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DE60133723D1 - Verabreichungssystemen für oral anzuwendende arzneimittel - Google Patents

Verabreichungssystemen für oral anzuwendende arzneimittel

Info

Publication number
DE60133723D1
DE60133723D1 DE60133723T DE60133723T DE60133723D1 DE 60133723 D1 DE60133723 D1 DE 60133723D1 DE 60133723 T DE60133723 T DE 60133723T DE 60133723 T DE60133723 T DE 60133723T DE 60133723 D1 DE60133723 D1 DE 60133723D1
Authority
DE
Germany
Prior art keywords
drug
medicinal products
administration systems
oral medicinal
multiparticulates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60133723T
Other languages
English (en)
Other versions
DE60133723T2 (de
Inventor
John Staniforth
Michael Tobyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmakodex Ltd
Original Assignee
Pharmakodex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0004701A external-priority patent/GB0004701D0/en
Application filed by Pharmakodex Ltd filed Critical Pharmakodex Ltd
Application granted granted Critical
Publication of DE60133723D1 publication Critical patent/DE60133723D1/de
Publication of DE60133723T2 publication Critical patent/DE60133723T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076—Medicament distribution means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/02—Pill counting devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076—Medicament distribution means
    • A61J7/0084—Medicament distribution means for multiple medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
DE60133723T 2000-02-28 2001-02-26 Verabreichungssystemen für oral anzuwendende arzneimittel Expired - Fee Related DE60133723T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0004701A GB0004701D0 (en) 2000-02-28 2000-02-28 Improvements in or relating to the delivery of powdered oral drugs
GB0004701 2000-02-28
GB0009023A GB0009023D0 (en) 2000-02-28 2000-04-12 Improvements in or relating to the delivery of oral drugs
GB0009023 2000-04-12
PCT/IB2001/000251 WO2001064182A2 (en) 2000-02-28 2001-02-26 Improvements in or relating to the delivery of oral drugs

Publications (2)

Publication Number Publication Date
DE60133723D1 true DE60133723D1 (de) 2008-06-05
DE60133723T2 DE60133723T2 (de) 2009-07-02

Family

ID=26243754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133723T Expired - Fee Related DE60133723T2 (de) 2000-02-28 2001-02-26 Verabreichungssystemen für oral anzuwendende arzneimittel

Country Status (16)

Country Link
US (3) US7089934B2 (de)
EP (2) EP1941868A3 (de)
JP (1) JP2003525081A (de)
CN (1) CN100341483C (de)
AT (1) ATE392885T1 (de)
AU (2) AU2001234005B2 (de)
BR (1) BR0108730A (de)
CA (1) CA2401288A1 (de)
DE (1) DE60133723T2 (de)
ES (1) ES2305057T3 (de)
HU (1) HUP0300491A2 (de)
MX (1) MXPA02008403A (de)
NO (1) NO20024072L (de)
NZ (1) NZ521034A (de)
PL (1) PL204106B1 (de)
WO (1) WO2001064182A2 (de)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
AU2002310085B2 (en) * 2001-05-24 2008-09-04 Alexza Pharmaceuticals, Inc. Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
WO2002094242A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
EP1423092A2 (de) * 2001-09-05 2004-06-02 Vectura Limited Funktionelle pulver zur oralen verabreichung
WO2003057188A1 (en) 2001-11-21 2003-07-17 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
GB0201677D0 (en) * 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
EP1490031A1 (de) * 2002-03-07 2004-12-29 Vectura Limited Schnell schmelzende multiteilchen-formulierungen für die orale abgabe
CN1642524B (zh) * 2002-03-12 2011-05-18 微计量治疗公司 通过吸入部位特异性递送联合施用的药物
DE60318938T2 (de) * 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
EP1503744A1 (de) 2002-05-13 2005-02-09 Alexza Molecular Delivery Corporation Verabreichung von aminenhaltigen arzneistoffen durch inhalation
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
AU2003294470B2 (en) 2002-11-26 2009-09-17 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
DE10300032B3 (de) * 2003-01-03 2004-05-27 E. Braun Gmbh Pulverinhalator
US20040255936A1 (en) * 2003-04-30 2004-12-23 David Urbanus Disposable metered dose inhaler with integrated electronic counter
CA2526475A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
EP1711220A1 (de) * 2004-01-16 2006-10-18 Biodel, Inc. Sublinguale arzneimittelabgabevorrichtung
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
ES2398318T3 (es) * 2004-03-12 2013-03-15 Biodel, Inc. Composiciones de suministro de fármacos de acción rápida
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006023849A2 (en) 2004-08-20 2006-03-02 Mannkind Corporation Catalysis of diketopiperazine synthesis
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
JP5258297B2 (ja) 2004-11-19 2013-08-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 個人別に療法を合わせるために可変用量の薬物併用製品を特注で調剤する方法
FR2881119B1 (fr) * 2005-01-25 2010-07-30 Valois Sas Dispositif de distribution de produit fluide.
EP2656860B1 (de) * 2005-06-17 2021-05-05 Wisconsin Alumni Research Foundation Topische gefässverengende Zubereitungen und Zellschutzverfahren für Chemotherapie und Strahlentherapie bei Krebs
AU2006290870B2 (en) 2005-09-14 2013-02-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
GB0520794D0 (en) * 2005-10-12 2005-11-23 Innovata Biomed Ltd Inhaler
DE102006009637A1 (de) * 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion
WO2008085764A1 (en) * 2007-01-05 2008-07-17 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8357114B2 (en) * 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8865743B2 (en) * 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US20070203907A1 (en) * 2006-02-03 2007-08-30 Polyglot Systems, Inc. User interface for entry of step changes
WO2007093020A1 (en) * 2006-02-17 2007-08-23 Bayer Healthcare Ag Package, or drug kit, or drug smooth administration presentation for the treatment of hypertension, cardiovascular diseases and decrease platelet aggregation.
MX2008010721A (es) 2006-02-22 2008-09-01 Mannkind Corp Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo.
AU2007238114B2 (en) * 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
KR20090055606A (ko) * 2006-09-27 2009-06-02 니코노범 에이비 지향성 용도
US20080142007A1 (en) * 2006-12-15 2008-06-19 Norton Healthcare Ltd Medicament dispenser for an inhaler
CA2672602C (en) 2006-12-18 2014-05-20 Electronic Dietary Foods Inc. Device for delivery of a substance
TW200843802A (en) * 2007-02-09 2008-11-16 Drugtech Corp Compositions for improving gastrointestinal nutrient and drug absorption
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
EP2011538B1 (de) * 2007-07-06 2016-02-17 Vectura Delivery Devices Limited Inhalator
US20090048155A1 (en) 2007-08-15 2009-02-19 Endacea, Inc. Methods for preventing and treating tissue injury and sepsis associated with Yersinia pestis infection
CA2709772A1 (en) 2007-12-21 2009-07-09 Endacea, Inc. A1 adenosine receptor antagonists
EP2077132A1 (de) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
WO2009089181A1 (en) * 2008-01-04 2009-07-16 Blodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
KR101548092B1 (ko) 2008-06-13 2015-08-27 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN102065942B (zh) 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US20100106137A1 (en) * 2008-10-29 2010-04-29 Warsaw Orthopedic, Inc. Drug Delivery System
US9352137B2 (en) * 2008-10-29 2016-05-31 Warsaw Orthopedic, Inc. Drug cartridge for delivering a drug depot comprising a bulking agent and/or cover
US20100106132A1 (en) * 2008-10-29 2010-04-29 Warsaw Orthopedic, Inc. Drug cartridge for delivering a drug depot comprising superior and inferior covers
US20100106136A1 (en) * 2008-10-29 2010-04-29 Warsaw Orthopedic, Inc. Drug delivery device with sliding cartridge
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
ES2873502T3 (es) 2009-03-27 2021-11-03 Bend Res Inc Proceso de secado por pulverización
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
US8333729B2 (en) * 2009-04-07 2012-12-18 Polybiotics Llc Multi-dose delivery system
US20100273822A1 (en) * 2009-04-22 2010-10-28 William Wayne Howard Immediate release compositions and methods for delivering drug formulations using strong acid ion exchange resins
EP3508239B1 (de) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US8734845B2 (en) 2009-06-12 2014-05-27 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
AU2010323220B2 (en) 2009-11-25 2015-04-23 Boehringer Ingelheim International Gmbh Nebulizer
CN104338219B (zh) 2010-01-05 2017-10-24 微剂量治疗技术公司 吸入设备和方法
WO2011094208A2 (en) 2010-01-26 2011-08-04 Endacea, Inc. Methods and pharmaceutical compositions for preventing and treating renal impairment
GB2479928A (en) * 2010-04-30 2011-11-02 R5 Pharmaceuticals Ltd Holder for a drug delivery device
EP2582421A1 (de) 2010-06-21 2013-04-24 MannKind Corporation System und verfahren zur verabreichung von arzneimitteln in trockenpulverform
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
EP2611529B1 (de) 2010-09-03 2019-01-23 Bend Research, Inc. Sprühtrocknungsverfahren
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
WO2012054878A2 (en) * 2010-10-21 2012-04-26 Gliders, LLC Delivery systems and method thereof
US8925726B2 (en) 2011-04-01 2015-01-06 Mannkind Corporation Blister package for pharmaceutical cartridges
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN102247641B (zh) * 2011-06-30 2012-11-28 南京大学 一次性预装急救药液的简易靶向气动雾化给药装置
CN102274563B (zh) * 2011-06-30 2012-09-26 南京大学 简易胶体颗粒可控式靶向气动雾化给药装置
CN102274564B (zh) * 2011-06-30 2013-01-16 南京大学 胶体颗粒可控式靶向气动雾化给药装置
DE202011104802U1 (de) * 2011-08-20 2012-01-26 Christian Kober Strohhalm zur Messung schädlicher Stoffe bzw. von Partydrogen in Getränken
US20140230811A1 (en) * 2011-10-10 2014-08-21 Koninklijke Philips N.V. Mouthpiece and method for delivering nebulized medicament to the airway of a subject
IN2014DN03093A (de) 2011-10-24 2015-05-15 Mannkind Corp
CN104114213B (zh) * 2011-12-16 2016-06-22 赛诺菲股份有限公司 通过吸入向病人施用粉末状药物的装置
GB2499597A (en) * 2012-02-21 2013-08-28 Innovata Biomed Ltd Dry powder inhaler with stepped rotation of metering member
US9033912B2 (en) 2012-03-28 2015-05-19 Warsaw Orthopedic, Inc. Drug delivery system
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
DE202012005997U1 (de) 2012-06-20 2012-07-18 Claus Linder Gefäß für Getränke und Flüssigkeiten jeglicher Art zur Messung schädlicher Stoffe bzw. Rauschgift und Partydrogen in Getränken
AU2013202919C1 (en) * 2012-07-03 2016-02-04 Advent Pharmaceuticals Pty Ltd Blister Pack
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US8920364B2 (en) * 2013-02-28 2014-12-30 Medtronic Xomed, Inc. Biomaterial delivery device
US8845578B2 (en) * 2013-02-28 2014-09-30 Medtronic Xomed, Inc. Biomaterial delivery device
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
PL2835146T3 (pl) 2013-08-09 2021-04-06 Boehringer Ingelheim International Gmbh Nebulizator
EP3030298B1 (de) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Vernebler
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10912334B2 (en) * 2014-04-28 2021-02-09 Philip Morris Products S.A. Flavoured nicotine powder inhaler
CA2943459C (en) * 2014-04-28 2023-05-02 Philip Morris Products S.A. Nicotine powder inhaler
JP6580070B2 (ja) 2014-05-07 2019-09-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 容器、ネブライザ、及び使用
HUE055604T2 (hu) 2014-05-07 2021-12-28 Boehringer Ingelheim Int Porlasztó
WO2015169428A2 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10080877B2 (en) 2014-07-25 2018-09-25 Warsaw Orthopedic, Inc. Drug delivery device and methods having a drug cartridge
GB201414796D0 (en) * 2014-08-20 2014-10-01 Nasaleze Patents Ltd Metered dose dispensing apparatus and method of use thereof
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
MY187877A (en) 2014-12-23 2021-10-26 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
CN113197851A (zh) 2015-05-06 2021-08-03 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
SI3297466T1 (sl) 2015-05-19 2021-02-26 Jt International Sa Naprava za generiranje aerosola in kapsula
EP3097803A1 (de) * 2015-05-26 2016-11-30 Fontem Holdings 1 B.V. Elektronische rauchvorrichtung
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
USD802757S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
CA3026203A1 (en) * 2016-07-21 2018-01-25 Philip Morris Products S.A. Dry powder inhaler
US20190122589A1 (en) * 2016-08-15 2019-04-25 William` G. Hupp Three-dimensional container label and method of use
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
CN106880500B (zh) * 2017-03-27 2019-09-24 孙洁 一种精神科用辅助喂药器及其使用方法
EP3628016A1 (de) * 2017-05-01 2020-04-01 Michael V. Quinn System zur dosierung und ausgabe von medikamenten
US9861578B1 (en) 2017-05-11 2018-01-09 Yuri Issac Busiashvili Sublingual dosimetric drip caged ball valve device
CN107137234A (zh) * 2017-06-23 2017-09-08 成都理工大学 一种定量给药装置
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
MX2020002769A (es) 2017-09-22 2020-07-20 Otitopic Inc Composiciones de polvo seco con estearato de magnesio.
GB201721065D0 (en) * 2017-12-15 2018-01-31 Ondosis Ab Delivery device for drug pellets
AU2019208104A1 (en) * 2018-01-15 2020-09-03 Hygieia Health Co., Limited Systems, methods, compositions and devices for personalized nutrition formulation and delivery system
CA3088387A1 (en) * 2018-01-19 2019-07-25 The Board Of Regents Of The University Of Texas System Hiccup relieving apparatus
CN108525091A (zh) * 2018-02-14 2018-09-14 张莹 一种呼吸内科用给药装置
US20210187211A1 (en) * 2018-05-08 2021-06-24 Omega Life Science Ltd. Nebulizers, nebulizer cartridges and uses thereof
US10188585B1 (en) 2018-07-20 2019-01-29 Yuri Busiashvili Device for the sublingual administration of a medication formed from dissolving a tablet in a liquid
USD1010104S1 (en) 2020-02-26 2024-01-02 Higher Innovations, Inc. Hiccup relieving apparatus
GB202004831D0 (en) * 2020-04-01 2020-05-13 Ondosis Ab Delivery device for oral dosage forms
WO2021246852A1 (ru) * 2020-06-03 2021-12-09 Малик Сейлханович АБДЫКАДИРОВ Портативный газовый ингалятор
CN115252432B (zh) * 2022-08-09 2024-10-29 扬州市职业大学(扬州开放大学) 一种辅助型喂药装置

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US512804A (en) * 1894-01-16 Automatic feed-water regulator
US697209A (en) * 1901-07-24 1902-04-08 Benno Koppenhagen Device for facilitating taking pills.
US2517482A (en) 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2587215A (en) 1949-04-27 1952-02-26 Frank P Priestly Inhalator
US3183907A (en) 1962-06-25 1965-05-18 Merck & Co Inc Device for inhalation aerosol
NL297349A (de) 1962-08-31
US3178748A (en) 1963-03-19 1965-04-20 Ideal Rubber Products Co Floor mop with wringer attachment
US3187748A (en) 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3356088A (en) 1963-09-25 1967-12-05 Trustees Of The Ohio State Uni Breath-controlled anesthetic applicator and method of operation
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3507277A (en) 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
GB1182779A (en) 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
US3456646A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456644A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1268051A (en) 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device
DE1813993C3 (de) 1968-12-11 1974-01-24 Paul Ritzau Pari-Werk Kg, 8135 Soecking Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
US3831606A (en) 1971-02-19 1974-08-27 Alza Corp Auto inhaler
GB1383761A (en) 1971-02-25 1974-02-12 Woodcraft Dc Inhalation device for use with an aerosol container
US3739950A (en) 1971-04-05 1973-06-19 J Gorman Aerosol inhalation apparatus
CH521758A (it) 1971-04-07 1972-04-30 Mora Maria Inalatore nasale tascabile
US3732864A (en) 1971-06-07 1973-05-15 Schering Corp Inhalation coordinated aerosol dispensing device
US3656070A (en) 1971-06-21 1972-04-11 Us Navy Variable axial ratio compensator
IT941426B (it) 1971-07-17 1973-03-01 Isf Spa Inalatore a camera di turbinio per sostanze medicamentose polveriformi
NO134730L (de) 1971-07-19 1900-01-01
GB1413285A (en) 1971-11-25 1975-11-12 Bespak Industries Ltd Aerosol devices
US4011864A (en) 1972-08-29 1977-03-15 Paul Guichard Respiratory apparatus
US3927806A (en) 1972-09-07 1975-12-23 Philip Meshberg Applicator for attachment to a spray mist dispenser
US3795244A (en) 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
DE2346914C3 (de) 1973-09-18 1980-10-16 Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg Inhalator für pulverförmige Substanzen
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3948264A (en) 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US3994421A (en) 1975-09-29 1976-11-30 American Cyanamid Company Unitary therapeutic aerosol dispenser
IT1066105B (it) 1976-08-13 1985-03-04 Sigma Tau Ind Farmaceuti Inalatore per sostanze in confezione spray
IE46865B1 (en) 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
US4147166A (en) 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
US4210155A (en) 1978-08-03 1980-07-01 Jerry Grimes Inspirational inhalation spirometer apparatus
US4227522A (en) 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
IT7920688V0 (it) 1979-02-05 1979-02-05 Chiesi Paolo Parma Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore.
SE415957B (sv) 1979-02-16 1980-11-17 Draco Ab Aerosolinhalationsanordning
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
US4274403A (en) 1979-08-29 1981-06-23 Struve Roger L Inhaler
US4265236A (en) 1980-03-31 1981-05-05 Pacella Angelo M Portable inhalator device
EP0045419B1 (de) 1980-08-04 1984-10-17 FISONS plc Inhalationsvorrichtung zum Verabreichen von Medikamenten
ES8206980A1 (es) 1980-10-30 1982-09-01 Riker Laboratories Inc Un dispositivo para facilitar la inhalacion oral de medica- mentos en forma de polvo
US4387809A (en) * 1981-05-01 1983-06-14 Botzler Paul C Multi-compartment combination package and stirrer device
US4454877A (en) 1981-05-26 1984-06-19 Andrew Boettner Portable nebulizer or mist producing device
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
ATE23272T1 (de) 1981-07-08 1986-11-15 Draco Ab Pulverinhalator.
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
EP0072046B1 (de) 1981-07-24 1986-01-15 FISONS plc Inhalierbare Arzneimittel, Verfahren zu deren Herstellung und pharmazeutische Formulierungen diese enthaltend
SE433443B (sv) 1981-09-15 1984-05-28 Draco Ab Aerosolinhalationsanordning
EP0079478A1 (de) 1981-11-03 1983-05-25 Miles Laboratories, Inc. Medikamentinhalationseinrichtung
US4509515A (en) 1982-02-23 1985-04-09 Fisons Plc Inhalation device
IE56059B1 (en) 1982-10-08 1991-04-10 Glaxo Group Ltd Devices for administering medicaments to patients
DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
JPS6032714A (ja) * 1983-08-01 1985-02-19 Teijin Ltd 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物
US4576157A (en) 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
GB8328808D0 (en) 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
DE3345722A1 (de) 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
US4637528A (en) 1984-01-19 1987-01-20 William H. Rorer, Inc. Articulated joint in aerosol medicament dispenser
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4644107A (en) 1984-10-26 1987-02-17 Ttc Voice-controlled telephone using visual display
US4648393A (en) 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
US4592348A (en) 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4805811A (en) 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
US4803978A (en) 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
SE8601351D0 (sv) 1986-03-24 1986-03-24 Nilsson Sven Erik Styrd administration av fysiologiskt aktiva emnen
US4817822A (en) 1986-04-25 1989-04-04 Glaxo Group Limited Indicating device
US4739754A (en) 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
US4790305A (en) 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
JPS63143081A (ja) 1986-12-05 1988-06-15 メクト株式会社 吸入器
CA1329526C (en) 1987-08-20 1994-05-17 Hiroshi Ikura Powdery medicine applicator device
US4896832A (en) 1987-09-07 1990-01-30 Bespak Plc Dispensing apparatus for metered quantities of pressurised fluid
US4852561A (en) 1988-07-27 1989-08-01 Sperry C R Inhalation device
ATE104867T1 (de) 1988-10-04 1994-05-15 Univ Johns Hopkins Inhalationsgeraet fuer aerosolen.
EP0373237A1 (de) 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Inhalationsgerät, insbesondere Taschen-Inhalationsgerät
US4981468A (en) 1989-02-17 1991-01-01 Eli Lilly And Company Delivery device for orally administered therapeutic agents
US5012804A (en) 1989-03-06 1991-05-07 Trudell Medical Medication inhaler with adult mask
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
CA2009326C (en) * 1989-05-09 1998-01-27 Lawrence J. Daher Aqueous granulation solution and a method of tablet granulation
US5176132A (en) 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
IT1230313B (it) 1989-07-07 1991-10-18 Somova Spa Inalatore per medicamenti in capsule.
US5002048A (en) * 1989-12-12 1991-03-26 Makiej Jr Walter J Inhalation device utilizing two or more aerosol containers
ATE90211T1 (de) * 1990-02-07 1993-06-15 Vetter & Co Apotheker Doppelkammerspritze und verwendungsverfahren.
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5020527A (en) 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
US5062423A (en) 1990-02-27 1991-11-05 Minnesota Mining And Manufacturing Company Equine aerosol drug delivery method and apparatus
IT1240750B (it) 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
FR2662672B1 (fr) * 1990-05-31 1992-08-21 Aerosols & Bouchage Dispensateur de melange.
IE61651B1 (en) * 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
IT1243344B (it) * 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5060643A (en) 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5115803A (en) 1990-08-31 1992-05-26 Minnesota Mining And Manufacturing Company Aerosol actuator providing increased respirable fraction
US5178138A (en) 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
SE9002895D0 (sv) 1990-09-12 1990-09-12 Astra Ab Inhalation devices for dispensing powders i
IT1244441B (it) 1990-09-13 1994-07-15 Chiesi Farma Spa Dispositivo per l'inalazione boccale di farmaci aerosol
FR2667509B1 (fr) * 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
US5304125A (en) 1990-10-05 1994-04-19 The University Of North Carolina Apparatus for administering solid particulate aerosols to the lungs
US5042472A (en) 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
US5290539A (en) 1990-12-21 1994-03-01 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
IT1249600B (it) 1991-02-21 1995-03-09 Elettro Plastica Spa Erogatore nasale di sostanze farmaceutiche nebulizzate
US5469750A (en) 1991-03-05 1995-11-28 Aradigm Corporation Method and apparatus for sensing flow in two directions and automatic calibration thereof
US5392768A (en) 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
WO1994016759A1 (en) 1991-03-05 1994-08-04 Miris Medical Corporation An automatic aerosol medication delivery system and methods
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5327883A (en) 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
IT1248059B (it) 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere
JPH0614756Y2 (ja) * 1991-06-26 1994-04-20 株式会社アルテ 組み立て式の２室式容器兼用注射器
AU662919B2 (en) 1991-07-02 1995-09-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5161524A (en) 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5287850A (en) 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
AU2513092A (en) 1991-08-26 1993-03-16 Minnesota Mining And Manufacturing Company Powder dispenser
DE4211475A1 (de) 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
US5320094A (en) * 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
MX9300110A (es) * 1992-01-13 1994-07-29 Gerhard Gergely Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.
US5476093A (en) 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
EP0558879B1 (de) 1992-03-04 1997-05-14 Astra Aktiebolag Wegwerfinhalator
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
EP0642366B1 (de) 1992-05-29 1997-10-08 GGU GESELLSCHAFT FÜR GESUNDHEITS- UND UMWELTFORSCHUNG MBH & CO. VERTRIEBS KG Vorrichtung zur erzeugung inhalierbarer wirkstoffpartikel
DK0572969T3 (de) 1992-06-05 1997-02-24 Hoechst Ag
AU659328B2 (en) 1992-06-12 1995-05-11 Teijin Limited Ultrafine powder for inhalation and production thereof
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
ES2127837T3 (es) 1992-10-19 1999-05-01 Dura Pharma Inc Inhalador para polvo seco.
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
WO1994014490A1 (de) 1992-12-23 1994-07-07 Bernhard Hugemann Verfestigter arzneistoffvorrat für die mechanische erzeugung inhalierbarer wirkstoffpartikel
FR2700279B1 (fr) 1993-01-14 1995-03-17 Valois Dispositif portatif pour projeter des doses d'une substance fluide à l'aide d'un flux d'air comprimé.
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
BR9405690A (pt) 1993-02-12 1995-11-21 Minnesota Mining & Mfg Aparelho apropriado para ser pelo menos parcialmente inserido em uma narina de um animal de grande porte tal como um cavalo aparelho sendo um conduto para administrar um aerossol respirável a um animal de grande porte e processo de aministrar um aerossol respirável a um animal de grande porte tal como um cavalo
US5372128A (en) 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
US5349947A (en) 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US5524613A (en) 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
DE4340768A1 (de) * 1993-11-30 1995-06-01 Bayer Ag Vorrichtung zum Inhalieren
DE69422900T2 (de) 1993-12-01 2000-06-08 Resmed Ltd., North Ryde Vorrichtung zur Erzeugung eines kontinuierlichen positiven Atemwegdruckes (CPAP)
US5505194A (en) 1994-03-23 1996-04-09 Abbott Laboratories Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions
US6102036A (en) 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
FI942196A (fi) * 1994-05-11 1995-11-12 Orion Yhtymae Oy Jauheinhalaattori
US5483954A (en) 1994-06-10 1996-01-16 Mecikalski; Mark B. Inhaler and medicated package
FR2722765B1 (fr) * 1994-07-25 1996-08-23 Oreal Recipient permettant le stockage d'au moins deux produits, le melange de ces produits et la distribution du melange ainsi obtenu
RU2157251C2 (ru) * 1994-09-16 2000-10-10 Лаборатуар Глаксо Велльком С.А. Устройство для ингаляции
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
US5965164A (en) * 1994-10-28 1999-10-12 Fuisz Technologies Ltd. Recipient-dosage delivery system
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US5628981A (en) * 1994-12-30 1997-05-13 Nano Systems L.L.C. Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
AU718851B2 (en) 1995-04-14 2000-04-20 Smithkline Beecham Corporation Metered dose inhaler for beclomethasone dipropionate
DE69630111T2 (de) 1995-04-14 2004-07-22 Smithkline Beecham Corp. Dosierinhalator für salmeterol
EP1870122A3 (de) 1995-04-14 2008-03-12 SmithKline Beecham Corporation Inhalator für abgemessene Dosen
US5622166A (en) 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
DE19518810A1 (de) * 1995-05-26 1996-11-28 Bayer Ag Nasal-Applikator
AU719449B2 (en) 1995-06-21 2000-05-11 Astrazeneca Ab Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
DE19525546C2 (de) 1995-07-13 2002-05-02 Schott Glas Vorrichtung zur Verabreichung von Substanzen, insbesondere Inhalationspräparate
SG80553A1 (en) * 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
SE9502800D0 (sv) 1995-08-10 1995-08-10 Astra Ab Disposable inhaler
US5617844A (en) 1995-09-21 1997-04-08 King; Russell W. Aerosol medication delivery system
US5848587A (en) 1995-09-21 1998-12-15 Medi-Nuclear Corporation, Inc. Aerosol medication delivery system
US5738087A (en) 1995-09-21 1998-04-14 King; Russell W. Aerosol medication delivery system
US5724986A (en) 1995-11-06 1998-03-10 Jones Medical Instrument Co. Casing and spirometer for metered dose inhaler
US5694920A (en) 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
ES2172763T3 (es) * 1996-02-21 2002-10-01 Schering Corp Inhalador de medicamento en polvo.
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5906202A (en) * 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
SE9700424D0 (sv) * 1997-02-07 1997-02-07 Astra Ab Powder inhaler
US5948787A (en) * 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
PT101988B (pt) * 1997-04-04 2004-02-27 Hovione Farmaciencia Sa Sistema de orientacao e posicionamento de um objecto
US5881720A (en) * 1997-04-29 1999-03-16 The Procter & Gamble Company Method of delivering halotherapy
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
US6116238A (en) 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5891476A (en) * 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
US6083514A (en) 1998-01-09 2000-07-04 Abbott Laboratories Polymethylpentene container for an inhalation anesthetic
US6074668A (en) 1998-01-09 2000-06-13 Abbott Laboratories Container for an inhalation anesthetic
US6142146A (en) 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6062213A (en) 1998-06-16 2000-05-16 Fuisz Technologies Ltd. Single unit dose inhalation therapy device
US6073818A (en) 1998-06-19 2000-06-13 Genzyme Transgenics Corporation Apparatus for controlled delivery of powdered solid materials
IT1301969B1 (it) * 1998-07-30 2000-07-20 Lisapharma Spa Sucralfato gel secco granulare e poroso procedimento per la suapreparazione, e composizioni farmaceutiche solide che lo contengono
US6531152B1 (en) * 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6116234A (en) 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
FI107126B (fi) 1999-04-23 2001-06-15 Orion Yhtymae Oyj Jauheinhalaattori yhdistelmälääkkeelle

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DE60133723T2 (de) 2009-07-02
NO20024072L (no) 2002-10-25
AU3400501A (en) 2001-09-12
ATE392885T1 (de) 2008-05-15
EP1261316B1 (de) 2008-04-23
AU2001234005B2 (en) 2006-01-19
PL204106B1 (pl) 2009-12-31
US20090011031A1 (en) 2009-01-08
JP2003525081A (ja) 2003-08-26
CN1429100A (zh) 2003-07-09
CN100341483C (zh) 2007-10-10
ES2305057T3 (es) 2008-11-01
WO2001064182A3 (en) 2002-01-31
US7089934B2 (en) 2006-08-15
NO20024072D0 (no) 2002-08-27
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US20010020147A1 (en) 2001-09-06
US20050158394A1 (en) 2005-07-21
WO2001064182A2 (en) 2001-09-07
BR0108730A (pt) 2002-11-05
EP1261316A2 (de) 2002-12-04
EP1941868A3 (de) 2011-06-29
WO2001064182A9 (en) 2002-08-08
CA2401288A1 (en) 2001-09-07

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