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DE69434888D1 - 5-ht4-rezeptor-antagonisten - Google Patents

5-ht4-rezeptor-antagonisten

Info

Publication number
DE69434888D1
DE69434888D1 DE69434888T DE69434888T DE69434888D1 DE 69434888 D1 DE69434888 D1 DE 69434888D1 DE 69434888 T DE69434888 T DE 69434888T DE 69434888 T DE69434888 T DE 69434888T DE 69434888 D1 DE69434888 D1 DE 69434888D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
hydrogen
line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69434888T
Other languages
English (en)
Other versions
DE69434888T2 (de
Inventor
Francis David King
Laramie Mary Gaster
Keith Raymond Mulholland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69434888D1 publication Critical patent/DE69434888D1/de
Publication of DE69434888T2 publication Critical patent/DE69434888T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
DE69434888T 1993-05-22 1994-05-16 5-ht4-rezeptor-antagonisten Expired - Fee Related DE69434888T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939310582A GB9310582D0 (en) 1993-05-22 1993-05-22 Pharmaceuticals
GB9310582 1993-05-22
PCT/EP1994/001583 WO1994027987A1 (en) 1993-05-22 1994-05-16 5-ht4 receptor antagonists

Publications (2)

Publication Number Publication Date
DE69434888D1 true DE69434888D1 (de) 2007-01-11
DE69434888T2 DE69434888T2 (de) 2007-06-14

Family

ID=10735954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434888T Expired - Fee Related DE69434888T2 (de) 1993-05-22 1994-05-16 5-ht4-rezeptor-antagonisten

Country Status (13)

Country Link
US (6) US5741801A (de)
EP (1) EP0699194B1 (de)
JP (1) JP3981406B2 (de)
CN (1) CN1126472A (de)
AT (1) ATE346850T1 (de)
AU (1) AU693449B2 (de)
CA (1) CA2163372A1 (de)
DE (1) DE69434888T2 (de)
ES (1) ES2277330T3 (de)
GB (1) GB9310582D0 (de)
NZ (1) NZ267099A (de)
WO (1) WO1994027987A1 (de)
ZA (1) ZA943493B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
EP0977558B1 (de) * 1996-02-15 2003-10-01 Janssen Pharmaceutica N.V. Verwendung von 5-ht4 antagonisten zur überwindung der gastrointestinalen beschädigung, die durch inhibitoren der serotonin-wiederaufnahme hervorgerufen werden
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
ES2283132T3 (es) 1998-09-10 2007-10-16 F. Hoffmann-La Roche Ag Dihidrobenzodiaxin carboxamida y derivados de cetona como antagonistas receptores de 5-ht4.
GB9820294D0 (en) * 1998-09-17 1998-11-11 Smithkline Beecham Plc Pharmaceuticals
US20030220907A1 (en) * 2001-08-24 2003-11-27 Sorensen Jens Erik Organizing ideas accumulated in a computer database
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
EP1831211B1 (de) * 2004-12-22 2010-06-02 Theravance, Inc. Indazolcarbonsäureamidverbindungen
KR20070107807A (ko) * 2005-03-02 2007-11-07 세라밴스 인코포레이티드 5-ｈｔ4 수용체 아고니스트인 퀴놀리논 화합물
WO2010065743A2 (en) * 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
EP2990140B1 (de) * 2014-08-27 2019-01-02 SLM Solutions Group AG Verfahren zur herstellung einer komponente mit einem eisenlegierungsmaterial, komponent und eisenlegierungsmaterial.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3445472A (en) * 1965-12-03 1969-05-20 American Home Prod Mono- and di-aroyl pyridylethyl and piperidylethyl indoles
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
FR2560873B1 (fr) * 1984-03-09 1986-09-26 Rhone Poulenc Sante Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation
DE3771376D1 (de) * 1986-03-17 1991-08-22 Glaxo Group Ltd Indol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EP0387431A1 (de) * 1989-03-14 1990-09-19 Beecham Group Plc Imidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als pharmazeutische Mittel
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
US5492919A (en) * 1991-08-03 1996-02-20 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
JPH06510283A (ja) * 1991-08-20 1994-11-17 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター拮抗薬
WO1993005038A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
JPH07500588A (ja) * 1991-10-24 1995-01-19 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ↓４拮抗薬としてのイミダゾピリジンおよびインドリジン
GB9204565D0 (en) * 1992-03-03 1992-04-15 Smithkline Beecham Plc Pharmaceuticals
SG50693A1 (en) * 1992-03-12 1998-07-20 Smithkline Beecham Plc Pharmaceuticals
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
NZ267296A (en) * 1993-05-26 1997-04-24 Syntex Inc 4-(aminophenyl) omega amino- or 4-piperidyl- alkyl ketone derivatives; pharmaceutical compositions
ES2283132T3 (es) * 1998-09-10 2007-10-16 F. Hoffmann-La Roche Ag Dihidrobenzodiaxin carboxamida y derivados de cetona como antagonistas receptores de 5-ht4.

Also Published As

Publication number Publication date
JPH08510266A (ja) 1996-10-29
DE69434888T2 (de) 2007-06-14
AU6928394A (en) 1994-12-20
NZ267099A (en) 1997-12-19
US5741801A (en) 1998-04-21
CA2163372A1 (en) 1994-12-08
CN1126472A (zh) 1996-07-10
ES2277330T3 (es) 2007-07-01
GB9310582D0 (en) 1993-07-07
US20030139389A1 (en) 2003-07-24
EP0699194A1 (de) 1996-03-06
JP3981406B2 (ja) 2007-09-26
AU693449B2 (en) 1998-07-02
US5872134A (en) 1999-02-16
US6114329A (en) 2000-09-05
EP0699194B1 (de) 2006-11-29
US20020019386A1 (en) 2002-02-14
ZA943493B (en) 1995-11-20
US20060094702A1 (en) 2006-05-04
WO1994027987A1 (en) 1994-12-08
ATE346850T1 (de) 2006-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee