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DE60105147D1 - Verfahren zur Herstellung einer stabilen mikronisierten Zusammensetzung von Formoterol mit einem Glucocorticosteroid - Google Patents

Verfahren zur Herstellung einer stabilen mikronisierten Zusammensetzung von Formoterol mit einem Glucocorticosteroid

Info

Publication number
DE60105147D1
DE60105147D1 DE60105147T DE60105147T DE60105147D1 DE 60105147 D1 DE60105147 D1 DE 60105147D1 DE 60105147 T DE60105147 T DE 60105147T DE 60105147 T DE60105147 T DE 60105147T DE 60105147 D1 DE60105147 D1 DE 60105147D1
Authority
DE
Germany
Prior art keywords
glucocorticosteroid
formoterol
preparation
micronized composition
stable micronized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60105147T
Other languages
English (en)
Other versions
DE60105147T2 (de
Inventor
Eva Trofast
Karin Malmqvist-Granlund
Per-Gunnar Nilsson
Kyrre Thalberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9892015&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60105147(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60105147D1 publication Critical patent/DE60105147D1/de
Application granted granted Critical
Publication of DE60105147T2 publication Critical patent/DE60105147T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60105147T 2000-05-19 2001-05-17 Verfahren zur Herstellung einer stabilen mikronisierten Zusammensetzung von Formoterol mit einem Glucocorticosteroid Expired - Lifetime DE60105147T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0012260.6A GB0012260D0 (en) 2000-05-19 2000-05-19 Novel composition
GB0012260 2000-05-19
PCT/SE2001/001118 WO2001089492A1 (en) 2000-05-19 2001-05-17 Novel composition

Publications (2)

Publication Number Publication Date
DE60105147D1 true DE60105147D1 (de) 2004-09-30
DE60105147T2 DE60105147T2 (de) 2005-09-08

Family

ID=9892015

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60132828T Revoked DE60132828T2 (de) 2000-05-19 2001-05-17 Zusammensetzung enthaltend Formoterol und ein Glucocorticosteroid
DE60105147T Expired - Lifetime DE60105147T2 (de) 2000-05-19 2001-05-17 Verfahren zur Herstellung einer stabilen mikronisierten Zusammensetzung von Formoterol mit einem Glucocorticosteroid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60132828T Revoked DE60132828T2 (de) 2000-05-19 2001-05-17 Zusammensetzung enthaltend Formoterol und ein Glucocorticosteroid

Country Status (22)

Country Link
US (2) US6869942B2 (de)
EP (3) EP1977740A1 (de)
JP (3) JP5663125B2 (de)
KR (1) KR100799432B1 (de)
CN (1) CN100384408C (de)
AT (2) ATE274345T1 (de)
AU (2) AU5900701A (de)
BR (1) BR0110946A (de)
CA (1) CA2409665C (de)
CY (1) CY1110379T1 (de)
DE (2) DE60132828T2 (de)
DK (2) DK1462100T3 (de)
ES (2) ES2298643T3 (de)
GB (1) GB0012260D0 (de)
IL (1) IL152470A0 (de)
MX (1) MXPA02011311A (de)
NO (1) NO333899B1 (de)
NZ (1) NZ522420A (de)
PT (2) PT1462100E (de)
SI (1) SI1289506T1 (de)
WO (1) WO2001089492A1 (de)
ZA (1) ZA200208709B (de)

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GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
GB0012261D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel process
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
SE0200312D0 (sv) 2002-02-01 2002-02-01 Astrazeneca Ab Novel composition
GB0219512D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Inhalation compositions with high drug ratios
GB0219511D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
JP4744876B2 (ja) * 2002-08-21 2011-08-10 ノートン・ヘルスケアー リミテッド 乾燥粉末吸入組成物の製造方法
WO2004030659A1 (en) * 2002-09-30 2004-04-15 Acusphere, Inc. Sustained release porous microparticles for inhalation
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
SE526509C2 (sv) * 2003-06-19 2005-09-27 Microdrug Ag Kombinerade doser av formoterol och budesonid separerade på en gemensam dosbädd
GB0315889D0 (en) 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
GB0321607D0 (en) * 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
CA2533887A1 (en) * 2003-09-30 2005-04-14 Acusphere, Inc. Injectable, oral, or topical sustained release pharmaceutical formulations
GB0323684D0 (en) 2003-10-09 2003-11-12 Jagotec Ag Improvements in or relating to organic compounds
JP2007513139A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
US20050277602A1 (en) * 2004-05-21 2005-12-15 Grunstein Michael M Methods employing agonists of P38 map kinase for the treatment of asthma
GB0501956D0 (en) * 2005-01-31 2005-03-09 Arrow Internat Nebulizer formulation
AU2006212966B2 (en) 2005-02-10 2008-09-11 DFE Pharma Technology GmbH. Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
ZA200711123B (en) 2005-06-27 2009-08-26 Biovail Lab Int Srl Modified-release formulations of a bupropion salt
WO2007011743A2 (en) 2005-07-14 2007-01-25 Lipothera, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
TW200738635A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
TW200734305A (en) * 2005-08-02 2007-09-16 Astrazeneca Ab New salt III
JP2010506941A (ja) * 2006-10-17 2010-03-04 リセラ，インク． 甲状腺眼症の治療のための方法、組成物及び製剤
EP2022796A1 (de) * 2007-08-07 2009-02-11 Nycomed GmbH Amorphes Ciclesonid
CN101474191B (zh) * 2009-01-21 2011-03-23 李虎山 一种治疗哮喘和慢性阻塞性肺病的药物组合物
EP2221048A1 (de) * 2009-02-18 2010-08-25 Siegfried Generics International AG Pharmazeutische Zusammensetzungen zur Inhalation
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
GB0918149D0 (en) 2009-10-16 2009-12-02 Jagotec Ag Improved medicinal aerosol formulation
CA2786618C (en) * 2010-01-15 2016-04-12 Lithera, Inc. Lyophilized cake formulations
DK2538922T3 (en) 2010-02-25 2016-07-04 Andi-Ventis Ltd The formulation of compositions for the treatment of inflammatory conditions
GB2485885B (en) 2010-11-24 2015-06-17 Neothetics Inc Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
WO2013091006A1 (en) * 2011-12-23 2013-06-27 Monash University Process for dry powder blending
UA118861C2 (uk) * 2013-12-06 2019-03-25 Оріон Корпорейшн Спосіб отримання сухих порошкових композицій для інгаляцій
KR20160038767A (ko) * 2014-09-30 2016-04-07 한미약품 주식회사 복합 활성성분의 안정성이 개선된 흡입 제형용 건조분말
WO2021058454A1 (en) 2019-09-24 2021-04-01 Chiesi Farmaceutici S.P.A. Novel carrier particles for dry powder formulations for inhalation
WO2023128918A1 (en) * 2021-12-31 2023-07-06 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi A process including a feeding gas system for preparing dry powder inhalation compositions
CN115364075B (zh) * 2022-09-16 2023-11-10 苏州易合医药有限公司 一种吸入颗粒组合物及其制备方法

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SE9302777D0 (sv) 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5874063A (en) 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
CA2356145A1 (en) * 1991-12-18 1993-06-24 Aktiebolaget Astra New combination of formoterol and budesonide
SE9700134D0 (sv) 1997-01-20 1997-01-20 Astra Ab New formulation
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EP0938467B1 (de) * 1996-11-11 2002-06-12 Sepracor, Inc. Verfahren zur herstellung von optisch reinen isomeren des formoterols
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
IT1302657B1 (it) * 1998-10-13 2000-09-29 Farmabios Srl Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r.
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GB9903759D0 (en) 1999-02-18 1999-04-14 Novartis Ag Organic compounds
GB9904919D0 (en) 1999-03-03 1999-04-28 Novartis Ag Organic compounds
SE9900834D0 (sv) * 1999-03-09 1999-03-09 Astra Ab Novel combination
DE19947235A1 (de) * 1999-09-30 2001-04-05 Asta Medica Ag Neue Kombination von Loteprednol und beta¶2¶-Adrenorezeptor-Agonisten
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GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition

Also Published As

Publication number Publication date
NZ522420A (en) 2004-04-30
JP2003534273A (ja) 2003-11-18
DE60132828T2 (de) 2009-03-05
CA2409665C (en) 2010-03-30
JP2015038118A (ja) 2015-02-26
ATE385788T1 (de) 2008-03-15
GB0012260D0 (en) 2000-07-12
CA2409665A1 (en) 2001-11-29
EP1462100B1 (de) 2008-02-13
IL152470A0 (en) 2003-06-24
CN1430508A (zh) 2003-07-16
EP1289506A1 (de) 2003-03-12
ZA200208709B (en) 2004-02-10
JP2012184271A (ja) 2012-09-27
US6869942B2 (en) 2005-03-22
JP5663125B2 (ja) 2015-02-04
ES2298643T3 (es) 2008-05-16
DE60132828D1 (de) 2008-03-27
EP1977740A1 (de) 2008-10-08
EP1462100A1 (de) 2004-09-29
MXPA02011311A (es) 2003-04-25
CY1110379T1 (el) 2015-04-29
NO20025221L (no) 2002-10-31
KR20030001515A (ko) 2003-01-06
DE60105147T2 (de) 2005-09-08
KR100799432B1 (ko) 2008-01-30
DK1289506T3 (da) 2004-11-15
ATE274345T1 (de) 2004-09-15
US20050207989A1 (en) 2005-09-22
US20030236238A1 (en) 2003-12-25
SI1289506T1 (en) 2005-02-28
WO2001089492A1 (en) 2001-11-29
AU2001259007B2 (en) 2005-11-17
NO20025221D0 (no) 2002-10-31
BR0110946A (pt) 2003-04-29
CN100384408C (zh) 2008-04-30
AU5900701A (en) 2001-12-03
PT1462100E (pt) 2008-04-18
US7354913B2 (en) 2008-04-08
NO333899B1 (no) 2013-10-14
DK1462100T3 (da) 2008-05-26
EP1289506B1 (de) 2004-08-25
ES2223844T3 (es) 2005-03-01
PT1289506E (pt) 2004-12-31

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings