DE4301401C2 - Device and method for the electronic and contactless identification of separation columns for chromatography - Google Patents
Device and method for the electronic and contactless identification of separation columns for chromatographyInfo
- Publication number
- DE4301401C2 DE4301401C2 DE19934301401 DE4301401A DE4301401C2 DE 4301401 C2 DE4301401 C2 DE 4301401C2 DE 19934301401 DE19934301401 DE 19934301401 DE 4301401 A DE4301401 A DE 4301401A DE 4301401 C2 DE4301401 C2 DE 4301401C2
- Authority
- DE
- Germany
- Prior art keywords
- chromatography
- microelectronic circuit
- column
- electronic
- information
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G07—CHECKING-DEVICES
- G07C—TIME OR ATTENDANCE REGISTERS; REGISTERING OR INDICATING THE WORKING OF MACHINES; GENERATING RANDOM NUMBERS; VOTING OR LOTTERY APPARATUS; ARRANGEMENTS, SYSTEMS OR APPARATUS FOR CHECKING NOT PROVIDED FOR ELSEWHERE
- G07C3/00—Registering or indicating the condition or the working of machines or other apparatus, other than vehicles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Description
Bei der chemischen Analyse mittels der Hochdruck flüssigkeitschromatografie (HPLC) werden Stoffgemi sche nach physikalisch-chemischen Kriterien auf sog. Trennsäulen zerlegt. Diese Trennsäulen bestehen aus einem homogenen Füllmaterial, an dem sich die zu un tersuchende, in einem Flüssigkeitsstrom befindliche Probe in ihre Bestandteile auftrennt.In chemical analysis using high pressure liquid chromatography (HPLC) are mixed materials according to physico-chemical criteria on so-called Disassembled columns. These columns consist of a homogeneous filling material on which the un searching, in a liquid flow Separates the sample into its components.
Die Trennung ist sehr stark abhängig von der Art des Füllmaterials, ferner von der Weise der Herstellung die ses Materials sowie von der Anzahl der auf eine solche Säule aufgebrachten Proben.The separation is very dependent on the type of Filling material, further on the way of manufacturing the material and the number of such materials Column applied samples.
Jede Säule wird bei der Füllung mit einer Probesub stanz getestet und das Testergebnis als Ausdruck beige legt. Ferner wird an der Säule ein Aufkleber oder ein Anhänger befestigt der die wichtigsten Informationen über Art und Größe des Füllmaterials und der verwen deten Charge trägt.Each column is filled with a sample sub punch tested and the test result as a printout beige sets. Furthermore, a sticker or a on the column Trailer attached the most important information about the type and size of the filling material and the use carries the batch.
Bei der Analyse von Proben im chemischen Labor wird die Trennsäule in die HPLC-Apparatur eingesetzt und meist für mehrere Proben verwendet.When analyzing samples in the chemical laboratory the separation column is inserted into the HPLC apparatus and mostly used for several samples.
Um eine spätere Kontrolle zu ermöglichen, müssen die Kenndaten der Säule schriftlich auf jedem Analysen protokoll vermerkt werden.To enable a later check, you have to the characteristics of the column in writing on each analysis protocol are noted.
Aus US 4975647 ist eine Vorrichtung zur Identifizierung von chromatographischen Trennsäulen gemäß dem Oberbegriff von Patentanspruch 1 bekannt. Dabei ist ein Mikrochip, der Informationen über die Säule enthält, mittels eines Konnektors mit einer Ausleseelektronik elektrisch leitend verbunden. Aus DE 40 10 194 ist eine Vorrichtung zur individuellen elektronischen Kennung von Kraftfahrzeugen mittels eines individuell codierten Chips bekannt, der von einer Sendestation angesprochen werden kann.From US 4975647 a device for the identification of chromatographic separation columns according to the preamble of claim 1 known. A microchip that contains information about the column is by means of a connector with a readout electronics electrically connected. Out DE 40 10 194 is a device for the individual electronic identification of Motor vehicles known by means of an individually coded chip by a Can be addressed.
Die erfindungsgemäße Einrichtung erlaubt es, die Trennsäule schon bei der Füllung mit einem elektronischen Kennblatt zu versehen, auf dem alle wichtigen Parameter gespeichert sind.The device according to the invention allows the separation column when filling with one electronic identification sheet on which all important parameters are stored.
Dazu wird ein normaler Computer mit dem Sende- und Empfangsgerät über die serielle Schnittstelle ver bunden. Die gewünschten Informationen werden vom Computer als ASCII-Zeichen an das Sende-Empfangs gerät übertragen.To do this, a normal computer with the and receiving device via the serial interface prevented. The requested information is from Computer as ASCII characters to the send-receive device transferred.
Die zu kennzeichnende Trennsäule wird mit dem Schaltkreis versehen und in die Nähe der Antenne des Sende-Empfangsgerätes gebracht.The separation column to be labeled is marked with the Circuit and close to the antenna of the Brought transceiver.
Durch elektromagnetische Strahlung wird der Schalt kreis über die Antenne aktiviert und gibt seine Informa tionen an die Antenne weiter, von dort werden sie drahtlos auf die Antenne des Sende-Empfangsgerätes übertragen.The switching is caused by electromagnetic radiation activated via the antenna and gives its information tions to the antenna, from there they become wirelessly to the antenna of the transceiver transfer.
Nun werden vom Anwender die gewünschten Infor mationen ebenfalls drahtlos auf den aktivierten Schalt kreis übertragen und dort gespeichert.Now the desired information from the user mations also wirelessly on the activated switch transfer circle and saved there.
Nach Abschalten der Sende-Empfangsvorrichtung bleibt die Information auf dem Schaltkreis ohne zusätz liche Energiezufuhr erhalten.After switching off the transceiver the information on the circuit remains without additional receive energy supply.
Soll nun eine chemische Analyse unter Verwendung der so gekennzeichneten Säule stattfinden, wird diese wieder in das Sende-Empfangsgerät eingelegt bzw. in die Nähe zu diesem gebracht, so daß sich über die An tenne eine Kopplung ergibt. Alle gespeicherten Infor mationen werden ausgelesen und an das Analysensy stem übertragen.Shall now use a chemical analysis the pillar marked in this way will take place inserted again in the transceiver or in brought the proximity to this, so that over the An tenne results in a coupling. All saved information Mations are read out and sent to the analysis system stem transferred.
Das Analysensystem speichert die Informationen für spätere Verwendung bzw. ordnet sie einer bestimmten Probe zu.The analysis system stores the information for later use or assigns them to a specific one Sample too.
Zusätzlich kann rückwärts auf den Schaltkreis die An zahl der Proben um jeweils eine erhöht werden, um die Belastung der Säule zu dokumentieren.In addition, the An number of samples should be increased by one each Document the load on the column.
Mit diesem System läßt sich jederzeit die Zuordnung einer bestimmten Säule zu einer bestimmten Probe durchführen, ferner können mit jeder Probe alle rele vanten Parameter der Säule automatisch erfaßt und dem Datensystem zugänglich gemacht werden. Ferner wird bereits während der Analyse die Säuleninforma tion bereitgestellt und nicht erst nach Erstellung eines Protokolls. Damit kann das Analysensystem fehlerhafte Säulen schon vor der Probenaufgabe erkennen und ent sprechend reagieren.With this system, the assignment can be made at any time a particular column to a particular sample carry out, furthermore with each sample all rele parameters of the column are automatically recorded and be made accessible to the data system. Further the column information is already during the analysis tion provided and not only after a Protocol. This means that the analysis system can be faulty Recognize and remove columns before sample loading react speaking.
Durch geeignete Abschirmmaßnahmen zwischen Säule mit Schaltkreis und Sende-Empfangsgerät wird sichergestellt, daß nur die Information der anliegenden Säule gelesen oder geschrieben wird.With suitable shielding measures between Pillar with circuit and transceiver ensured that only the information of the adjacent Column is read or written.
Claims (2)
die alphanumerischen Informationen auf dem mikroelektronischen Schaltkreis ohne Stromquelle speicherbar sind,
der mikroelektronische Schaltkreis mit einer Antenne versehen ist,
und eine Sende- und Empfangseinrichtung für elektromagnetische Wellen vorgesehen ist, mit der die alphanumerischen Informationen zum Zwecke der Speicherung drahtlos auf den mikroelektronischen Schaltkreis übertragbar und von dort zum Zwecke einer berührungslosen Identifizierung der Trennsäule drahtlos auslesbar sind.1. Device for the electronic identification of a separation column for chromatography, which comprises a microelectronic circuit connected to the separation column, on which alphanumeric information can be stored permanently, characterized in that
the alphanumeric information can be stored on the microelectronic circuit without a power source,
the microelectronic circuit is provided with an antenna,
and a transmitting and receiving device for electromagnetic waves is provided with which the alphanumeric information can be wirelessly transmitted to the microelectronic circuit for the purpose of storage and can be wirelessly read out from there for the purpose of contactless identification of the separation column.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19934301401 DE4301401C2 (en) | 1993-01-20 | 1993-01-20 | Device and method for the electronic and contactless identification of separation columns for chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19934301401 DE4301401C2 (en) | 1993-01-20 | 1993-01-20 | Device and method for the electronic and contactless identification of separation columns for chromatography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE4301401A1 DE4301401A1 (en) | 1994-07-21 |
| DE4301401C2 true DE4301401C2 (en) | 2002-10-02 |
Family
ID=6478554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19934301401 Expired - Fee Related DE4301401C2 (en) | 1993-01-20 | 1993-01-20 | Device and method for the electronic and contactless identification of separation columns for chromatography |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE4301401C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119344B2 (en) | 2003-07-31 | 2006-10-10 | Carl Zeiss Nts Gmbh | Electron beam device having a specimen holder |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5690893A (en) * | 1994-06-10 | 1997-11-25 | Hitachi, Ltd. | Analyzer having sensor with memory device |
| US6017496A (en) | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
| US6331273B1 (en) | 1995-04-25 | 2001-12-18 | Discovery Partners International | Remotely programmable matrices with memories |
| US5925562A (en) * | 1995-04-25 | 1999-07-20 | Irori | Remotely programmable matrices with memories |
| US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| DE19540527A1 (en) * | 1995-10-31 | 1997-05-07 | Hewlett Packard Gmbh | Identification modules for exchangeable components in analytical instruments |
| DE19631425A1 (en) * | 1996-08-06 | 1998-02-12 | Wolf & Beck Gmbh Dr | Identification method for interchangeable accessories of machines tools |
| US6136274A (en) * | 1996-10-07 | 2000-10-24 | Irori | Matrices with memories in automated drug discovery and units therefor |
| NL1005914C2 (en) | 1997-04-28 | 1998-10-29 | Sgt Exploitatie Bv | Device for storing and / or treating chemicals. |
| NL1016403C2 (en) * | 2000-10-13 | 2002-04-16 | Varian B V | Information carrier for a chromatography column. |
| US11977058B2 (en) * | 2018-02-02 | 2024-05-07 | Shimadzu Corporation | Chromatography system |
| WO2020183760A1 (en) * | 2019-03-13 | 2020-09-17 | 株式会社島津製作所 | Chromatography system |
| WO2020183761A1 (en) * | 2019-03-13 | 2020-09-17 | 株式会社島津製作所 | Chromatography system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975647A (en) * | 1987-06-01 | 1990-12-04 | Nova Biomedical Corporation | Controlling machine operation with respect to consumable accessory units |
| DE4010194A1 (en) * | 1990-03-30 | 1991-10-02 | Schreiber Hans | Procedure and device for electronic detection vehicles - uses vehicle mounted antenna with electronic chip and memory to store transmissions |
-
1993
- 1993-01-20 DE DE19934301401 patent/DE4301401C2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975647A (en) * | 1987-06-01 | 1990-12-04 | Nova Biomedical Corporation | Controlling machine operation with respect to consumable accessory units |
| DE4010194A1 (en) * | 1990-03-30 | 1991-10-02 | Schreiber Hans | Procedure and device for electronic detection vehicles - uses vehicle mounted antenna with electronic chip and memory to store transmissions |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119344B2 (en) | 2003-07-31 | 2006-10-10 | Carl Zeiss Nts Gmbh | Electron beam device having a specimen holder |
Also Published As
| Publication number | Publication date |
|---|---|
| DE4301401A1 (en) | 1994-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8122 | Nonbinding interest in granting licenses declared | ||
| 8127 | New person/name/address of the applicant |
Owner name: HEWLETT-PACKARD CO., PALO ALTO, CALIF., US |
|
| 8128 | New person/name/address of the agent |
Representative=s name: HARBACH, T., DIPL.-PHYS., 71034 BOEBLINGEN |
|
| 8110 | Request for examination paragraph 44 | ||
| 8127 | New person/name/address of the applicant |
Owner name: HEWLETT-PACKARD CO. (N.D.GES.D.STAATES DELAWARE), |
|
| 8127 | New person/name/address of the applicant |
Owner name: AGILENT TECHNOLOGIES, INC. (N.D.GES.D.STAATES DELA |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: AGILENT TECHNOLOGIES, INC. (N.D.GES.D. STAATES, US |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Effective date: 20110802 |