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DE60015098D1 - 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose - Google Patents

3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose

Info

Publication number
DE60015098D1
DE60015098D1 DE60015098T DE60015098T DE60015098D1 DE 60015098 D1 DE60015098 D1 DE 60015098D1 DE 60015098 T DE60015098 T DE 60015098T DE 60015098 T DE60015098 T DE 60015098T DE 60015098 D1 DE60015098 D1 DE 60015098D1
Authority
DE
Germany
Prior art keywords
cyclopropylmethoxy
treatment
multiple sclerosis
difluormethoxy
benzamid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60015098T
Other languages
English (en)
Other versions
DE60015098T2 (de
Inventor
Hermann Amschler
Armin Hatzelmann
Christian Schudt
Hans-Peter Kley
Karl Sanders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of DE60015098D1 publication Critical patent/DE60015098D1/de
Publication of DE60015098T2 publication Critical patent/DE60015098T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60015098T 1999-03-10 2000-03-01 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose Expired - Lifetime DE60015098T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99104793 1999-03-10
EP99104793 1999-03-10
PCT/EP2000/001703 WO2000053182A2 (en) 1999-03-10 2000-03-01 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
DE60015098D1 true DE60015098D1 (de) 2004-11-25
DE60015098T2 DE60015098T2 (de) 2006-02-02

Family

ID=8237737

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60015098T Expired - Lifetime DE60015098T2 (de) 1999-03-10 2000-03-01 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose

Country Status (12)

Country Link
US (1) US6531493B1 (de)
EP (1) EP1161239B1 (de)
JP (1) JP2002538207A (de)
AT (1) ATE279924T1 (de)
AU (1) AU3284000A (de)
CA (1) CA2364258C (de)
DE (1) DE60015098T2 (de)
DK (1) DK1161239T3 (de)
ES (1) ES2231162T3 (de)
PT (1) PT1161239E (de)
SI (1) SI1161239T1 (de)
WO (1) WO2000053182A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1199074A1 (de) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
EP1188438A1 (de) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
WO2002088079A2 (en) * 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
US20030092706A1 (en) * 2001-11-09 2003-05-15 Johannes Barsig Combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
ES2319517T3 (es) 2002-05-28 2009-05-08 Nycomed Gmbh Preparacion farmaceutica aplicable topicamente.
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
WO2004080967A1 (en) 2003-03-10 2004-09-23 Altana Pharma Ag Novel process for the preparation of roflumilast
DE102004046235A1 (de) 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
WO2006097456A1 (en) * 2005-03-16 2006-09-21 Nycomed Gmbh Taste masked dosage form containing roflumilast

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002465A1 (en) * 1992-07-28 1994-02-03 Rhone-Poulenc Rorer Limited INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF
DE122010000043I1 (de) * 1993-07-02 2011-01-27 Nycomed Gmbh Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
DE69532238T2 (de) * 1994-04-21 2004-10-21 Schering Ag Pde iv-inhibitoren zur behandlung der multiplen sklerose

Also Published As

Publication number Publication date
JP2002538207A (ja) 2002-11-12
DE60015098T2 (de) 2006-02-02
CA2364258C (en) 2008-12-30
SI1161239T1 (en) 2005-06-30
EP1161239B1 (de) 2004-10-20
US6531493B1 (en) 2003-03-11
WO2000053182A3 (en) 2001-04-12
DK1161239T3 (da) 2005-02-14
AU3284000A (en) 2000-09-28
EP1161239A2 (de) 2001-12-12
PT1161239E (pt) 2005-02-28
ES2231162T3 (es) 2005-05-16
CA2364258A1 (en) 2000-09-14
WO2000053182A2 (en) 2000-09-14
ATE279924T1 (de) 2004-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE