DE60233338D1 - Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex - Google Patents

Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Info

Publication number: DE60233338D1
Authority: DE; Germany
Prior art keywords: reversible binding; substrate formation; improved substrate; paramagnetic complex; paramagnetic
Prior art date: 2001-10-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60233338T

Other languages

English (en)

Inventor

Enzo Terreno

Silvio Aime

Mauro Botta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bracco Imaging SpA

Original Assignee

Bracco Imaging SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-11

Filing date

2002-10-09

Publication date

2009-09-24

2002-10-09 Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA

2009-09-24 Application granted granted Critical

2009-09-24 Publication of DE60233338D1 publication Critical patent/DE60233338D1/de

2022-10-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Radiology & Medical Imaging (AREA)
Medicinal Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

DE60233338T 2001-10-11 2002-10-09 Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex Expired - Lifetime DE60233338D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01124440A EP1302465A1 (de)	2001-10-11	2001-10-11	Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
PCT/EP2002/011271 WO2003033479A1 (en)	2001-10-11	2002-10-09	Enhanced substrate imaging by reversible binding to a paramagnetic complex

Publications (1)

Publication Number	Publication Date
DE60233338D1 true DE60233338D1 (de)	2009-09-24

Family

ID=8178947

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60233338T Expired - Lifetime DE60233338D1 (de)	2001-10-11	2002-10-09	Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Country Status (6)

Country	Link
US (1)	US7608249B2 (de)
EP (2)	EP1302465A1 (de)
JP (1)	JP4817600B2 (de)
AT (1)	ATE439350T1 (de)
DE (1)	DE60233338D1 (de)
WO (1)	WO2003033479A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1331012A1 (de)	2002-01-29	2003-07-30	BRACCO IMAGING S.p.A.	Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
US20080125403A1 (en)	2004-04-02	2008-05-29	Merck & Co., Inc.	Method of Treating Men with Metabolic and Anthropometric Disorders
EP1716870A1 (de)	2005-04-29	2006-11-02	Bracco Imaging S.p.A.	Kontrastmittel für Kernspintomographie mit konzentrationsunabhängiger Empfanglichkeit
EP2051739A2 (de) *	2006-08-18	2009-04-29	GE Healthcare AS	Bildgebungsmedium mit laktat und hyperpolarisiertem 13c-pyruvat
US8431552B2 (en)	2007-01-16	2013-04-30	Chien-Hung Chen	Composition for treating metabolic syndrome
CA2666036C (en)	2008-05-16	2017-09-12	Chien-Hung Chen	Novel compositions and methods for treating hyperproliferative diseases
WO2010056590A2 (en) *	2008-11-14	2010-05-20	University Of Maryland, Baltimore	Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
WO2011024156A1 (en) *	2009-08-31	2011-03-03	Brain Watch Ltd.	Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders
FR3025317B1 (fr) *	2014-08-26	2022-09-23	Imabiotech	Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4885363A (en) *	1987-04-24	1989-12-05	E. R. Squibb & Sons, Inc.	1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4933441A (en) *	1987-01-27	1990-06-12	Gibby Wendell A	Contrast enhancing agents for magnetic resonance images
US5756065A (en) *	1988-06-24	1998-05-26	The Dow Chemical Company	Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
US5597548A (en) *	1990-07-18	1997-01-28	Board Of Regents, The University Of Texas System	13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
FR2725449B1 (fr) *	1994-10-05	1996-12-27	Air Liquide	Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
IT1293778B1 (it) *	1997-07-25	1999-03-10	Bracco Spa	1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
CA2249173C (en) *	1997-10-06	2008-12-16	Tokyo Gas Co., Ltd.	Diagnostic agent for liver function
IT1304501B1 (it) *	1998-12-23	2001-03-19	Bracco Spa	Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
FR2802928B1 (fr) *	1999-12-22	2003-01-31	Air Liquide	Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds

2001
- 2001-10-11 EP EP01124440A patent/EP1302465A1/de not_active Withdrawn
2002
- 2002-10-09 JP JP2003536219A patent/JP4817600B2/ja not_active Expired - Fee Related
- 2002-10-09 US US10/492,231 patent/US7608249B2/en not_active Expired - Fee Related
- 2002-10-09 AT AT02801319T patent/ATE439350T1/de not_active IP Right Cessation
- 2002-10-09 WO PCT/EP2002/011271 patent/WO2003033479A1/en active Application Filing
- 2002-10-09 DE DE60233338T patent/DE60233338D1/de not_active Expired - Lifetime
- 2002-10-09 EP EP02801319A patent/EP1434768B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE439350T1 (de)	2009-08-15
EP1434768B1 (de)	2009-08-12
JP2005508965A (ja)	2005-04-07
US20040258618A1 (en)	2004-12-23
JP4817600B2 (ja)	2011-11-16
US7608249B2 (en)	2009-10-27
EP1302465A1 (de)	2003-04-16
EP1434768A1 (de)	2004-07-07
WO2003033479A1 (en)	2003-04-24

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Legal Events

Date	Code	Title	Description
2010-09-02	8364	No opposition during term of opposition