Nothing Special   »   [go: up one dir, main page]

DE69704269D1 - Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung - Google Patents

Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung

Info

Publication number
DE69704269D1
DE69704269D1 DE69704269T DE69704269T DE69704269D1 DE 69704269 D1 DE69704269 D1 DE 69704269D1 DE 69704269 T DE69704269 T DE 69704269T DE 69704269 T DE69704269 T DE 69704269T DE 69704269 D1 DE69704269 D1 DE 69704269D1
Authority
DE
Germany
Prior art keywords
dendritic
lysine
drug delivery
targeted drug
containing polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69704269T
Other languages
English (en)
Other versions
DE69704269T2 (de
Inventor
Alexander T Florence
Thiagarajan Sakthivel
Andrew F Wilderspin
Istvan Toth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Publication of DE69704269D1 publication Critical patent/DE69704269D1/de
Application granted granted Critical
Publication of DE69704269T2 publication Critical patent/DE69704269T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE69704269T 1997-06-11 1997-06-11 Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung Expired - Fee Related DE69704269T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97304060A EP0884327B1 (de) 1997-06-11 1997-06-11 Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung

Publications (2)

Publication Number Publication Date
DE69704269D1 true DE69704269D1 (de) 2001-04-19
DE69704269T2 DE69704269T2 (de) 2001-11-22

Family

ID=8229369

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69704269T Expired - Fee Related DE69704269T2 (de) 1997-06-11 1997-06-11 Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung

Country Status (4)

Country Link
US (1) US6194543B1 (de)
EP (1) EP0884327B1 (de)
JP (1) JPH11124396A (de)
DE (1) DE69704269T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526456A (ja) 1998-09-23 2002-08-20 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン カチオン性化合物およびマクロ分子担体としてのそれらの使用
GB9912911D0 (en) 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6774102B1 (en) * 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
EP1355672A2 (de) 2000-12-01 2003-10-29 Cell Works Inc. "konjugate von glykosylierten/galaktosylierten peptiden, bifunktionellen linkern und nukleotid?monomeren/polymeren, damit zusammenhängende zusammensetzungen, sowie verfahren zu ihrer verwendung"
US7314956B2 (en) 2001-08-08 2008-01-01 Vaxim, Inc. Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell
KR20080031421A (ko) * 2005-07-18 2008-04-08 더 스크립스 리서치 인스티튜트 양쪽성 덴드리머의 제조방법
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
WO2008017122A1 (en) 2006-08-11 2008-02-14 Starpharma Pty Ltd Polylysine dendrimer contrast agent
ES2834916T3 (es) * 2006-08-11 2021-06-21 Starpharma Pty Ltd Agente terapéutico dirigido de dendrímero de polilisina
US20110150837A1 (en) * 2009-12-23 2011-06-23 Flamel Technologies Amphiphilic polymer functionalized by methionine
CN102936337B (zh) * 2012-10-30 2014-10-22 中国科学院长春应用化学研究所 聚(γ-炔丙基-L-谷氨酸酯)-聚氨基酸嵌段共聚物、功能化嵌段共聚物及制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
GB2217319A (en) 1988-04-19 1989-10-25 Synpharm Ltd Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
US5580563A (en) * 1992-05-01 1996-12-03 Tam; James P. Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof
GB9215780D0 (en) * 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
WO1994011015A1 (en) * 1992-11-12 1994-05-26 Molecular Dynamics, Inc. Lipophilic peptide-based carriers for targeted drug delivery using rational drug-binding design
WO1995000540A1 (en) * 1993-06-18 1995-01-05 Robert Webber Synthetic carrier and immunogen
US5795582A (en) * 1996-02-07 1998-08-18 Novavax, Inc. Adjuvant properties of poly (amidoamine) dendrimers

Also Published As

Publication number Publication date
EP0884327B1 (de) 2001-03-14
JPH11124396A (ja) 1999-05-11
US6194543B1 (en) 2001-02-27
EP0884327A1 (de) 1998-12-16
DE69704269T2 (de) 2001-11-22

Similar Documents

Publication Publication Date Title
BR9801027B1 (pt) sistema de distribuiÇço de medicamentos.
ZA983930B (en) Excitatory amino acid receptor modulators.
DE50008130D1 (de) Pumpenanordnung zur förderung von kraftstoff
PT1042359E (pt) Peptidos optioides para o receptor kapa
DE69821457D1 (de) Zusammensetzungen mit kontrollierter Wirkstoffabgabe
NO20000735L (no) Legemiddel leveringsanordning for vedvarende frigivelse
DE69812820D1 (de) Pumpsystem zur Kraftstoffeinspritzung
EP0758843A4 (de) Modifizierte aminosäuren zur verabreichung von medikamenten
HK1030768A1 (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents.
EE200000546A (et) Aerosoolistatud toimeaine manustamissüsteem
DE69831421D1 (de) Zusammensetzungen zur nasalen verabreichung
ATE270880T1 (de) Im magen verweilende mikrosphären mit gesteuerter freisetzung zur verbesserten arzneistoffabgabe
BR9915761B1 (pt) sistema de distribuiÇço de droga protÉica usando mimÉticos de membrana.
IL110024A0 (en) Protein drugs delivery system
IL146451A0 (en) C-terminal protein tagging
DE69810189D1 (de) Zusammensetzungen mit kontrollierter Wirkstoffabgabe
PT964856E (pt) Aminoacidos aromaticos biciclicos
IT1301950B1 (it) Dispositivo per pompare combustibile
DE69704269D1 (de) Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung
FI982504A (fi) Palvelun toimitus
DE69705017D1 (de) Medikamente bindendes Protein
WO2002007671A3 (en) Intracellular delivery system for protein phosphatases and other polypeptides
AU2420997A (en) Oligopeptides for drug delivery
DE59811071D1 (de) Präparation umfassend Thiolgruppen-haltige Proteine
DE69806110D1 (de) Integriertes System zur Abgabe mehrerer Toner

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication of lapse of patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee