DE69839768D1 - Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung - Google Patents

Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Info

Publication number: DE69839768D1
Authority: DE; Germany
Prior art keywords: lactoferrin; derived proteins; plants; production; plant cell
Prior art date: 1997-05-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69839768T

Other languages

English (en)

Inventor

Dominique Legrand

Valerie Salmon

Genevieve Spik

Veronique Gruber

Philippe Bournat

Bertrand Merot

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Meristem Therapeutics SA

Original Assignee

Meristem Therapeutics SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-02

Filing date

1998-05-04

Publication date

2008-09-04

1998-05-04 Application filed by Meristem Therapeutics SA filed Critical Meristem Therapeutics SA

2008-09-04 Application granted granted Critical

2008-09-04 Publication of DE69839768D1 publication Critical patent/DE69839768D1/de

2018-05-05 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000010445 Lactoferrin Human genes 0.000 title abstract 4
108010063045 Lactoferrin Proteins 0.000 title abstract 4
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title abstract 4
229940078795 lactoferrin Drugs 0.000 title abstract 4
235000021242 lactoferrin Nutrition 0.000 title abstract 4
235000018102 proteins Nutrition 0.000 abstract 3
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
239000002299 complementary DNA Substances 0.000 abstract 2
230000035897 transcription Effects 0.000 abstract 2
238000013518 transcription Methods 0.000 abstract 2
101000798114 Homo sapiens Lactotransferrin Proteins 0.000 abstract 1
102000050459 human LTF Human genes 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Cell Biology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fertilizers (AREA)

DE69839768T 1997-05-02 1998-05-04 Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung Expired - Fee Related DE69839768D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9705699A FR2762850B1 (fr)	1997-05-02	1997-05-02	Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
PCT/FR1998/000895 WO1998050543A1 (fr)	1997-05-02	1998-05-04	Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

Publications (1)

Publication Number	Publication Date
DE69839768D1 true DE69839768D1 (de)	2008-09-04

Family

ID=9506722

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69839768T Expired - Fee Related DE69839768D1 (de)	1997-05-02	1998-05-04	Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Country Status (9)

Country	Link
US (3)	US6569831B1 (de)
EP (1)	EP0981617B1 (de)
JP (1)	JP2001527406A (de)
AT (1)	ATE402260T1 (de)
AU (1)	AU7659298A (de)
CA (1)	CA2288435A1 (de)
DE (1)	DE69839768D1 (de)
FR (1)	FR2762850B1 (de)
WO (1)	WO1998050543A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2762850B1 (fr) *	1997-05-02	2000-02-11	Biocem	Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
IT1299565B1 (it) *	1998-07-17	2000-03-16	Plantechno S R L	Polinucleotide sintetico codificante per la lattoferrina umana, vettori, cellule e piante transgeniche che lo contengono.
US6399570B1 (en) *	1999-02-05	2002-06-04	Agennix, Inc.	Antimicrobial/endotoxin neutralizing polypeptide
WO2000055337A1 (en) *	1999-03-17	2000-09-21	University Of Victoria Innovation And Development Corporation	Transgenic plants that are resistant to a broad spectrum of pathogens
US6835868B1 (en)	1999-03-17	2004-12-28	University Of Victoria Innovation And Development Corporation	Transgenic plants expressing dermaseptin peptides providing broad spectrum resistance to pathogens
WO2001083792A2 (en)	2000-05-02	2001-11-08	Applied Phytologics, Inc.	Enhanced gene expression in plants using transcription factors
US7304208B2 (en)	2000-05-02	2007-12-04	Ventria Bioscience	Expression of human serum albumin (HSA) in monocot seeds
US7417178B2 (en) *	2000-05-02	2008-08-26	Ventria Bioscience	Expression of human milk proteins in transgenic plants
US7138150B2 (en) *	2000-05-02	2006-11-21	Ventria Bioscience	Method of making an anti-infective composition for treating oral infections
US20080050503A1 (en) *	2000-05-02	2008-02-28	Ning Huang	Expression of human milk proteins in transgenic plants
US6991824B2 (en) *	2000-05-02	2006-01-31	Ventria Bioscience	Expression of human milk proteins in transgenic plants
AU2012202697B2 (en) *	2001-02-14	2015-05-07	Ventria Bioscience	Expression of human milk proteins in transgenic plants
ES2467155T3 (es) *	2001-02-14	2014-06-12	Ventria Bioscience	Expresión de proteínas de leche humana en plantas transgénicas
AU2002250127B2 (en) *	2001-02-14	2007-06-21	Ventria Bioscience	Expression of human milk proteins in transgenic plants
WO2002063975A2 (en) *	2001-02-14	2002-08-22	Ventria Bioscience	Feed additive compositions and methods
SE0200598D0 (sv) *	2002-02-27	2002-02-27	A & Science Invest Ab	Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences
WO2004060392A1 (en) *	2002-12-20	2004-07-22	Ventria Bioscience	Lactoferrin protein with iron for treating iron deficiency and anemia
WO2005056578A2 (en) *	2003-12-09	2005-06-23	Ventria Bioscience	High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers
CA2551392A1 (en) *	2003-12-23	2005-07-28	Ventria Bioscience	Methods of expressing heterologous protein in plant seeds using monocot non seed-storage protein promoters
KR20080039885A (ko) *	2005-06-28	2008-05-07	벤트리아 바이오사이언스	식물 세포로부터 생산된 세포 배양 배지의 성분
US20110070201A1 (en)	2005-07-18	2011-03-24	Protalix Ltd.	Mucosal or enteral administration of biologically active macromolecules
CN101494970B (zh) *	2005-09-28	2012-09-26	文特里亚生物科学公司	用于肠道病症和/或补水的口服制剂
EP1808491A1 (de) *	2006-01-13	2007-07-18	Meristem Therapeutics S.A.	Genetisch modifizierte Pflanze mit verändertem Gehalt an Reserveproteinen
NZ555163A (en)	2007-05-14	2010-05-28	Fonterra Co Operative Group	Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
AU2010215959A1 (en)	2009-02-20	2011-08-04	Ventria Bioscience	Cell culture media containing combinations of proteins
US10947552B1 (en)	2020-09-30	2021-03-16	Alpine Roads, Inc.	Recombinant fusion proteins for producing milk proteins in plants
EP4222167A1 (de)	2020-09-30	2023-08-09	Nobell Foods, Inc.	Rekombinante milchproteine und lebensmittelzusammensetzungen damit
US10894812B1 (en)	2020-09-30	2021-01-19	Alpine Roads, Inc.	Recombinant milk proteins
CN118324930B (zh) *	2024-06-13	2024-08-20	广州暨南大学医药生物技术研究开发中心有限公司	重组人源化乳铁蛋白及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995030339A1 (en) *	1994-05-05	1995-11-16	Ferrodynamics, Inc.	Cloning, expression, and uses of human lactoferrin
KR0154495B1 (ko) *	1995-05-22	1998-10-15	김은영	인체 락토페린 유전자로 형질전환된 항바이러스성 식물체의 제조방법
FR2736930B1 (fr)	1995-07-17	1997-09-19	Biocem	Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
JP2000516812A (ja) *	1996-08-14	2000-12-19	ノバルティスアクチエンゲゼルシャフト	植物病原性真菌に対する阻害活性を有するペプチド
FR2762850B1 (fr) *	1997-05-02	2000-02-11	Biocem	Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

