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DE69941330D1 - Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region - Google Patents

Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Info

Publication number
DE69941330D1
DE69941330D1 DE69941330T DE69941330T DE69941330D1 DE 69941330 D1 DE69941330 D1 DE 69941330D1 DE 69941330 T DE69941330 T DE 69941330T DE 69941330 T DE69941330 T DE 69941330T DE 69941330 D1 DE69941330 D1 DE 69941330D1
Authority
DE
Germany
Prior art keywords
protein
recipes
leucine
mammals
extra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941330T
Other languages
English (en)
Inventor
Aaron J Hsueh
Sheau Yu Hsu
Shan-Guang Liang
Der Spek Petrus Johannes Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69941330D1 publication Critical patent/DE69941330D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69941330T 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region Expired - Lifetime DE69941330D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7950198P 1998-03-26 1998-03-26
PCT/US1999/006573 WO1999048921A1 (en) 1998-03-26 1999-03-25 Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions

Publications (1)

Publication Number Publication Date
DE69941330D1 true DE69941330D1 (de) 2009-10-08

Family

ID=22150958

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69941330T Expired - Lifetime DE69941330D1 (de) 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Country Status (6)

Country Link
EP (1) EP1066324B1 (de)
JP (2) JP2002507406A (de)
AT (1) ATE440865T1 (de)
DE (1) DE69941330D1 (de)
ES (1) ES2332025T3 (de)
WO (1) WO1999048921A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US20020061556A1 (en) * 2000-04-27 2002-05-23 Walke D. Wade Novel membrane proteins and polynucleotides encoding the same
AU6181500A (en) * 1999-07-29 2001-02-19 Helix Research Institute Gene encoding novel tsp1-like protein
EP1204748A2 (de) * 1999-08-19 2002-05-15 MERCK PATENT GmbH An ein g-protein gekoppelter rezeptor und dazugehörige dns
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
GB9924956D0 (en) * 1999-10-21 1999-12-22 Pfizer Ltd Novel polypeptide
NZ518662A (en) * 1999-11-17 2004-10-29 Arena Pharm Inc Endogenous and non-endogenous versions of human G protein-coupled receptors
AU2001239756A1 (en) * 2000-02-08 2001-08-20 Curagen Corporation Novel proteins and nucleic acids encoding same
EP1290030A2 (de) * 2000-05-30 2003-03-12 Bayer Aktiengesellschaft Regulation eines menschlichen lgr4-ähnlichen g protein-gekoppelten rezeptors
WO2002000689A2 (en) * 2000-06-30 2002-01-03 Ingenium Pharmaceuticals Ag HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR11, AND USES THEREOF
WO2002004640A1 (fr) * 2000-07-07 2002-01-17 Takeda Chemical Industries, Ltd. Nouvelle proteine du type recepteur couple aux proteines g et adn correspondant
MXPA03001183A (es) * 2000-08-10 2003-06-30 Amgen Inc Proteina g que contiene una repeticion rica en leucina. acoplada con moleculas del receptor 8 y usos de la misma.
EP1332212A2 (de) * 2000-08-25 2003-08-06 Curagen Corporation Proteine und dafür kodierende nukleinsäuren
WO2002026824A2 (en) * 2000-09-27 2002-04-04 Bristol-Myers Squibb Company A novel human g-protein coupled receptor, hgprbmy5, expressed highly in brain and ovarian tissues
JP2005503111A (ja) * 2001-02-07 2005-02-03 インサイト・ゲノミックス・インコーポレイテッド Ｇタンパク質共役受容体
US20030088884A1 (en) 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
WO2003093827A2 (en) * 2002-05-02 2003-11-13 Bayer Healthcare Ag Diagnostics and drug screening for diseases associated with leucine-rich repeat-containing g-protein coupled receptor 7 (lgr7)
EP1380644A1 (de) * 2002-07-08 2004-01-14 Kylix B.V. Verwendung spezifischer TCF Zielgene zur Identifizierung von Medikamenten zur Behandlung von Krebsarten, insbesondere Colorectalkrebs, bei denen TCF/beta-catenin/WNT Signaltransduktion eine zentrale Rolle spielt
EP1998177A3 (de) * 2003-01-06 2009-02-18 Wyeth Zusammensetzungen und Verfahren zur Diagnostizierung und Behandlung von Dickdarmkrebs
DE10339820A1 (de) * 2003-08-22 2005-03-17 Hinzmann, Bernd, Dr. Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
WO2005040828A2 (en) * 2003-10-24 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
US7189539B2 (en) 2003-11-25 2007-03-13 Bristol-Myers Squibb Company Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
WO2009005809A2 (en) * 2007-07-02 2009-01-08 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
EP2216344B1 (de) 2007-11-14 2017-06-28 Chugai Seiyaku Kabushiki Kaisha Diagnose und behandlung von krebs mit einem anti-gpr49-antikörper
JP5801557B2 (ja) * 2008-12-26 2015-10-28 国立大学法人 東京大学 抗ｌｇｒ７抗体を用いる癌の診断および治療
US20120135422A1 (en) * 2009-03-31 2012-05-31 Mie University Anti-gpcr antibody and the method of producing the same
EP2731625B1 (de) 2011-07-15 2018-04-18 OncoMed Pharmaceuticals, Inc. Rspo-bindende stoffe und ihre verwendung
IN2015KN00350A (de) 2012-07-13 2015-07-10 Oncomed Pharm Inc
MA40574A (fr) 2014-09-16 2016-03-24 Oncomed Pharm Inc Traitement de maladies fibrotiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5858716A (en) * 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
EP1017709A4 (de) * 1997-09-24 2001-12-12 Merck & Co Inc Über g-protein gekuppelter glykoprotein-hormonrezeptor aomf05

Also Published As

Publication number Publication date
EP1066324A4 (de) 2005-06-15
WO1999048921A1 (en) 1999-09-30
JP2002507406A (ja) 2002-03-12
ES2332025T3 (es) 2010-01-22
ATE440865T1 (de) 2009-09-15
EP1066324A1 (de) 2001-01-10
EP1066324B1 (de) 2009-08-26
JP2010166923A (ja) 2010-08-05

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