-12-10 2015-09-22 Sy Kimball Portable, nitric oxide generator
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
CA2537222A1 (en) * 2003-07-09 2005-01-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
BRPI0414813A (pt) * 2003-09-26 2006-11-14 David R Whitlock método para o uso de bactéria que oxidam a amÈnia
US7552731B2 (en) * 2003-11-14 2009-06-30 Remcore, Inc. Remote control gas regulation system
US20050255178A1 (en) * 2004-02-04 2005-11-17 Bloch Kenneth D Enhancing the effectiveness of an inhaled therapeutic gas
US20050191245A1 (en) * 2004-02-27 2005-09-01 Adams Christopher P. Nasal administration of calcium channel, blockers for treatment of hypertension and other cardiovascular disorders
CA2557814A1 (en) * 2004-03-01 2005-09-15 Lumen Therapeutics, Llc Compositions and methods for treating diseases
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
JP2008500965A (ja) * 2004-03-17 2008-01-17 エムペックス・ファーマシューティカルズ・インコーポレーテッド 細菌の排出ポンプ阻害剤の使用および投与
CA2563493A1 (en) 2004-05-11 2005-11-24 Sensormedics Corporation Intermittent dosing of nitric oxide gas
US8518457B2 (en) * 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
EP2724742B1 (de) * 2004-08-18 2017-11-01 Geno LLC Umwandlung von stickstoffdioxid (no2) zu stickoxid (no)
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US20070154570A1 (en) * 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
US7814901B2 (en) * 2005-03-09 2010-10-19 Ric Investments, Llc Nebulizing drug delivery device with increased flow rate
US7721729B2 (en) * 2005-03-09 2010-05-25 Ric Investments, Llc Nebulizing drug delivery device for ventilator
US8056557B2 (en) * 2005-03-09 2011-11-15 Ric Investments, Llc Nebulizing drug delivery device with barrier
US7631643B2 (en) 2005-03-09 2009-12-15 Ric Investments, Llc Nebulizing drug delivery device with interlock detection and temperature protection
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
EP2021131B1 (de) * 2005-05-23 2011-07-13 Biosonic Australia Pty. Ltd. Vorrichtung zur zerstäubung und flüssigkeitsfiltration
US7523752B2 (en) * 2005-09-21 2009-04-28 Ino Therapeutics, Llc System and method of administering a pharmaceutical gas to a patient
US8893717B2 (en) 2005-09-21 2014-11-25 Ino Therapeutics Llc Systems and methods of administering a pharmaceutical gas to a patient
US7566308B2 (en) * 2005-10-13 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for pulmonary artery pressure signal isolation
WO2007057763A2 (en) * 2005-11-18 2007-05-24 Pulmonox Technologies Corporation Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
EP1962869B1 (de) * 2005-12-21 2013-03-20 SolAeroMed Inc. Behandlung von atemwegserkrankungen
US8790715B2 (en) 2006-02-16 2014-07-29 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use
US20100313883A1 (en) * 2006-04-20 2010-12-16 Koninklijke Philips Electronics N.V. Ultrasonic bebulilzer with metal coated ultrasonic genrator
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
EP3023389B1 (de) 2006-07-05 2020-03-18 BSN medical GmbH Vorrichtung zur photolytischen erzeugung von stickstoffmonoxid
US8079998B2 (en) * 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide
TWI474824B (zh) * 2006-11-07 2015-03-01 Gen Hospital Corp 血管活性氧載劑所引發之血管收縮之減輕
US20100143503A1 (en) * 2006-12-22 2010-06-10 Ikaria, Inc. Combinations of nitric oxide and sulfide and methods of use and manufacture thereof
US20080193566A1 (en) * 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
US8176915B2 (en) * 2007-03-15 2012-05-15 Koninklijke Philips Electronics N.V. End-tidal gas estimation system and method
US8166971B2 (en) * 2007-03-15 2012-05-01 Ric Investments, Llc End-tidal gas estimation system and method
EP2131903B1 (de) 2007-03-23 2018-01-24 Geno LLC Umwandlung von stickstoffdioxid (no2) in stickoxid (no)
US7943667B2 (en) * 2007-10-11 2011-05-17 Duke University Potentiating the effect of compound comprising nitric oxide
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
EP2237788A4 (de) * 2007-12-27 2013-06-05 Aires Pharmaceuticals Inc Aerosolisierte nitrit- und stickoxidspendende verbindungen und ihre verwendung
US7914743B2 (en) 2008-01-28 2011-03-29 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
WO2009099998A2 (en) * 2008-01-31 2009-08-13 Vanderbilt University Therapeutic treatment for lung conditions
US8720436B2 (en) * 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
US8434475B2 (en) * 2008-01-31 2013-05-07 Genosys, Inc. Nitric oxide reactor and distributor apparatus and method
CN102369006A (zh) 2008-01-31 2012-03-07 范德比尔特大学 治疗冠状动脉和动脉的动脉瘤性蛛网膜下腔出血的方法和组合物
US9649467B2 (en) 2008-01-31 2017-05-16 Syk Technologies, Llc Nitric oxide reactor and distributor apparatus and method
US8501090B2 (en) * 2008-03-24 2013-08-06 Christian S. Minton Anti-microbial gas apparatus and method
WO2010017633A1 (en) * 2008-08-13 2010-02-18 Chris Miller Use of nitric oxide
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
US10960168B2 (en) 2008-08-21 2021-03-30 Vero Biotech LLC Delivery of high concentration nitric oxide
US10780241B2 (en) * 2008-08-21 2020-09-22 Vero Biotech LLC Devices and methods for minimizing and treating high-altitude sickness
GB2463883A (en) * 2008-09-25 2010-03-31 Pharma Patents Ltd A pharmaceutical composition comprising an A-SMase inhibitor and an NO-donor
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
CN106511273A (zh) * 2009-05-15 2017-03-22 瑞克欧制药有限公司 舌下右美托咪定组合物及其使用方法
MX2011012467A (es) * 2009-05-27 2012-01-31 Ino Therapeutics Llc Dispositivos y metodos para engranar un montaje de valvula indexada y deposito presurizado con un zuncho, y para el accionamiento lineal mediante un montaje de embolo en comunicacion fluida con un dispsoitivo para regular la administracion de farmacos.
CA2763804C (en) 2009-06-22 2018-02-06 Geno Llc Nitric oxide therapies
CA2671029A1 (en) 2009-06-30 2010-12-30 James S. Baldassarre Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
WO2011063335A1 (en) * 2009-11-20 2011-05-26 Geno Llc Nitric oxide delivery system
JP5911475B2 (ja) 2010-04-26 2016-04-27 ゲノ エルエルシー 超高純度一酸化窒素（ｎｏ）の送達
DE102010016699A1 (de) 2010-04-29 2011-11-03 Maquet Gmbh & Co. Kg Verfahren und Vorrichtung zur Applikation mindestens eines medizinischen Gases an einen mit Hilfe eines Beatmungsgeräts beatmeten Patienten
US8685467B2 (en) 2010-08-03 2014-04-01 J. W. Randolph Miller Nitric oxide generation, dilution, and topical application apparatus and method
ES2711974T3 (es) * 2010-09-10 2019-05-08 Ino Therapeutics Llc Composiciones, métodos y artículos que se refieren al óxido nítrico farmacéutico y los sistemas controlados de administración al paciente del mismo
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN103269973B (zh) * 2010-12-03 2016-03-23 皇家飞利浦电子股份有限公司 产生一氧化氮的方法和设置
MX346401B (es) 2011-01-06 2017-03-16 Mallinckrodt Hospital Products Ip Ltd Dispositivo y sistema de entrega de gas.
US10445846B2 (en) * 2011-04-14 2019-10-15 Elwha Llc Cost-effective resource apportionment technologies suitable for facilitating therapies
US9626650B2 (en) * 2011-04-14 2017-04-18 Elwha Llc Cost-effective resource apportionment technologies suitable for facilitating therapies
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
FR2976260B1 (fr) † 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement de melanges no/n2 avec etapes de purge et rincage gazeux prealable
CA2841832C (en) 2011-07-12 2019-06-04 Pursuit Vascular, Inc. Device for delivery of antimicrobial agent into a trans-dermal catheter
CA2850935C (en) 2011-10-03 2018-08-07 Nitric Generation Technologies Llc Apparatus and method for generating nitric oxide in controlled and accurate amounts
EP2776047A4 (de) * 2011-11-07 2015-07-22 Gen Hospital Corp Behandlung von erythrozyten
EP2787970B1 (de) 2011-12-11 2018-04-11 Recro Pharma, Inc. Intranasale dexmedetomidinzusammensetzungen und verfahren zur verwendung davon
US10556086B2 (en) 2012-03-15 2020-02-11 Mallinckrodt Hospital IP Limited Methods of administering high concentrations of nitric oxide
FR2991025B1 (fr) 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement d'un melange gazeux no/azote a haute concentration en no
FR2990858B1 (fr) * 2012-05-24 2015-04-03 Air Liquide Sante Int Melange gazeux no/azote a teneur elevee en no pour traiter les detresses respiratoires hypoxemiantes severes
FR2991026B1 (fr) 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement a haute pression d'un melange gazeux no/azote
US9795756B2 (en) 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
US8770199B2 (en) 2012-12-04 2014-07-08 Ino Therapeutics Llc Cannula for minimizing dilution of dosing during nitric oxide delivery
CA2902965C (en) 2013-02-28 2023-08-29 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics
EP3431129A1 (de) 2013-03-15 2019-01-23 The General Hospital Corporation Synthese von stickoxidgas zur inhalation
KR102317818B1 (ko) 2013-03-15 2021-10-26 더 제너럴 하스피탈 코포레이션 산화질소의 흡기 합성
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
US20140373836A1 (en) 2013-06-25 2014-12-25 Ino Therapeutics Llc Methods of Reducing the Risk of Mortality Associated With a Medical Treatment
US9566407B2 (en) 2013-06-28 2017-02-14 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Nasal cannula assembly with flow control passage communicating with a deformable reservoir
US9486600B2 (en) 2013-06-28 2016-11-08 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Nasal cannula assembly with inhalation valves communicating with a deformable reservoir
US9517318B2 (en) 2013-06-28 2016-12-13 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Method of delivering medical gases via a nasal cannula assembly with flow control passage communicating with a deformable reservoir
US9522248B2 (en) 2013-06-28 2016-12-20 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Breathing assistance apparatus for delivery of nitric oxide to a patient by means of a nasal cannula assembly with flow control passage
US9522247B2 (en) 2013-06-28 2016-12-20 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Method of treating a patient having pulmonary hypertension by long term NO therapy
US9492626B2 (en) 2013-06-28 2016-11-15 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Breathing assistance assemblies suitable for long term no therapy
WO2015009615A1 (en) * 2013-07-15 2015-01-22 Vanderbilt University Methods for the production of collagen iv
FR3015000B1 (fr) 2013-12-12 2016-05-27 Air Liquide Sante (International) Systeme de stockage et de distribution de melanges no/azote
SI3104854T1 (sl) 2014-02-10 2020-09-30 Respivant Sciences Gmbh Stabilizatorji mastocitov za zdravljenje pljučnih bolezni
US9962363B2 (en) 2014-02-10 2018-05-08 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
EP3129092A4 (de) * 2014-04-09 2017-12-27 12th Man Technologies, Inc. Systeme und verfahren zur ausgabe von hochkonzentriertem stickoxid
US11225640B2 (en) 2014-04-15 2022-01-18 Aobiome Llc Ammonia oxidizing bacteria for treatment of psoriasis
CN106456678A (zh) 2014-04-15 2017-02-22 Ao生物医学有限责任公司 氨氧化型亚硝化单胞菌菌株d23
EP2937089A1 (de) 2014-04-23 2015-10-28 Linde AG Vorrichtung zur Behandlung von, zur Behandlung von Komplikationen aufgrund von und/oder Vorbeugung von Atemwegserkrankungen
EP3137122B1 (de) 2014-05-02 2019-09-04 Excelsior Medical Corporation Streifenverpackung für antiseptische kappe
EP3209360B1 (de) 2014-10-20 2022-12-07 VERO Biotech LLC Speicherkassette für stickstoffdioxid
WO2016064863A1 (en) 2014-10-20 2016-04-28 The General Hospital Corpoation Systems and methods for the synthesis of nitric oxide
US10905836B2 (en) 2015-04-02 2021-02-02 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
WO2017027387A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
JP2018532710A (ja) * 2015-09-09 2018-11-08 アドバンスド インハラーション セラピーズ（エーアイティー） リミテッド 細気管支炎を有する乳幼児のための一酸化窒素吸入療法
US9744190B2 (en) 2016-01-15 2017-08-29 Thomas Tait Continuous gas generator
US10052348B2 (en) 2016-01-27 2018-08-21 Syk Technologies, Llc Nitric oxide topical application apparatus and methods
FI3970730T3 (fi) * 2016-02-12 2024-05-28 Mallinckrodt Pharmaceuticals Ireland Ltd Järjestelmä inhaloidun typpioksidin käyttöä ja valvontaa varten vasemman kammion apulaitteiden kera
MX2018011433A (es) 2016-03-25 2019-01-10 Massachusetts Gen Hospital Sistemas de suministro y metodos para sintesis en plasma electrico de oxido nitrico.
CN110139646A (zh) 2016-08-31 2019-08-16 瑞思皮万特科学有限责任公司 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物
EP3522983A4 (de) 2016-10-07 2020-06-03 Respivant Sciences GmbH Cromolynzusammensetzung zur behandlung von lungenfibrose
FI3525865T3 (fi) 2016-10-14 2023-01-13 Desinfioivia korkkeja lääkinnällisiin liittimiin
WO2018157175A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
CA3054656A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for generating nitric oxide
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
CN110475562A (zh) 2017-03-31 2019-11-19 通用医疗公司 用于冷却一氧化氮发生器的系统和方法
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
EP3703562A4 (de) * 2017-11-02 2022-04-06 Beyond Air, Inc. Inhalation von stickoxid
JP6618976B2 (ja) * 2017-11-14 2019-12-11 イノ セラピューティクス エルエルシー 指標付弁と襟部を有する加圧容器組立体を係合するため、かつ薬物送達を調整するための装置と流体連通したプランジャ組立体により直線的に作動させるための装置および方法
US20210386944A1 (en) * 2018-10-12 2021-12-16 Sanotize Research Development Corp. Gas-evolving compositions and container and delivery systems
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11433215B2 (en) 2018-11-21 2022-09-06 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
KR20210138685A (ko) * 2019-04-19 2021-11-19 코쿠리츠켄큐카이하츠호징 붓시쯔 자이료 켄큐키코 질소계 가스 서방제 및 이것으로 구성된 질소계 가스 서방체, 그리고 그 서방체를 사용한 질소계 가스의 서방 방법, 호흡 기구, 포장체 및 서방 장치
JP2022533628A (ja) 2019-05-15 2022-07-25 サード ポール，インコーポレイテッド 一酸化窒素生成用電極
EP3969416A4 (de) 2019-05-15 2023-11-01 Third Pole, Inc. Systeme und vorrichtungen zur erzeugung von stickoxid
FR3103110B1 (fr) 2019-11-15 2021-10-08 Air Liquide Dispositif de fourniture de gaz thérapeutique, en particulier de NO ou de N2O, à un patient
CA3158501A1 (en) 2019-11-25 2021-06-03 Beyond Air, Inc. System and method for delivery of gas to a tissue
WO2021142472A1 (en) 2020-01-11 2021-07-15 Third Pole, Inc. Systems and methods for nitric oxide generation with humidity control
EP4167920A4 (de) 2020-06-18 2024-06-12 Third Pole, Inc. Systeme und verfahren zur vorbeugung und behandlung von infektionen mit stickoxid
EP4433066A1 (de) * 2020-11-12 2024-09-25 Thermolife International, LLC Verfahren zur erhöhung der blutsauerstoffsättigung
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法
JP2024534608A (ja) 2021-09-23 2024-09-20 サード ポール，インコーポレイテッド 一酸化窒素を送達するシステム及び方法
FR3127408B1 (fr) 2021-09-29 2024-05-10 Inosystems Chariot hospitalier de transport de bouteille de gaz, notamment de NO médical
FR3131538A1 (fr) 2022-01-05 2023-07-07 Inosystems Dispositif de délivrance de NO avec système de dosage d’urgence
FR3137841B1 (fr) 2022-07-18 2024-06-14 Inosystems Dispositif de délivrance de NO avec système de dosage d’urgence
EP4209243B1 (de) 2022-01-05 2024-08-14 Inosystems No-ausgabevorrichtung mit notfalldosiersystem
FR3132025A1 (fr) 2022-01-24 2023-07-28 Inosystems Cartouche de stockage d’un mélange NO/azote et installation de fourniture de gaz associée
FR3133315B1 (fr) 2022-03-09 2024-03-22 Inosystems Appareil de délivrance de NO à deux sorties de gaz
FR3133317B1 (fr) 2022-03-09 2024-03-01 Inosystems Appareil de délivrance de NO avec système de ventilation manuelle
FR3133316B1 (fr) 2022-03-09 2024-04-12 Inosystems Dispositif de délivrance de NO avec circuit de secours
FR3133318B1 (fr) 2022-03-09 2024-03-22 Inosystems Dispositif de délivrance de NO avec circuit de secours à débit contrôlé
FR3136986B1 (fr) 2022-06-24 2024-06-14 Inosystems Affichage de la dose de NO par un dispositif de fourniture de NO en phase de pause
FR3138773B1 (fr) 2022-08-11 2024-08-02 Inosystems Installation de fourniture de gaz comprenant un ventilateur médical et un dispositif de délivrance de NO avec un système de dosage d’urgence
FR3145873A1 (fr) 2023-02-20 2024-08-23 Inosystems Appareil de fourniture de gaz, tel du NO, à un patient avec comptage du temps total de traitement effectif
FR3146810A1 (fr) 2023-03-21 2024-09-27 Inosystems Dispositif de calibration des capteurs d’un appareil de délivrance de NO
FR3148373A1 (fr) 2023-05-04 2024-11-08 Inosystems Appareil de délivrance de monoxyde d’azote gazeux en mode pulsé

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3367332A (en) * 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3785377A (en) * 1970-11-12 1974-01-15 S Jorgensen Plant, preferably for anaesthesia
US3745991A (en) * 1971-02-22 1973-07-17 Champion Spark Plug Co Environmental contamination control device
US4010897A (en) * 1976-03-31 1977-03-08 Charles F. Kettering Foundation Method and apparatus for home production and application of nitrogen fertilizer
IL57239A (en) * 1979-05-08 1982-04-30 Alamaro Moshe Production of nitric oxides
US4297123A (en) * 1980-02-07 1981-10-27 Wyse Harold G Method and apparatus for producing a nitrate fertilizer
US4336798A (en) * 1980-10-06 1982-06-29 Anthony V. Beran Medical corrugated respiratory tube
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4675174A (en) * 1985-08-16 1987-06-23 Alza Corporation Veterinary dispenser delivering beneficial agent by gas power generated in situ
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US4877589A (en) * 1988-09-19 1989-10-31 Hare Louis R O Nitrogen fixation by electric arc and catalyst
US4915915A (en) * 1988-10-11 1990-04-10 Treharne Richard W Water-powdered piezoelectric unit for producing nitrogen fertilizer
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5007419A (en) * 1989-09-25 1991-04-16 Allan Weinstein Inhaler device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5187305A (en) * 1990-11-26 1993-02-16 Glaxo Inc. S-nitroso-N-alkonoylpenicillamines
DE560928T1 (de) 1990-12-05 1994-09-22 The General Hospital Corp., Charlestown, Mass. Vorrichtung zum behandeln einer lungengefässverengung und von asthma.
US5396882A (en) * 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
IL101406A (en) * 1991-03-29 1998-02-08 Brigham & Womens Hospital Pharmaceutical compositions containing s-nitrosothiol derivatives
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
AU3237193A (en) * 1991-12-11 1993-07-19 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation

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ATE367842T2 (de) 2007-08-15
LV12201A (lv) 1999-01-20
WO1992010228A1 (en) 1992-06-25
DK1516639T3 (da) 2007-11-26
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DE69133584T4 (de) 2009-11-19
EP0786264A2 (de) 1997-07-30
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LU90886I2 (fr) 2002-03-25
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ATE376850T1 (de) 2007-11-15
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