1997
- 1997-05-02 FR FR9705699A patent/FR2762850B1/fr not_active Expired - Lifetime
1998
- 1998-05-04 AU AU76592/98A patent/AU7659298A/en not_active Abandoned
- 1998-05-04 DE DE69839768T patent/DE69839768D1/de not_active Expired - Fee Related
- 1998-05-04 WO PCT/FR1998/000895 patent/WO1998050543A1/fr active IP Right Grant
- 1998-05-04 US US09/423,097 patent/US6569831B1/en not_active Expired - Lifetime
- 1998-05-04 AT AT98924373T patent/ATE402260T1/de not_active IP Right Cessation
- 1998-05-04 EP EP98924373A patent/EP0981617B1/de not_active Expired - Lifetime
- 1998-05-04 JP JP54778398A patent/JP2001527406A/ja active Pending
- 1998-05-04 CA CA002288435A patent/CA2288435A1/fr not_active Abandoned
2003
- 2003-05-27 US US10/446,234 patent/US7354902B2/en not_active Expired - Fee Related
2008
- 2008-04-08 US US12/099,462 patent/US8334254B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0981617A1 (de)	2000-03-01
US7354902B2 (en)	2008-04-08
AU7659298A (en)	1998-11-27
US6569831B1 (en)	2003-05-27
FR2762850B1 (fr)	2000-02-11
FR2762850A1 (fr)	1998-11-06
CA2288435A1 (fr)	1998-11-12
US20110092411A1 (en)	2011-04-21
WO1998050543A1 (fr)	1998-11-12
US20030229925A1 (en)	2003-12-11
JP2001527406A (ja)	2001-12-25
US8334254B2 (en)	2012-12-18
ATE402260T1 (de)	2008-08-15
EP0981617B1 (de)	2008-07-23

Publication	Publication Date	Title
DE69839768D1 (de)	2008-09-04	Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung
ATE308614T1 (de)	2005-11-15	Durch pflanzen hergestelltes rekombinantes kollagen, verfahren zu ihrer herstellung und verwendung
ATE339509T1 (de)	2006-10-15	Stress-gekoppelter transkriptionsfaktor und dessen verwendung in pflanzen
ATE286126T1 (de)	2005-01-15	Glialmitogene faktoren, ihre herstellung und verwendung
ATE252157T1 (de)	2003-11-15	Nucleinsäuremoleküle aus pflanzen codierend enzyme, die an der stärkesynthese beteiligt sind
DE69737507D1 (de)	2007-05-03	Neue nukleinsäuremoleküle aus mais und deren verwendung zur herstellung modifizierter stärke
ATE447855T1 (de)	2009-11-15	Verfahren zur herstellung einer modifizierten stärke
PT917571E (pt)	2005-04-29	Gene relacionado com agouti
DE69030539D1 (de)	1997-05-28	Wachstumsfaktor aus parenchymalen Lebenszellen, dafür kodierendes Gen, Verfahren zur Herstellung dieses Faktors und Transformanten
DE69635675D1 (de)	2006-02-02	Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor
DE68907608D1 (de)	1993-08-19	Verfahren zur herstellung von lignin-peroxidase durch verwendung von nichtproliferierenden phanerochaete chryosporium-zellen.
DE69332148D1 (de)	2002-08-29	Verwendung einer dna sequenz, kodierende für ein protein mit der fäligkeit oxalsäure abzubauen, zur genselektion
DE59404358D1 (de)	1997-11-20	Verfahren zur herstellung von 1,4-butandiol
WO1996033277A3 (fr)	1996-11-28	Lipases preduodenales recombinantes et polypeptides derives produits par les plantes, leurs procedes d'obtention et leurs utilisations
DE69634753D1 (de)	2005-06-23	"targeting" polypeptide der inneren plastidenhüllmembran; ihre herstellung und verwendung
DE50010015D1 (de)	2005-05-12	Tetrahydropyrimidin-dioxygenase-gen, dadurch kodierte polypeptide und verfahren zur deren herstellung
DE68920358D1 (de)	1995-02-16	Verfahren zur Herstellung von Schwefelwasserstoff.
ATA186592A (de)	1996-05-15	Nukleotidsequenz, die für den transforming growth faktor-beta2 kodiert, transforming growth faktor-beta2 sowie verfahren und zellen zur herstellung desselben

Legal Events

Date	Code	Title	Description
2009-08-13	8364	No opposition during term of opposition
2010-03-25	8339	Ceased/non-payment of the annual fee