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DE59711013D1 - Substituted 2,3-benzodiazepine derivatives, processes and intermediates for their preparation and pharmaceutical preparations containing them and their use - Google Patents

Substituted 2,3-benzodiazepine derivatives, processes and intermediates for their preparation and pharmaceutical preparations containing them and their use

Info

Publication number
DE59711013D1
DE59711013D1 DE59711013T DE59711013T DE59711013D1 DE 59711013 D1 DE59711013 D1 DE 59711013D1 DE 59711013 T DE59711013 T DE 59711013T DE 59711013 T DE59711013 T DE 59711013T DE 59711013 D1 DE59711013 D1 DE 59711013D1
Authority
DE
Germany
Prior art keywords
alkyl
substituted
intermediates
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59711013T
Other languages
German (de)
Inventor
Dr Ling
Abraham Gizella
Dr Berzsenyi
Dr Tarnawa
Dr Solyom
Dr Andrasi
Tamas Dr Hamori
Emese Csuzdi
Katalin Dr Horvath
Melinda Dr Gal
Imre Moravcsik
Marta Szoellosy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9600871A external-priority patent/HU9600871D0/en
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DE59711013D1 publication Critical patent/DE59711013D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Mono- or di-halo substituted 2,3-benzodiazepine derivatives of formula (I), their isomers and acid addition salts are new. R1, R2 = H, halogen, 1-4C alkyl, 1-4C alkoxy, nitro, CF3 or NR8R9; R3 = 1-4C alkyl, 3-5C cycloalkyl or COR13; R4, R5 = H or 1-3C alkyl; R6, R7 = H, Cl or Br, provided that not both are H at the same time; R8, R9 = H, 1-4C alkyl or COR10; R10, R13 = H, optionally substituted 1-6C alkyl, 6-10C aryl, 1-4C alkoxy, 3-5C cycloalkyl, 2-6C alkenyl, 3-5C cycloalkoxy or NR11R12; and R11, R12 = H, 1-4C alkyl, 3-5C cycloalkyl or 6-10C aryl.
DE59711013T 1996-04-04 1997-04-04 Substituted 2,3-benzodiazepine derivatives, processes and intermediates for their preparation and pharmaceutical preparations containing them and their use Expired - Fee Related DE59711013D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9600871A HU9600871D0 (en) 1996-04-04 1996-04-04 New 2,3-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
DE59711013D1 true DE59711013D1 (en) 2003-12-24

Family

ID=89993864

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59711013T Expired - Fee Related DE59711013D1 (en) 1996-04-04 1997-04-04 Substituted 2,3-benzodiazepine derivatives, processes and intermediates for their preparation and pharmaceutical preparations containing them and their use

Country Status (11)

Country Link
KR (1) KR970069997A (en)
AT (1) ATE254608T1 (en)
AU (1) AU720745B2 (en)
BE (1) BE1010962A4 (en)
DE (1) DE59711013D1 (en)
ES (1) ES2127699B1 (en)
IT (1) IT1290453B1 (en)
NZ (1) NZ314517A (en)
UA (1) UA45358C2 (en)
YU (1) YU13197A (en)
ZA (1) ZA972746B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU219778B (en) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Process for producing n-acyl-2,3-benzodiazepine derivatives, their acid additional salts and pharmaceutical compositions containing them and a grop of the compounds and pharmaceutical compositions containing them
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
ES2170804T3 (en) * 1994-08-31 2002-08-16 Lilly Co Eli DERIVATIVES OF DIHIDRO-2,3-BENZODIAZEPINA.

Also Published As

Publication number Publication date
KR970069997A (en) 1997-11-07
YU13197A (en) 1999-09-27
ITMI970776A1 (en) 1998-10-04
AU1773497A (en) 1997-10-09
ATE254608T1 (en) 2003-12-15
UA45358C2 (en) 2002-04-15
BE1010962A4 (en) 1999-03-02
ES2127699A1 (en) 1999-04-16
NZ314517A (en) 2000-03-27
ZA972746B (en) 1998-10-09
ES2127699B1 (en) 2000-01-16
AU720745B2 (en) 2000-06-08
IT1290453B1 (en) 1998-12-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee