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DE69131580D1 - GDF-1 und UOG1 Proteine - Google Patents

GDF-1 und UOG1 Proteine

Info

Publication number
DE69131580D1
DE69131580D1 DE69131580T DE69131580T DE69131580D1 DE 69131580 D1 DE69131580 D1 DE 69131580D1 DE 69131580 T DE69131580 T DE 69131580T DE 69131580 T DE69131580 T DE 69131580T DE 69131580 D1 DE69131580 D1 DE 69131580D1
Authority
DE
Germany
Prior art keywords
gdf
protein
uog1
proteins
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131580T
Other languages
English (en)
Other versions
DE69131580T2 (de
Inventor
Se-Jin Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carnegie Institution of Washington
Original Assignee
Carnegie Institution of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Institution of Washington filed Critical Carnegie Institution of Washington
Application granted granted Critical
Publication of DE69131580D1 publication Critical patent/DE69131580D1/de
Publication of DE69131580T2 publication Critical patent/DE69131580T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69131580T 1990-06-15 1991-06-14 GDF-1 und UOG1 Proteine Expired - Fee Related DE69131580T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53837290A 1990-06-15 1990-06-15
US61445290A 1990-11-16 1990-11-16
PCT/US1991/004096 WO1992000382A1 (en) 1990-06-15 1991-06-14 Gdf-1

Publications (2)

Publication Number Publication Date
DE69131580D1 true DE69131580D1 (de) 1999-10-07
DE69131580T2 DE69131580T2 (de) 2000-01-13

Family

ID=27065793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131580T Expired - Fee Related DE69131580T2 (de) 1990-06-15 1991-06-14 GDF-1 und UOG1 Proteine

Country Status (10)

Country Link
US (2) US20040039162A1 (de)
EP (1) EP0652951B1 (de)
JP (1) JPH06500466A (de)
AT (1) ATE184052T1 (de)
AU (1) AU666291B2 (de)
CA (1) CA2085134C (de)
DE (1) DE69131580T2 (de)
ES (1) ES2137931T3 (de)
HK (1) HK1013847A1 (de)
WO (1) WO1992000382A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
CA2116559C (en) * 1991-08-30 2005-05-10 Thangavel Kuberasampath Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
WO1994003200A1 (en) * 1992-07-31 1994-02-17 Creative Biomolecules, Inc. Morphogen-induced nerve regeneration and repair
CA2153654A1 (en) * 1993-01-12 1994-07-21 Se-Jin Lee Growth differentiation factor-5
US5821056A (en) 1993-01-12 1998-10-13 The Johns Hopkins University School Of Medicine Growth differentiation factor-9
CA2165778A1 (en) 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-7
EP0804214A4 (de) * 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-6
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
DK0776337T3 (da) * 1994-07-08 2005-12-12 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-11
US5831054A (en) * 1994-07-13 1998-11-03 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-12
CN1181885C (zh) 1996-03-22 2004-12-29 通用医疗公司 中枢神经系统局部缺血或损伤后多肽生长因子的给药
US6524802B1 (en) 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
WO1998034655A1 (en) 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
AU742663B2 (en) 1997-05-30 2002-01-10 Stryker Corporation Methods for evaluating tissue morphogenesis and activity
WO1999058671A2 (en) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Human and nematode homologues of the yeast longevity assurance gene lag1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
EP1094863A4 (de) * 1998-07-06 2005-02-02 Cambridge Neuroscience Inc Verfahren zur behandlung von neurologischen verletzungen und erkrankungen
US6872698B2 (en) * 1998-07-06 2005-03-29 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
PL1737734T3 (pl) 2004-03-10 2011-02-28 Scil Tech Gmbh Powlekane implanty, ich wytwarzanie i zastosowanie
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
AU2005247440B2 (en) 2004-05-25 2011-09-29 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
WO2007142818A2 (en) 2006-05-17 2007-12-13 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CA2671925A1 (en) 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
WO2009020744A1 (en) 2007-08-07 2009-02-12 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
WO2009102966A2 (en) 2008-02-13 2009-08-20 Keith Hruska Method of treating vascular sclerosis
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
JP5819733B2 (ja) 2009-02-12 2015-11-24 ストライカー コーポレイションＳｔｒｙｋｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 障害および疾患に対する全身治療のためのＴＧＦ−βスーパーファミリーメンバー含有タンパク質の末梢投与
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US20110224138A1 (en) 2009-09-09 2011-09-15 Julie Krop Methods for treating pain induced by injuries and diseases of an articular joint
WO2011035094A1 (en) 2009-09-17 2011-03-24 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
PE20140135A1 (es) 2010-08-20 2014-02-20 Wyeth Llc Proteina osteogenicas de diseno
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses

Also Published As

Publication number Publication date
CA2085134C (en) 2003-03-18
EP0652951A1 (de) 1995-05-17
US20030040611A1 (en) 2003-02-27
DE69131580T2 (de) 2000-01-13
ES2137931T3 (es) 2000-01-01
AU666291B2 (en) 1996-02-08
US20040039162A1 (en) 2004-02-26
JPH06500466A (ja) 1994-01-20
WO1992000382A1 (en) 1992-01-09
EP0652951A4 (de) 1993-08-16
ATE184052T1 (de) 1999-09-15
AU8496491A (en) 1992-01-23
CA2085134A1 (en) 1991-12-16
HK1013847A1 (en) 1999-12-10
EP0652951B1 (de) 1999-09-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee