Nothing Special   »   [go: up one dir, main page]

DE60132323D1 - EARLY DIAGNOSIS OF BLOOD TUMOR IN URINE SAMPLES - Google Patents

EARLY DIAGNOSIS OF BLOOD TUMOR IN URINE SAMPLES

Info

Publication number
DE60132323D1
DE60132323D1 DE60132323T DE60132323T DE60132323D1 DE 60132323 D1 DE60132323 D1 DE 60132323D1 DE 60132323 T DE60132323 T DE 60132323T DE 60132323 T DE60132323 T DE 60132323T DE 60132323 D1 DE60132323 D1 DE 60132323D1
Authority
DE
Germany
Prior art keywords
marker
early diagnosis
urine samples
rna
blood tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60132323T
Other languages
German (de)
Inventor
Giorgio Stanta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macrochip SRL
Original Assignee
Macrochip SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrochip SRL filed Critical Macrochip SRL
Application granted granted Critical
Publication of DE60132323D1 publication Critical patent/DE60132323D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4742Keratin; Cytokeratin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514CD4
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A method for early diagnosis of bladder tumor in a urine sample, which comprises a step of amplification of the RNA extracted from cells present in the urine by using a marker for the messenger RNA of the catalytic component of telomerase (hTRT), a marker for beta -actin to demonstrate RNA accessibility and as standard for quantitative estimation, in combination with at least one additional marker chosen from the group that comprises: a marker for a protein of the cytokeratin family, a lymphocyte marker which is suitable to detect inflammatory cells associated with neoplastic infiltration, and a final step of detecting the amplified material.
DE60132323T 2000-05-08 2001-05-04 EARLY DIAGNOSIS OF BLOOD TUMOR IN URINE SAMPLES Expired - Lifetime DE60132323D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI001002A IT1318504B1 (en) 2000-05-08 2000-05-08 METHOD AND EQUIPMENT FOR EARLY DIAGNOSIS OF BLADDER TUMORS ON URINE SAMPLES.
PCT/EP2001/005054 WO2001086288A2 (en) 2000-05-08 2001-05-04 Early diagnosis of bladder tumor in urine samples

Publications (1)

Publication Number Publication Date
DE60132323D1 true DE60132323D1 (en) 2008-02-21

Family

ID=11444995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60132323T Expired - Lifetime DE60132323D1 (en) 2000-05-08 2001-05-04 EARLY DIAGNOSIS OF BLOOD TUMOR IN URINE SAMPLES

Country Status (6)

Country Link
EP (1) EP1281087B1 (en)
AT (1) ATE383578T1 (en)
AU (1) AU2001270505A1 (en)
DE (1) DE60132323D1 (en)
IT (1) IT1318504B1 (en)
WO (1) WO2001086288A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355158A1 (en) * 2002-04-19 2003-10-22 B.R.A.H.M.S Aktiengesellschaft Method for diagnosing inflammatory and infectious diseases by detecting the phosphoprotein LASP-1 as inflammation marker
US7217515B2 (en) 2002-09-30 2007-05-15 Chi Mei Foundation Medical Center HURP gene as a molecular marker for bladder cancer
CA2862993C (en) * 2004-07-23 2019-01-15 Pacific Edge Biotechnology Ltd. Urine markers for detection of bladder cancer
ES2304306B1 (en) * 2007-03-20 2009-07-07 Indas Biotech, S.L.U. METHOD OF DIAGNOSIS AND / OR FORECAST OF CANCER VESICAL.
GB201814040D0 (en) * 2018-08-29 2018-10-10 Oncologica Uk Ltd Testing and therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863726A (en) * 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
JPH09262100A (en) * 1996-03-27 1997-10-07 Mount Sinai School Medicine City Univ New York Detection of human urinary bladder cancer cell in urine sample by measuring existence of telomerase activity
ATE309389T1 (en) * 1996-06-28 2005-11-15 Rebio Gen Inc METHOD FOR DISCOVERING TELOMERASE ACTIVITY
GB2321642B8 (en) * 1996-10-01 2006-08-22 Geron Corp Human telomerase reverse transcriptase promoter
DE19757300A1 (en) * 1997-12-22 1999-06-24 Roche Diagnostics Gmbh Detection of bladder cancer in a urine sample

Also Published As

Publication number Publication date
WO2001086288A3 (en) 2002-05-16
AU2001270505A1 (en) 2001-11-20
ITMI20001002A0 (en) 2000-05-08
IT1318504B1 (en) 2003-08-27
ITMI20001002A1 (en) 2001-11-08
EP1281087B1 (en) 2008-01-09
EP1281087A2 (en) 2003-02-05
ATE383578T1 (en) 2008-01-15
WO2001086288A2 (en) 2001-11-15

Similar Documents

Publication Publication Date Title
SE0000538D0 (en) Methods and kits for proximity probing
DE60230672D1 (en) NUCLEIC ENRICHMENT
EA200200698A1 (en) The method of RNA isolation from fixed formalin and filled into paraffin tissue samples
DK1461618T3 (en) Homogeneous immunoassays for multiple allergens
ATE319093T1 (en) METHOD FOR DIAGNOSING LIVER DISEASE USING BIOCHEMICAL CHARACTERISTICS
DE60142254D1 (en) COMPOSITIONS, METHODS AND REAGENTS FOR NUCLEIC ACID INSULATION USING SURFACE-ACTIVE SUBSTANCES AND PROTEASES
DE60105411D1 (en) METHOD FOR DIAGNOSING CANCER
ATE335815T1 (en) ISOLATION OF NUCLEIC ACIDS
ATE452338T1 (en) DETECTION METHOD FOR EARLY KIDNEY DISEASE IN ANIMALS
ATE513851T1 (en) HUMAN GENE CRITICAL TO FERTILITY
WO2003100006A3 (en) Method of improved prostate cancer detection
ATE553386T1 (en) BLOOD TYPING
DE60132323D1 (en) EARLY DIAGNOSIS OF BLOOD TUMOR IN URINE SAMPLES
ES2183399T3 (en) METHOD FOR THE DETERMINATION OF THE OPERATION OF THE LIVER.
WO2005033330A3 (en) Fluorescent probes for use in protein kinase inhibitor binding assay
ATE372392T1 (en) METHOD FOR DETERMINING THE AMOUNT OF A TARGET NUCLEIC ACID IN A SAMPLE
DK1214447T3 (en) Detection of faecal pyruvate kinase isoenzymes
CA2518933A1 (en) Method of detecting colon cancer marker
DE69604051D1 (en) METHOD FOR SENSITIVELY DETECTING REVERSER TRANSCRIPTASE
ATE427494T1 (en) METHOD FOR QUANTIFYING ACT PROTEIN EXPRESSION
DE60332370D1 (en) BACTERIENT TEST PROCEDURE WITH BINDING OF INTRA CELLULAR ENZYMES
DK1057021T3 (en) Method for measuring total analyte
DK1337849T3 (en) Methods and compositions for sorting and / or determining microorganisms
ATE386140T1 (en) METHODS AND REAGENTS FOR IN SITU AMPLIFICATION
DE602005024254D1 (en)

Legal Events

Date Code Title Description
8332 No legal effect for de