DE60331479D1 - Pyrimidin-derivate zur behandlung von anormalem zellwachstum - Google Patents

Pyrimidin-derivate zur behandlung von anormalem zellwachstum

Info

Publication number: DE60331479D1
Authority: DE; Germany
Prior art keywords: cell growth; abnormal cell; pyrimidine derivatives; treating abnormal; treating
Prior art date: 2002-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60331479T

Other languages

English (en)

Inventor

John Charles Kath

Michael Joseph Luzzio

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Products Inc

Original Assignee

Pfizer Products Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-20

Filing date

2003-12-08

Publication date

2010-04-08

2003-12-08 Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc

2010-04-08 Application granted granted Critical

2010-04-08 Publication of DE60331479D1 publication Critical patent/DE60331479D1/de

2023-12-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE60331479T 2002-12-20 2003-12-08 Pyrimidin-derivate zur behandlung von anormalem zellwachstum Expired - Lifetime DE60331479D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US43567002P	2002-12-20	2002-12-20
US50074203P	2003-09-05	2003-09-05
PCT/IB2003/005883 WO2004056807A1 (en)	2002-12-20	2003-12-08	Pyrimidine derivatives for the treatment of abnormal cell growth

Publications (1)

Publication Number	Publication Date
DE60331479D1 true DE60331479D1 (de)	2010-04-08

Family

ID=32685406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60331479T Expired - Lifetime DE60331479D1 (de)	2002-12-20	2003-12-08	Pyrimidin-derivate zur behandlung von anormalem zellwachstum

Country Status (31)

Country	Link
US (4)	US7109335B2 (de)
EP (1)	EP1625121B1 (de)
AP (1)	AP2385A (de)
AR (1)	AR043682A1 (de)
AT (1)	ATE458731T1 (de)
AU (2)	AU2003285614B2 (de)
CA (1)	CA2529611C (de)
CR (2)	CR8266A (de)
CY (1)	CY1110069T1 (de)
DE (1)	DE60331479D1 (de)
DK (1)	DK1625121T3 (de)
DO (1)	DOP2003000793A (de)
EA (1)	EA013248B1 (de)
EC (1)	ECSP066406A (de)
ES (1)	ES2338545T3 (de)
GE (1)	GEP20084357B (de)
IL (1)	IL172047A (de)
MX (1)	MXPA06002608A (de)
MY (1)	MY142109A (de)
NL (1)	NL1025067C2 (de)
NZ (1)	NZ543719A (de)
OA (1)	OA13309A (de)
PA (1)	PA8593001A1 (de)
PE (1)	PE20041016A1 (de)
PL (1)	PL379330A1 (de)
PT (1)	PT1625121E (de)
RS (1)	RS20060097A (de)
SI (1)	SI1625121T1 (de)
TN (1)	TNSN06074A1 (de)
TW (1)	TWI283673B (de)
WO (1)	WO2004056807A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7109337B2 (en)	2002-12-20	2006-09-19	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
ATE458731T1 (de)	2002-12-20	2010-03-15	Pfizer Prod Inc	Pyrimidin-derivate zur behandlung von anormalem zellwachstum
DE10349423A1 (de) *	2003-10-16	2005-06-16	Schering Ag	Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
MXPA06011658A (es)	2004-05-14	2006-12-14	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
CN1953974A (zh) *	2004-05-14	2007-04-25	辉瑞产品有限公司	治疗异常细胞生长的嘧啶衍生物
MXPA06013165A (es)	2004-05-14	2007-02-13	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
US20060205945A1 (en) *	2004-05-14	2006-09-14	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
JP2007537230A (ja)	2004-05-14	2007-12-20	ファイザー・プロダクツ・インク	異常細胞増殖の処置用のピリミジン誘導体
JP4812763B2 (ja) *	2004-05-18	2011-11-09	ライジェルファーマシューティカルズ，インコーポレイテッド	シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
WO2005123191A1 (en) *	2004-06-21	2005-12-29	Pharmacia & Upjohn Company Llc	Pyk2 inhibitors for stimulation of osteoblast function
EP1741709A1 (de) *	2005-06-28	2007-01-10	Sanofi-Aventis Deutschland GmbH	Heteroaryl substituierte Amide mit gesättigtem Linker, und deren Verwendung als Pharmaka
TW200800963A (en) *	2005-10-28	2008-01-01	Astrazeneca Ab	Chemical compounds
CA2632149C (en) *	2005-12-01	2011-11-15	Pfizer Products Inc.	Pyrimidine derivatives for the treatment of abnormal cell growth
WO2008049123A2 (en) *	2006-10-19	2008-04-24	Rigel Pharmaceuticals, Inc.	2,4-pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
DE102007010801A1 (de) *	2007-03-02	2008-09-04	Bayer Cropscience Ag	Diaminopyrimidine als Fungizide
WO2008115443A1 (en) *	2007-03-16	2008-09-25	University Of Florida Research Foundation	Kinase protein binding inhibitors
EP2146779B1 (de) *	2007-04-18	2016-08-10	Pfizer Products Inc.	Sulfonylamid-derivate zur behandlung von abnormalem zellwachstum
KR101294731B1 (ko) *	2007-06-04	2013-08-16	삼성디스플레이 주식회사	어레이 기판, 이를 갖는 표시패널 및 이의 제조방법
BRPI0814432A2 (pt)	2007-07-17	2017-05-09	Rigel Pharmaceuticals Inc	pirimidinadiaminas substituídas por amina cíclica como inibidores de pkc
CL2009000600A1 (es) *	2008-03-20	2010-05-07	Bayer Cropscience Ag	Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas.
EP2161259A1 (de)	2008-09-03	2010-03-10	Bayer CropScience AG	4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide
US8410126B2 (en) *	2009-05-29	2013-04-02	Boehringer Ingelheim International Gmbh	Pyrimidine inhibitors of PKTK2
TW201100441A (en) *	2009-06-01	2011-01-01	Osi Pharm Inc	Amino pyrimidine anticancer compounds
JP5539518B2 (ja)	2009-08-14	2014-07-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
CN103003264B (zh)	2010-05-21	2014-08-06	切米利亚股份公司	嘧啶衍生物
EP2395001A1 (de)	2010-05-21	2011-12-14	Chemilia AB	Neue Pyrimidinderivate
US10420665B2 (en)	2010-06-13	2019-09-24	W. L. Gore & Associates, Inc.	Intragastric device for treating obesity
US9526648B2 (en)	2010-06-13	2016-12-27	Synerz Medical, Inc.	Intragastric device for treating obesity
US10010439B2 (en)	2010-06-13	2018-07-03	Synerz Medical, Inc.	Intragastric device for treating obesity
US8628554B2 (en)	2010-06-13	2014-01-14	Virender K. Sharma	Intragastric device for treating obesity
DE102010034699A1 (de)	2010-08-18	2012-02-23	Merck Patent Gmbh	Pyrimidinderivate
US20120244141A1 (en)	2010-09-28	2012-09-27	Boehringer Ingelheim International Gmbh	Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
EP2646448B1 (de)	2010-11-29	2017-08-30	OSI Pharmaceuticals, LLC	Makrocyclische kinasehemmer
US20130324532A1 (en)	2011-02-17	2013-12-05	Cancer Therapeutics Crc Pty Limited	Fak inhibitors
DK2675794T3 (da)	2011-02-17	2019-05-06	Cancer Therapeutics Crc Pty Ltd	Selektive fak-inhibitorer
EP2502924A1 (de)	2011-03-24	2012-09-26	Chemilia AB	Neue Pyrimidinderivate
JP5886411B2 (ja)	2011-03-24	2016-03-16	ノビガ・リサーチ・エービーＮｏｖｉｇａＲｅｓｅａｒｃｈＡＢ	新規のピリミジン誘導体
DE102011111400A1 (de)	2011-08-23	2013-02-28	Merck Patent Gmbh	Bicyclische heteroaromatische Verbindungen
MX348606B (es) *	2011-11-29	2017-06-21	Genentech Inc	Derivados de aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2).
JP2015500862A (ja)	2011-12-23	2015-01-08	セルゾームリミティッド	キナーゼ阻害剤としてのピリミジン−２，４−ジアミン誘導体
EP2711365A1 (de)	2012-09-21	2014-03-26	Chemilia AB	4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidine verwendbar für die Behandlung von Krebs
EP2711364A1 (de)	2012-09-21	2014-03-26	Chemilia AB	4-(Indolyl oder benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidine verwendbar für die Behandlung von Krebs
US10779980B2 (en)	2016-04-27	2020-09-22	Synerz Medical, Inc.	Intragastric device for treating obesity
WO2019117813A1 (en) *	2017-12-15	2019-06-20	National University Of Singapore	Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
TW202304434A (zh) *	2021-04-08	2023-02-01	大陸商杭州阿諾生物醫藥科技有限公司	一種高活性的ｈｐｋ１激酶抑制劑

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4507146A (en)	1982-12-28	1985-03-26	Ciba-Geigy Corporation	2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity
GB8607683D0 (en)	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
US4983608A (en)	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines
DE4029650A1 (de)	1990-09-19	1992-03-26	Hoechst Ag	2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
CA2102780C (en)	1991-05-10	2007-01-09	Alfred P. Spada	Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
NZ243082A (en)	1991-06-28	1995-02-24	Ici Plc	4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
DE4131184A1 (de)	1991-09-19	1993-03-25	Bayer Ag	Wasserbasierte, loesungsmittel- und emulgatorfreie mikrobizide wirkstoffkombination
DE4137291A1 (de)	1991-11-13	1993-05-19	Bayer Ag	Verfahren zur kontinuierlichen umsetzung von halogenpyrimidinen mit aminen
WO1993010086A1 (de)	1991-11-13	1993-05-27	MTA Központi Kémiai Kutató Intézete	Verfahren zur herstellung von n-(arylsulfonyl)-carbamid-säure-derivaten und den in diesem verfahren verwendbaren intermedieren
GB9300059D0 (en)	1992-01-20	1993-03-03	Zeneca Ltd	Quinazoline derivatives
FR2686339B1 (fr)	1992-01-22	1994-03-11	Adir Cie	Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
EP0642502B1 (de)	1992-05-22	2000-07-12	E.I. Du Pont De Nemours And Company	Fungizide imidazolinone
US6177401B1 (en)	1992-11-13	2001-01-23	Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften	Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
GB9323290D0 (en)	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
GB9314893D0 (en)	1993-07-19	1993-09-01	Zeneca Ltd	Quinazoline derivatives
GB9314884D0 (en)	1993-07-19	1993-09-01	Zeneca Ltd	Tricyclic derivatives
GB9510757D0 (en)	1994-09-19	1995-07-19	Wellcome Found	Therapeuticaly active compounds
GB9424233D0 (en)	1994-11-30	1995-01-18	Zeneca Ltd	Quinazoline derivatives
KR100258052B1 (ko)	1995-10-02	2000-08-01	프리돌린 클라우스너, 롤란드 비. 보레르	5ht2c-수용체 길항제로서의 피리미딘 유도체 및 이를 포함하는 약물
GB9523675D0 (en) *	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
GB9603095D0 (en)	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline derivatives
TW440563B (en)	1996-05-23	2001-06-16	Hoffmann La Roche	Aryl pyrimidine derivatives and a pharmaceutical composition thereof
CZ8799A3 (cs)	1996-07-13	1999-06-16	Glaxo Group Limited	Bicyklické heteroaromatické sloučeniny, způsob jejich výroby a farmaceutický prostředek
PT912559E (pt)	1996-07-13	2003-03-31	Glaxo Group Ltd	Compostos heterociclicos fundidos como inibidores de proteina tirosina quinase
HRP970371A2 (en)	1996-07-13	1998-08-31	Kathryn Jane Smith	Heterocyclic compounds
AU709203B2 (en)	1996-08-06	1999-08-26	Pfizer Inc.	Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
CA2264798A1 (en)	1996-09-04	1998-03-12	Pfizer Inc.	Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
ID18494A (id)	1996-10-02	1998-04-16	Novartis Ag	Turunan pirazola leburan dan proses pembuatannya
DE19701931C1 (de)	1997-01-21	1998-05-28	Siemens Ag	Verfahren zur Detektion von Synchronizität zwischen mehreren digitalen Meßreihen mit Hilfe eines Rechners
PT968206E (pt)	1997-02-19	2007-02-28	Pharmacopeia Inc	Derivados n-heterocíclicos como inibidores de nos
TW436485B (en)	1997-08-01	2001-05-28	American Cyanamid Co	Substituted quinazoline derivatives
JP2001522853A (ja)	1997-11-11	2001-11-20	ファイザー・プロダクツ・インク	抗癌剤として有用なチエノピリミジンおよびチエノピリジン誘導体
IL137922A0 (en)	1998-02-17	2001-10-31	Tularik Inc	Anti-viral pyrimidine derivatives
ATE342892T1 (de)	1998-08-29	2006-11-15	Astrazeneca Ab	Pyrimidine verbindungen
US6297258B1 (en)	1998-09-29	2001-10-02	American Cyanamid Company	Substituted 3-cyanoquinolines
EP1117649A1 (de)	1998-09-29	2001-07-25	American Cyanamid Company	Substituierte 3-cyanochinoline als protein tyrosine kinase inhibitoren
GB9828511D0 (en) *	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9922171D0 (en)	1999-09-21	1999-11-17	Zeneca Ltd	Chemical compounds
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
AU3704101A (en) *	2000-02-17	2001-08-27	Amgen Inc	Kinase inhibitors
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en) *	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
KR100817423B1 (ko)	2000-03-13	2008-03-27	와이어쓰 홀딩스 코포레이션	시아노퀴놀린을 포함하는 결장 폴립의 치료 또는 억제를 위한 약제학적 조성물
US6525051B2 (en)	2000-03-27	2003-02-25	Schering Aktiengesellschaft	N-heterocyclic derivatives as NOS inhibitors
WO2002008193A2 (en)	2000-07-07	2002-01-31	Cancer Research Technology Limited	Therapeutic acridone and acridine compounds
IL154034A0 (en)	2000-08-09	2003-07-31	Astrazeneca Ab	Indole, azaindole and indazole derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals
IL153805A0 (en)	2000-08-09	2003-07-31	Astrazeneca Ab	Cinnoline compounds
AU2001277621A1 (en)	2000-08-09	2002-03-04	Astrazeneca Ab	Antiangiogenic bicyclic derivatives
KR20080027400A (ko)	2000-08-21	2008-03-26	아스트라제네카 아베	퀴나졸린 유도체
JO2654B1 (en)	2000-09-04	2012-06-17	شركة جانسين فارماسوتيكا ان. في	Multiple aryl caroxa amides are useful as lipid - lowering agents
ES2556946T3 (es)	2000-12-21	2016-01-21	Novartis Ag	Pirimidinaminas como moduladores de la angiogénesis
PL367130A1 (en)	2001-05-29	2005-02-21	Schering Aktiengesellschaft	Cdk inhibiting pyrimidines, production thereof and their use as medicaments
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
JP2005500294A (ja)	2001-06-19	2005-01-06	ブリストル−マイヤーズ　スクイブ　カンパニー	ホスホジエステラーゼ７に対するピリミジン阻害剤
US6939874B2 (en)	2001-08-22	2005-09-06	Amgen Inc.	Substituted pyrimidinyl derivatives and methods of use
WO2003020276A1 (en)	2001-08-30	2003-03-13	Merck & Co., Inc.	Tyrosine kinase inhibitors
WO2003030909A1 (en)	2001-09-25	2003-04-17	Bayer Pharmaceuticals Corporation	2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
EP1453516A2 (de)	2001-10-17	2004-09-08	Boehringer Ingelheim Pharma GmbH & Co.KG	5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
EP2090571B1 (de)	2001-10-17	2012-05-16	Boehringer Ingelheim Pharma GmbH & Co. KG	Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
BR0307375A (pt)	2002-02-05	2004-12-07	Wyeth Corp	Processo para a sìntese de ácidos n-acil-2-amino-4-alcóxi-5-nitro-benzóicos
DE10205336A1 (de)	2002-02-07	2003-08-21	Bdd Group Holding Ag Zug	Deuterierte Biphenylderivate
GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
AU2003231231A1 (en)	2002-05-06	2003-11-11	Bayer Pharmaceuticals Corporation	Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
US7109337B2 (en) *	2002-12-20	2006-09-19	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
ATE458731T1 (de)	2002-12-20	2010-03-15	Pfizer Prod Inc	Pyrimidin-derivate zur behandlung von anormalem zellwachstum
UA80767C2 (en) *	2002-12-20	2007-10-25	Pfizer Prod Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
EP1950206A1 (de)	2002-12-20	2008-07-30	Sosei R&D Ltd.	Benzoxazocine und ihr Einsatz als Monoamin-Wiederaufnahmehemmer
WO2005023780A1 (en)	2003-09-05	2005-03-17	Pfizer Products Inc.	Selective synthesis of cf3-substituted pyrimidines
JP2007537230A (ja) *	2004-05-14	2007-12-20	ファイザー・プロダクツ・インク	異常細胞増殖の処置用のピリミジン誘導体
MXPA06013165A (es)	2004-05-14	2007-02-13	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
MXPA06011658A (es)	2004-05-14	2006-12-14	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento del crecimiento celular anormal.

2003
- 2003-12-08 AT AT03778613T patent/ATE458731T1/de active
- 2003-12-08 WO PCT/IB2003/005883 patent/WO2004056807A1/en active Application Filing
- 2003-12-08 GE GEAP20039074A patent/GEP20084357B/en unknown
- 2003-12-08 PL PL379330A patent/PL379330A1/pl not_active Application Discontinuation
- 2003-12-08 EP EP03778613A patent/EP1625121B1/de not_active Expired - Lifetime
- 2003-12-08 MX MXPA06002608A patent/MXPA06002608A/es active IP Right Grant
- 2003-12-08 OA OA1200600067A patent/OA13309A/en unknown
- 2003-12-08 ES ES03778613T patent/ES2338545T3/es not_active Expired - Lifetime
- 2003-12-08 EA EA200600122A patent/EA013248B1/ru not_active IP Right Cessation
- 2003-12-08 AP AP2005003438A patent/AP2385A/xx active
- 2003-12-08 DE DE60331479T patent/DE60331479D1/de not_active Expired - Lifetime
- 2003-12-08 RS YUP-2006/0097A patent/RS20060097A/sr unknown
- 2003-12-08 PT PT03778613T patent/PT1625121E/pt unknown
- 2003-12-08 CA CA002529611A patent/CA2529611C/en not_active Expired - Lifetime
- 2003-12-08 SI SI200331771T patent/SI1625121T1/sl unknown
- 2003-12-08 DK DK03778613.4T patent/DK1625121T3/da active
- 2003-12-08 AU AU2003285614A patent/AU2003285614B2/en not_active Expired
- 2003-12-11 US US10/733,215 patent/US7109335B2/en not_active Expired - Lifetime
- 2003-12-16 TW TW092135619A patent/TWI283673B/zh not_active IP Right Cessation
- 2003-12-17 DO DO2003000793A patent/DOP2003000793A/es unknown
- 2003-12-17 MY MYPI20034835A patent/MY142109A/en unknown
- 2003-12-18 NL NL1025067A patent/NL1025067C2/nl not_active IP Right Cessation
- 2003-12-18 AR ARP030104715A patent/AR043682A1/es unknown
- 2003-12-18 PA PA20038593001A patent/PA8593001A1/es unknown
2004
- 2004-01-05 PE PE2004000041A patent/PE20041016A1/es not_active Application Discontinuation
- 2004-12-08 NZ NZ543719A patent/NZ543719A/en not_active IP Right Cessation
2005
- 2005-11-20 IL IL172047A patent/IL172047A/en active IP Right Grant
2006
- 2006-03-02 CR CR8266A patent/CR8266A/es unknown
- 2006-03-03 EC EC2006006406A patent/ECSP066406A/es unknown
- 2006-03-03 TN TNP2006000074A patent/TNSN06074A1/en unknown
- 2006-08-17 US US11/506,689 patent/US7351712B2/en not_active Expired - Lifetime
2008
- 2008-03-31 US US12/059,889 patent/US7674796B2/en not_active Expired - Lifetime
- 2008-07-29 US US12/181,991 patent/US7741336B2/en not_active Expired - Lifetime
2009
- 2009-08-14 AU AU2009208172A patent/AU2009208172B2/en not_active Expired
2010
- 2010-04-20 CY CY20101100360T patent/CY1110069T1/el unknown
2011
- 2011-07-06 CR CR20110380A patent/CR20110380A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
US7741336B2 (en)	2010-06-22
US7351712B2 (en)	2008-04-01
AU2003285614B2 (en)	2009-05-14
AR043682A1 (es)	2005-08-10
PE20041016A1 (es)	2004-12-30
AP2005003438A0 (en)	2005-12-31
IL172047A0 (en)	2009-02-11
NL1025067A1 (nl)	2004-06-22
TNSN06074A1 (en)	2007-10-03
SI1625121T1 (sl)	2010-04-30
RS20060097A (en)	2008-11-28
WO2004056807A1 (en)	2004-07-08
EA013248B1 (ru)	2010-04-30
EP1625121B1 (de)	2010-02-24
NZ543719A (en)	2007-01-26
US20050009853A1 (en)	2005-01-13
CR20110380A (es)	2011-08-08
AU2003285614A1 (en)	2004-07-14
PT1625121E (pt)	2010-03-11
AP2385A (en)	2012-03-23
EP1625121A1 (de)	2006-02-15
EA200600122A1 (ru)	2006-06-30
GEP20084357B (en)	2008-04-29
CA2529611A1 (en)	2004-07-08
TWI283673B (en)	2007-07-11
AU2009208172B2 (en)	2011-06-16
OA13309A (en)	2007-04-13
PL379330A1 (pl)	2006-08-21
ES2338545T3 (es)	2010-05-10
CR8266A (es)	2007-01-18
CY1110069T1 (el)	2015-01-14
US20080300234A1 (en)	2008-12-04
AU2009208172A1 (en)	2009-09-10
PA8593001A1 (es)	2005-02-04
IL172047A (en)	2012-04-30
DK1625121T3 (da)	2010-05-10
ATE458731T1 (de)	2010-03-15
US7674796B2 (en)	2010-03-09
DOP2003000793A (es)	2011-07-31
MXPA06002608A (es)	2007-01-23
MY142109A (en)	2010-09-15
TW200426148A (en)	2004-12-01
ECSP066406A (es)	2006-09-18
US20060281774A1 (en)	2006-12-14
US20080182840A1 (en)	2008-07-31
US7109335B2 (en)	2006-09-19
CA2529611C (en)	2009-12-15
NL1025067C2 (nl)	2005-02-15

Publication	Publication Date	Title
DE60331479D1 (de)	2010-04-08	Pyrimidin-derivate zur behandlung von anormalem zellwachstum
DE602006018354D1 (de)	2010-12-30	Verfahren zur behandlung von abnormalem zellwachstum
EE200200710A (et)	2004-06-15	Asendatud bitsüklilised derivaadid ebanormaalse rakukasvu raviks
AU2003288603A8 (en)	2004-07-14	Pyrimidine derivates for the treatment of abnormal cell growth
DE60325770D1 (de)	2009-02-26	Verwendung von rimexolon zur behandlung von augentrockenheit
DE60321130D1 (de)	2008-07-03	Variation von parametern zur neurostimulation
DE602004030907D1 (de)	2011-02-17	Zur behandlung von durch crth2 vermittelten krankheiten geeignete pyrimidinderivate
DE60011570D1 (de)	2004-07-22	Arylpiperazinyl-cyclohexyl indolderivate zur behandlung von depressionen
ATE433978T1 (de)	2009-07-15	5,7-diaminopyrazolo 4,3-d pyrimidine zur verwendung in der behandlung von bluthochdruck
IL161908A0 (en)	2005-11-20	Quinazoline derivatives for the treatment of abnormal cell growth
IL178828A0 (en)	2007-03-08	Pyrimidine derivatives for the treatment of abnormal cell growth
DE602006003094D1 (de)	2008-11-20	4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
DE602004022035D1 (de)	2009-08-27	Verwendung von pthalide derivativen zur behandlung
NO20053483D0 (no)	2005-07-18	4-Anilinokinazolinderivater for behandling av unormal cellevekst
DE60325496D1 (de)	2009-02-05	Verwendung von dihydroimidazolonen zur behandlung von epilepsie bei hunden
ATE413867T1 (de)	2008-11-15	Methode zur behandlung von bewegungsstörungen mit barbitursäure derivaten.
ATE516040T1 (de)	2011-07-15	Zusammensetzung und verwendung zur vorbeugung oder behandlung von stomatitis
ATE373477T1 (de)	2007-10-15	Cci-779 zur behandlung von mantelzelllymphom
DE60315376D1 (de)	2007-09-20	Vorrichtung zur Behandlung von Erntegut
DE59904564D1 (de)	2003-04-17	Verwendung von acetylcholinesterase-inhibitoren zur behandlung von delirien
DE602004003252D1 (de)	2006-12-28	Verwendung von 2h-ä1,3ü-oxazinoä3,2-aüindol-derivaten zur behandlung von neuropathischem schmerz
DE602004007546D1 (de)	2007-08-23	Verwendung von pentadiensäure-derivaten zur behandlung von hyperurikämie
DE502004002479D1 (de)	2007-02-08	Verwendung von acylcyclohexandion-derivaten zusammen mit ethephon zur behandlung von kernobst
DE50301813D1 (de)	2006-01-05	Verwendung von wachsartigen verbindungen in fototonern
DE502004009105D1 (de)	2009-04-16	Verwendung von desoxypeganin zur behandlung schizophrener psychosen

Legal Events

Date	Code	Title	Description
2011-03-17	8364	No opposition during term of opposition