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DE60017374D1 - Antibakterielle mittel - Google Patents

Antibakterielle mittel

Info

Publication number
DE60017374D1
DE60017374D1 DE60017374T DE60017374T DE60017374D1 DE 60017374 D1 DE60017374 D1 DE 60017374D1 DE 60017374 T DE60017374 T DE 60017374T DE 60017374 T DE60017374 T DE 60017374T DE 60017374 D1 DE60017374 D1 DE 60017374D1
Authority
DE
Germany
Prior art keywords
antibacterial agents
atoms
fused
optionally substituted
heterocyclic ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60017374T
Other languages
English (en)
Other versions
DE60017374T2 (de
Inventor
P Beckett
Mark Whittaker
Marie Spavold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Publication of DE60017374D1 publication Critical patent/DE60017374D1/de
Application granted granted Critical
Publication of DE60017374T2 publication Critical patent/DE60017374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • C07D211/76Oxygen atoms attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D225/00Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D245/00Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60017374T 1999-03-29 2000-03-28 Antibakterielle mittel Expired - Fee Related DE60017374T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9907055.9A GB9907055D0 (en) 1999-03-29 1999-03-29 Antibacterial agents
GB9907055 1999-03-29
PCT/GB2000/001175 WO2000058294A1 (en) 1999-03-29 2000-03-28 Antibacterial agents

Publications (2)

Publication Number Publication Date
DE60017374D1 true DE60017374D1 (de) 2005-02-17
DE60017374T2 DE60017374T2 (de) 2005-12-01

Family

ID=10850463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017374T Expired - Fee Related DE60017374T2 (de) 1999-03-29 2000-03-28 Antibakterielle mittel

Country Status (9)

Country Link
US (1) US6503897B1 (de)
EP (1) EP1165532B1 (de)
JP (1) JP2002540197A (de)
AT (1) ATE286887T1 (de)
AU (1) AU3565700A (de)
DE (1) DE60017374T2 (de)
ES (1) ES2235844T3 (de)
GB (1) GB9907055D0 (de)
WO (1) WO2000058294A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003257637A1 (en) * 2002-08-23 2004-03-11 Dainippon Pharmaceutical Co., Ltd. Proline derivatives
ES2390767T3 (es) * 2002-12-11 2012-11-16 Glaxosmithkline Llc Inhibidores de la péptido desformilasa
CN100410251C (zh) * 2003-06-26 2008-08-13 诺瓦提斯公司 可用于制备某些抗菌n-甲酰基羟胺的中间体的制备方法
KR100753796B1 (ko) * 2006-07-28 2007-08-31 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
TWI507137B (zh) * 2009-12-28 2015-11-11 Ajinomoto Kk Lanthionine derivatives
CN102452998B (zh) * 2010-10-20 2014-12-10 天津药物研究院 N-甲酰羟胺类化合物及其制备方法和用途
KR101462851B1 (ko) 2012-10-24 2014-11-18 일동제약주식회사 신규 펩티드 데포르밀라제 저해제 화합물 및 그 제조방법
US9889204B2 (en) 2014-08-11 2018-02-13 The Regents Of The University Of California Polymeric antibiotics
AU2023252875A1 (en) 2022-04-14 2024-10-31 W. L. Gore & Associates, Inc. No-releasing coating

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
KR100347646B1 (ko) * 1993-08-05 2002-12-05 신텍스(미국) 인크. 매트릭스메탈로프로테아제억제제
JP2000511882A (ja) 1996-04-12 2000-09-12 ブリストル―マイヤーズ・スクイブ・カンパニー Ace阻害剤及び/またはnep阻害剤として有用なn―ホルミルヒドロキシルアミン化合物
AU749699B2 (en) * 1998-02-07 2002-07-04 British Biotech Pharmaceuticals Limited Antibacterial agents
US6288063B1 (en) * 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
EP1165532B1 (de) 2005-01-12
WO2000058294A1 (en) 2000-10-05
US6503897B1 (en) 2003-01-07
EP1165532A1 (de) 2002-01-02
JP2002540197A (ja) 2002-11-26
DE60017374T2 (de) 2005-12-01
ATE286887T1 (de) 2005-01-15
AU3565700A (en) 2000-10-16
GB9907055D0 (en) 1999-05-19
ES2235844T3 (es) 2005-07-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee