DE69834032D1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents
Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagierenInfo
- Publication number
- DE69834032D1 DE69834032D1 DE69834032T DE69834032T DE69834032D1 DE 69834032 D1 DE69834032 D1 DE 69834032D1 DE 69834032 T DE69834032 T DE 69834032T DE 69834032 T DE69834032 T DE 69834032T DE 69834032 D1 DE69834032 D1 DE 69834032D1
- Authority
- DE
- Germany
- Prior art keywords
- peptides
- interact
- poly
- nucleic acid
- copying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97106753 | 1997-04-23 | ||
EP97106753 | 1997-04-23 | ||
PCT/EP1998/002420 WO1998048008A1 (en) | 1997-04-23 | 1998-04-23 | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69834032D1 true DE69834032D1 (de) | 2006-05-18 |
DE69834032T2 DE69834032T2 (de) | 2006-12-07 |
Family
ID=8226724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69834032T Expired - Lifetime DE69834032T2 (de) | 1997-04-23 | 1998-04-23 | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
Country Status (7)
Country | Link |
---|---|
US (2) | US6348315B1 (de) |
EP (1) | EP0975748B1 (de) |
JP (1) | JP4086325B2 (de) |
AT (1) | ATE321849T1 (de) |
CA (1) | CA2289691C (de) |
DE (1) | DE69834032T2 (de) |
WO (1) | WO1998048008A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4086325B2 (ja) * | 1997-04-23 | 2008-05-14 | プリュックテュン,アンドレアス | 標的分子と相互作用する(ポリ)ペプチドをコードする核酸分子の同定方法 |
US6927025B1 (en) | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
ATE311443T1 (de) * | 1997-09-03 | 2005-12-15 | Biovation Ltd | Methoden zur durchforstung (screenen) von proteinen |
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP2365097A1 (de) | 1999-05-14 | 2011-09-14 | Enterprise Ireland (trading as BioResearch Ireland) | Tests auf Basis einer Nukleinsäuresonde für prokaryotische und eukaryotische Organismen |
US7074557B2 (en) * | 2000-03-31 | 2006-07-11 | Cambridge Antibody Technology Limited | Ribosome display |
ES2335861T3 (es) | 2000-09-08 | 2010-04-06 | Universitat Zurich | Grupos de proteinas repetitivas que comprenden modulos repetitivos. |
CA2428732C (en) * | 2000-11-15 | 2018-07-31 | Minerva Biotechnologies Corporation | Methods and kit for simultaneous screening of interactions between a plurality of chemical or biological species and uses thereof |
DE10060959A1 (de) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Isolierung und Identifizierung von Effektoren |
AU2003209398A1 (en) * | 2002-01-25 | 2003-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Translation profiling |
US20050123973A1 (en) * | 2002-02-08 | 2005-06-09 | Shaobing Hua | Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
EP1558643B1 (de) * | 2002-11-09 | 2009-05-27 | Immunocore Ltd. | T zell rezeptor "display" |
GB0316314D0 (en) * | 2003-07-12 | 2003-08-13 | Univ Belfast | Method |
GB0411771D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Nucleoproteins displaying native T cell receptor libraries |
EA013162B1 (ru) | 2005-04-18 | 2010-02-26 | Микромет Аг | Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека |
US20070111237A1 (en) * | 2005-09-14 | 2007-05-17 | Maurizio Zanetti | Process for identifying antigenized antibodies using ribosome cell free expression system |
JP2009520949A (ja) | 2005-11-16 | 2009-05-28 | アンブルックス,インコーポレイテッド | 非天然アミノ酸を含んでいる組成物および方法 |
AU2007205974A1 (en) * | 2006-01-17 | 2007-07-26 | Somalogic, Incorporated | Multiplexed analyses of test samples |
AR059448A1 (es) | 2006-02-13 | 2008-04-09 | Divergence Inc | Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal |
EP1894939A1 (de) * | 2006-09-01 | 2008-03-05 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Neues Supertag und seine Verwendung |
WO2008133705A2 (en) * | 2006-10-20 | 2008-11-06 | Binax, Inc. | Assays and devices for identifying pathogens |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
JP5781762B2 (ja) * | 2007-08-10 | 2015-09-24 | プロテリックス、インク | ユニバーサルiii型フィブロネクチン結合ドメインのライブラリ |
US8877688B2 (en) * | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
JP5933894B2 (ja) | 2007-09-14 | 2016-06-15 | アディマブ, エルエルシー | 合理的に設計された、合成抗体ライブラリおよびその使用 |
RU2396336C2 (ru) | 2007-09-27 | 2010-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
EP3189831A1 (de) | 2007-11-30 | 2017-07-12 | AbbVie Biotechnology Ltd | Proteinformulierungen und verfahren zur herstellung davon |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
US8865179B2 (en) * | 2008-01-26 | 2014-10-21 | Swey-Shen Alexchen | Aptameric IgE peptides in a protein scaffold as an allergy vaccine |
EP2088432A1 (de) * | 2008-02-11 | 2009-08-12 | MorphoSys AG | Verfahren zur Identifikation eines Antikörpers oder eines Targets |
EP3629022A1 (de) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Proteinscreeningverfahren |
US8901076B2 (en) | 2008-11-03 | 2014-12-02 | Molecular Partner AG | Binding proteins inhibiting the VEGF-A receptor interaction |
US9139825B2 (en) | 2009-10-30 | 2015-09-22 | Novartis Ag | Universal fibronectin type III bottom-side binding domain libraries |
JP5863045B2 (ja) | 2010-03-11 | 2016-02-16 | 国立研究開発法人理化学研究所 | ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用 |
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
WO2012009568A2 (en) | 2010-07-16 | 2012-01-19 | Adimab, Llc | Antibody libraries |
SG187225A1 (en) | 2010-07-30 | 2013-02-28 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
AU2011333666B2 (en) | 2010-11-26 | 2017-02-02 | Molecular Partners Ag | Improved capping modules for designed ankyrin repeat proteins |
JP5948673B2 (ja) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法 |
US9880160B2 (en) | 2011-03-15 | 2018-01-30 | X-Body, Inc. | Antibody screening methods |
KR102112204B1 (ko) | 2011-04-28 | 2020-06-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 샘플과 연관된 폴리뉴클레오티드의 식별 |
KR20140039203A (ko) | 2011-04-29 | 2014-04-01 | 얀센 바이오테크 인코포레이티드 | Il4/il13 결합 반복 단백질 및 용도 |
JP6057297B2 (ja) | 2011-05-23 | 2017-01-11 | 国立研究開発法人理化学研究所 | 核酸構築物、核酸−蛋白質複合体、及びその利用 |
CN104105708B (zh) | 2011-12-05 | 2018-04-03 | X博迪生物科学公司 | PDGF受体β结合多肽 |
MX356550B (es) | 2012-03-27 | 2018-06-01 | Green Cross Corp | Epitopes de antigeno de superficie de receptor de factor de crecimiento epidermico y uso de los mismos. |
AU2013283296A1 (en) | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
EP2738180A1 (de) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Bindeproteine mit mindestens zwei Bindedomänen gegen HER2 |
EP2989239B1 (de) | 2013-04-25 | 2018-07-04 | Sutro Biopharma, Inc. | Auswahl von fab-fragmenten anhand von ribosomaler display-technik |
US9896685B2 (en) | 2013-04-25 | 2018-02-20 | Sutro Biopharma, Inc. | Use of LAMBDA-GAM protein in ribosomal display technology |
EP3014271B1 (de) | 2013-06-28 | 2020-03-18 | X-Body, Inc. | Zielantigenerkennung, phänotypische masken und verwendung davon zur identifikation zielzellspezifischer zielepitope |
ES2827281T3 (es) | 2013-09-23 | 2021-05-20 | X Body Inc | Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular |
CN108472360B (zh) | 2015-04-10 | 2023-01-17 | 阿迪马布有限责任公司 | 从亲代同源二聚抗体种类中纯化异源二聚多特异性抗体的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3127158B2 (ja) * | 1989-10-05 | 2001-01-22 | オプテイン,インコーポレイティド | 新規の遺伝子及びポリペチドの無細胞合成並びに単離 |
WO1993003172A1 (en) * | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5466580A (en) * | 1993-09-22 | 1995-11-14 | Xoma Corporation | Method for quantifying BPI in body fluids |
WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
JP4086325B2 (ja) * | 1997-04-23 | 2008-05-14 | プリュックテュン,アンドレアス | 標的分子と相互作用する(ポリ)ペプチドをコードする核酸分子の同定方法 |
-
1998
- 1998-04-23 JP JP54503898A patent/JP4086325B2/ja not_active Expired - Fee Related
- 1998-04-23 EP EP98924190A patent/EP0975748B1/de not_active Expired - Lifetime
- 1998-04-23 DE DE69834032T patent/DE69834032T2/de not_active Expired - Lifetime
- 1998-04-23 AT AT98924190T patent/ATE321849T1/de active
- 1998-04-23 CA CA002289691A patent/CA2289691C/en not_active Expired - Fee Related
- 1998-04-23 WO PCT/EP1998/002420 patent/WO1998048008A1/en active IP Right Grant
-
1999
- 1999-10-22 US US09/425,585 patent/US6348315B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/953,321 patent/US6589741B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2001521395A (ja) | 2001-11-06 |
EP0975748B1 (de) | 2006-03-29 |
CA2289691A1 (en) | 1998-10-29 |
JP4086325B2 (ja) | 2008-05-14 |
US20020115083A1 (en) | 2002-08-22 |
CA2289691C (en) | 2008-01-15 |
US6589741B2 (en) | 2003-07-08 |
WO1998048008A1 (en) | 1998-10-29 |
DE69834032T2 (de) | 2006-12-07 |
ATE321849T1 (de) | 2006-04-15 |
EP0975748A1 (de) | 2000-02-02 |
US6348315B1 (en) | 2002-02-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |