DE3677842D1 - Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln. - Google Patents

Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.

Info

Publication number: DE3677842D1
Authority: DE; Germany
Prior art keywords: piperidylides; azoderivates; cycloheptenes; dihydrodibenzo; preparation
Prior art date: 1985-05-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE8686106257T

Other languages

English (en)

Inventor

Doris Pickel Schumacher

Frank J Villani

Jesse Kwok-Keung Wong

Bruce Lee Murphy

Jon Edward Clark

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-13

Filing date

1986-05-07

Publication date

1991-04-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3677842(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-03-12 Priority claimed from US06/838,974 external-priority patent/US4659716A/en

1986-03-12 Priority claimed from US06/839,016 external-priority patent/US4731447A/en

1986-05-07 Application filed by Schering Corp filed Critical Schering Corp

1991-04-11 Application granted granted Critical

1991-04-11 Publication of DE3677842D1 publication Critical patent/DE3677842D1/de

2006-05-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE8686106257T 1985-05-13 1986-05-07 Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln. Expired - Lifetime DE3677842D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73342885A	1985-05-13	1985-05-13
US06/838,974 US4659716A (en)	1984-02-15	1986-03-12	Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US06/839,016 US4731447A (en)	1985-05-13	1986-03-12	Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof

Publications (1)

Publication Number	Publication Date
DE3677842D1 true DE3677842D1 (de)	1991-04-11

Family

ID=27419175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE8686106257T Expired - Lifetime DE3677842D1 (de)	1985-05-13	1986-05-07	Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.

Country Status (15)

Country	Link
EP (1)	EP0208855B1 (de)
JP (2)	JP2511412B2 (de)
AR (1)	AR241463A1 (de)
AU (2)	AU600665B2 (de)
CA (1)	CA1272480A (de)
DE (1)	DE3677842D1 (de)
DK (1)	DK173765B1 (de)
ES (1)	ES8800679A1 (de)
FI (2)	FI90977C (de)
HK (1)	HK75993A (de)
HU (1)	HU199138B (de)
IE (1)	IE59110B1 (de)
IL (1)	IL78771A (de)
PT (1)	PT82570B (de)
SG (1)	SG69193G (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804666A (en) *	1985-08-14	1989-02-14	Schering Corporation	Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) *	1986-10-31	1989-05-02	Schering Corporation	6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JPH0678315B2 (ja) *	1988-04-28	1994-10-05	シェリング・コーポレーション	新規なベンゾピリド‐ピペリジン、ピペリジリデンおよびピペラジン化合物、組成物、製造法および利用法
US4863931A (en) *	1988-09-15	1989-09-05	Schering Corporation	Antihistaminic fluoro substituted benzocycloheptapyridines
AU620996B2 (en) *	1989-07-04	1992-02-27	Hokuriku Pharmaceutical Co. Ltd.	4-{(dibenzocycloheptene) or (dibenzoxepin)}-1-substituted piperidines
ES2080700B1 (es) *	1994-07-27	1996-10-16	Farmihispania S A	Nuevo procedimiento para la obtencion de loratadina.
ES2080699B1 (es) *	1994-07-27	1996-10-16	Farmahispania S A	Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
CN1047774C (zh) *	1996-09-10	1999-12-29	上海华联制药有限公司	氮杂二苯并环庚烯酮类化合物的制备方法
EP0978281B1 (de) *	1997-04-25	2002-07-17	Schering-Plough Kabushiki Kaisha	Augentropfen enthaltend ein loratidinmetabolit
UA62976C2 (en) *	1997-07-02	2004-01-15	Schering Corp	Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
WO2000005215A1 (en) *	1998-07-24	2000-02-03	Russinsky Limited	A process for preparing benzocycloheptapyridin-11-ones
US6372909B1 (en)	1998-11-20	2002-04-16	Schering Corporation	Synthesis of intermediates useful in preparing tricyclic compounds
WO2000030589A2 (en) *	1998-11-20	2000-06-02	Schering Corporation	Synthesis of intermediates useful in preparing tricyclic compounds
CO5251403A1 (es) *	1998-12-18	2003-02-28	Schering Corp	Proceso para preparar compuestos triciclicos que tienen actividad antihistaminica, en especial loratadina y descarboetoxiloratadina
HU226998B1 (en) *	2000-11-23	2010-04-28	Richter Gedeon Nyrt	Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
BRPI0712532A2 (pt)	2006-06-01	2013-04-02	Schering Plough Healthcare Prod Inc	formulaÇÕes e composiÇÕes farmacÊuticas de fenilefrina para absorÇço colânica
TR200806298A2 (tr)	2008-08-22	2010-03-22	Bi̇lgi̇ç Mahmut	Farmasötik formülasyon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL132137C (de) *	1963-04-24
US3717647A (en) *	1971-04-09	1973-02-20	Schering Corp	Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) *	1973-10-11	1977-10-19	Beecham Group Ltd	Reduced bicyclic pyridone derivatives
US4282233B1 (en) *	1980-06-19	2000-09-05	Schering Corp	Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
WO1985003707A1 (en) *	1984-02-15	1985-08-29	Schering Corporation	8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

1986
- 1986-05-07 DE DE8686106257T patent/DE3677842D1/de not_active Expired - Lifetime
- 1986-05-07 EP EP86106257A patent/EP0208855B1/de not_active Expired - Lifetime
- 1986-05-13 HU HU861976A patent/HU199138B/hu unknown
- 1986-05-13 AU AU57374/86A patent/AU600665B2/en not_active Expired
- 1986-05-13 CA CA000508985A patent/CA1272480A/en not_active Expired - Lifetime
- 1986-05-13 AR AR86303933A patent/AR241463A1/es active
- 1986-05-13 IE IE125986A patent/IE59110B1/en not_active IP Right Cessation
- 1986-05-13 DK DK198602209A patent/DK173765B1/da not_active IP Right Cessation
- 1986-05-13 FI FI861987A patent/FI90977C/fi not_active IP Right Cessation
- 1986-05-13 JP JP61109366A patent/JP2511412B2/ja not_active Expired - Lifetime
- 1986-05-13 ES ES554898A patent/ES8800679A1/es not_active Expired
- 1986-05-13 IL IL78771A patent/IL78771A/xx not_active IP Right Cessation
- 1986-05-13 PT PT82570A patent/PT82570B/pt unknown
1990
- 1990-05-09 FI FI902315A patent/FI87648C/fi not_active IP Right Cessation
- 1990-06-12 AU AU57026/90A patent/AU638019B2/en not_active Expired
1993
- 1993-05-27 SG SG691/93A patent/SG69193G/en unknown
- 1993-07-29 HK HK759/93A patent/HK75993A/xx not_active IP Right Cessation
1995
- 1995-08-29 JP JP7220838A patent/JP2519880B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI90977B (fi)	1994-01-14
FI87648B (fi)	1992-10-30
AR241463A1 (es)	1992-07-31
HK75993A (en)	1993-08-06
AU5702690A (en)	1990-10-04
FI902315A0 (fi)	1990-05-09
HUT41731A (en)	1987-05-28
HU199138B (en)	1990-01-29
IE59110B1 (en)	1994-01-12
IL78771A (en)	1990-11-29
JP2519880B2 (ja)	1996-07-31
PT82570B (pt)	1988-11-30
PT82570A (en)	1986-06-01
FI90977C (fi)	1994-04-25
EP0208855A1 (de)	1987-01-21
FI861987A (fi)	1986-11-14
DK220986D0 (da)	1986-05-13
ES8800679A1 (es)	1987-11-16
ES554898A0 (es)	1987-11-16
IE861259L (en)	1986-11-13
AU5737486A (en)	1986-12-18
JPS61289087A (ja)	1986-12-19
AU638019B2 (en)	1993-06-17
SG69193G (en)	1993-08-06
IL78771A0 (en)	1986-08-31
AU600665B2 (en)	1990-08-23
JP2511412B2 (ja)	1996-06-26
DK220986A (da)	1986-11-14
EP0208855B1 (de)	1991-03-06
FI861987A0 (fi)	1986-05-13
FI87648C (fi)	1993-02-10
JPH0859657A (ja)	1996-03-05
DK173765B1 (da)	2001-09-17
CA1272480A (en)	1990-08-07

Publication	Publication Date	Title
DE3780226D1 (de)	1992-08-13	Neue pharmazeutische praeparate zur topischen applikation, verfahren zu ihrer herstellung und ihre verwendung.
DE3680578D1 (de)	1991-09-05	Dipeptid-derivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und ihre anwendung.
DE3781195D1 (de)	1992-09-24	Substituierte benzamidderivate, verfahren zu deren herstellung und diese enthaltende medikamente.
DE3677842D1 (de)	1991-04-11	Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
ATE58529T1 (de)	1990-12-15	Verfahren zur herstellung von 2,2,6,6,-tetraalkyl-4-piperidylamine.
DE3575724D1 (de)	1990-03-08	Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
AT379811B (de)	1986-03-10	Verfahren zur herstellung von neuen chinolinen, chinoxalinen und chinazolinen und deren pharmazeutisch verwendbaren derivaten
DE3680877D1 (de)	1991-09-19	Thiazolverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE68908374D1 (de)	1993-09-16	Propenonoximether, verfahren zu dessen herstellung sowie diese enthaltende arzneinmittel.
DE3770982D1 (de)	1991-08-01	Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
DE3674582D1 (de)	1990-10-31	(s)-(-)-1-propyl-2',6'-pipecoloxylidid-hydrochloridmonohydrat, verfahren zu seiner herstellung und es enthaltendes pharmazeutisches praeparat.
DE3777122D1 (de)	1992-04-09	Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3670642D1 (de)	1990-05-31	Polymere von substituierten 1,3-butadienverbindungen und verfahren zu deren herstellung.
DE3685210D1 (de)	1992-06-11	1-benzensulfonyl-2-oxo-5-alkoxypyrrolidine, verfahren zu deren herstellung und deren anwendung als heilmittel sowie diese enthaltende zusammenstellungen.
DE3483515D1 (de)	1990-12-06	Zuckerdragiertes arzneimittel und verfahren zu dessen herstellung.
DE3766299D1 (de)	1991-01-03	4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
DE3675714D1 (de)	1991-01-03	Substituierte hexahydroarylchinolizinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3672132D1 (de)	1990-07-26	Neue pyridaziniumverbindungen, verfahren zu deren herstellung und diese enthaltende fungizide und algizide mittel.
DE3680227D1 (de)	1991-08-22	N-cyklohexyl-polycarboxamide verbindung und ihre derivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von acceptor-donor-komplexen.
DE3681334D1 (de)	1991-10-17	Androstane-17-beta-carbonsaeureester, verfahren zu deren herstellung und pharmazeutische praeparate die diese enthalten.
DE3767894D1 (de)	1991-03-14	1,2-dithiol-3-thion-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellung.
DE3789657D1 (de)	1994-05-26	Synthetische alkali-metall-alumino-silicate, verfahren und verwendungen, zubereitungen, sowie deren verfahren zur herstellung.
DE3583780D1 (de)	1991-09-19	2,3-dihydro-1h-inden-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3577443D1 (de)	1990-06-07	Derivate von dihydroorotsaeure, deren verfahren zur herstellung und deren pharmazeutische zusammensetzungen.
DE3670635D1 (de)	1990-05-31	Neue benzisoselenazolonyl-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.

Legal Events

Date	Code	Title	Description
1992-04-02	8364	No opposition during term of opposition