DE69435246D1 - Verwendung von Docosahexaensäure zur Herstellung eines Arzneimittels zur Behandlung der senilen Demenz und Alzheimer-Erkrankung - Google Patents
Verwendung von Docosahexaensäure zur Herstellung eines Arzneimittels zur Behandlung der senilen Demenz und Alzheimer-ErkrankungInfo
- Publication number
- DE69435246D1 DE69435246D1 DE69435246T DE69435246T DE69435246D1 DE 69435246 D1 DE69435246 D1 DE 69435246D1 DE 69435246 T DE69435246 T DE 69435246T DE 69435246 T DE69435246 T DE 69435246T DE 69435246 D1 DE69435246 D1 DE 69435246D1
- Authority
- DE
- Germany
- Prior art keywords
- alzheimer
- medicament
- disease
- manufacture
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 title 2
- 206010039966 Senile dementia Diseases 0.000 title 1
- 229940090949 docosahexaenoic acid Drugs 0.000 title 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 8
- 229940114079 arachidonic acid Drugs 0.000 abstract 4
- 235000021342 arachidonic acid Nutrition 0.000 abstract 4
- 239000003921 oil Substances 0.000 abstract 3
- 230000000813 microbial effect Effects 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Psychiatry (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Ophthalmology & Optometry (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7350593A | 1993-06-09 | 1993-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69435246D1 true DE69435246D1 (de) | 2009-12-03 |
Family
ID=22114083
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433713T Expired - Lifetime DE69433713T2 (de) | 1993-06-09 | 1994-06-02 | Für die behandlung neurologischer erkrankungen nützliche methoden und pharmazeutische zusammensetzungen |
DE69435246T Expired - Lifetime DE69435246D1 (de) | 1993-06-09 | 1994-06-02 | Verwendung von Docosahexaensäure zur Herstellung eines Arzneimittels zur Behandlung der senilen Demenz und Alzheimer-Erkrankung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433713T Expired - Lifetime DE69433713T2 (de) | 1993-06-09 | 1994-06-02 | Für die behandlung neurologischer erkrankungen nützliche methoden und pharmazeutische zusammensetzungen |
Country Status (11)
Country | Link |
---|---|
EP (3) | EP0707487B1 (de) |
JP (3) | JPH08511533A (de) |
AT (2) | ATE264099T1 (de) |
AU (1) | AU693450B2 (de) |
CA (2) | CA2596241C (de) |
DE (2) | DE69433713T2 (de) |
DK (1) | DK0707487T3 (de) |
ES (2) | ES2335991T3 (de) |
MX (1) | MX263227B (de) |
PT (1) | PT707487E (de) |
WO (1) | WO1994028913A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5658767A (en) * | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
US5583019A (en) * | 1995-01-24 | 1996-12-10 | Omegatech Inc. | Method for production of arachidonic acid |
EP0823475B1 (de) * | 1995-04-17 | 2009-06-17 | National Institute of Advanced Industrial Science and Technology | Hoch ungesättigte fettsäurenproduzierende mikroorganismen und verfahren zur herstellung von hoch ungesättigten fettsäuren durch verwendung dieser mikroorganismen |
IL122405A (en) * | 1995-06-07 | 2003-04-10 | Martek Biosciences Corp | Methods for preparation of pharmaceutical composition for treatment of specific diseases using oils enriched in dha |
GB9519661D0 (en) * | 1995-09-27 | 1995-11-29 | Scotia Holdings Plc | Fatty acid treatment |
WO1997037032A2 (en) * | 1996-03-28 | 1997-10-09 | Gist-Brocades B.V. | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
WO1997039759A2 (en) * | 1996-04-24 | 1997-10-30 | Brigham And Women's Hospital | Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder |
WO1997043362A1 (en) * | 1996-05-15 | 1997-11-20 | Gist-Brocades B.V. | Sterol extraction with polar solvent to give low sterol, high triglyceride, microbial oil |
GB9617847D0 (en) | 1996-08-27 | 1996-10-09 | Scotia Holdings Plc | Fatty acid treatment |
JP3792309B2 (ja) | 1996-08-30 | 2006-07-05 | サントリー株式会社 | 不飽和脂肪酸含有油脂の製造方法 |
JP4633204B2 (ja) * | 1996-10-11 | 2011-02-16 | サントリーホールディングス株式会社 | アラキドン酸含有食用油脂およびそれを含有する食品 |
US6852870B2 (en) | 1999-03-22 | 2005-02-08 | Andrew Stoll | Omega-3 fatty acids in the treatment of depression |
US6344482B1 (en) | 1997-04-23 | 2002-02-05 | Andrew L. Stoll | Omega-3 fatty acids in the treatment of bipolar disorder |
US5993221A (en) * | 1997-05-01 | 1999-11-30 | Beth Israel Deaconess Medical Center, Inc. | Dietary formulation comprising arachidonic acid and methods of use |
FR2782921B1 (fr) | 1998-09-09 | 2002-09-20 | Dior Christian Parfums | Extrait lipidique de l'algue skeletonema, procede de preparation et utilisation dans des domaines cosmetique et pharmaceutique, notamment dermatologique |
EP2292223A1 (de) * | 1998-10-15 | 2011-03-09 | DSM IP Assets B.V. | Polyungesättigen Fettsäuren Nährungsergänzung |
US6191154B1 (en) * | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
US6610324B2 (en) | 1999-04-07 | 2003-08-26 | The Mclean Hospital Corporation | Flupirtine in the treatment of fibromyalgia and related conditions |
GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
EP1178103A1 (de) | 2000-08-02 | 2002-02-06 | Dsm N.V. | Reinigung von rohen PUFA-reichen Ölen |
JP2003048831A (ja) * | 2001-08-02 | 2003-02-21 | Suntory Ltd | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
NL1019368C2 (nl) | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
US8729124B2 (en) | 2002-03-05 | 2014-05-20 | Pronova Biopharma Norge As | Use of EPA and DHA in secondary prevention |
EP2255667A1 (de) | 2002-06-19 | 2010-12-01 | DSM IP Assets B.V. | Pasteurisationsverfahren für mikrobielle Zellen und mikrobielles Öl |
SE0202188D0 (sv) | 2002-07-11 | 2002-07-11 | Pronova Biocare As | A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product |
EP2295529B2 (de) | 2002-07-11 | 2022-05-18 | Basf As | Verfahren zur Verminderung von Umweltschadstoffen in einem Öl oder einem Fett und Fischfutterprodukt |
NZ569868A (en) | 2002-09-27 | 2010-01-29 | Martek Biosciences Corp | Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation |
EP1558237A4 (de) | 2002-09-27 | 2007-01-17 | Martek Biosciences Corp | VERBESSERTE BLUTZUCKERKONTROLLE F RPRû-DIABETES UND/ODER DIABETES TYP II UNTER VERWENDUNG VON DOCOSAHEXAENSûURE |
JP4993852B2 (ja) | 2004-09-17 | 2012-08-08 | サントリーホールディングス株式会社 | ストレスに起因する行動異常を伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
US8324276B2 (en) | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
EP1845999A4 (de) * | 2005-01-24 | 2010-09-22 | Pronova Biocare As | Verwendung einer fettsäurezusammensetzung mit dha zur herstellung eines medizinischen produkts oder eines nahrungsmittels zur behandlung von krankheiten in verbindung mit amyloidose |
BRPI0613274A2 (pt) * | 2005-05-23 | 2009-08-04 | Massachusetts Inst Technology | composições que contêm pufa e métodos de uso das mesmas |
JP5967855B2 (ja) | 2005-06-30 | 2016-08-10 | サントリーホールディングス株式会社 | 日中活動量の低下および/又はうつ症状の改善作用を有する組成物 |
FR2894772B1 (fr) * | 2005-12-20 | 2008-03-14 | Pierre Fabre Medicament Sa | Procede d'enrichissement en dha |
ES2277557B1 (es) * | 2005-12-21 | 2008-07-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
KR101256448B1 (ko) * | 2005-12-21 | 2013-04-19 | 브루디 테크놀로지 에스엘 | 세포의 산화적 손상과 연관된 병리상태를 치료하기 위한dha, epa 또는 dha 유래의 epa의 용도 |
NL1032840C2 (nl) * | 2006-11-09 | 2008-05-13 | Friesland Brands Bv | Probiotische hydrolysaatvoeding voor kinderen. |
US8383677B2 (en) | 2006-12-28 | 2013-02-26 | Suntory Holdings Limited | Nerve-regenerating agent |
DE102007031039A1 (de) * | 2007-07-04 | 2009-01-08 | Süd-Chemie AG | Verfahren zur schonenden Raffination von Pflanzenölen mit Naturbleicherde |
EP2939671A1 (de) * | 2009-02-02 | 2015-11-04 | DSM IP Assets B.V. | Verfahren zur verbesserung der kognitiven funktion und verringerung der herzfrequenz |
MX356532B (es) | 2009-03-19 | 2018-06-01 | Martek Biosciences Corp | Traustoquitridos, composiciones de acidos grasos y metodos de produccion y uso de los mismos. |
GB0907601D0 (en) * | 2009-05-01 | 2009-06-10 | Equateq Ltd | Novel methods |
WO2011153246A2 (en) * | 2010-06-01 | 2011-12-08 | Martek Biosciences Corporation | Extraction of lipid from cells and products therefrom |
JP6025568B2 (ja) * | 2010-12-28 | 2016-11-16 | 株式会社藤野ブレインリサーチ | 認知症を血液サンプルで判定するための検査方法 |
JP2014515928A (ja) * | 2011-05-19 | 2014-07-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 認知機能減退に対する医療食品 |
EP3831952A1 (de) * | 2011-07-21 | 2021-06-09 | DSM IP Assets B.V. | Verfahren zu herstellung von eicosapentaensäure in mikroorganismen |
JP5496163B2 (ja) * | 2011-10-19 | 2014-05-21 | サントリーホールディングス株式会社 | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
FR2991337B1 (fr) * | 2012-05-29 | 2016-09-02 | Roquette Freres | Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues |
EP2958982B1 (de) | 2013-12-20 | 2019-10-02 | Mara Renewables Corporation | Verfahren zur rückgewinnung von öl aus mikroorganismen |
DE102015109352A1 (de) * | 2015-06-12 | 2016-12-15 | K. D. Pharma Bexbach Gmbh | Anwendung von Omega-3- und/oder Omega-6-Fettsäure(n) |
US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
CA3082441A1 (en) | 2016-11-17 | 2018-05-24 | University Of Debrecen | Precursor compounds for providing retinoids of the vitamin a5 pathway and uses thereof |
KR101946362B1 (ko) * | 2017-10-27 | 2019-02-11 | 파이코일바이오텍코리아(주) | 뇌 염증성 질환 예방, 개선 또는 치료용 조성물 |
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---|---|---|---|---|
GB8524275D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
GB8601915D0 (en) * | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
US5198468A (en) * | 1987-06-24 | 1993-03-30 | Efamol Holdings Plc | Essential fatty acid composition |
KR890701751A (ko) * | 1987-07-20 | 1989-12-21 | 원본 미기재 | 오메가-3(n-3) 지질의 미생물 생성물 |
JP2524217B2 (ja) * | 1988-04-18 | 1996-08-14 | マルハ株式会社 | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤または痴呆治療剤 |
JPH01279827A (ja) * | 1988-05-02 | 1989-11-10 | Taiyo Fishery Co Ltd | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤、痴呆治療剤、または脳機能改善効果を有する機能性食品 |
GB8813766D0 (en) * | 1988-06-10 | 1988-07-13 | Efamol Holdings | Essential fatty acid compositions |
US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
JP2730081B2 (ja) * | 1988-09-24 | 1998-03-25 | 日本油脂株式会社 | 微生物によるアラキドン酸含有油脂の製造方法 |
DE3920679A1 (de) * | 1989-06-23 | 1991-01-10 | Milupa Ag | Fettmischung zur herstellung von nahrungen, insbesondere saeuglingsnahrungen |
US5407957A (en) * | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
BR9205526A (pt) * | 1991-01-24 | 1994-04-19 | Martek Corp Sociedade Norte Am | Misturas de oleos microbianos e usos dos mesmos |
PH11992043811B1 (en) * | 1991-01-24 | 2002-08-22 | Martek Corp | Arachidonic acid and methods for the production and use thereof |
GB9224809D0 (en) * | 1992-11-26 | 1993-01-13 | Scotia Holdings Plc | Schizophrenia |
CA2121986A1 (en) * | 1993-04-26 | 1994-10-27 | Daizo Takeuchi | Processes for culturing marine microalgae and producing docosahexaenoic acid using the same |
-
1994
- 1994-06-02 JP JP7501997A patent/JPH08511533A/ja not_active Withdrawn
- 1994-06-02 ES ES04075413T patent/ES2335991T3/es not_active Expired - Lifetime
- 1994-06-02 PT PT94918217T patent/PT707487E/pt unknown
- 1994-06-02 DK DK94918217T patent/DK0707487T3/da active
- 1994-06-02 AT AT94918217T patent/ATE264099T1/de not_active IP Right Cessation
- 1994-06-02 EP EP94918217A patent/EP0707487B1/de not_active Expired - Lifetime
- 1994-06-02 AT AT04075413T patent/ATE446101T1/de not_active IP Right Cessation
- 1994-06-02 AU AU69635/94A patent/AU693450B2/en not_active Ceased
- 1994-06-02 WO PCT/US1994/006317 patent/WO1994028913A1/en active IP Right Grant
- 1994-06-02 CA CA2596241A patent/CA2596241C/en not_active Expired - Fee Related
- 1994-06-02 DE DE69433713T patent/DE69433713T2/de not_active Expired - Lifetime
- 1994-06-02 EP EP09013195A patent/EP2140863A1/de not_active Withdrawn
- 1994-06-02 DE DE69435246T patent/DE69435246D1/de not_active Expired - Lifetime
- 1994-06-02 EP EP04075413A patent/EP1419780B1/de not_active Revoked
- 1994-06-02 CA CA002164291A patent/CA2164291C/en not_active Expired - Fee Related
- 1994-06-02 ES ES94918217T patent/ES2218525T3/es not_active Expired - Lifetime
- 1994-06-08 MX MX9404334A patent/MX263227B/es not_active IP Right Cessation
-
2007
- 2007-12-19 JP JP2007327930A patent/JP2008133286A/ja active Pending
-
2011
- 2011-02-03 JP JP2011021979A patent/JP2011121978A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2164291A1 (en) | 1994-12-22 |
DK0707487T3 (da) | 2004-08-02 |
CA2164291C (en) | 2007-10-30 |
AU693450B2 (en) | 1998-07-02 |
EP0707487A4 (de) | 1998-09-02 |
EP1419780A1 (de) | 2004-05-19 |
DE69433713T2 (de) | 2005-04-07 |
ATE264099T1 (de) | 2004-04-15 |
DE69433713D1 (de) | 2004-05-19 |
EP0707487B1 (de) | 2004-04-14 |
CA2596241C (en) | 2011-04-19 |
JP2008133286A (ja) | 2008-06-12 |
EP0707487A1 (de) | 1996-04-24 |
PT707487E (pt) | 2004-08-31 |
MX263227B (en) | 2008-12-17 |
WO1994028913A1 (en) | 1994-12-22 |
JP2011121978A (ja) | 2011-06-23 |
ES2218525T3 (es) | 2004-11-16 |
AU6963594A (en) | 1995-01-03 |
CA2596241A1 (en) | 1994-12-22 |
JPH08511533A (ja) | 1996-12-03 |
EP1419780B1 (de) | 2009-10-21 |
ES2335991T3 (es) | 2010-04-07 |
ATE446101T1 (de) | 2009-11-15 |
EP2140863A1 (de) | 2010-01-06 |
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