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DE3574014D1 - Novel biologically active compound having anti-prolyl endopeptidase activity - Google Patents

Novel biologically active compound having anti-prolyl endopeptidase activity

Info

Publication number
DE3574014D1
DE3574014D1 DE8585109544T DE3574014T DE3574014D1 DE 3574014 D1 DE3574014 D1 DE 3574014D1 DE 8585109544 T DE8585109544 T DE 8585109544T DE 3574014 T DE3574014 T DE 3574014T DE 3574014 D1 DE3574014 D1 DE 3574014D1
Authority
DE
Germany
Prior art keywords
prolyl endopeptidase
active compound
biologically active
endopeptidase activity
novel biologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585109544T
Other languages
English (en)
Inventor
Takaharu Tanaka
Naoki Higuchi
Masayuki Saito
Masaki Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of DE3574014D1 publication Critical patent/DE3574014D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8585109544T 1984-07-31 1985-07-30 Novel biologically active compound having anti-prolyl endopeptidase activity Expired DE3574014D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16099484A JPS6137764A (ja) 1984-07-31 1984-07-31 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物

Publications (1)

Publication Number Publication Date
DE3574014D1 true DE3574014D1 (en) 1989-12-07

Family

ID=15726550

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585109544T Expired DE3574014D1 (en) 1984-07-31 1985-07-30 Novel biologically active compound having anti-prolyl endopeptidase activity

Country Status (6)

Country Link
US (1) US4743616A (de)
EP (1) EP0172458B1 (de)
JP (1) JPS6137764A (de)
AT (1) ATE47711T1 (de)
AU (1) AU575668B2 (de)
DE (1) DE3574014D1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0201741B1 (de) * 1985-04-16 1991-07-31 Suntory Limited Dipeptid-Derivate, Verfahren zur Herstellung, pharmazeutische Zusammensetzungen und ihre Anwendung
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US5198458A (en) * 1986-02-04 1993-03-30 Suntory Limited Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
US4880827A (en) * 1986-03-18 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3786229T2 (de) * 1986-11-20 1993-10-07 Ono Pharmaceutical Co Prolinalderivate.
US5254550A (en) * 1986-11-20 1993-10-19 Ono Pharmaceutical Co., Ltd. Prolinal derivatives and pharmaceutical compositions thereof
US5262431A (en) * 1986-12-29 1993-11-16 Ono Pharmaceutical Co., Ltd. Prolinal derivatives and pharmaceutical compositions thereof
DE3783754T2 (de) * 1986-12-29 1993-08-05 Ono Pharmaceutical Co Prolin-derivate.
ATE87306T1 (de) * 1987-02-04 1993-04-15 Ono Pharmaceutical Co Prolinalderivate.
ES2103287T3 (es) * 1987-02-23 1997-09-16 Ono Pharmaceutical Co Nuevos derivados de tiazolidina.
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
JPH0774194B2 (ja) * 1987-06-11 1995-08-09 財団法人微生物化学研究会 生理活性を有する新規なアクチノニン誘導体
JP2691442B2 (ja) * 1989-02-20 1997-12-17 株式会社ヤクルト本社 新規なプロリン誘導体
EP0419683A4 (en) * 1989-04-13 1992-03-11 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
US5073549A (en) * 1990-03-22 1991-12-17 Bristol-Myers Squibb Company BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
US4999349A (en) * 1990-03-22 1991-03-12 Bristol-Myers Squibb Co. BU-4164E - A and B, prolyl endopeptidase inhibitors
FR2669029B1 (fr) * 1990-11-14 1994-09-02 Adir Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK0584223T3 (da) * 1991-05-09 2000-03-13 Vertex Pharma Hidtil ukendte immunsuppressive forbindelser
US5723459A (en) * 1991-05-09 1998-03-03 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
MX9202466A (es) * 1991-05-24 1994-06-30 Vertex Pharma Compuestos inmunosupresores novedosos.
US5439930A (en) * 1992-04-14 1995-08-08 Russian-American Institute For New Drug Development Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
EP1228061A4 (de) * 1999-11-12 2004-12-15 Guilford Pharm Inc Dipeptidyl-peptidase-iv-inhibitoren, verfahren zu deren herstellung sowie deren verwendung
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
NZ546887A (en) 2003-11-03 2009-04-30 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1824846A2 (de) 2003-11-03 2007-08-29 Probiodrug AG Neue verbindungen zur behandlung neurologischer erkrankungen
CA2554809C (en) 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
ES2355571T3 (es) * 2004-03-26 2011-03-29 Dsm Ip Assets B.V. Conjugados de ácidos arilalquílicos con aminoácidos y péptidos para usos cosméticos.
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
NZ579310A (en) 2007-03-01 2012-03-30 Probiodrug Ag Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
US20100273835A1 (en) * 2007-07-10 2010-10-28 Probiodrug Ag Novel compounds
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
SG183229A1 (en) 2010-03-10 2012-09-27 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3461819B1 (de) 2017-09-29 2020-05-27 Probiodrug AG Hemmer der glutaminylcyclase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4154937A (en) * 1977-02-11 1979-05-15 E. R. Squibb & Sons, Inc. Hydroxycarbamoylalkylacylpipecolic acid compounds
US4226775A (en) * 1979-06-01 1980-10-07 American Cyanamid Company Substituted thio-substituted benzyl-propionyl-L-prolines
ZA802552B (en) * 1979-05-21 1981-04-29 Ici Ltd 1-phenyl-2-aminoethanol derivatives
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4439611A (en) * 1982-06-28 1984-03-27 American Cyanamid Company Isolation of [S-(R*, S*]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline from a diastereomeric mixture

Also Published As

Publication number Publication date
EP0172458B1 (de) 1989-11-02
AU4559785A (en) 1986-02-06
EP0172458A3 (en) 1987-01-07
US4743616A (en) 1988-05-10
AU575668B2 (en) 1988-08-04
JPH0479334B2 (de) 1992-12-15
JPS6137764A (ja) 1986-02-22
ATE47711T1 (de) 1989-11-15
EP0172458A2 (de) 1986-02-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee