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DE656260C - Process for obtaining the heart-active glucosides from Boviea volubilis - Google Patents

Process for obtaining the heart-active glucosides from Boviea volubilis

Info

Publication number
DE656260C
DE656260C DEJ52167D DEJ0052167D DE656260C DE 656260 C DE656260 C DE 656260C DE J52167 D DEJ52167 D DE J52167D DE J0052167 D DEJ0052167 D DE J0052167D DE 656260 C DE656260 C DE 656260C
Authority
DE
Germany
Prior art keywords
heart
chloroform
boviea
volubilis
glucosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEJ52167D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FRIEDRICH SCHEERMESSER
ROBERT JARETZKY DR
Original Assignee
FRIEDRICH SCHEERMESSER
ROBERT JARETZKY DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRIEDRICH SCHEERMESSER, ROBERT JARETZKY DR filed Critical FRIEDRICH SCHEERMESSER
Priority to DEJ52167D priority Critical patent/DE656260C/en
Application granted granted Critical
Publication of DE656260C publication Critical patent/DE656260C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G3/00—Glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Description

Verfahren zur Gewinnung der herzwirksamen Glucoside aus Boviea volubilis Seit langer Zeit werden zur Anregung der Herztätigkeit pflanzliche Präparate verwendet, so z. B. die aus Digitalis purpurea, Convallaria majalis und anderen Pflanzen erhältlichen Glucoside. Durch die Erforschung Afrikas wurde die zu den Liliaceen gehörende Boviea volubilis als stark wirkende, gelegentlich zu Vergiftungen Anlaß gebende Pflanze bekannt. Die Medizinmänner der Eingeborenen wandten sie als Mittel gegen Wassersucht an.Process for obtaining the heart-active glucosides from Boviea volubilis Herbal preparations have been used for a long time to stimulate the heart, so z. B. those available from Digitalis purpurea, Convallaria majalis and other plants Glucosides. Through the exploration of Africa, the Boviea, which belongs to the Liliaceae, became volubilis as a powerful plant that occasionally gives rise to poisoning known. The indigenous medicine men used them as a remedy for dropsy at.

Es wurde nun bei eingehender Untersuchung der Pflanze gefunden, daß sie Stoffe enthält, die ähnlich den Digitalisglucosiden eine starke Wirkung auf das Herz ausüben. Hierbei übertrifft der Wirkungsgrad der Zwiebel den der Digitalis um das Dreißigfache, der der Blüten den der Digitalis um das Fünfzig- bis Sechzigfache. Diese Wirkung wird von zwei verschiedenen Glucosiden hervorgerufen, die aus der getrockneten Zwiebel nach folgendem Verfahren gewonnen werden.It has now been found on detailed examination of the plant that it contains substances that have a strong effect similar to digitalis glucosides exercise the heart. The efficiency of the onion exceeds that of the digitalis thirty times that of flowers, fifty to sixty times that of digitalis. This effect is caused by two different glucosides that are derived from the dried onions can be obtained using the following procedure.

i kg stark zerkleinerte Droge wird mit i kg Ammonsulfat, Ammonnitrat oder Ammonchlorid gründlich gemischt und viermal hintereinander je 8 Stunden mit je 2 kg Essigester in der Kälte im Rührwerk extrahiert. Die vereinigten Auszüge werden im Vakuum eingedunstet und der Rückstand wiederholt mit wasserfreiem Äther digeriert. Der so behandelte Rückstand stellt ein Rohglucosidgemisch mit einer Wirkungsstärke von rund 2 Mil-?ionenF.D. an Frühjahrsfröschen dar. Dieses Glucosidgernisch läßt sich durch Behandeln mit Chloroform in einen chloroformlöslichen Teil mit annähernd 2,5 Millionen F. D. und einen chloroformunlöslichen Teil mit rund 1,6 Millionen F. D. zerlegen. Den in Chlorororm löslichen Teil der Glucoside fällt man nach dem Trocknen der Lösung über Natriumsulfat und darauffolgendem Einengen mit Petroläther unter Zusatz von etwas Äther. Beide Glucoside, die man in einer Ausbeute von je o,17 g erhält, geben die gleichen Reaktionen nach Liebermann-Burchard und Keller-Kiliani. Durch Extrahieren der reinen Droge im Sophlet mit Chloroform kann nur der chloroformlösliche Teil der Glucoside erhalten werden.i kg of heavily comminuted drug is mixed with i kg of ammonium sulfate, ammonium nitrate or ammonium chloride mixed thoroughly and four times in a row for 8 hours each time 2 kg each of ethyl acetate extracted in the cold in a stirrer. The combined extracts are evaporated in vacuo and the residue is repeated with anhydrous ether digested. The residue treated in this way is a crude glucoside mixture with a potency of around 2 million F.D. of spring frogs. This mixture of glucosides leaves by treating with chloroform into a chloroform-soluble portion with approximately 2.5 million F.D. and a chloroform-insoluble part with around 1.6 million F. D. disassemble. The part of the glucosides which is soluble in Chlorororm is precipitated after Drying the solution over sodium sulfate and subsequent concentration with petroleum ether with the addition of a little ether. Both glucosides that you get in a yield of each o, 17 g, give the same reactions according to Liebermann-Burchard and Keller-Kiliani. By extracting the pure drug in the sophlet with chloroform, only the chloroform-soluble can be made Part of the glucosides can be obtained.

Claims (1)

PATEN TAN SPRUCH Verfahren zur Gewinnung der herzwirksamen Glucoside aus Boviea volubilis, dadurch gekennzeichnet, daß man einen Teil der zerkleinerten Droge mit einem Teil Ammonsulfat, Ammonnitrat oder Ammonchlorid innig mischt, mehrmals hintereinander mit je zwei Teilen Essigester im Rührwerk je 8 Stunden ausrührt und nach dem Einengen der vereinigten Auszüge im Vakuum den Rückstand mit Äther digeriert und das so erhaltene Rohglucosidgemisch durch Auswaschen mit Chloroform in einen chloroformlöslichen und einen chloroformunlöslichen Teil zerlegt.PATEN TAN SPRUCH Process for obtaining the heart-active glucosides from Boviea volubilis, characterized in that one part of the crushed Drug intimately mixed with a part of ammonium sulfate, ammonium nitrate or ammonium chloride, several times one after the other with two parts of ethyl acetate each in a stirrer for 8 hours each and after the combined extracts have been concentrated in vacuo, the residue is digested with ether and the crude glucoside mixture thus obtained into one by washing out with chloroform chloroform-soluble and a chloroform-insoluble part.
DEJ52167D 1935-04-21 1935-04-21 Process for obtaining the heart-active glucosides from Boviea volubilis Expired DE656260C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEJ52167D DE656260C (en) 1935-04-21 1935-04-21 Process for obtaining the heart-active glucosides from Boviea volubilis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEJ52167D DE656260C (en) 1935-04-21 1935-04-21 Process for obtaining the heart-active glucosides from Boviea volubilis

Publications (1)

Publication Number Publication Date
DE656260C true DE656260C (en) 1938-02-01

Family

ID=7206857

Family Applications (1)

Application Number Title Priority Date Filing Date
DEJ52167D Expired DE656260C (en) 1935-04-21 1935-04-21 Process for obtaining the heart-active glucosides from Boviea volubilis

Country Status (1)

Country Link
DE (1) DE656260C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615016A (en) * 1950-03-20 1952-10-21 Knoll Ag Method of extracting cardioactive glycosides from boviea volubilis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615016A (en) * 1950-03-20 1952-10-21 Knoll Ag Method of extracting cardioactive glycosides from boviea volubilis

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