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DE69813988D1 - Transdermal Patch enthaltend eine Kombination von zwei oder mehr Fettalkohole oder Fettsäure als Hautpenetrationbeschleuniger, ein Klebrigmacher und ein Haftmittel zur Verbesserung der Hafteigenschaften - Google Patents

Transdermal Patch enthaltend eine Kombination von zwei oder mehr Fettalkohole oder Fettsäure als Hautpenetrationbeschleuniger, ein Klebrigmacher und ein Haftmittel zur Verbesserung der Hafteigenschaften

Info

Publication number
DE69813988D1
DE69813988D1 DE69813988T DE69813988T DE69813988D1 DE 69813988 D1 DE69813988 D1 DE 69813988D1 DE 69813988 T DE69813988 T DE 69813988T DE 69813988 T DE69813988 T DE 69813988T DE 69813988 D1 DE69813988 D1 DE 69813988D1
Authority
DE
Germany
Prior art keywords
adhesive
tackifier
improve
combination
transdermal patch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813988T
Other languages
English (en)
Inventor
Dario Carrara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antares Pharma IPL AG
Original Assignee
Permatec Technologie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Permatec Technologie AG filed Critical Permatec Technologie AG
Application granted granted Critical
Publication of DE69813988D1 publication Critical patent/DE69813988D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/58Adhesives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69813988T 1997-09-17 1998-09-15 Transdermal Patch enthaltend eine Kombination von zwei oder mehr Fettalkohole oder Fettsäure als Hautpenetrationbeschleuniger, ein Klebrigmacher und ein Haftmittel zur Verbesserung der Hafteigenschaften Expired - Lifetime DE69813988D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI002106A IT1294748B1 (it) 1997-09-17 1997-09-17 Formulazione per un dispositivo transdermico

Publications (1)

Publication Number Publication Date
DE69813988D1 true DE69813988D1 (de) 2003-06-05

Family

ID=11377881

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813988T Expired - Lifetime DE69813988D1 (de) 1997-09-17 1998-09-15 Transdermal Patch enthaltend eine Kombination von zwei oder mehr Fettalkohole oder Fettsäure als Hautpenetrationbeschleuniger, ein Klebrigmacher und ein Haftmittel zur Verbesserung der Hafteigenschaften

Country Status (14)

Country Link
US (1) US6231885B1 (de)
EP (1) EP0913158B1 (de)
JP (1) JPH11152224A (de)
KR (1) KR19990029891A (de)
AR (1) AR019001A1 (de)
AT (1) ATE238777T1 (de)
AU (1) AU742399B2 (de)
CA (1) CA2247767A1 (de)
DE (1) DE69813988D1 (de)
IL (1) IL126267A0 (de)
IT (1) IT1294748B1 (de)
NZ (1) NZ331904A (de)
TW (1) TW493994B (de)
ZA (1) ZA988421B (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
DE19828274C2 (de) * 1998-06-25 2002-11-28 Rottapharm Bv Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren
US20020160995A1 (en) * 1998-08-03 2002-10-31 Easterling W. Jerry Medication and method for remediating existing scars through transdermal, topical delivery of calcium channel blockers
WO2000074661A2 (en) * 1999-06-05 2000-12-14 Noven Pharmaceuticals, Inc. Solubility enhancement of drugs in transdermal drug delivery systems and methods of use
DE19950066A1 (de) * 1999-10-16 2001-04-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut
WO2001052823A2 (en) 2000-01-20 2001-07-26 Noven Pharmaceuticals, Inc. Compositions to effect the release profile in the transdermal administration of drugs
DE10015783C2 (de) * 2000-03-30 2003-12-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
KR20020037616A (ko) * 2000-11-15 2002-05-22 서경배 케토롤락의 경피흡수제제
TWI287455B (en) * 2000-12-05 2007-10-01 Noven Pharma Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
US20040170672A1 (en) * 2001-03-07 2004-09-02 Thorsten Selzer Transdermal therapeutic system for administration of partial dopamine-d2 agonists
KR100846642B1 (ko) * 2001-03-07 2008-07-16 히사미쓰 세이야꾸 가부시키가이샤 첩부제
US20050208117A1 (en) * 2001-03-16 2005-09-22 Venkatraman Subramanian S Transdermal administration of fentanyl and analogs thereof
MXPA03008349A (es) * 2001-03-16 2004-10-15 Johnson & Johnson Parche transdermico para administrar fentanilo.
DE10114382A1 (de) * 2001-03-23 2002-09-26 Beiersdorf Ag Feuchtigkeitsaufnehmende Matrix auf Silikonbasis insbesondere zur Wundversorgung und/oder pharmazeutisch/kosmetischen Hautbehandlung
AU2002308612B2 (en) 2001-05-01 2008-04-10 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
ES2587187T3 (es) * 2001-05-01 2016-10-21 A. V. Topchiev Institute Of Petrochemical Synthesis Composición bioadhesiva absorbente de agua bifásica
US20050215727A1 (en) * 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US20030018074A1 (en) * 2001-07-06 2003-01-23 Robert Kleiman Antiviral composition and treatment method
CN1541112A (zh) * 2001-08-10 2004-10-27 �ù���ҩ��ʽ���� 经皮吸收制剂
CA2460352C (en) * 2001-08-17 2013-05-14 Lavipharm Laboratories Inc. Composition and transdermal drug delivery device
DE10159120B4 (de) * 2001-12-01 2006-08-17 Lts Lohmann Therapie-Systeme Ag Steroidhormonhaltige transdermale therapeutische Systeme enthaltend Propylenglycolmonocaprylat und seine Verwendung
US7921999B1 (en) 2001-12-20 2011-04-12 Watson Laboratories, Inc. Peelable pouch for transdermal patch and method for packaging
WO2003066130A2 (en) * 2002-02-07 2003-08-14 Massachusetts Institute Of Technology Transdermal drug delivery systems
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20040001882A1 (en) * 2002-03-06 2004-01-01 Hexal Ag Transdermal system with fentanyl
ATE501712T1 (de) 2002-04-23 2011-04-15 Durect Corp Transdermale analgetische systeme mit reduziertem missbrauchspotential
ES2589077T3 (es) 2002-06-25 2016-11-10 Acrux Dds Pty Ltd Control de la tasa de administración transdérmica usando composiciones farmacéuticas amorfas
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
JP4354678B2 (ja) 2002-08-28 2009-10-28 久光製薬株式会社 貼付剤
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
CA2453013C (en) * 2002-12-13 2011-02-15 Gary W. Cleary Dermal, transdermal, mucosal or transmucosal ingredient delivery devices
DE10304988A1 (de) * 2003-02-07 2004-09-09 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit verbessertem Hautklebeverhalten
ME00524B (me) 2003-03-10 2011-10-10 Astrazeneca Ab Novi postupak za dobijanje roflumilasta
MY141815A (en) * 2003-04-30 2010-06-30 Purdue Pharma Lp Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
US8790689B2 (en) 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US7888546B2 (en) * 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
WO2005011662A1 (ja) * 2003-07-31 2005-02-10 Hisamitsu Pharmaceutical Co., Inc. 貼付剤
US20070059351A1 (en) * 2003-10-17 2007-03-15 Murrell George A C Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods
US20070053966A1 (en) * 2003-10-17 2007-03-08 Robert Ang Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue
US20060286159A1 (en) * 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect
US20060286158A1 (en) * 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
CA2554649C (en) 2004-01-30 2015-10-27 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
WO2005084678A1 (en) * 2004-03-03 2005-09-15 Vital Health Sciences Pty Ltd Alkaloid formulations
EP2269650A3 (de) * 2004-08-03 2012-05-16 Vital Health Sciences Pty Ltd. Träger zur enteralen Verabreichung
WO2006017807A2 (en) * 2004-08-05 2006-02-16 Corium International, Inc. Adhesive composition
ES2265239B1 (es) * 2004-09-23 2008-02-01 Laboratorio Reig Jofre, S.A. Composicion farmaceutica para administracion transdermica.
US8252320B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
CN101146523B (zh) 2004-10-21 2010-12-29 杜雷科特公司 透皮给药系统
US20060188558A1 (en) * 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
US20090239827A1 (en) * 2005-03-03 2009-09-24 Esra Ogru Compounds having lipid lowering properties
CA2601250C (en) * 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
ITMI20050477A1 (it) * 2005-03-23 2006-09-24 Bouty S P A Cerotto transdermico
EP1893159B1 (de) 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. Träger umfassend ein oder mehrere di- und/oder monophosphatderivate von elektronentransfermitteln
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
US7884158B2 (en) * 2005-09-06 2011-02-08 L'Oré´al Cosmetic compositions containing block copolymers, tackifiers and phenylated silicones
WO2007035941A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal galantamine delivery system
EP1948142B1 (de) 2005-09-23 2014-04-09 ALZA Corporation Polyacrylatformulierung mit hoher beladung von verstärkenden substanzen für transdermale anwendungen
US20070098772A1 (en) * 2005-09-23 2007-05-03 Westcott Tyler D Transdermal norelgestromin delivery system
DE102005056393A1 (de) * 2005-11-24 2007-05-31 Grünenthal GmbH Multicyclische Verbindungen in druckempfindlichen Klebstoffen
US20070122699A1 (en) * 2005-11-30 2007-05-31 Rovcal, Inc. Electrochemical cells having improved gelling agents
US20070202155A1 (en) * 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
US20070259026A1 (en) * 2006-04-20 2007-11-08 Robert Ang Vasodialating dressing for use with intravenous catheters
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
WO2008115224A2 (en) * 2007-03-20 2008-09-25 Bayer Healthcare Llc Method of analyzing an analyte
DE102007041557B4 (de) * 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend längliche Hohlkörper
US8470360B2 (en) 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
MY188123A (en) * 2007-10-15 2021-11-22 Alza Corp Once-a-day replacement transdermal administration of fentanyl
DE102007060175A1 (de) 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
EP2259780A2 (de) 2008-02-28 2010-12-15 Syntropharma Limited Pharmazeutische zusammensetzung mit naltrexon
US20090263456A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and Compositions for Reducing Preventing and Treating Adhesives
EP2387394B1 (de) 2009-01-14 2018-05-02 Corium International, Inc. Transdermale verabreichung von tamsulosin
WO2011068722A1 (en) * 2009-12-01 2011-06-09 Noven Pharmaceuticals, Inc. Transdermal testosterone device and delivery
AU2011213557B2 (en) 2010-02-05 2015-05-07 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
TWI507193B (zh) 2010-03-30 2015-11-11 Phosphagenics Ltd 經皮輸送貼劑
KR20120137373A (ko) 2010-04-30 2012-12-20 테이코쿠 팔마 유에스에이, 인코포레이티드 프로필아미노인단 경피 조성물
EP2685992A4 (de) 2011-03-15 2014-09-10 Phosphagenics Ltd Aminochinoline als kinasehemmer
JP5906302B2 (ja) 2011-03-24 2016-04-20 テイコク ファーマ ユーエスエー インコーポレーテッド 作用剤層および作用剤変換層を含む経皮組成物
CN102895358A (zh) * 2011-07-29 2013-01-30 苏州知微堂生物科技有限公司 一种三黄汤整合型新剂型制备技术及其生产方法
EP2773333B1 (de) * 2011-11-04 2019-10-02 Agile Therapeutics, Inc. Zusammensetzung für dermale freisetzung und verfahren dafür
US9913812B2 (en) 2011-11-09 2018-03-13 Teikoku Pharma Usa, Inc. Methods for the treatment of skin neoplasms
US10918607B2 (en) 2012-11-02 2021-02-16 Teikoku Pharma Usa, Inc. Propynylaminoindan transdermal compositions
EP3150205B1 (de) * 2014-05-28 2021-02-17 Teikoku Seiyaku Co., Ltd. Transdermales präparat
US10238648B2 (en) 2014-07-18 2019-03-26 Buzzz Pharmaceuticals Ltd. Abuse deterrent opioid/opioid-antagonist transdermal patch
US9789070B2 (en) 2015-07-28 2017-10-17 Elc Management Llc Sheet packs for treating facial or body surfaces
CA3007587C (en) 2015-12-09 2023-12-05 Phosphagenics Limited Pharmaceutical formulation
JP6556873B2 (ja) * 2016-01-28 2019-08-07 久光製薬株式会社 経皮吸収製剤
WO2018006069A1 (en) * 2016-06-30 2018-01-04 Teva Pharmaceuticals International Gmbh Improved formulations for transdermal pharmaceutical systems
MX2019006845A (es) 2016-12-21 2019-10-15 Avecho Biotechnology Ltd Proceso.
US10406114B2 (en) * 2017-06-11 2019-09-10 Masoumeh Nasrollahzadeh Abyazani Antibiotic-loaded transdermal patch

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626539A (en) 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4764381A (en) 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US5023084A (en) 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4816258A (en) 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4788062A (en) 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
ATE132751T1 (de) 1988-10-27 1996-01-15 Schering Ag Mittel zur transdermalen applikation enthaltend gestoden
IL92537A (en) * 1988-12-15 1994-04-12 Riker Laboratories Inc Topical preparations and dermal systems containing 1-isobutyl-H1-imidazo [C-4,5] quinoline-4-amine
US4973468A (en) 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5091186A (en) 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
SE8904296D0 (sv) 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
GB9021674D0 (en) 1990-10-05 1990-11-21 Ethical Pharma Ltd Transdermal device
US5225198A (en) 1991-08-27 1993-07-06 Cygnus Therapeutic Systems Transdermal administration of short or intermediate half-life benzodiazepines
US5229130A (en) 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
DE69326461T2 (de) 1992-06-11 2000-05-04 Theratech Inc., Salt Lake City Verwendung von glyzerin zur dämpfung der transdermalen arzneimittelverabreichung
JPH09503997A (ja) 1993-07-08 1997-04-22 シグナス,インコーポレイテッド モノリシックなマトリックス経皮送達システム
US5466465A (en) 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
WO1995029678A1 (en) 1994-04-28 1995-11-09 F.Hoffmann-La Roche Ag Pharmaceutical composition for transdermal delivery

Also Published As

Publication number Publication date
AR019001A1 (es) 2001-12-26
AU742399B2 (en) 2002-01-03
US6231885B1 (en) 2001-05-15
IT1294748B1 (it) 1999-04-12
IL126267A0 (en) 1999-05-09
ITMI972106A1 (it) 1999-03-17
CA2247767A1 (en) 1999-03-17
AU8423098A (en) 1999-04-01
JPH11152224A (ja) 1999-06-08
EP0913158A1 (de) 1999-05-06
EP0913158B1 (de) 2003-05-02
ATE238777T1 (de) 2003-05-15
ZA988421B (en) 1999-03-17
KR19990029891A (ko) 1999-04-26
TW493994B (en) 2002-07-11
NZ331904A (en) 1999-03-29

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