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DE69113470D1 - Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln. - Google Patents

Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln.

Info

Publication number
DE69113470D1
DE69113470D1 DE69113470T DE69113470T DE69113470D1 DE 69113470 D1 DE69113470 D1 DE 69113470D1 DE 69113470 T DE69113470 T DE 69113470T DE 69113470 T DE69113470 T DE 69113470T DE 69113470 D1 DE69113470 D1 DE 69113470D1
Authority
DE
Germany
Prior art keywords
intraorbital
intraocular
implant
drug delivery
controlled drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113470T
Other languages
English (en)
Other versions
DE69113470T2 (de
Inventor
Jean Marie Parel
Richard K Parrish
Lourdes Portugal
Karl R Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of DE69113470D1 publication Critical patent/DE69113470D1/de
Application granted granted Critical
Publication of DE69113470T2 publication Critical patent/DE69113470T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/147Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1694Capsular bag spreaders therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902Method of implanting
    • Y10S623/905Eye
    • Y10S623/907Method of manipulating parts of intraocular lens structure for implantation

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
DE69113470T 1989-03-23 1991-11-29 Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln. Expired - Fee Related DE69113470T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32798989A 1989-03-23 1989-03-23

Publications (2)

Publication Number Publication Date
DE69113470D1 true DE69113470D1 (de) 1995-11-02
DE69113470T2 DE69113470T2 (de) 1996-03-07

Family

ID=23279013

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113470T Expired - Fee Related DE69113470T2 (de) 1989-03-23 1991-11-29 Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln.

Country Status (5)

Country Link
US (1) US5098443A (de)
EP (1) EP0544948B1 (de)
DE (1) DE69113470T2 (de)
ES (1) ES2077813T3 (de)
RU (1) RU2099031C1 (de)

Families Citing this family (218)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
EP0633907A1 (de) * 1992-03-30 1995-01-18 Alza Corporation Additive für bioerodierbare polymere um die abbau zu regulieren
US5178635A (en) * 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5354331A (en) * 1992-07-15 1994-10-11 Schachar Ronald A Treatment of presbyopia and other eye disorders
US6966927B1 (en) 1992-08-07 2005-11-22 Addition Technology, Inc. Hybrid intrastromal corneal ring
BR9306848A (pt) * 1992-08-07 1998-12-08 Keravision Inc Anel polimérico dividido para introdução no estroma
AU4847793A (en) * 1992-09-03 1994-03-29 Keravision, Inc. Astigmatic correcting intrastromal corneal ring
US5323788A (en) * 1992-09-21 1994-06-28 Keravision Overlapping split ring device for corneal curvature adjustment
US5300118A (en) * 1992-09-21 1994-04-05 Keravision Adjustable devices for corneal curvature adjustment
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
ATE195065T1 (de) * 1993-02-26 2000-08-15 Santen Pharmaceutical Co Ltd Biologisch abbaubarer sklerastopfen
AU727908C (en) * 1993-08-02 2001-10-18 Keravision, Inc. Segmented pre-formed intrastromal corneal insert
US5876438A (en) * 1993-08-02 1999-03-02 Houston Biotechnology Incorporated Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract
SG87083A1 (en) * 1993-08-02 2002-03-19 Keravision Inc Segmented preformed intrastromal corneal insert
DE69433625T2 (de) * 1993-08-02 2005-02-03 Addition Technology, Inc., Des Plaines Zusammenlegbarer, intrastromaler, kornealer einsatz aus mehreren segmenten
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
AU731486B2 (en) * 1993-11-15 2001-03-29 Allergan, Inc. Biocompatible ocular implants
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US6063116A (en) * 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US6063396A (en) * 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US5612027A (en) * 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5972326A (en) * 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
WO1996040005A1 (en) * 1995-06-07 1996-12-19 Keravision, Inc. Radial intrastromal corneal insert and a method of insertion
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
US6135118A (en) 1997-05-12 2000-10-24 Dailey; James P. Treatment with magnetic fluids
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6050999A (en) * 1997-12-18 2000-04-18 Keravision, Inc. Corneal implant introducer and method of use
US20020055753A1 (en) * 1997-12-18 2002-05-09 Thomas A. Silvestrini Corneal implant methods and pliable implant therefor
DE19818487C1 (de) * 1998-04-24 1999-09-30 Antonia J M Joussen Implantat in den Kapselsack in Verbindung mit einer Kataraktoperation
EP0958796B1 (de) * 1998-05-11 2003-10-15 Tobias Dr. Neuhann Intraokularlinse
US9962255B1 (en) * 1998-09-10 2018-05-08 Jeffrey N. Weiss One piece self-locking scleral buckle with placement instrument
FR2787991B1 (fr) 1998-12-31 2001-05-25 Medicale De Prec S M P Sa Soc Dispositif pour traiter la presbytie ou autre affection oculaire
US6554424B1 (en) 1999-03-01 2003-04-29 Boston Innovative Optices, Inc. System and method for increasing the depth of focus of the human eye
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
FR2794965B1 (fr) * 1999-06-21 2001-07-20 Ioltechnologie Production Anneau de tension intraoculaire pour la correction de la presbytie
US6702832B2 (en) 1999-07-08 2004-03-09 Med Logics, Inc. Medical device for cutting a cornea that has a vacuum ring with a slitted vacuum opening
US6699285B2 (en) * 1999-09-24 2004-03-02 Scieran Technologies, Inc. Eye endoplant for the reattachment of a retina
FR2801192B1 (fr) * 1999-11-19 2002-08-09 Corneal Ind Anneau pour sac capsulaire et ensemble constitue par un tel anneau et son injecteur
US6852688B2 (en) 2000-03-10 2005-02-08 University Of Florida Compositions for treating diabetic retinopathy and methods of using same
US20070031473A1 (en) * 2005-08-05 2007-02-08 Peyman Gholam A Drug delivery system and method
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
AU2001271417B2 (en) 2000-08-30 2006-10-05 Johns Hopkins University Devices for intraocular drug delivery
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
AR032839A1 (es) * 2001-02-23 2003-11-26 Ras Holding Corp Instrumento quirurgico para hacer incisiones para implantes en la esclerotica ocular
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US7431710B2 (en) * 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7678065B2 (en) * 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
WO2002089699A2 (en) * 2001-05-03 2002-11-14 Glaukos Corporation Medical device and methods of use for glaucoma treatment
ATE506929T1 (de) 2001-06-12 2011-05-15 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US20030078545A1 (en) * 2001-10-23 2003-04-24 Janet Howie System for administering a drug delivery device
GB2399753B (en) * 2002-01-18 2006-04-19 Michael E Snyder Method of making a sustained release ophthalmological device
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
US6899717B2 (en) * 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
TWI282271B (en) 2002-09-18 2007-06-11 Allergan Inc Apparatus for delivery of ocular implants
CA2498489C (en) * 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
AR042920A1 (es) * 2003-01-24 2005-07-06 Control Delivery Sys Inc Liberacion controlada de agentes muy solubles
US8017135B1 (en) * 2003-01-31 2011-09-13 The Regents Of The University Of California Lipid-drug conjugates for local therapy of eye diseases
US7483750B2 (en) * 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
JP4824549B2 (ja) * 2003-05-02 2011-11-30 サーモディクス,インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US7628810B2 (en) * 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
NZ543864A (en) * 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20050046794A1 (en) * 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20050250737A1 (en) * 2003-11-12 2005-11-10 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
WO2005059158A2 (en) * 2003-12-15 2005-06-30 Dailey James P Magnetized scleral buckle with polymerizing magnetic polymers
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
WO2006014484A2 (en) 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
ATE439123T1 (de) * 2004-07-02 2009-08-15 Novagali Pharma Sa Verwendung von emulsionen zur intra- und periocularen injection
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
EP1868661A1 (de) * 2005-04-08 2007-12-26 SurModics, Inc. Implantate mit verzögerter freisetzung zur subretinalen verabreichung
US7976577B2 (en) * 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
US20060292222A1 (en) * 2005-06-21 2006-12-28 Matthew Jonasse Drug delivery device having zero or near zero-order release kinetics
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
KR101005287B1 (ko) * 2005-10-31 2011-01-04 라이프 스프링 바이오텍 컴퍼니 리미티드 공막돌륭술 밴드 및 이의 제조 방법
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2007065149A2 (en) * 2005-12-01 2007-06-07 Innfocus, Llc Ocular implant
NZ571758A (en) 2006-03-31 2012-06-29 Quadra Logic Tech Inc A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
US7981096B2 (en) * 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
US7811252B2 (en) * 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
WO2008005873A2 (en) * 2006-06-30 2008-01-10 Aquesys Inc. Methods, systems and apparatus for relieving pressure in an organ
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US20120123316A1 (en) 2010-11-15 2012-05-17 Aquesys, Inc. Intraocular shunts for placement in the intra-tenon's space
AU2007272963B2 (en) * 2006-07-11 2013-05-23 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
EP2526909B1 (de) * 2006-07-11 2020-06-24 Refocus Group, Inc. Vorrichtung zur Sicherung von Augengewebe
US9039761B2 (en) * 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
ATE475686T1 (de) * 2006-10-31 2010-08-15 Surmodics Pharmaceuticals Inc Kugelförmige polymer-teilchen
US7927372B2 (en) * 2007-08-02 2011-04-19 Refocus Group, Inc. Scleral prosthesis having crossbars for treating presbyopia and other eye disorders
US20110236501A1 (en) * 2007-09-05 2011-09-29 Vanderbilt University Injectable dual delivery allograph bone/polymer composite for treatment of open fractures
BRPI0817075A2 (pt) 2007-09-07 2016-07-26 Qlt Plug Delivery Inc núcleos de fármaco para liberação prolongada de agentes terapêuticos
WO2009035571A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Lacrimal implant detection
US8480638B2 (en) * 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
CN101969898B (zh) 2007-11-08 2013-09-18 阿利梅拉科学公司 眼用植入设备
EP2257250A2 (de) 2008-01-29 2010-12-08 Gilbert H. Kliman Arzneimittelspendevorrichtungen, kits und verfahren dafür
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
EP2276471B1 (de) 2008-04-30 2018-08-08 Mati Therapeutics Inc. Träneneinsatz aus verbundstoff und zugehöriges verfahren
CA2722971C (en) * 2008-05-09 2019-05-07 Qlt Plug Delivery, Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
AU2009246520B2 (en) * 2008-05-12 2012-04-19 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10588855B2 (en) 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
TWI531362B (zh) * 2008-07-21 2016-05-01 艾爾康股份有限公司 具有治療劑遞送能力之眼科裝置
WO2010024930A2 (en) 2008-08-28 2010-03-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses therof
CN101386203B (zh) * 2008-10-15 2011-09-14 广州卫视博生物科技有限公司 折叠式人工玻璃体制造方法及其模具
US20100152848A1 (en) * 2008-11-19 2010-06-17 Refocus Group, Inc. Artificial intraocular lens, altered natural crystalline lens, or refilled natural crystalline lens capsule with one or more scleral prostheses for improved performance
NZ592645A (en) * 2008-11-20 2013-01-25 Insight Innovations Llc Biocompatible biodegradable intraocular implant system
US9943402B2 (en) 2008-11-20 2018-04-17 Insight Innovations, Llc Micropatterned intraocular implant
US8551167B2 (en) 2008-11-20 2013-10-08 Insight Innovations, Llc Intraocular implant cell migration inhibition system
US20120232649A1 (en) * 2008-11-20 2012-09-13 Insight Innovations, Llc Intraocular Lens Cell Migration Inhibition System
US20100189765A1 (en) * 2008-11-26 2010-07-29 Erickson Signe R Implantable ocular drug delivery device and methods
US8545554B2 (en) * 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010101758A1 (en) * 2009-03-03 2010-09-10 Alcon Research, Ltd. Peri-corneal drug delivery device
US20100292788A1 (en) * 2009-04-27 2010-11-18 Morris Robert E Unitary scleral buckling element and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP5695035B2 (ja) 2009-06-03 2015-04-01 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 前眼部薬物供給
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
RU2012108951A (ru) 2009-08-13 2013-09-20 Акуфокус, Инк. Скрытые интраокулярные имплантанты и линзы
IN2012DN02153A (de) 2009-08-13 2015-08-07 Acufocus Inc
US8808257B2 (en) * 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask
US8343106B2 (en) * 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
MX2012006598A (es) 2009-12-23 2012-06-19 Alcon Res Ltd Canula trocar de valvula oftalmica.
CA2785468A1 (en) * 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
EP2383286A1 (de) 2010-04-30 2011-11-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und Zusammensetzungen zur Behandlung von degenerativen Netzhauterkrankungen
GB201011313D0 (en) 2010-07-05 2010-08-18 Ucl Business Plc Implantation devices, methods and implants
DK2600812T3 (da) 2010-08-05 2021-10-18 Forsight Vision4 Inc Apparat til at behandle et øje
DK2600930T3 (da) 2010-08-05 2021-03-01 Forsight Vision4 Inc Injektionsapparat til lægemiddelafgivelse
CA2807537C (en) 2010-08-05 2018-09-18 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US20160256319A1 (en) 2010-11-15 2016-09-08 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8889672B2 (en) 2011-04-29 2014-11-18 The Regents Of The University Of Michigan Compounds, formulations, and methods of protein kinase C inhibition
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP2739252A4 (de) 2011-08-05 2015-08-12 Forsight Vision4 Inc Abgabe kleiner moleküle über eine implantierbare therapeutische vorrichtung
US8597318B2 (en) 2011-08-08 2013-12-03 Refocus Group, Inc. Apparatus and method for forming incisions in ocular tissue
EP3659495B1 (de) 2011-09-13 2022-12-14 Dose Medical Corporation Intraokularer physiologischer sensor
KR102071083B1 (ko) 2011-09-14 2020-01-29 포사이트 비젼5, 인크. 안내 삽입물 장치 및 방법
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
JP6046160B2 (ja) 2011-12-02 2016-12-14 アキュフォーカス・インコーポレーテッド 選択的分光透過性を有する眼科マスク
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US9241829B2 (en) * 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
WO2013124477A1 (en) 2012-02-24 2013-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of retinal degenerative diseases
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US9308355B2 (en) 2012-06-01 2016-04-12 Surmodies, Inc. Apparatus and methods for coating medical devices
SG10201701178PA (en) * 2012-08-15 2017-03-30 Univ Nanyang Tech A Drug Eluting Member, A Method Of Attaching The Same And A Method Of Fabricating The Same, A Device For Holding The Same And A Drug Eluting Device
KR101400701B1 (ko) * 2012-10-19 2014-05-30 주식회사 루시드코리아 백내장 수술용 전낭절개 가이드 장치
DK2911623T3 (da) 2012-10-26 2019-10-28 Forsight Vision5 Inc Oftalmisk system til langvarig frigivelse af lægemiddel til øjet
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
ES2972168T3 (es) 2013-03-28 2024-06-11 Forsight Vision4 Inc Implante oftálmico para administración de sustancias terapéuticas
US20150100046A1 (en) * 2013-10-09 2015-04-09 Balamurali K. Ambati Intraocular drug delivery device and associated methods
PE20211075A1 (es) 2013-11-14 2021-06-09 Aquesys Inc Insertador de derivacion intraocular
WO2015100420A1 (en) 2013-12-24 2015-07-02 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
CA2950187A1 (en) 2014-05-29 2015-12-03 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
ES2803102T3 (es) 2014-07-15 2021-01-22 Forsight Vision4 Inc Dispositivo de administración de implante ocular
WO2016022750A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CN107249515B (zh) 2014-11-10 2019-10-01 弗赛特影像4股份有限公司 可膨胀药物递送装置和使用方法
FR3028410A1 (fr) 2014-11-18 2016-05-20 Pierre Coulon Implant capsulaire multifonctionnel
WO2016081493A1 (en) 2014-11-19 2016-05-26 Acufocus, Inc. Fracturable mask for treating presbyopia
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
WO2016182932A1 (en) 2015-05-08 2016-11-17 President And Fellows Of Harvard College Cortistatin analogues, syntheses, and uses thereof
AU2016268867B2 (en) 2015-05-28 2021-11-11 Page Surgical Innovations, Llc Capsular tension ring inserter and method
CA2987953C (en) 2015-06-03 2023-04-04 Aquesys, Inc. Ab externo intraocular shunt placement
EP3316889A4 (de) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin-analoga sowie synthese und verwendungen davon
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
EP3359987B1 (de) 2015-10-05 2024-02-28 AcuFocus, Inc. Verfahren zum formen von intraokularlinsen
CN113069681B (zh) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
WO2017091520A1 (en) 2015-11-24 2017-06-01 Acufocus, Inc. Toric small aperture intraocular lens with extended depth of focus
CN109475756A (zh) 2016-02-17 2019-03-15 儿童医疗中心有限公司 Ffa1(gpr40)作为神经血管生成疾病或病症的治疗标靶
CN113017981B (zh) 2016-04-05 2023-07-25 弗赛特影像4股份有限公司 药物递送装置
CN115120405A (zh) 2016-04-20 2022-09-30 多斯医学公司 生物可吸收眼部药物的递送装置
EP3463228A4 (de) 2016-06-02 2020-03-04 Aquesys, Inc. Intraokulare wirkstoffabgabe
AU2018322432A1 (en) 2017-08-23 2020-02-13 Refocus Group, Inc. Surgical tool for forming incisions in ocular tissue with tip providing visibility and related apparatus and method
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
WO2019161378A1 (en) 2018-02-19 2019-08-22 University Of Miami Cyclophosphamide for treating ophthalmic inflammation
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
WO2019217471A1 (en) 2018-05-09 2019-11-14 Acufocus, Inc. Intraocular implant with removable optic
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2021174039A1 (en) 2020-02-28 2021-09-02 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
US11571333B2 (en) 2020-05-18 2023-02-07 Refocus Group, Inc. Apparatus and method for securing ocular tissue and providing surgical tool positioning points
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995635A (en) * 1971-09-09 1976-12-07 Alza Corporation Ocular insert
GB1529143A (en) * 1977-08-22 1978-10-18 Alza Corp Ocular inserts
US4300557A (en) * 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4439198A (en) * 1981-07-09 1984-03-27 University Of Illinois Foundation Biodegradable ocular insert for controlled delivery of ophthalmic medication
US4573998A (en) * 1982-02-05 1986-03-04 Staar Surgical Co. Methods for implantation of deformable intraocular lenses
US4519801A (en) * 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4731080A (en) * 1985-01-18 1988-03-15 Galin Miles A Coated intraocular lens
SE8505518D0 (sv) * 1985-11-22 1985-11-22 Swedish Graft Tech Ab Implantationslins, forfarande for framsstellning derav och anordning for att utfora forfarandet
US4919130A (en) * 1986-11-07 1990-04-24 Nestle S.A. Tool for inserting compressible intraocular lenses into the eye and method
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4955906A (en) * 1989-01-12 1990-09-11 Coggins Peter R Mammary prosthesis injector

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RU2099031C1 (ru) 1997-12-20
US5098443A (en) 1992-03-24
EP0544948A1 (de) 1993-06-09
ES2077813T3 (es) 1995-12-01
DE69113470T2 (de) 1996-03-07

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