DE68920796D1 - Chinolinderivate, ihre Herstellung und Verwendung. - Google Patents

Chinolinderivate, ihre Herstellung und Verwendung.

Info

Publication number: DE68920796D1
Authority: DE; Germany
Prior art keywords: quinoline derivatives; production; acyltransferase; coa; cholesterol
Prior art date: 1988-07-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE68920796T

Other languages

English (en)

Other versions

DE68920796T2 (de

Inventor

Kanji Meguro

Hitoshi Ikeda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-12

Filing date

1989-07-11

Publication date

1995-03-09

1989-07-11 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1995-03-09 Application granted granted Critical

1995-03-09 Publication of DE68920796D1 publication Critical patent/DE68920796D1/de

1995-07-06 Publication of DE68920796T2 publication Critical patent/DE68920796T2/de

2009-07-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

DE68920796T 1988-07-12 1989-07-11 Chinolinderivate, ihre Herstellung und Verwendung. Expired - Fee Related DE68920796T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP17413788		1988-07-12
JP21426688		1988-08-29
JP7592589		1989-03-27

Publications (2)

Publication Number	Publication Date
DE68920796D1 true DE68920796D1 (de)	1995-03-09
DE68920796T2 DE68920796T2 (de)	1995-07-06

Family

ID=27301993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE68920796T Expired - Fee Related DE68920796T2 (de)	1988-07-12	1989-07-11	Chinolinderivate, ihre Herstellung und Verwendung.

Country Status (17)

Country	Link
US (1)	US5254565A (de)
EP (1)	EP0354994B1 (de)
KR (1)	KR900001656A (de)
AT (1)	ATE117681T1 (de)
AU (1)	AU616542B2 (de)
CA (1)	CA1333068C (de)
DE (1)	DE68920796T2 (de)
DK (1)	DK345989A (de)
ES (1)	ES2066808T3 (de)
FI (1)	FI93353C (de)
GR (1)	GR3015554T3 (de)
HU (1)	HU210861B (de)
IE (1)	IE892088L (de)
IL (1)	IL90815A (de)
NO (1)	NO177300C (de)
NZ (1)	NZ229911A (de)
PT (1)	PT91121B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW205037B (de) *	1989-10-06	1993-05-01	Takeda Pharm Industry Co Ltd
JPH03181465A (ja) *	1989-12-11	1991-08-07	Takeda Chem Ind Ltd	キノリン誘導体
DE4014171A1 (de) *	1990-05-03	1991-11-07	Basf Ag	Cyanochinolinverbindungen
US5256782A (en) *	1990-08-17	1993-10-26	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives which are intermediates
US5143919A (en) *	1990-08-17	1992-09-01	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives and their pharmaceutical use
US5668136A (en) *	1990-09-25	1997-09-16	Eisai Co., Ltd.	Trisubstituted benzene derivatives, composition and methods of treatment
JPH059179A (ja) *	1990-09-27	1993-01-19	Takeda Chem Ind Ltd	複素環化合物、その製造法及びａｃａｔ阻害剤
JPH0776215B2 (ja) *	1991-04-26	1995-08-16	フアイザー・インコーポレイテツド	４−アリール−３−（ヘテロアリールウレイド）キノリン誘導体
IL101785A0 (en) *	1991-05-10	1992-12-30	Fujisawa Pharmaceutical Co	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
WO1993015058A1 (en) *	1992-01-23	1993-08-05	Pfizer Inc.	4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5364875A (en) *	1992-05-11	1994-11-15	The Du Pont Merck Pharmaceutical Company	Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) *	1992-05-11	1994-05-10	The Du Pont Merck Pharmaceutical Company	Imidazoles for the treatment of atherosclerosis
DE69314929T2 (de) *	1992-07-20	1998-03-19	Eisai Co Ltd	Benzolderivate
EP0585913B1 (de) *	1992-09-04	1997-12-29	Takeda Chemical Industries, Ltd.	Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
US5565472A (en) *	1992-12-21	1996-10-15	Pfizer Inc.	4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
GB9302275D0 (en) *	1993-02-05	1993-03-24	Smithkline Beecham Plc	Novel compounds
NZ264063A (en) *	1993-08-13	1995-11-27	Nihon Nohyaku Co Ltd	N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5596001A (en) *	1993-10-25	1997-01-21	Pfizer Inc.	4-aryl-3-(heteroarylureido)quinoline derivatves
TW263498B (de) *	1993-11-10	1995-11-21	Takeda Pharm Industry Co Ltd
US5491152A (en) *	1994-03-23	1996-02-13	The Du Pont Merck Pharmaceutical Company	Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
JP3720395B2 (ja)	1994-09-20	2005-11-24	京都薬品工業株式会社	新規ヘテロ環誘導体、その製造方法およびその医薬用途
WO1996038445A1 (fr) *	1995-05-31	1996-12-05	Sumitomo Pharmaceuticals Company, Limited	Nouveaux derives de naphtyridine
CZ292632B6 (cs)	1995-10-05	2003-11-12	Kyoto Pharmaceutical Industries, Ltd.	Indolinový, indolový nebo tetrahydrochinolinový derivát a farmaceutický přípravek s jeho obsahem
CA2190708A1 (en) *	1995-12-08	1997-06-09	Johannes Aebi	Aminoalkyl substituted benzo-heterocyclic compounds
DE19627430A1 (de) *	1996-07-08	1998-01-15	Bayer Ag	Bicyclisch kondensierte Pyridine
US7429612B2 (en) *	2002-07-17	2008-09-30	Kyoto Pharmaceutical Industries, Ltd.	Indoline compound and medicinal use thereof
CA2603345C (en) *	2005-04-01	2017-05-02	Insa Rouen	New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
US20160332971A1 (en) *	2015-05-15	2016-11-17	University Of Kentucky Research Foundation	Arylquinoline, arylquinolone and arylthioquinolone derivatives and use thereof to treat cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO133758C (de) *	1970-04-04	1976-06-23	Takeda Chemical Industries Ltd
BE770249A (fr) *	1970-07-23	1971-12-01	Takeda Chemical Industries Ltd	Derives de quinoline
JPS555502B1 (de) *	1971-07-31	1980-02-07

1989
- 1989-06-27 IE IE892088A patent/IE892088L/xx unknown
- 1989-06-30 IL IL90815A patent/IL90815A/xx not_active IP Right Cessation
- 1989-07-10 NO NO892851A patent/NO177300C/no unknown
- 1989-07-11 PT PT91121A patent/PT91121B/pt not_active IP Right Cessation
- 1989-07-11 DE DE68920796T patent/DE68920796T2/de not_active Expired - Fee Related
- 1989-07-11 FI FI893361A patent/FI93353C/fi not_active IP Right Cessation
- 1989-07-11 AU AU38025/89A patent/AU616542B2/en not_active Ceased
- 1989-07-11 HU HU893485A patent/HU210861B/hu not_active IP Right Cessation
- 1989-07-11 EP EP89112683A patent/EP0354994B1/de not_active Expired - Lifetime
- 1989-07-11 ES ES89112683T patent/ES2066808T3/es not_active Expired - Lifetime
- 1989-07-11 NZ NZ229911A patent/NZ229911A/en unknown
- 1989-07-11 AT AT89112683T patent/ATE117681T1/de active
- 1989-07-11 CA CA000605291A patent/CA1333068C/en not_active Expired - Fee Related
- 1989-07-12 DK DK345989A patent/DK345989A/da not_active Application Discontinuation
- 1989-07-12 KR KR1019890009937A patent/KR900001656A/ko active IP Right Grant
1991
- 1991-12-16 US US07/807,813 patent/US5254565A/en not_active Expired - Fee Related
1995
- 1995-03-28 GR GR950400730T patent/GR3015554T3/el unknown

Also Published As

Publication number	Publication date
IL90815A (en)	1993-07-08
NO177300C (no)	1995-08-23
AU616542B2 (en)	1991-10-31
HU210861B (en)	1995-08-28
EP0354994A2 (de)	1990-02-21
IL90815A0 (en)	1990-01-18
FI93353C (fi)	1995-03-27
FI893361A0 (fi)	1989-07-11
NZ229911A (en)	1991-08-27
IE892088L (en)	1990-01-12
AU3802589A (en)	1990-01-18
ES2066808T3 (es)	1995-03-16
FI893361A (fi)	1990-01-13
KR900001656A (ko)	1990-02-27
DE68920796T2 (de)	1995-07-06
FI93353B (fi)	1994-12-15
NO892851L (no)	1990-01-15
ATE117681T1 (de)	1995-02-15
DK345989D0 (da)	1989-07-12
GR3015554T3 (en)	1995-06-30
US5254565A (en)	1993-10-19
NO177300B (no)	1995-05-15
PT91121A (pt)	1990-02-08
EP0354994A3 (de)	1991-05-15
HUT52059A (en)	1990-06-28
EP0354994B1 (de)	1995-01-25
CA1333068C (en)	1994-11-15
NO892851D0 (no)	1989-07-10
DK345989A (da)	1990-01-13
PT91121B (pt)	1995-01-31

Publication	Publication Date	Title
DE68920796D1 (de)	1995-03-09	Chinolinderivate, ihre Herstellung und Verwendung.
ATE82966T1 (de)	1992-12-15	Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel.
FI862757A (fi)	1986-12-29	Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
ATE116301T1 (de)	1995-01-15	Chinolinderivate, deren herstellung und verwendung.
ZA93267B (en)	1993-08-23	Novel arylcyloakyl derivatives their production and their use
DE3572170D1 (de)	1989-09-14	Quinolonecarboxylic acid derivatives
ES543153A0 (es)	1987-02-16	Metodo de preparar derivados de b-carbolin-3-oxadiazolilo
DE3882895D1 (de)	1993-09-09	Imid-derivate, ihre herstellung und verwendung.
ATE170516T1 (de)	1998-09-15	Alkylendiaminderivate

Legal Events

Date	Code	Title	Description
1996-02-29	8364	No opposition during term of opposition
2005-05-12	8339	Ceased/non-payment of the annual fee