DE3574014D1 - Novel biologically active compound having anti-prolyl endopeptidase activity - Google Patents
Novel biologically active compound having anti-prolyl endopeptidase activityInfo
- Publication number
- DE3574014D1 DE3574014D1 DE8585109544T DE3574014T DE3574014D1 DE 3574014 D1 DE3574014 D1 DE 3574014D1 DE 8585109544 T DE8585109544 T DE 8585109544T DE 3574014 T DE3574014 T DE 3574014T DE 3574014 D1 DE3574014 D1 DE 3574014D1
- Authority
- DE
- Germany
- Prior art keywords
- prolyl endopeptidase
- active compound
- biologically active
- endopeptidase activity
- novel biologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16099484A JPS6137764A (ja) | 1984-07-31 | 1984-07-31 | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3574014D1 true DE3574014D1 (en) | 1989-12-07 |
Family
ID=15726550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585109544T Expired DE3574014D1 (en) | 1984-07-31 | 1985-07-30 | Novel biologically active compound having anti-prolyl endopeptidase activity |
Country Status (6)
Country | Link |
---|---|
US (1) | US4743616A (de) |
EP (1) | EP0172458B1 (de) |
JP (1) | JPS6137764A (de) |
AT (1) | ATE47711T1 (de) |
AU (1) | AU575668B2 (de) |
DE (1) | DE3574014D1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873342A (en) * | 1985-04-16 | 1989-10-10 | Suntory Limited | Dipeptide derivative and synthesis and use thereof |
JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途 |
CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
US4880827A (en) * | 1986-03-18 | 1989-11-14 | Sumitomo Pharmaceuticals Company, Ltd. | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase |
JPH08806B2 (ja) * | 1986-11-18 | 1996-01-10 | サントリー株式会社 | プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体 |
DE3786229T2 (de) * | 1986-11-20 | 1993-10-07 | Ono Pharmaceutical Co | Prolinalderivate. |
US5254550A (en) * | 1986-11-20 | 1993-10-19 | Ono Pharmaceutical Co., Ltd. | Prolinal derivatives and pharmaceutical compositions thereof |
ES2046195T3 (es) * | 1986-12-29 | 1994-02-01 | Ono Pharmaceutical Co., Ltd. | Un procedimiento para la preparacion de los derivados de prolinal. |
US5262431A (en) * | 1986-12-29 | 1993-11-16 | Ono Pharmaceutical Co., Ltd. | Prolinal derivatives and pharmaceutical compositions thereof |
ATE87306T1 (de) * | 1987-02-04 | 1993-04-15 | Ono Pharmaceutical Co | Prolinalderivate. |
EP0280956B1 (de) * | 1987-02-23 | 1992-10-21 | Ono Pharmaceutical Co., Ltd. | Thiazolidin-Derivate |
DE3712365A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
DE3712364A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
JPH0774194B2 (ja) * | 1987-06-11 | 1995-08-09 | 財団法人微生物化学研究会 | 生理活性を有する新規なアクチノニン誘導体 |
JP2691442B2 (ja) * | 1989-02-20 | 1997-12-17 | 株式会社ヤクルト本社 | 新規なプロリン誘導体 |
WO1990012005A1 (en) * | 1989-04-13 | 1990-10-18 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
FR2669029B1 (fr) * | 1990-11-14 | 1994-09-02 | Adir | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5620971A (en) * | 1991-05-09 | 1997-04-15 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
ATE183178T1 (de) * | 1991-05-09 | 1999-08-15 | Vertex Pharma | Neue immunsuppressive verbindungen |
US5723459A (en) * | 1991-05-09 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
US5439930A (en) * | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
JP2003535034A (ja) * | 1999-11-12 | 2003-11-25 | ギルフォード ファーマシューティカルズ インコーポレイテッド | ジペプチジルペプチダーゼiv阻害剤並びにジペプチジルペプチダーゼiv阻害剤の製造及び使用法 |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
EP1824846A2 (de) | 2003-11-03 | 2007-08-29 | Probiodrug AG | Neue verbindungen zur behandlung neurologischer erkrankungen |
JP2007509898A (ja) | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
KR101099206B1 (ko) | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
US20080234344A1 (en) * | 2004-03-26 | 2008-09-25 | Jochen Klock | Amino Acid and Peptide Conjugates of Arylalkylic Acids for Cosmetic Use |
EP2089383B1 (de) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten |
SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
WO2009007415A2 (en) * | 2007-07-10 | 2009-01-15 | Probiodrug Ag | Novel compounds |
JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
EA022420B1 (ru) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
US4154937A (en) * | 1977-02-11 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Hydroxycarbamoylalkylacylpipecolic acid compounds |
US4226775A (en) * | 1979-06-01 | 1980-10-07 | American Cyanamid Company | Substituted thio-substituted benzyl-propionyl-L-prolines |
ZA802552B (en) * | 1979-05-21 | 1981-04-29 | Ici Ltd | 1-phenyl-2-aminoethanol derivatives |
US4374847A (en) * | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
US4479963A (en) * | 1981-02-17 | 1984-10-30 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
US4439611A (en) * | 1982-06-28 | 1984-03-27 | American Cyanamid Company | Isolation of [S-(R*, S*]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline from a diastereomeric mixture |
-
1984
- 1984-07-31 JP JP16099484A patent/JPS6137764A/ja active Granted
-
1985
- 1985-07-30 AT AT85109544T patent/ATE47711T1/de not_active IP Right Cessation
- 1985-07-30 EP EP85109544A patent/EP0172458B1/de not_active Expired
- 1985-07-30 DE DE8585109544T patent/DE3574014D1/de not_active Expired
- 1985-07-30 AU AU45597/85A patent/AU575668B2/en not_active Ceased
- 1985-07-30 US US06/760,411 patent/US4743616A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0172458A2 (de) | 1986-02-26 |
ATE47711T1 (de) | 1989-11-15 |
EP0172458B1 (de) | 1989-11-02 |
JPH0479334B2 (de) | 1992-12-15 |
AU4559785A (en) | 1986-02-06 |
AU575668B2 (en) | 1988-08-04 |
US4743616A (en) | 1988-05-10 |
JPS6137764A (ja) | 1986-02-22 |
EP0172458A3 (en) | 1987-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3574014D1 (en) | Novel biologically active compound having anti-prolyl endopeptidase activity | |
EP0201742A3 (en) | N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use | |
MY111370A (en) | Dual action inhibitors | |
IL100086A0 (en) | Retroviral protease inhibitors | |
MY106606A (en) | Cycloalkyl-substituted glutaramide antihypertensive agents. | |
NO942064L (no) | yminhibitorer | |
MX9606744A (es) | Acidos hidroxamicos sustituidos por sulfonamido arilico como inhibidores de metaloproteinasa de matriz. | |
MX9601360A (es) | Mezcla estabilizante sinergistica. | |
MX9703564A (es) | Inhibidores de proteasa multicatalitica. | |
CA2081970A1 (en) | Hiv protease inhibitors useful for the treatment of aids | |
EP0677048A1 (de) | Cyclische sulfone als inhibitoren retroviralen proteasen. | |
IE810474L (en) | Anti-hypertensive agents | |
PL309282A1 (en) | Application of 2-amino-6-n-propyl-amino- 4,5,6,7-tetrahydrobenzothiasole (pramipexol) as an antidepressant | |
TW223630B (en) | Retroviral protease inhibitors | |
MY105128A (en) | Bu-3608 derivatives. | |
ES8205126A1 (es) | Un procedimiento para la preparacion de un inhibidor del enzima convertidor de la angiotensina. | |
AU1235288A (en) | Antidepressant compositions | |
ES2065843A1 (es) | Aplicacion de ent-11 , 16-dihidroxi-18-nor-4a -carboximetil-oxido de manoilo como inhibidor de la adenilatociclasa. | |
ES2065844A1 (es) | Aplicacion de ent-16,18-dihidroxi-6-oxo-oxido de manoilo como inhibidor de la adenilatociclasa. | |
MX9801683A (es) | Composiciones y metodos para controlar hongos perjudiciales. | |
SU1170760A1 (ru) | Дигидробромид 2-(2-морфолиноэтилтио)бензимидазола, повышающий физическую работоспособность и ускоряющий процессы восстановления после физических нагрузок и длительного стресса | |
UA18258A (uk) | Фуhгіцидhа композиція | |
SE9304065D0 (sv) | New compound |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |