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DE69013601D1 - Heteroaryl Piperazine als antipsychotische Mittel. - Google Patents

Heteroaryl Piperazine als antipsychotische Mittel.

Info

Publication number
DE69013601D1
DE69013601D1 DE69013601T DE69013601T DE69013601D1 DE 69013601 D1 DE69013601 D1 DE 69013601D1 DE 69013601 T DE69013601 T DE 69013601T DE 69013601 T DE69013601 T DE 69013601T DE 69013601 D1 DE69013601 D1 DE 69013601D1
Authority
DE
Germany
Prior art keywords
antipsychotic agent
heteroaryl piperazines
piperazines
heteroaryl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69013601T
Other languages
English (en)
Other versions
DE69013601T2 (de
Inventor
Harry R Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE69013601D1 publication Critical patent/DE69013601D1/de
Application granted granted Critical
Publication of DE69013601T2 publication Critical patent/DE69013601T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Treating Waste Gases (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Gas Separation By Absorption (AREA)
DE69013601T 1989-07-07 1990-06-29 Heteroaryl Piperazine als antipsychotische Mittel. Expired - Fee Related DE69013601T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/002954 WO1991000863A1 (en) 1989-07-07 1989-07-07 Heteroaryl piperazine antipsychotic agents

Publications (2)

Publication Number Publication Date
DE69013601D1 true DE69013601D1 (de) 1994-12-01
DE69013601T2 DE69013601T2 (de) 1995-03-02

Family

ID=22215102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69013601T Expired - Fee Related DE69013601T2 (de) 1989-07-07 1990-06-29 Heteroaryl Piperazine als antipsychotische Mittel.

Country Status (11)

Country Link
EP (1) EP0409435B1 (de)
JP (1) JPH0717633B2 (de)
AT (1) ATE113282T1 (de)
CA (1) CA2020611A1 (de)
DE (1) DE69013601T2 (de)
DK (1) DK0409435T3 (de)
ES (1) ES2062374T3 (de)
FI (1) FI920023A0 (de)
IE (1) IE63134B1 (de)
PT (1) PT94608A (de)
WO (1) WO1991000863A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
EP1546143A1 (de) * 2002-09-17 2005-06-29 Warner-Lambert Company LLC Heterocyclisch substituierte piperazine zur behandlung von schizophrenie
MXPA05002003A (es) * 2002-09-26 2005-08-03 Warner Lambert Co Piperazinas sustituidas heterociclicas para el tratamiento de la esquizofrenia.
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AP2007004244A0 (en) 2005-05-10 2007-12-31 Intermune Inc Method of modulating stress-activated protein kinase system
TWI329641B (en) 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
US20100004452A1 (en) 2006-09-26 2010-01-07 Barbara Bertani 5-quinolinone derivatives as 5ht1a receptor modulators for treating sexual dysfunction, cognition impairment, psychotic disorders, anxiety, depression, etc.
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
RS56352B2 (sr) 2009-06-25 2023-02-28 Alkermes Pharma Ireland Ltd Heterociklična jedinjenja za lečenje neuroloških i psiholoških poremećaja
JP5732453B2 (ja) 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
CN112451477B (zh) 2011-03-18 2022-12-30 奥克梅斯制药爱尔兰有限公司 包含脱水山梨糖醇酯的药物组合物
EP2790734B1 (de) 2011-12-15 2019-02-20 Alkermes Pharma Ireland Limited Prodrugs von sekundären aminverbindungen
NZ630703A (en) 2012-03-19 2017-02-24 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising glycerol esters
NZ630643A (en) 2012-03-19 2017-08-25 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising fatty acid esters
JP6333802B2 (ja) 2012-03-19 2018-05-30 アルカームス ファーマ アイルランド リミテッド ベンジルアルコールを含む医薬組成物
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
MA39495A (fr) 2014-03-20 2015-09-24 Alkermes Pharma Ireland Ltd Formulations d'aripiprazole présentant des vitesses d'injection plus élevées
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン（又はピペラジン）誘導体及びその統合失調症治療のための使用
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
AU2019230014B2 (en) 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
EP0316723B1 (de) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituierte-4-Piperazinyl)butyl]-4-Thiazolidinone, Verfahren zu deren Herstellung und ihre Anwendung als Arzneimittel
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity

Also Published As

Publication number Publication date
JPH0344388A (ja) 1991-02-26
EP0409435B1 (de) 1994-10-26
EP0409435A1 (de) 1991-01-23
PT94608A (pt) 1991-03-20
IE902450A1 (en) 1991-02-13
JPH0717633B2 (ja) 1995-03-01
IE63134B1 (en) 1995-03-22
DK0409435T3 (da) 1994-11-21
FI920023A0 (fi) 1992-01-03
CA2020611A1 (en) 1991-01-08
ES2062374T3 (es) 1994-12-16
ATE113282T1 (de) 1994-11-15
DE69013601T2 (de) 1995-03-02
WO1991000863A1 (en) 1991-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee