DE602005015756D1 - Verfahren zum funktionellen nachweis von masps und dessen komplexen - Google Patents
Verfahren zum funktionellen nachweis von masps und dessen komplexenInfo
- Publication number
- DE602005015756D1 DE602005015756D1 DE602005015756T DE602005015756T DE602005015756D1 DE 602005015756 D1 DE602005015756 D1 DE 602005015756D1 DE 602005015756 T DE602005015756 T DE 602005015756T DE 602005015756 T DE602005015756 T DE 602005015756T DE 602005015756 D1 DE602005015756 D1 DE 602005015756D1
- Authority
- DE
- Germany
- Prior art keywords
- gly
- sample
- activity
- determining
- masps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 3
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 abstract 2
- 102000004856 Lectins Human genes 0.000 abstract 2
- 108090001090 Lectins Proteins 0.000 abstract 2
- 102000004528 Mannose-Binding Protein-Associated Serine Proteases Human genes 0.000 abstract 2
- 108010042484 Mannose-Binding Protein-Associated Serine Proteases Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 239000002523 lectin Substances 0.000 abstract 2
- 108010073863 saruplase Proteins 0.000 abstract 2
- 108091035707 Consensus sequence Proteins 0.000 abstract 1
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 abstract 1
- FMIIKPHLJKUXGE-GUBZILKMSA-N Lys-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN FMIIKPHLJKUXGE-GUBZILKMSA-N 0.000 abstract 1
- 102000009112 Mannose-Binding Lectin Human genes 0.000 abstract 1
- 108010087870 Mannose-Binding Lectin Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- -1 aliphatic amino acid Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Rehabilitation Therapy (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078507 | 2004-12-23 | ||
| PCT/NL2005/000874 WO2006068469A1 (en) | 2004-12-23 | 2005-12-19 | Methods for the functional determination of mannan-binding-lectin associated serine proteases (masps) and complexes thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005015756D1 true DE602005015756D1 (de) | 2009-09-10 |
Family
ID=34928774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005015756T Active DE602005015756D1 (de) | 2004-12-23 | 2005-12-19 | Verfahren zum funktionellen nachweis von masps und dessen komplexen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7811771B2 (de) |
| EP (1) | EP1828775B1 (de) |
| JP (1) | JP5014149B2 (de) |
| AT (1) | ATE438100T1 (de) |
| DE (1) | DE602005015756D1 (de) |
| DK (1) | DK1828775T3 (de) |
| WO (1) | WO2006068469A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108220389A (zh) * | 2017-12-25 | 2018-06-29 | 丽珠集团丽珠制药厂 | 尿激酶效价的测定方法 |
| SG11202106244RA (en) | 2018-12-28 | 2021-07-29 | Catalyst Biosciences Inc | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0691409B1 (de) * | 1994-07-07 | 2002-10-23 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Modifizierte Proenzyme als Substrate für proteolische Enzyme |
| DK1303591T3 (da) * | 2000-07-13 | 2009-11-02 | Helion Biotech Aps | MASP-2, et komplementfikserende enzym, og anvendelser af det |
| US20050118603A1 (en) * | 2002-10-11 | 2005-06-02 | Ahram Biosystems Inc. | Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer |
| EP1443116A1 (de) * | 2003-01-31 | 2004-08-04 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Verbessertes Verfahren zum Nachweis von proteolytischen Enzymen |
-
2005
- 2005-12-19 DK DK05822941T patent/DK1828775T3/da active
- 2005-12-19 US US11/793,851 patent/US7811771B2/en not_active Expired - Fee Related
- 2005-12-19 EP EP05822941A patent/EP1828775B1/de not_active Not-in-force
- 2005-12-19 DE DE602005015756T patent/DE602005015756D1/de active Active
- 2005-12-19 JP JP2007548110A patent/JP5014149B2/ja not_active Expired - Fee Related
- 2005-12-19 AT AT05822941T patent/ATE438100T1/de not_active IP Right Cessation
- 2005-12-19 WO PCT/NL2005/000874 patent/WO2006068469A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006068469A1 (en) | 2006-06-29 |
| EP1828775A1 (de) | 2007-09-05 |
| DK1828775T3 (da) | 2009-11-30 |
| ATE438100T1 (de) | 2009-08-15 |
| WO2006068469A8 (en) | 2007-08-02 |
| EP1828775B1 (de) | 2009-07-29 |
| US20080286803A1 (en) | 2008-11-20 |
| US7811771B2 (en) | 2010-10-12 |
| JP5014149B2 (ja) | 2012-08-29 |
| JP2008525016A (ja) | 2008-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |