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DE60119711D1 - METHOD FOR PRODUCING FUNCTIONALIZED POLYALKYLENEIMINES, COMPOSITIONS AND THEIR USES THEREOF - Google Patents

METHOD FOR PRODUCING FUNCTIONALIZED POLYALKYLENEIMINES, COMPOSITIONS AND THEIR USES THEREOF

Info

Publication number
DE60119711D1
DE60119711D1 DE60119711T DE60119711T DE60119711D1 DE 60119711 D1 DE60119711 D1 DE 60119711D1 DE 60119711 T DE60119711 T DE 60119711T DE 60119711 T DE60119711 T DE 60119711T DE 60119711 D1 DE60119711 D1 DE 60119711D1
Authority
DE
Germany
Prior art keywords
polyalkyleneimines
compositions
producing functionalized
functionalized polyalkyleneimines
functionalized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60119711T
Other languages
German (de)
Other versions
DE60119711T2 (en
Inventor
Francoise Leclerc
Jean Herscovici
Daniel Scherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTELION VITRY SUR SEINE
Original Assignee
CENTELION VITRY SUR SEINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0002059A external-priority patent/FR2805271B1/en
Application filed by CENTELION VITRY SUR SEINE filed Critical CENTELION VITRY SUR SEINE
Application granted granted Critical
Publication of DE60119711D1 publication Critical patent/DE60119711D1/en
Publication of DE60119711T2 publication Critical patent/DE60119711T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a process for preparing functionalized polyalkyleneimines which are useful for formulating nucleic acids intended to be transfected into cells. This process consists in treating polyalkyleneimines with a functionalized hemiacetal in the presence of titanium (IV) isopropoxide and sodium borohydride.
DE60119711T 2000-02-18 2001-02-15 METHOD FOR PRODUCING FUNCTIONALIZED POLYALKYLENEIMINES, COMPOSITIONS AND THEIR USES THEREOF Expired - Lifetime DE60119711T2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0002059A FR2805271B1 (en) 2000-02-18 2000-02-18 PROCESS FOR THE PREPARATION OF FUNCTIONALIZED POLYALKYLENIMINES, COMPOSITIONS CONTAINING THEM AND USES THEREOF
FR0002059 2000-02-18
US20390700P 2000-05-12 2000-05-12
US203907P 2000-05-12
PCT/FR2001/000460 WO2001060890A2 (en) 2000-02-18 2001-02-15 Method for preparing functionalised polyalkylenimines, composition containing same and uses thereof

Publications (2)

Publication Number Publication Date
DE60119711D1 true DE60119711D1 (en) 2006-06-22
DE60119711T2 DE60119711T2 (en) 2007-02-22

Family

ID=26212187

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60119711T Expired - Lifetime DE60119711T2 (en) 2000-02-18 2001-02-15 METHOD FOR PRODUCING FUNCTIONALIZED POLYALKYLENEIMINES, COMPOSITIONS AND THEIR USES THEREOF

Country Status (17)

Country Link
US (1) US6825341B2 (en)
EP (1) EP1268609B1 (en)
KR (1) KR100751105B1 (en)
CN (1) CN1178973C (en)
AT (1) ATE326499T1 (en)
AU (2) AU3569501A (en)
CA (1) CA2400666C (en)
CY (1) CY1105416T1 (en)
DE (1) DE60119711T2 (en)
DK (1) DK1268609T3 (en)
ES (1) ES2263589T3 (en)
HU (1) HU227264B1 (en)
IL (2) IL151289A0 (en)
MX (1) MXPA02007956A (en)
NZ (1) NZ521420A (en)
PT (1) PT1268609E (en)
WO (1) WO2001060890A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518470A (en) * 2002-02-22 2005-06-23 インサート セラピューティクス インコーポレイテッド Carbohydrate-modified polymer compositions and methods of use thereof
JP2005248144A (en) * 2004-02-05 2005-09-15 Nippon Shokubai Co Ltd Polyalkyleneimine-based polymer, producing method therefor, and its application
CN1317317C (en) * 2005-06-03 2007-05-23 中国科学院上海应用物理研究所 Photochemical synthesis method of polyalkylene imine gel
WO2007034586A1 (en) * 2005-09-22 2007-03-29 Toto Ltd. Photocatalytic titanium dioxide microparticle, dispersion liquid thereof and process for producing the same
AU2006307134B2 (en) * 2005-10-26 2012-07-12 Toto Ltd. Ultrasonic cancer therapy accelerator and cytotoxic agent
FR2894984B1 (en) * 2005-12-20 2009-01-16 Millipore Corp COMPOSITION FOR INCREASING THE PERMEABILITY OF MICRO - ORGANISM WALLS AND METHOD FOR MEMBRANE DETECTION OF MICROORGANISMS.
WO2007122956A1 (en) * 2006-03-24 2007-11-01 Toto Ltd. Titanium oxide complex particle, dispersion solution of the particle, and process for production of the particle
GB0724253D0 (en) * 2007-12-12 2008-01-30 Fermentas Uab Transfection reagent
US8252834B2 (en) * 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
US8889635B2 (en) * 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
GB0917792D0 (en) 2009-10-12 2009-11-25 Fermentas Uab Delivery agent
US9856456B2 (en) 2009-10-12 2018-01-02 Thermo Fisher Scientific Baltics Uab Delivery agent
WO2011059609A2 (en) 2009-10-13 2011-05-19 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
BR112012030453A2 (en) * 2010-05-31 2016-08-09 Basf Se process for the preparation of polyalkylene polyamines, polyalkylene polyamine, polyethyleneimine, and use of polyalkylene polyamines
KR101039701B1 (en) * 2010-11-29 2011-06-08 주식회사 유성엔지니어링 Sludge collecting apparatus
CN102181053B (en) * 2011-02-25 2012-12-05 苏州大学 Hydrophobic-group-modified polyethyleneimine derivative and application thereof
IN2014CN03935A (en) * 2011-11-25 2015-09-04 Basf Se
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
US10889866B2 (en) 2015-09-01 2021-01-12 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic SF3B1 mutants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2244997T3 (en) * 1996-05-03 2005-12-16 THE PROCTER & GAMBLE COMPANY POLYMERS TO FREE THE DIRT IN COTTON FABRICS.
DE19726186A1 (en) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Complexes for the transport of nucleic acid into higher eukaryotic cells
DE19743135A1 (en) * 1997-09-30 1999-04-01 Hoechst Marion Roussel De Gmbh Biologically compatible low molecular weight polyethyleneimines
US5962400A (en) * 1998-12-22 1999-10-05 National Starch And Chemical Investment Holding Corporation Amino acid copolymers having pendent polysaccharide moieties and uses thereof

Also Published As

Publication number Publication date
HU227264B1 (en) 2010-12-28
US20010031498A1 (en) 2001-10-18
HUP0300144A3 (en) 2005-10-28
IL151289A (en) 2007-03-08
US6825341B2 (en) 2004-11-30
KR100751105B1 (en) 2007-08-22
EP1268609B1 (en) 2006-05-17
CN1178973C (en) 2004-12-08
WO2001060890A2 (en) 2001-08-23
DK1268609T3 (en) 2006-09-18
CY1105416T1 (en) 2010-04-28
PT1268609E (en) 2006-10-31
DE60119711T2 (en) 2007-02-22
ES2263589T3 (en) 2006-12-16
HUP0300144A2 (en) 2003-05-28
IL151289A0 (en) 2003-04-10
MXPA02007956A (en) 2004-09-10
CA2400666A1 (en) 2001-08-23
AU2001235695B2 (en) 2006-01-12
ATE326499T1 (en) 2006-06-15
KR20030009362A (en) 2003-01-29
WO2001060890A3 (en) 2002-09-19
CN1441820A (en) 2003-09-10
AU3569501A (en) 2001-08-27
NZ521420A (en) 2006-01-27
EP1268609A2 (en) 2003-01-02
CA2400666C (en) 2011-01-18

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