Nothing Special   »   [go: up one dir, main page]

DE69832628D1 - Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz - Google Patents

Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz

Info

Publication number
DE69832628D1
DE69832628D1 DE69832628T DE69832628T DE69832628D1 DE 69832628 D1 DE69832628 D1 DE 69832628D1 DE 69832628 T DE69832628 T DE 69832628T DE 69832628 T DE69832628 T DE 69832628T DE 69832628 D1 DE69832628 D1 DE 69832628D1
Authority
DE
Germany
Prior art keywords
prothrombin time
recombinant rabbit
factor based
time reagent
rabbit factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69832628T
Other languages
English (en)
Other versions
DE69832628T2 (de
Inventor
Cheryl Brucato
Cynthia Birr
Paul Bruguera
Juan Ruiz
Demetrio Sanchez-Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instrumentation Laboratory SpA
Original Assignee
Instrumentation Laboratory SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21932957&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69832628(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Instrumentation Laboratory SpA filed Critical Instrumentation Laboratory SpA
Publication of DE69832628D1 publication Critical patent/DE69832628D1/de
Application granted granted Critical
Publication of DE69832628T2 publication Critical patent/DE69832628T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69832628T 1997-04-23 1998-04-22 Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz Expired - Fee Related DE69832628T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4454197P 1997-04-23 1997-04-23
US44541P 1997-04-23
PCT/US1998/007769 WO1998048283A1 (en) 1997-04-23 1998-04-22 Recombinant rabbit tissue factor based prothrombin time reagent

Publications (2)

Publication Number Publication Date
DE69832628D1 true DE69832628D1 (de) 2006-01-05
DE69832628T2 DE69832628T2 (de) 2006-09-07

Family

ID=21932957

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69832628T Expired - Fee Related DE69832628T2 (de) 1997-04-23 1998-04-22 Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz

Country Status (10)

Country Link
US (1) US6100072A (de)
EP (1) EP1015890B1 (de)
JP (1) JP3246749B2 (de)
AT (1) ATE311601T1 (de)
AU (1) AU7129598A (de)
CA (1) CA2288058A1 (de)
DE (1) DE69832628T2 (de)
ES (1) ES2255157T3 (de)
IL (1) IL132529A0 (de)
WO (1) WO1998048283A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
CA2382143C (en) * 1999-09-03 2005-10-18 Roche Diagnostics Corporation Method, reagent and test cartridge for determining clotting time
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
JP4526152B2 (ja) * 2000-03-08 2010-08-18 シスメックス株式会社 プロトロンビン時間測定試薬
US6645768B1 (en) * 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
EP1229048A1 (de) * 2001-02-05 2002-08-07 International Reagents Corporation Thromboplastinreagenz und Verfahren zu dessen Herstellung
US6902909B2 (en) * 2002-07-09 2005-06-07 Synthecon, Inc. Methods for efficient production of mammalian recombinant proteins
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
US7049087B2 (en) * 2002-11-05 2006-05-23 Lifescan, Inc. Method for manufacturing a tissue factor-based prothrombin time reagent
WO2004081034A2 (en) * 2003-03-11 2004-09-23 Advanced Biocatalytics Corporation Altering metabolism in biological processes
US8323949B2 (en) * 2003-03-11 2012-12-04 Advanced Biocatalytics Corporation Altering metabolism in biological processes
CN1806176A (zh) * 2003-05-16 2006-07-19 国家生物标准及控制研究所 混合物
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
DE602004004775T2 (de) * 2004-08-12 2007-11-22 Roche Diagnostics Gmbh Verfahren zur Diagnose von Leberfibrose.
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
JP2008530208A (ja) * 2005-02-16 2008-08-07 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 万能前凝固薬
WO2006096345A2 (en) * 2005-03-04 2006-09-14 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
US7932021B2 (en) * 2005-07-28 2011-04-26 American Diagnostica, Inc. Lupus anticoagulant testing
JP5073270B2 (ja) 2006-11-14 2012-11-14 シスメックス株式会社 凝固検査用試薬及びその製造方法
EP1939218A1 (de) * 2006-12-29 2008-07-02 Thrombotargets Europe, S.L. Mikrovesikel aus rekombinanter Hefe mit blutstillender Wirkung und Verwendung dafür
GB0701821D0 (en) * 2007-02-01 2007-03-14 Pentapharm Ag Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid
JP4999613B2 (ja) * 2007-08-31 2012-08-15 シスメックス株式会社 血液凝固測定用試薬及び血液凝固時間測定方法
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
DE102007062323A1 (de) * 2007-12-21 2009-06-25 Siemens Healthcare Diagnostics Products Gmbh Langzeitstabiles Thromboplastin-Reagenz
JP2011133396A (ja) * 2009-12-25 2011-07-07 Sysmex Corp 活性化部分トロンボプラスチン時間測定試薬、活性化部分トロンボプラスチン時間測定方法、及び血液凝固抑制物質の有無の判定方法
EP2380905A1 (de) * 2010-04-19 2011-10-26 Thrombotargets Europe, S.L. Phospholipidangereicherte Vesikel mit Gewebefaktor mit blutstillenden Aktivitäten sowie Verwendungen davon
EA028016B1 (ru) * 2013-06-06 2017-09-29 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор для измерения параметров системы гемостаза в образце крови или ее компонентов
CN104991079B (zh) * 2015-07-16 2016-04-06 青岛古高生物科技有限公司 一种凝血试剂用抗氧化剂
JP6652873B2 (ja) * 2016-03-30 2020-02-26 シスメックス株式会社 プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
JP6626761B2 (ja) 2016-03-30 2019-12-25 シスメックス株式会社 プロトロンビン時間測定用試薬およびその製造方法
RU2698206C1 (ru) * 2018-07-02 2019-08-23 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор реагентов для диагностики степени нейровоспаления
CN110346559A (zh) * 2019-07-16 2019-10-18 山东艾科达生物科技有限公司 一种冻干型测定pt试剂制备方法
CN110887970B (zh) * 2019-11-29 2023-10-31 北京赛科希德科技股份有限公司 抽提缓冲液、兔脑抽提液、pt检测试剂及pt检测试剂盒

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755461A (en) * 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US5270451A (en) * 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
JP3348228B2 (ja) * 1988-11-23 2002-11-20 デイド ベーリング インコーポレーテッド トロンボプラスチン試薬を製造するための改良された抽出方法
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
US5472850A (en) * 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
US5314695A (en) * 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
US5504064A (en) * 1991-04-10 1996-04-02 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with an activator of FVII
US5374617A (en) * 1992-05-13 1994-12-20 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with FVIIa
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
WO1993007492A1 (en) * 1991-10-04 1993-04-15 Baxter Diagnostics Inc. Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids
US5358853A (en) * 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
US5502651A (en) * 1994-05-02 1996-03-26 Jackson; R. David Potentiophotometric fibrinogen determination
US5418141A (en) * 1994-05-06 1995-05-23 Avocet Medical, Inc. Test articles for performing dry reagent prothrombin time assays

Also Published As

Publication number Publication date
ES2255157T3 (es) 2006-06-16
WO1998048283A1 (en) 1998-10-29
JP3246749B2 (ja) 2002-01-15
US6100072A (en) 2000-08-08
EP1015890B1 (de) 2005-11-30
AU7129598A (en) 1998-11-13
EP1015890A1 (de) 2000-07-05
CA2288058A1 (en) 1998-10-29
JPH11514101A (ja) 1999-11-30
DE69832628T2 (de) 2006-09-07
ATE311601T1 (de) 2005-12-15
IL132529A0 (en) 2001-03-19

Similar Documents

Publication Publication Date Title
DE69832628D1 (de) Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
ATE126894T1 (de) Verfahren zur bestimmung des spiegels von exogenen und endogenen gerinnungsfaktoren und von protein c.
PT807691E (pt) Metodo para a pesquisa quanto a presenca de um defeito genetico associado a trombose e/ou fraca resposta anticoagulante a proteina c activada
ATE78098T1 (de) Testverfahren mit oberflaechengebundenem fibrinogen und loesliches markiertes fibrinogen.
DE59813326D1 (de) Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe und Verfahren zur Bestimmung der Glykosilierung von Thrombomodulin
ATE148923T1 (de) Funktioneller test und reagenz zur bestimmung von fibrinogen
DK0486515T3 (da) Fremgangsmåde til bestemmelse af den funktionelle aktivitet af frit protein S eller protein C i en plasmaprøve
DE69932845D1 (de) Methoden zur quantifizierung von hla-dr und cd11b
ES2043612T3 (es) Procedimiento para la determinacion fotometrica de la actividad de proteina c y/o proteina s.
ATE69108T1 (de) Elektrophoretisches gel hoher aufloesung sowie methode zur abscheidung von serumproteinen.
DK0830608T3 (da) Thromboseriskotest
AU2893697A (en) Method of carrying out blood tests
SE9403833D0 (sv) Analysförfarande och kit
DE59810848D1 (de) REAGENS ZUR BESTIMMUNG DER aPTT
DE69629976D1 (de) Typ I Prokollagen aminoterminales Propeptid, dessen Antikörper und Testverfahren unter Verwendung davon
ATE176822T1 (de) Reagens zur bestimmung der aktivierten partiellen thromboplastinzeit (aptt)
FI932194A0 (fi) Anvaendningen av protrombinfragment
ATE242883T1 (de) Verfahren zur bestimmung von blutgerinnungsfaktoren viii und ix
AUPP159698A0 (en) Improved blood coagulation test
ATE269971T1 (de) Verfahren zur prüfung von immunokompetenz
UA31304A (uk) Спосіб прогнозування тромботичних ускладнень в акушерській практиці

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee