DE102013219508A1 - Mixture useful as a catalyst for hydroformylating unsaturated compound or its mixture, comprises e.g. 6,6'-(3,3'-di-tert-butyl-5,5'-dimethoxybiphenyl-2,2'-diyl)bis(oxy)bis(2,4,8,10-tetramethyldibenzo(d,f)(1,3,2)dioxaphosphepine) - Google Patents

Abstract

Mixture comprises 4,8-di-tert-butyl-2,10-dimethoxy-6-(3,3',5,5'-tetramethyl-2'-(2,4,8,10-tetramethyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yloxy)biphenyl-2-yloxy)dibenzo[d,f][1,3,2]dioxaphosphepine (I) and 6,6'-(3,3'-di-tert-butyl-5,5'-dimethoxybiphenyl-2,2'-diyl)bis(oxy)bis(2,4,8,10-tetramethyldibenzo[d,f][1,3,2]dioxaphosphepine) (II). Mixture comprises 4,8-di-tert-butyl-2,10-dimethoxy-6-(3,3',5,5'-tetramethyl-2'-(2,4,8,10-tetramethyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yloxy)biphenyl-2-yloxy)dibenzo[d,f][1,3,2]dioxaphosphepine of formula (I) and 6,6'-(3,3'-di-tert-butyl-5,5'-dimethoxybiphenyl-2,2'-diyl)bis(oxy)bis(2,4,8,10-tetramethyldibenzo[d,f][1,3,2]dioxaphosphepine) of formula (II). Independent claims are also included for: (1) preparing the mixture, comprising (i) carrying out oxidative coupling of 2,4-dimethylphenol to obtain 3,3',5,5'-tetramethyl-2,2'-dihydroxybiphenyl, (ii) carrying out oxidative coupling of 3-tert-butyl-4-hydroxyanisole to obtain 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl, (iii) reacting 3,3',5,5'-tetramethyl-2,2'-dihydroxybiphenyl obtained from the step (i) with phosphorus trichloride under inert gas atmosphere to obtain phosphorochloridite derivative, and (iv) reacting at least 2 equivalents phosphorochloridite derivative obtained from the step (iii) with 1 equivalent 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl obtained from the step (ii) under inert gas atmosphere; (2) a complex mixture comprising complex compounds of formula (III) and (IV); (3) a composition comprising the above complex mixture, and bases, organic amines, epoxides, buffer solutions or ion exchangers; and (4) hydroformylating an unsaturated compound or a mixture of unsaturated compounds, comprising (a) providing the above mixture or the composition, (b) introducing a gas mixture which comprises carbon monoxide and hydrogen, and (c) adding at least one unsaturated compound or a mixture of unsaturated compounds. M : Fe, Ru, Os, Co, Rh, Ir, Ni, Pd or Pt, where M optionally forms additional bonds. [Image] [Image] [Image] [Image].

Description

The invention relates to mixtures of constitutionally is bisphosphites, a process for their preparation, and their reaction with metals to mixtures containing complex compounds from the constitution isomeric bisphosphites and the metal and their use as catalytically active composition in hydroformylation reactions, wherein the hydroformylierungsaktiven composition in addition to the complex compounds of metal and the constitutive isomeric bisphosphites, unbound bisphosphites of the constitutionally isomeric bisphosphites and at least one further component.

The reactions between olefin compounds, carbon monoxide and hydrogen in the presence of a catalyst to give the C-atom richer aldehydes is known as hydroformylation or oxination. As catalysts in these reactions, compounds of the transition metals of Group VIII of the Periodic Table of the Elements are frequently used. Known ligands are, for example, compounds from the classes of phosphines, phosphites and phosphonites, each with trivalent phosphorus P ^III . A good overview of the state of the hydroformylation of olefins can be found in B. CORNILS, WA HERRMANN, "Applied Homogeneous Catalysis with Organometallic Compounds", Vol. 1 & 2, VCH, Weinheim, New York, 1996 respectively. R. Franke, D. Selent, A. Börner, "Applied Hydroformylation", Chem. Rev., 2012, DOI: 10.1021 / cr3001803 ,

Each catalytically active composition has its specific advantages. Depending on the starting material and target product therefore different catalytically active compositions are used.

The patents US 4,694,109 and U.S. 4,879,416 describe bisphosphine ligands and their use in the hydroformylation of olefins at low synthesis gas pressures. Especially in the hydroformylation of propene, ligands of this type achieve high activities and high n / i selectivities (n / i = the ratio of linear aldehyde (= n) to branched (= iso) aldehyde). In WO 95/30680 bidentate phosphine ligands and their use in catalysis, including hydroformylation reactions, are disclosed. Ferrocene-bridged bisphosphines are described, for example, in the patents US 4,169,861 . US 4,201,714 and US 4,193,943 described as ligands for hydroformylations.

The disadvantage of bidentate and polydentate phosphine ligands is a relatively high cost, which is necessary for their presentation. Therefore, it is often not profitable to use such systems in technical processes. In addition, there is a comparatively low activity, which must be compensated by high residence times reaction technology. This in turn leads to undesirable side reactions of the products.

Rhodium monophosphite complexes in catalytically active compositions are suitable for the hydroformylation of branched olefins with internal double bonds, but the selectivity for terminally oxidized compounds is low. Out EP 0 155 508 is the use of bisarylene-substituted monophosphites in the rhodium-catalyzed hydroformylation of sterically hindered olefins, e.g. As isobutene known.

Catalytically active compositions based on rhodium bisphosphite complexes are suitable for the hydroformylation of linear olefins having terminal and internal double bonds, predominantly terminally hydroformylated products being formed. In contrast, branched olefins with internal double bonds are converted only to a small extent. These phosphites, when coordinated to a transition metal center, provide catalysts of increased activity, but the pot life of these catalytically active compositions is unsatisfactory, among other reasons because of the hydrolysis sensitivity of the phosphite ligands. By using substituted bisaryldiols as building blocks for the phosphite ligands, as in EP 0 214 622 or EP 0 472 071 described significant improvements could be achieved.

According to the literature, the catalytically active compositions of these rhodium-based ligands are extremely active in the hydroformylation of α-olefins. In the patents US 4,668,651 . US 4,748,261 and U.S. 4,885,401 Polyphosphite ligands are described with which α-olefins, but also 2-butene with high n / i selectivity to the terminally oxidized products can be implemented. Bidentate ligands of this type have also been used for the hydroformylation of butadiene ( US 5,312,996 ).

In the EP 1 294 731 disclosed bisphosphites have in the hydroformylation of n-octene mixtures olefin conversions up to 98%. However, the likewise desired n-selectivity to nonanal with 36.8% to a maximum of 57.6% is in need of improvement. This is even more so than that the use of the catalytic active composition requires a service life in technical processes, which is measured in days instead of hours.

The synthesis of symmetrically structured bisphosphites, as has been known since the literature US 4769498 and their use in catalytically active, transition metal-containing compositions for the hydroformylation of unsaturated compounds.

The synthesis of symmetrically structured bisphosphites, as has been known since the literature US 4769498 and their use in catalytically active, transition metal-containing compositions for the hydroformylation of unsaturated compounds.

In US 4769498 as well as in US 5723641 For example, symmetrically constructed bisphosphites are prepared and used as ligands for hydroformylation. The symmetrically constructed bisphosphite ligands used in the hydroformylation are prepared at low temperatures. Compliance with these low temperatures is imperative because higher temperatures according to these US documents would lead to rearrangements and ultimately to asymmetrically constructed bisphosphites, but this is not desirable here.

When used as a ligand in transition metal-catalyzed hydroformylation, these asymmetrically structured bisphosphites have significantly lower reactivities and lower n-regioselectivity; see in Rhodium catalyzed hydroformylation, ed. By PWNM van Leeuwen et C. Claver, Kluwer Academic Publishers 2006, AA Dordrecht, NL, pages 45-46 ,

As pointed out by van Leeuwen, the symmetrical bisphosphites have not only higher selectivities, but also greater reactivity. In addition to the aim of high reactivity and n-selectivity with respect to the unsaturated compounds to be carbonylated, the stability - specifically the service life - of the catalytically active composition of respectively used metal, ligands and other components with activating effect with regard to the ligands used Bisphophite a constant task of research. This applies in particular with regard to olefin-containing mixtures, especially in the hydroformylation of mixtures of linear olefins.

In US 5364950 as well as in US 5763677 and in "Catalyst Separation, Recovery and Recycling", edited by DJ Cole-Hamilton, RP Tooze, 2006, NL, pages 25-26 , the formation of so-called poisoning phosphites is described as a minor or ligand degradation reaction. These poisoning phosphites are formed by the use of aryl phosphite-modified rhodium complexes during the hydroformylation reaction. In the course of the ligand degradation, an aryl group is replaced by an alkyl group of the hydroformylation product. In addition to the formation of the unwanted "poisoning phosphites", the phosphite ligand can also be degraded in the course of a hydrolysis reaction by the traces of water formed during the aldehyde condensation.

A consequence of these degradation reactions of the ligands is that the concentration of hydroformylation-active rhodium complex species decreases over time and is associated with a loss of reactivity.

It is generally known that in the case of a continuous procedure of the hydroformylation, ligand (s) and-optionally further components-are metered in during the course of the reaction, ie, they must be additionally added after the beginning of the reaction (see DE 10 2008 002 187 A1 ).

• 1.) eine hohe Aktivität;
• 2.) eine hohe n-Regioseliktivität in Bezug auf die Hydroformylierung und
• 3.) eine hohe Standzeit.

The technical object of the present invention is to provide new ligands which, in the hydroformylation of unsaturated compounds, do not have the drawbacks previously indicated in the prior art but have the following properties:

• 1.) a high activity;
• 2.) a high n-regioselivity in terms of hydroformylation and
• 3.) a long service life.

A long service life means that the hydroformylation-active composition comprising the ligands, among other components, has a low tendency to degrade these ligands and / or the decomposition of these ligands into hydroformylation-inhibiting components, e.g. having the so-called "poisoning phosphites".

The object is achieved by a mixture of the compounds of the formulas (1a) and (2a):

• a) Gemische konstitutionsisomerer Bisphosphite der Formeln (1a) und (2a);
• b) Verfahren zu deren Herstellung;
• c) Metall-Komplexgemische der Formeln (1b) und (2b), wobei M ein Metall der 4. bis 10. Gruppe des Periodensystems der Elemente (Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt) darstellt und zusätzliche Bindungen eingehen kann und die Konstitutionsisomeren der Formeln (1a) und (2a) vorliegen, die nicht an das Metall M gebunden sind;
  
• d) Zusammensetzungen, enthaltend die unter a) genannten Konstitutionsisomeren, Metalle der 4. bis 10. Gruppe des Periodensystems der Elemente (Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt) sowie freie, d.h. ungebundene konstitutionsisomere Bisphosphite der Formeln (1a) und (2a) und zumindest eine weitere Komponente, ausgewählt aus der Gruppe, welche Basen, organische Amine, Epoxide, Ionenaustauscher, Puffersysteme umfasst;
• e) Verfahren zur Hydroformylierung ungesättigter Verbindungen und deren Gemischen unter Verwendung von Zusammensetzungen nach d), eines Gasgemisches bestehend aus Kohlenmonoxid und Wasserstoff, ungesättigter Verbindungen und deren Gemischen unter den für eine Hydroformylierung erforderlichen Reaktionsbedingungen;
• f) Mehrphasiges Reaktionsgemisch bestehend aus: f1) mindestens einer Zusammensetzung nach d); f2) einem Gasgemisch umfassend Kohlenmonoxid und Wasserstoff; f3) mindestens einer ungesättigten Verbindung als Substrat sowie; f4) mindestens einem Hydroformylierungsprodukt aus den Substraten.

The invention comprises the following items:

• a) mixtures of constitutionally isomeric bisphosphites of the formulas (1a) and (2a);
• b) process for their preparation;
• c) metal complex mixtures of the formulas (1b) and (2b), wherein M represents a metal of the 4th to 10th group of the Periodic Table of the Elements (Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt) and additional bonds can be formed and the constitutional isomers of the formulas (1a) and (2a) are present, which are not bound to the metal M;
  
• d) Compositions containing the constitutional isomers mentioned under a), metals of the 4th to 10th group of the Periodic Table of the Elements (Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt) as well as free, ie unbound, constitutionally isomeric bisphosphites of the formulas (1a) and (2a) and at least one further component selected from the group comprising bases, organic amines, epoxides, ion exchangers, buffer systems;
• e) Process for the hydroformylation of unsaturated compounds and mixtures thereof using compositions according to d), a gas mixture consisting of carbon monoxide and hydrogen, unsaturated compounds and mixtures thereof under the reaction conditions required for a hydroformylation;
• f) Multiphase reaction mixture consisting of: f1) at least one composition according to d); f2) a gas mixture comprising carbon monoxide and hydrogen; f3) at least one unsaturated compound as substrate and; f4) at least one hydroformylation product from the substrates.

In one embodiment, the content of isomers of the formula (1a) is in a range of 74 to 99% by mass, the content of isomers of the formula (2a) in a range of 1 to 26% by mass. The contents of constitutional isomers of the formula (1a) and the formula (2a) add up to 100% by mass. These defined mixtures of the constitutionally isomeric bisphosphites can be initially introduced, for example, directly at the beginning of a hydroformylation reaction. This procedure thus differs from the general procedure in a stability study, in which a defined isomer is presented and the other isomers form only in the course of the reaction.

Normally, as pure as possible ligands are used in the hydroformylation reaction in the prior art, since the other isomer exerts strong negative influences on the overall performance of the system. In general, the asymmetric isomer would be present as a minor component, since only symmetrical ligands are used in the hydroformylation,

In Rhodium catalyzed hydroformylation, ed. By PWNM van Leeuwen et C. Claver, Kluwer Academic Publishers 2006, AA Dordrecht, NL, pages 45-46 Table 2 describes the hydroformylation results of the symmetric biphephos ligand and its unsymmetrical isomer. It is clear that the symmetric biphephos ligand (in the reference Ligand 5a) is characterized by a significantly higher n / i selectivity and a higher activity than its asymmetric isomer (in the reference Ligand 7). In the hydroformylation reaction of propene, the symmetric ligand has an n / i selectivity of 53 and a reaction rate of 402, whereas the unsymmetrical ligand exhibits only an n / i selectivity of 1.2 and a reaction rate of 280. If one were to use a mixture of both ligands, this would lead to significantly poorer yields and n / i selectivities. A significantly worse overall performance was also recorded with the isomeric mixture of the ligands (7) and (8). If the isomer mixture according to the invention is used in the hydroformylation, this is not the case, and the other isomer can be present as a minor component in the isomer mixture without negatively influencing the overall performance of the system.

This is particularly advantageous because during ligand preparation, no further purification steps are necessary to obtain an isomer of 100% purity. This is particularly favorable because any further purification step in ligand production leads to an increase in the cost of the same. In general, these solvents used various solvents and it may be necessary to different Aufreinigugen, such as recrystallizations, which inevitably lead to product losses. This, in turn, makes the ligand significantly more expensive to produce and, in turn, adversely affects the overall economics of a large scale process. Thus, it is particularly advantageous if it is possible to dispense with expensive purification steps and to use corresponding isomer mixtures in a large-scale hydroformylation process.

• i) oxidative Kopplung von 2,4-Dimethylphenol zu 3,3´,5,5`-Tetramethyl-2,2´-dihydroxybiphenyl;
• ii) oxidative Kopplung von 3-tert.-Butyl-4-Hydroxyanisol zu 5,5´-Dimethoxy-3,3´-di-tert.-Butyl-2,2´-dihydroxybiphenyl;
• iii) Umsetzung von 3,3´,5,5`-Tetramethyl-2,2´-dihydroxybiphenyl aus i) mit PCl₃ zu einem Phosphorochloriditderivat unter Inertgasatmosphäre;
• iv) Umsetzung von zumindest 2 Äquivalenten des Phophorochloriditderivats aus iii) mit 1 Äquivalent des 5,5´-Dimethoxy-3,3´-di-tert.-Butyl-2,2´-dihydroxybiphenyl aus ii) unter Inertgasatmosphäre.

The process according to the invention for preparing the mixture of the costly isomeric compounds of the formulas (1a) and (2a) comprises the steps:

• i) oxidative coupling of 2,4-dimethylphenol to 3,3', 5,5'-tetramethyl-2,2'-dihydroxybiphenyl;
• ii) oxidative coupling of 3-tert-butyl-4-hydroxyanisole to 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl;
• iii) reaction of 3,3', 5,5'-tetramethyl-2,2'-dihydroxybiphenyl from i) with PCl ₃ to give a phosphorochloridite derivative under an inert gas atmosphere;
• iv) reaction of at least 2 equivalents of the phosphorochloridite derivative from iii) with 1 equivalent of the 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl from ii) under an inert gas atmosphere.

In a variant of the method, process step iv) uses a solvent mixture.

In a variant, the mixture of the constitutionally isomeric bisphosphites (1a) and (2a) is obtainable, the solvent mixture used in process step iv) being selected from: organic nitrogen compounds, organic esters, aromatics.

In a particular embodiment, the organic nitrogen compounds are selected from: nitriles, amines, amides.

In a preferred embodiment, the organic nitrogen compounds are selected from: pyridine, triethylamine, dimethylaminobutane, tributylamine, tripentylamine, trihexylamine.

In one embodiment, in process step iv), a solvent mixture is used which comprises two organic nitrogen compounds. Preferably, the two organic nitrogen compounds are selected from: pyridine, triethylamine, dimethylaminobutane, tributylamine, tripentylamine, trihexylamine.

In a preferred embodiment, acetonitrile, triethylamine, dimethylaminobutane, di-i-propylethylamine, N-methylpyrolidone, pyridine, ethyl acetate, toluene are used.

In particularly preferred variants of the process, the process step iv) takes place in an aprotic-polar solvent, or a mixture which comprises at least one aprotic-polar solvent.

In the context of this application, the term aprotic solvent is understood as meaning nonaqueous solvents which do not contain an ionizable proton in the molecule, which are further subdivided into aprotic-apolar and aprotic-polar solvents (see Thieme Römpp online).

The term aprotic-nonpolar or apolar aprotic solvents includes aliphatic and aromatic as well as halogenated hydrocarbons (alkanes, alkenes, alkynes, benzene, aromatics having aliphatic or aromatic side chains), perhalogenated hydrocarbons such as carbon tetrachloride and hexafluorobenzene, tetramethylsilane and carbon disulfide.

Aprotic-nonpolar solvents are characterized by low relative permittivities (εr <15), low dipole moments (μ <2.5 D) and low ETN values (0.0-0.3; ETN = normalized values of the empirical parameters of the solvent polarity) , Aprotic-nonpolar solvents are lipophilic and hydrophobic. Van der Waals interactions prevail between their molecules.

The solvents combined under the term aprotic-polar or dipolar aprotic solvents have strongly polarizing functional groups and therefore show a certain permanent dipole moment, which is added to the now subordinate Vander-Waals interactions. Their solubility for polar substances is therefore usually better than that of the aprotic nonpolar solvents. Examples of aprotic polar solvents are ketones such as acetone, ethers, esters, N, N-disubstituted amides such as dimethylformamide, tertiary amines, pyridine, furan, thiophene, 1,1,1-trichloroethane, nitroalkanes such as nitromethane, nitriles such as acetonitrile, sulfoxides such as dimethylsulfoxide, Sulfones, hexamethylphosphoric triamide, liquid sulfur dioxide, selenoxychloride. These have large permittivities (εr> 15), dipole moments (μ> 2.5 D) and ETN values in the range of 0.3-0.5.

The aprotic solvent mixture which is used for the preparation according to the invention of the constitutive isomeric bisphosphites (1a) and (2a) is selected from organic nitrogen compounds, organic esters and aromatics.

In addition to the mixture, a complex mixture is claimed.

wobei M jeweils für ein Element steht ausgewählt aus: Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt und M zusätzliche Bindungen eingehen kann. Complex mixture of compounds of the formulas (1b) and (2b):

where each M is an element selected from: Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt and M can form additional bonds.

Here, Co, Rh, Ru, Ir, Fe are preferred; and Rh is particularly preferred.

In one embodiment, the complex mixture additionally comprises at least one of the compounds (1a) or (2a) which are not bound to the metal M.

The complex compounds of the formulas (1b) and (2b) according to the invention are formed in situ during the hydroformylation reaction.

wobei M jeweils für ein Element steht ausgewählt aus: Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt. In a particular embodiment of the invention, the complex compounds (1c) and (2c) are present as a mixture in addition to the constitution isomeric bisphosphites of the formulas (1a) and (2a),

wherein each M is an element selected from: Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt.

Here, Co, Rh, Ru, Ir, Fe are preferred; and Rh is particularly preferred and is disclosed as Compound (1ca) in 1 ,

In addition to the complex mixture, a composition comprising this is claimed.

• – ein zuvor beschriebenes Komplexgemisch,
• – eine weitere Komponente ausgewählt aus: Basen, organische Amine, Epoxide, Pufferlösungen, Ionenaustauscher.

Composition comprising:

• A previously described complex mixture,
• - Another component selected from: bases, organic amines, epoxides, buffer solutions, ion exchangers.

In US 4567306 . US 5364950 . US 5741942 and US 5763677 Examples of these further components are disclosed.

wobei Ra, Rb, Rc, Rd, Re und Rf gleiche oder unterschiedliche Kohlenwasserstoffreste, die auch untereinander verbunden sein können, sind. In a preferred embodiment, sterically hindered secondary amines compounds having the general formula (I) are used as further components,

wherein Ra, Rb, Rc, Rd, Re and Rf are identical or different hydrocarbon radicals, which may also be interconnected.

mit R gleich H, wie das 2,2,6,6-Tetramethylpiperidin selbst, einem organischen Rest R, einer Hydroxylgruppe oder einem Halogen. Der organische Rest R kann auch ein über ein Heteroatom, beispielsweise ein Sauerstoffatom, an die 2,2,6,6-Tetramethylpiperidin-Struktureinheit gebundener, organischer Rest sein. Insbesondere kann der organische Rest polymere Strukturen aufweisen oder ein 1 bis 50 Kohlenstoffatome und gegebenenfalls Heteroatome aufweisender organischer Rest sein. Besonders bevorzugt weist der organische Rest Carbonylgruppen, wie Keto-, Ester- oder Säureamid-Gruppen auf. Der organische, gegebenenfalls Heteroatome aufweisende Rest kann insbesondere ein substituierter oder unsubstituierter, aliphatischer, alicyclischer, aliphatisch-alicyclischer, heterocyclischer, aliphatisch-heterocyclischer, aromatischer, aromatisch-aromatischer oder aliphatisch-aromatischer Kohlenwasserstoffrest mit 1 bis 50 Kohlenstoffatomen sein, wobei die substituierten Kohlenwasserstoffreste Substituenten, ausgewählt aus primären, sekundären oder tertiären Alkylgruppen, alicyclischen Gruppen, aromatischen Gruppen, -N(R¹)₂, -NHR¹, -NH₂, Fluor, Chlor, Brom, Jod, -CN, -C(O)-R¹, -C(O)H oder -C(O)O-R¹, -CF₃, -O-R¹, -C(O)N-R¹, -OC(O)-R¹ und/oder -Si(R¹)₃, mit R gleich einem monovalenten, bevorzugt 1 bis 20 Kohlenstoffatome aufweisenden Kohlenwasserstoffrest, aufweisen können. Sind 1mehrere Kohlenwasserstoffreste R vorhanden, so können diese gleich oder unterschiedlich sein. Die Substituenten sind vorzugsweise beschränkt auf solche, die keinen Einfluss auf die Reaktion selbst haben. Besonders bevorzugte Substituenten können ausgewählt sein aus den Halogenen, wie z. B. Chlor, Brom oder Jod, den Alkylresten, wie z. B. Methyl, Ethyl, Propyl, iso-Propyl, Butyl, sec-Butyl, t-Butyl, neo-Pentyl, sec-Amyl, t-Amyl, iso-Octyl, t-Octyl, 2-Ethylhexyl, iso-Nonyl, iso-Decyl oder Octadecyl, den Arylresten, wie z. B. Phenyl, Naphthyl oder Anthracyl, den Alkylarylresten, wie z. B. Tolyl, Xylyl, Dimethylphenyl, Diethylphenyl, Trimethylphenyl, Triethylphenyl oder p-Alkylphenyl, den Aralkylresten, wie z. B. Benzyl oder Phenylethyl, den alicyclischen Resten, wie z. B. Cyclopentyl, Cyclohexyl, Cyclooctyl, Cyclohexylethyl oder 1-Methylcyclohexyl, den Alkoxyresten, wie z. B. Methoxy, Ethoxy, Propoxy, Butoxy oder Pentoxy, den Aryloxyresten, wie z. B. Phenoxy oder Naphthoxy, -OC(O)R¹ oder -C(O)R¹, wie z. B. Acetyl, Propionyl, Trimethylacetoxy, Triethylacetoxy oder Triphenylacetoxy, und den drei Kohlenwasserstoffreste aufweisenden Silylresten -Si(R¹)₃, wie z. B. Trimethylsilyl, Triethylsilyl oder Triphenylsilyl. Besonders bevorzugt sind Verbindungen der Formel IIa, die als Reste R solche aufweisen, die einen 2,2,6,6,-Tetramethylpiperidin-Rest und gegebenenfalls eine weitere -N(R¹)₂, -NHR¹ und/oder -NH₂ Gruppe enthalten.In a preferred embodiment, the organic amine has a structure according to formula (Ia):

where R is H, such as the 2,2,6,6-tetramethylpiperidine itself, an organic radical R, a hydroxyl group or a halogen. The organic radical R can also be an organic radical bonded via a heteroatom, for example an oxygen atom, to the 2,2,6,6-tetramethylpiperidine structural unit. In particular, the organic radical may have polymeric structures or be an organic radical having 1 to 50 carbon atoms and optionally heteroatoms. The organic radical particularly preferably has carbonyl groups, such as keto, ester or acid amide groups. The organic, optionally heteroatom-containing radical may be in particular a substituted or unsubstituted, aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic or aliphatic-aromatic hydrocarbon radical having 1 to 50 carbon atoms, wherein the substituted hydrocarbon radicals substituents selected from primary, secondary or tertiary alkyl groups, alicyclic groups, aromatic groups, -N (R ¹ ) ₂ , -NHR ¹ , -NH ₂ , fluoro, chloro, bromo, iodo, -CN, -C (O) -R ¹ , -C (O) H or -C (O) OR ¹ , -CF ₃ , -OR ¹ , -C (O) NR ¹ , -OC (O) -R ¹ and / or -Si (R ¹ ) ₃ , with R equal to a monovalent, preferably 1 to 20 carbon atoms having hydrocarbon radical may have. If 1 more hydrocarbon radicals R are present, they may be the same or different. The substituents are preferably limited to those which have no influence on the reaction itself. Particularly preferred substituents can be selected from the halogens, such as. As chlorine, bromine or iodine, the alkyl radicals, such as. Methyl, ethyl, propyl, iso -propyl, butyl, sec-butyl, t-butyl, neo-pentyl, sec-amyl, t-amyl, isooctyl, t-octyl, 2-ethylhexyl, iso-nonyl, iso-decyl or octadecyl, the aryl radicals, such as. As phenyl, naphthyl or anthracyl, the alkylaryl radicals, such as. For example, tolyl, xylyl, dimethylphenyl, diethylphenyl, trimethylphenyl, triethylphenyl or p-alkylphenyl, the aralkyl radicals, such as. B. benzyl or phenylethyl, the alicyclic radicals, such as. For example, cyclopentyl, cyclohexyl, cyclooctyl, cyclohexylethyl or 1-methylcyclohexyl, the alkoxy radicals, such as. For example, methoxy, ethoxy, propoxy, butoxy or pentoxy, the aryloxy, such as. Phenoxy or naphthoxy, -OC (O) R ¹ or -C (O) R ¹ , such as. As acetyl, propionyl, trimethylacetoxy, triethylacetoxy or triphenylacetoxy, and the three hydrocarbon radicals having silyl radicals -Si (R ¹ ) ₃ , such as. B. trimethylsilyl, triethylsilyl or triphenylsilyl. Particular preference is given to compounds of the formula IIa which have, as radicals R, those which contain a 2,2,6,6-tetramethylpiperidine radical and, if appropriate, another -N (R ¹ ) ₂ , -NHR ¹ and / or -NH ₂ Group included.

As secondary amines which have a structural unit of the formula (I) it is very particularly possible to use the compounds listed below having the structural formulas (Ib) to (Ig) or derivatives thereof.

It is also possible to use mixtures containing two or more sterically hindered amines.

The composition comprises a previously described mixture which comprises, in addition to the mixture, at least one amine having a 2,2,6,6-tetramethylpiperidine moiety.

In particular, in the process according to the invention, the amine having the formula (Ib), sebacic di-4- (2,2,6,6-tetramethylpiperidinyl) ester, is preferably used. A particularly preferred metal in the composition of the invention is rhodium.

Furthermore, a process for the hydroformylation of unsaturated compounds and their mixtures is claimed.

A particular advantage of the present invention resides in the use of the complex mixtures (1b) and (2b) described above, in particular (1c) and (2c), in the hydroformylation in that the use according to the invention of the constitutionally isomeric bisphophites instead of a pure isomer is complicated and eliminates costly separation of the constitutionally isomeric bisphosphites. The prior art expected a reduced reactivity and lower n / i selectivity due to the presence of the unbalanced constitution isomeric bisphosphite (1a), in particular its derivative (1ca). As disclosed in the subsequent hydroformylation experiments, the constitutionally isomeric bisphosphites (1a) and (2a) surprisingly have, in addition to high reactivities and n / i selectivities, a significantly longer service life compared with the bisphosphites known from the prior art.

• a) Vorlegen einer Verbindung nach den Formeln (1a) und (2a), (1b) und (2b) und/oder (1c) und (2c) oder einer Zusammensetzung enthaltend die Verbindungen der Formeln (1a) und (2a), (1b) und (2b) und (1c) und (2c) zusammen mit einer weiteren Komponente ausgewählt aus Basen, organischen Aminen, Epoxiden, Pufferlösungen, Ionenaustauschern;
• b) Einleiten eines Gasgemisches umfassend Kohlenmonoxid und Wasserstoff;
• c) Zugabe mindestens einer ungesättigten Verbindung oder eines Gemisches von ungesättigten Verbindungen.

The process according to the invention for the hydroformylation of an unsaturated compound or a mixture of unsaturated compounds comprises the steps:

• a) the preparation of a compound of the formulas (1a) and (2a), (1b) and (2b) and / or (1c) and (2c) or of a composition comprising the compounds of the formulas (1a) and (2a), ( 1b) and (2b) and (1c) and (2c) together with a further component selected from bases, organic amines, epoxides, buffer solutions, ion exchangers;
• b) introducing a gas mixture comprising carbon monoxide and hydrogen;
• c) adding at least one unsaturated compound or a mixture of unsaturated compounds.

The unsaturated compounds that are hydroformylated in the process of the present invention include hydrocarbon mixtures obtained in petrochemical processing plants. These include, for example, so-called C ₄ cuts. Typical compositions of C ₄ cuts from which most of the polyunsaturated hydrocarbons have been removed and which can be used in the process according to the invention are listed in the following Table 1 (see DE 10 2008 002188 ). Table 1:

Explanation:

• HCC ₄ : typical of a C ₄ mixture obtained from the C _{4 cut of} a high-severity steam after the hydrogenation of the 1,3-butadiene without additional moderation of the catalyst.
• HCC ₄ / SHP: composition HCC ₄ , in which residues of 1,3-butadiene were further reduced in a selective hydrogenation process / SHP.
• Raff. I (raffinate I): typical of a C ₄ mixture obtained from the C _{4 cut of} a high-severity steam separation plant after separation of the 1,3-butadiene, for example by NMP extractive rectification.
• - Raff. I / SHP: Composition Raff. I, in which residues of 1,3-butadiene were further reduced in a selective hydrogenation process / SHP.
• CC ₄ : typical composition of a C _{4 cut} obtained from a catalytic cracking unit.
• - CC ₄ / SHP: Composition of a C _{4 cut} in which residues of 1,3-butadiene were further reduced in a selective hydrogenation / SHP process.

• – Kohlenwasserstoffgemischen aus Dampfspaltanlagen;
• – Kohlenwasserstoffgemischen aus katalytisch betriebenen Spaltanlagen, wie z.B. FCC-Spaltanlagen;
• – Kohlenwasserstoffgemischen aus Oligomerisierungsprozessen in homogener Phase sowie heterogenen Phasen, wie z.B. dem OCTOL-, DIMERSOL.-, Fischer-Tropsch-, Polygas-, CatPoly-, InAlk-, Polynaphtha-, Selectopol-, MOGD-, COD-, EMOGAS-, NExOCTANE- oder SHOP-Prozess;
• – Kohlenwasserstoffgemischen umfassend mehrfach ungesättigte Verbindungen;
• – ungesättigten Carbonsäurederivaten.

In a variant of the process, the unsaturated compound or its mixture is selected from:

• - Hydrocarbon mixtures from steam cracking plants;
• - Hydrocarbon mixtures from catalytically operated cleavage systems, such as FCC slitting plants;
• Hydrocarbon mixtures from oligomerization processes in homogeneous phase and heterogeneous phases, such as the OCTOL, DIMERSOL., Fischer-Tropsch, Polygas, CatPoly, InAlk, Polynaphtha, Selectopol, MOGD, COD, EMOGAS, NExOCTANE or SHOP process;
• - Hydrocarbon mixtures comprising polyunsaturated compounds;
• - unsaturated carboxylic acid derivatives.

In a variant of the process, the mixture comprises unsaturated compounds having 2 to 30 carbon atoms.

In a particular variant of the process, the mixture has unsaturated compounds having 2 to 8 carbon atoms.

In a further variant of the process, the mixture has polyunsaturated hydrocarbons. In a particular embodiment, the mixture comprises butadienes.

The unsaturated compounds which are hydroformylated in the process of the invention further comprise unsaturated carboxylic acid derivatives. In a particular embodiment, these unsaturated carboxylic acid derivatives are selected from fatty acid esters.

The implementation of the method according to the invention takes place in different embodiments, which are disclosed in detail in the examples.

In addition to a gas mixture consisting of carbon monoxide and hydrogen, the multiphase reaction mixture according to the invention comprises at least one unsaturated compound as disclosed above and comprises, in addition to hydrocarbon mixtures derived from steam cracking, catalytically operated cracking or oligomerization processes or other sources of monounsaturated and / or polyunsaturated Carbon compounds or unsaturated carboxylic acid derivatives include at least one hydroformylation product of these unsaturated compounds as listed in the examples below and the particular composition used as previously disclosed.

Description of Figures: Calculation of Complex Compound (1ca)

The complex compounds of the formulas (1c) and (2c) according to the invention are formed in situ during the hydroformylation reaction.

In a particular embodiment of the invention, the complex compounds (1c) and (2c) are present in addition to the unbound constitutive isomeric bisphosphites (1a) and (2a).

The characterization of the hydridocarbonyl complex of the ligand (1a) with rhodium as the metal of the compound (1ca) according to the invention was carried out by means of theoretical calculations. The result is in the 1 shown in the appendix.

The structure calculation was performed with the BP86 functional and the def SV (P) basis set. The structure calculations for the model structures were carried out with the Turbomole program package ( R. Ahlrichs, M. Baer, M. Häser, H. Horn, C. Kölmel, Chem. Phys. Lett., 1989, 162, 16; TURBOMOLE V6.3 2011, a development of University of Karlsruhe and Research Center Karlsruhe GmbH, 1989-2007, TURBOMOLE GmbH, since 2007. http://www.turbomole.com ) based on density functional theory (DFT). The BP86 functional was used ( SH Vosko, L. Wilk, M. Nusair, Can. J. Phys. , 1980, 58, 1200; AD Becke, Phys. Rev. A, 1988, 38, 3098; J. Perdew, Phys. Rev. B, 1986, 33, 8822 ) and the def SV (P) base rate ( A. Schäfer, H. Horn and R. Ahlrichs, J. Chem. Phys., 1992, 97, 2571 ).

2 in the appendix provides all calculated coordinates, distances and angles of the connection (1ca).

Examples

General reaction equation

Abbreviations:

VE water

= demineralized water

KPG

= Core-drawn precision glassware

ACN

= Acetonitrile

EtOAc

= Ethyl acetate

DMAB

= Dimethylaminobutane

NMP

= N-methylpyrrolidone

public transport

= Oil vacuum

acac

= acetylacetonate

NEt ₃

= Triethylamine

TIPB

= 1,2,4,5-tetraisopropylbenzene

Synthesis of 2,2'-bis (3,5-dimethylphenol) (4)

The biphenol (4) used as precursor was prepared according to the following synthesis instructions.

In a 500 ml Schlenk with KPG stirrer, intermediate attachment and glass stirrer were 1.42 g (0.005 mol) of iron (II) sulfate heptahydrate and 12.35 g (0.1 mol) of 2,4-dimethylphenol in 150 ml of deionized water and 5 ml of cyclohexane and heated to 40 ° C. 25.36 g (0.146 mol) of sodium peroxodisulfate in 80 ml of demineralized water were dissolved in a 100 ml beaker. To start the reaction, a small portion of Na ₂ S ₂ O ₈ solution was added to the phenol. Subsequently, a smaller portion of the solution was added every 10 minutes. After 30 minutes, the Na ₂ S ₂ O ₈ solution was added. After a reaction time of 5 h, 300 ml of cyclohexane and 200 ml of water were added to the reaction solution, left stirring for 20 min, then warm into the separating funnel transferred. The organic phase was separated and concentrated to dryness. The product could be obtained in 69% yield (10.6 g).

All subsequent preparations were performed with standard Schlenk technique under inert gas. The solvents were dried before use over suitable desiccants ( Purification of Laboratory Chemicals, WLF Armarego (Author), Christina Chai (Author), Butterworth Heinemann (Elsevier), 6th Edition, Oxford 2009 ). The product was characterized by NMR spectroscopy (Bruker Avance 500 MHz FT-NMR spectrometer). Chemical shifts (δ) are reported in ppm. Referencing of the P NMR signals was according to: SR _31P = SR _1H * (BF _31P / BF _1H ) = SR _1H x 0.4048. ( Robin K. Harris, Edwin D. Becker, Sonia M. Cabral de Menezes, Robin Goodfellow, and Pierre Granger, Pure Appl. Chem., 2001, 73, 1795-1818 ; Robin K. Harris, Edwin D. Becker, Sonia M. Cabral de Menezes, Pierre Granger, Roy E. Hoffman and Kurt W. Zilm, Pure Appl. Chem., 2008, 80, 59-84 ). By P-NMR, the quantitative ratio of the two ligands (ligand (1a) and ligand (2a)) was determined to each other. The asymmetric ligand (1a) is characterized by two phosphorus signals in the range of (δ) = 140.6 ppm to (δ) = 142.8 ppm, whereas for the symmetric ligand (2a) only one phosphorus signal in the range (δ) = 139 , 1 ppm to (δ) = 139.8 ppm. Synthesis of 2,2'-bis- (3,5-dimethylphenol) chlorophosphite (5)

In a seked 2 L Schlenk with magnetic stirrer 440 ml (692.56 g) of phosphorus trichloride were submitted. In a second filtered 1 L Schlenk, 120 g of 2,2'-bis (3,5-dimethylphenol) were weighed and added with stirring to 500 ml of dried toluene. The biphenol-toluene suspension was dosed within 4 h at 63 ° C to the phosphorus trichloride. After complete addition, the reaction mixture was stirred overnight at temperature. The next morning, the solution was concentrated in the heat (45 ° C) and the product could be obtained in 96.5% yield (153 g). ³¹ P-NMR: 175.59 (94.8% 2,2'-bis (3,5-dimethylphenol) chlorophosphite), 4.4% various PCl compounds, 0.8% PH compound.

Synthesis variants according to the invention for the preparation of the isomer mixture consisting of the ligands (1a) and (2a):

Variant 1: ACN / NEt ₃

In a 1000 ml Schlenk 38.75 g (0.121 mol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite dissolved in 150 ml of degassed ACN under inert gas and heated to 35 ° C. In a second Schlenk (500 ml) were added 20.1 g (0.056 mol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol dissolved in 150 ml of degassed ACN and treated while stirring with 40.9 ml of degassed triethylamine (0.29 mol). Then, the biphenol / triethylamine solution was slowly dropped to the chlorophosphite solution. After an after-reaction time of 1 h, the reaction solution was stirred overnight at 45.degree. The solution was then filtered and the solid was washed three times with 100 ml of warm (45 ° C) ACN. The target product could be obtained as a white solid (43.3 g, 86%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.5 and 140.9 (95.4%) 139.2 (4.6%).

Variant 2: EtOAc / NEt ₃

7.3 g (21.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 15 ml of degassed ethyl acetate in a 100 ml Schlenk under protective gas and heated to 35.degree. In a second Schlenk (100 ml), 3.9 g (9.5 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 'diol dissolved in 7.0 ml NEt ₃ . Subsequently, the biphenol / triethylamine solution was dropped slowly over 20 minutes to the chlorophosphite solution. The solution was stirred for a further hour at 35 ° C and then at 45 ° C overnight. The next day the solution was filtered and the solid washed three times with ACN. The target product could be obtained as a white solid (6.7 g, 78%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.5 and 140.9 (91.3%), 139.5 (8.7%).

Variant 3: EtOAc / pyridine

10.07 g (31.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 20 ml of degassed ethyl acetate in a 250 ml Schlenk under protective gas and heated to 45.degree. In a second Schlenk (50 mL) was added 5.54 g (15 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol dissolved in 26 ml of ethyl acetate and 5.2 ml of degassed pyridine. Subsequently, the biphenol / pyridine solution was slowly dropped to the chlorophosphite solution within 30 minutes. The solution was stirred overnight at 45 ° C. The next day the solution was filtered and the solid washed with ACN. The target product could be obtained as a white solid (4.2 g, 31%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (100%).

Variant 4: ACN / DMAB (dimethylaminobutane)

6 g (19.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 20 ml of degassed ACN under protective gas in a 100 ml Schlenk and heated to 35 ° C. In a second Schlenk (50 ml), 3.4 g (9.0 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 15 ml of dimethylaminobutane (DMAB) and then added dropwise slowly to the chlorophosphite solution. The reaction was allowed to stir at 35 ° C overnight. The next day the solution was filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (5.3 g, 66%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.8 and 141.2 (97.5%), 139.4 (2.5%).

Variant 5: ACN / NMP (N-methylpyrrolidone)

6 g (19.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 20 ml of degassed ACN under protective gas in a 100 ml Schlenk and heated to 35 ° C. In a second Schlenk (50 ml), 3.4 g (9.0 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 9.4 ml of N-methylpyrrolidione (NMP) and slowly added dropwise to the chlorophosphite solution. The reaction was allowed to stir at 35 ° C overnight. The solution was then filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (3.4 g, 42%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.0 (96.1%), 139.8 (3.9%).

Variant 6: ACN / diisopropylethylamine

Under a protective gas, 19.4 g (61.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were suspended in 75 ml of degassed ACN in a 500 ml Schlenk flask. In a second Schlenk (250 ml), 10.5 g (28.5 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 'diol suspended in 75 ml of acetonitrile and 39 ml of diisopropylamine and added slowly to the chlorophosphite solution. The reaction was allowed to stir overnight. The solution was then filtered and the solid washed three times with ACN. The target product could as a white solid (14.6 g, 57%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (76.8%), 139.1 (23.2%).

Variant 7: toluene / dimethylaminobutane (DMAB)

7.7 g (24.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 15 ml of degassed toluene under protective gas in a 100 ml Schlenk tube and heated to 35.degree. In a second Schlenk (50 ml), 3.4 g (9.0 mol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 15 ml of dimethylaminobutane (DMAB) and slowly added dropwise to the chlorophosphite solution. The reaction was allowed to stir at 45 ° C for 4 days. Subsequently, after further addition of 120 ml of toluene, the solution was heated to 75 ° C. for 30 minutes. The solution was then filtered, the filtrate was concentrated to dryness and dried. The target product could be obtained as a white solid (7.2g, 88%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.5 and 140.9 (91.4%), 139.2 (23.2%).

Variant 8: Amine Amount Variation (ACN / NEt ₃ )

• A: 17.81 g (0.073 mol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite in 60 ml degassed ACN were added under protective gas in a 500 ml Schlenk flask and heated to 35 ° C. In a second Schlenk (250 mL) was added 9.91 g (0.0276 mol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 60 ml of degassed ACN and treated with stirring with 38.4 ml of degassed triethylamine. This biphenol / triethylamine solution was then dripped slowly to the chlorophosphite solution. After an after-reaction time of 1 h, the reaction solution was stirred overnight at 35.degree. The solution was then filtered and the solid washed with ACN. The target product could be obtained as a white solid (27.8 g, 86%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.8 and 141.2 (91.6%), 139.4 (8.4%).
• B: 1.57 g (5.1 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite in 7 ml of degassed ACN were added under protective gas in a 250 ml Schlenk flask and heated to 35 ° C. In a second Schlenk (100 ml), 0.932 g (2.6 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol Dissolved in 9 ml of degassed ACN and treated with stirring with 2.09 ml of degassed triethylamine. Then, the biphenol / triethylamine solution was slowly dropped to the chlorophosphite solution. After an after-reaction time of 1 h, the reaction solution was stirred overnight at 35.degree. The solution was then filtered and the solid washed with ACN. The target product could be obtained as a white solid in 40% yield. ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.8 and 141.8 (92.4%), 139.3 (7.6%).

Variant 9: Shorter reaction times

A (8 hours): EtOAc / NEt ₃

8 g (25.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 20 ml of degassed ethyl acetate in a 100 ml Schlenk under protective gas and heated to 45.degree. In a second Schlenk (50 ml), 4.48 g (12.5 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 'diol suspended in 20 ml of ethyl acetate and 8.0 ml of NEt ₃ . Subsequently, the biphenol / triethylamine suspension was dropped slowly over 30 minutes to the chlorophosphite solution. The solution was stirred at 45 ° C for eight hours.

Subsequently, the solution was filtered. The target product could be obtained as a white solid (12.26 g, 84.7%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (88.1), 139.1 (11.9).

B (4 hours): EtOAc / NEt ₃

10.07 g (31.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 20 ml of degassed ethyl acetate in a 100 ml Schlenk under protective gas and heated to 45.degree. In a second Schlenk (50 mL) was added 5.54 g (15 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol suspended in 26 ml ethyl acetate and 9.0 ml NEt ₃ . Subsequently, the biphenol / triethylamine suspension was dropped slowly over 30 minutes to the chlorophosphite solution. The solution was stirred at 45 ° C for four hours. The solution was then filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (6.4 g, 47%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (99.3%), 139.1 (0.7%).

C (4 hours): ACN / pyridine

In a 250 ml Schlenk 10 g (31.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite was dissolved in 40 ml of degassed ACN under inert gas and heated to 45 ° C. In a second Schlenk (50 mL), 5.5 g (15.0 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 'diol dissolved in 40 ml of ACN and 8.8 ml of pyridine. Then, the resulting clear biphenol / pyridine solution was slowly dropped to the chlorophosphite solution in 30 minutes. After a reaction time of 4 hours, the solution was filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (8.5 g, 63%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (98.4%), 139.4 (1.6%).

Variant 10: Cryogenic tests (ACN / NEt ₃ )

• A: In a 250 ml Schlenk 8.0 g (0.025 mol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite was dissolved in 30 ml of degassed ACN under protective gas and cooled to -40 ° C. In a second Schlenk (100 ml), 4.32 g (0.012 mol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol Dissolved in 30 ml of degassed ACN and treated with stirring with 8.5 ml of degassed triethylamine. Then, the biphenol / triethylamine solution was slowly dropped to the chlorophosphite solution. After a post-reaction time of 1 h, the reaction solution was slowly brought to room temperature overnight. The solution was then filtered and the solid washed with cold ACN. The target product could be obtained as a white solid (8.9 g, 82%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.5 and 140.9 (98.4%), 139.4 (1.6%).

Variant 11: Carrying out at different reaction temperatures (ACN / pyridine)

• A: 9.4 g (28.8 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite were dissolved in 100 ml of degassed ACN under protective gas in a 250 ml Schlenk flask. In a second Schlenk (100 mL), 5.0 g (14.4 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 8.8 ml of pyridine. Then, the biphenol / pyridine solution was slowly dropped to the chlorophosphite solution within 1.5 hours. The solution was stirred at room temperature for a further 2 hours and then at 60 ° C. overnight. The solution was then filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (9.5 g, 73%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.8 and 141.2 (90%), 139.5 (10%).
• B: In a 250 ml Schlenk 10 g (31.0 mmol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite was dissolved in 40 ml of degassed ACN under inert gas and heated to 45 ° C. In a second Schlenk (50 mL), 5.5 g (15.0 mmol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2 Dissolved diol in 40 ml of ACN and 8.8 ml of pyridine. Then, the resulting clear biphenol / pyridine solution was slowly dropped to the chlorophosphite solution in 30 minutes. The solution was stirred overnight at 45 ° C. The next morning the solution was filtered and the solid was washed twice with ACN. The target product could be obtained as a white solid (9.5 g, 72%). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1. (89.9%), 139.1 (10.1%).

Comparative Example Variant 12: "one-pot synthesis", not according to the invention

In a seked 250 ml Schlenk were 8.45 g (0.0335 mol) of 2,2'-bis (3,5-dimethylphenol) and 5.95 g (0.0166 mol) of 3,3'-di-tert .-Butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'diol and suspended with stirring in 50 ml of dried toluene. Then, 7.1 g (0.051 mol) of phosphorus trichloride and 0.1 ml (0.001 mol) of pyridine were successively added to the suspension at 0 ° C, and this suspension was brought to RT within 60 minutes. The reaction mixture was then warmed to 35 ° C and stirred at this temperature overnight. In the morning, the excess phosphorus trichloride and the solvent were removed by RT at room temperature. Subsequently, with stirring, 25 ml of degassed ACN was added and the solution cooled to 0 ° C. In a second Schlenk (50 ml) 25 ml of degassed ACN were introduced and added with stirring 10.2 g = 14 ml (0.1 mol) of triethylamine. The resulting solution was within 45 min. dropped into the cooled reaction mixture. The mixture was then warmed to RT with stirring overnight. In the morning, the solid was filtered off, followed by rinsing with 2 x 25 ml of degassed ACN. The desired target product could be obtained in 77% yield (13 g). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.2 and 141.1 (96.4%), 139.2 (3.6%).

Influence of the base / base mixture

General Synthesis Instructions

In a 1000 ml Schlenk 38.75 g (0.121 mol) of 2,2'-bis (3,5-dimethylphenyl) chlorophosphite dissolved in 150 ml of degassed ACN under inert gas and heated to 45 ° C. In a second Schlenk (500 ml) were added 20.1 g (0.056 mol) of 3,3'-di-tert-butyl-5,5'-dimethoxy- [1,1'-biphenyl] -2,2'-diol dissolved in 150 ml of degassed ACN and added with stirring with the appropriate base (the amount used is based on the chlorophosphite). Then, the biphenol / base solution was slowly dropped to the chlorophosphite solution. After an after-reaction time of 1 h, the reaction solution was stirred overnight at 45.degree. (Other temperatures or reaction times are given in Tables.) The solution was then filtered and the solid washed with 100 mL of warm (45 ° C) ACN. Compound 1a could be obtained as a white solid (% yield). ³¹ P-NMR (202.4 MHz, toluene-d ₈ ): 142.5 and 140.9 (ligand 1a in%), 139.2 (ligand 2a in%).

Synthesis Route:

A) pyridine and derivatives

Table 2:

As can be clearly seen in Table 2, it is possible to control the isomer distribution of the two constitutional isomers (1a) and (2a) by the choice of the base or the corresponding amount of base. Thus, for example, it is possible to obtain a 1: 1 mixture of the two isomers (1a) and (2a) by using DMAP as the base at lower temperatures.

B) different alkylamines

Table 3: Equivalent base base Share 1a in [% by mass] Share 2a in [% by mass] Yield in [%] 2.2 NEt3 95.4 4.6 86 2.3 DMAB 97.4 2.6 86 2.2 tributylamine 94.4 5.6 90 2 tripentylamine 96.0 4.0 nb 2 trihexylamine 97.8 2.2 94 NEt ₃ : triethylamine
DMAB: dimethylaminobutane
nb: not determined

As can be clearly seen in Table 3, it is possible by the choice of trialkylamines as base to obtain an isomeric mixture in which the asymmetric isomer (1a) with a purity of> 90% is the main component and the symmetrical isomer (2a) the corresponding Represents secondary component.

C) different base mixtures

Table 4: bases relationship Share 1a in [% by mass] Share 2a in [% by mass] Yield in [%] Pyr / NEt ₃ 4: 1 78.2 21.8 56 Pyr / NEt ₃ 4: 0.5 59.6 40.4 87 Pyr / NEt ₃ 4: 0.25 59.7 40.3 80 Pyr / NEt ₃ 3: 0.5 62.4 37.6 81 Pyr / NEt ₃ 2: 0.5 69.1 30.9 84 Pyr / NBu ₃ 2: 0.5 72.4 27.6 78 Pyr / NBu ₃ 2: 0.25 47.9 52.1 81 Pyr / NBu ₃ 2: 2 91.8 8.2 83 Pyr / NBu ₃ 2.5: 0.2 81.0 19.0 80 Pyr / NBu ₃ 2.5: 2 92.6 7.4 69 NBu ₃ : triethylamine
DMAP: dimethylaminopyridine
Pyr: Pyridine

As clearly seen in Table 4, it is possible to control the isomer distribution of the two constitutional isomers (1a) and (2a) through the use of base mixtures and their corresponding base amount. It is thus possible to influence the isomer distribution of the two constitutional isomers (1a) and (2a) by the choice of the base or base mixture used such that an isomer is present as the main component. By the choice of trialkylamines as the base, it is possible to obtain an isomeric mixture in which the asymmetric isomer (1a) with a purity of> 90% is present as the main component and the symmetrical isomer (2a) represents the corresponding secondary component. Since this mixture also shows a very good overall performance in the hydroformylation, further purification steps can be dispensed with.

Working instructions for the catalysis tests of the isomer mixtures

Experiment description - general

The experiments were carried out in 100 ml autoclave from Parr Instrument. The autoclaves are equipped with electric heating. The pressure is maintained by means of mass flow meter and pressure regulator. During the test period, a precisely defined quantity of starting material can be injected under reaction conditions via a syringe pump. Using capillary tubes and HPLC valves, samples can be drawn during the experimental period and analyzed by both GC and LC-MS analysis.

• [a] Bedingungen: cis-2-Buten, Rh(acac)(CO)₂ ([Rh]= 95 ppm), L/Rh = 6:1, 40 ml Toluol, Verbindung (Ib), 120°C, 20 bar CO/H₂ (1:1), 1,2,4,5-Tetra-isopropyl-benzol als internen GC-Standard.
• [b] GC-Analyse mit 1,2,4,5-Tetra-isopropyl-benzol als internen GC-Standard.
  
  weitere Nebenkomponenten u.a. nicht umgesetztes Chlorophosphit in größeren Mengen enthalten. Die gewünschte Zusammensetzung aus den beiden Liganden (1a) und (2a) ist nur in einer Reinheit von 30% in einem Gemisch mit anderen Komponenten/Verunreinigungen enthalten.

Inventive Results of Testing Various Mixtures of Constitutional Bisphosphites Consisting of Ligands (1a) and (2a) in Hydroformylation ^[a] : TABLE 5

• [a] Conditions: cis-2-butene, Rh (acac) (CO) ₂ ([Rh] = 95 ppm), L / Rh = 6: 1, 40 ml toluene, compound (Ib), 120 ° C, 20 bar CO / H ₂ (1: 1), 1,2,4,5-tetra-isopropylbenzene as internal GC standard.
• [b] GC analysis with 1,2,4,5-tetra-isopropylbenzene as internal GC standard.
  
  other minor components include unreacted chlorophosphite in larger quantities. The desired composition of the two ligands (1a) and (2a) is contained only in a purity of 30% in a mixture with other components / impurities.

A comparison of the different ligand mixtures of the ligands (1a) and (2a) (Table 5, entries 2-6) with the hydroformylation result of the pure ligand (1a) (Table 5, entry 1) shows that the mixtures have very good pentanal selectivities and yields. Even with the use of a ligand mixture in which the ligand (1a) is contained only in a purity of about 30% (Table 5, entry 7) could still be generated a very good yield and selectivity. By using this mixture of constitutive isomeric bisphosphites consisting of ligand (1a) and (2a), the technical problem could thus be completely fulfilled and the corresponding aldehydes are obtained in good to very good selectivities and yields.

Experiment description - long-term trial

The Rh precursor (Rh (acac) (CO) ₂ ) (acac = acetylacetonate) and the ligand are introduced into 40 ml of isononyl benzoate in an autoclave. The Rh concentration is 100 ppm based on the total reaction mass used. The excess ligand is molar 4: 1 based on rhodium. As a further component, the compound (Ib) is added as amine in a ratio of 2: 1 to the ligand. As a GC standard, 0.5 g of 1,2,4,5-tetraisopropylbenzene is added. Reaction temperature is 120 ° C. The reaction pressure is 20 bar synthesis gas (H ₂ : CO = 50:50 vol%).

As olefin, 4 ml of cis-2-butene were metered in at intervals of about 1 day with the syringe pump. GC samples were taken at 1, 2, 4 hours and before the next dose. The following ligands were tested for stability:

sowie eine Mischung aus Ligand (7) und Ligand (8) (³¹P-NMR bestimmtes Mengenverhältnis: L7 = 75% + L8 = 25%)

Further, a mixture of constitution isomeric bisphosphites consisting of the ligands (1a) and (2a) ( ³¹ P-NMR specific ratio: L1a = 91% + L2a = 9%) was investigated.

and a mixture of ligand (7) and ligand (8) ( ³¹ P-NMR specific quantitative ratio: L7 = 75% + L8 = 25%)

Results - long term trials

The relative activities are determined by the ratio of k 1st order to k0, ie the k value at time 0 of the reaction (reaction start), and describe the relative decrease in activity during the experimental period. The 1st order k values are obtained from a plot of (-ln (1-turnover)) versus time. Table 6:

Conclusion: The activity decrease of the catalyst with the ligands biphephos and ligand (7) is (Table 6, entries 1-4, 16-19) significantly stronger than with the ligand (1a). It is noteworthy that the relative activity of ligand (1a) after almost twice the reaction time (Table 6, entry 11) is still more than twice that of the other two ligands after half the reaction time (Table 6, entries 4 and 19) ) with still very good n / i selectivities.

If the mixture of constitution isomeric bisphosphites consisting of the ligands (1a) and (2a) and the pure ligand (1a) (Table 6, entries 8-11, 12-15) is compared, the mixture exhibits a comparable after 117 hours of runtime Activity and selectivity as the pure ligand (1a). Both the pure ligand (1a) and the mixture of constitution isomeric bisphosphites consisting of the ligands (1a) and (2a) are thus characterized by an excellent service life. The mixture of constitutional isomers Bisphosphites, consisting of the ligands (7) and (8), shows from the outset a significantly poorer selectivity than the pure ligand (7) as well as the mixture of constitution isomeric bisphosphites consisting of the ligands (1a) and (2a), ( Table 6, entries 5-7, 12-15 and 16-19).

Addition of the unsymmetrical ligand (8) to the symmetric ligand (7) leads to a drastic decrease in selectivity (Table 6, entries 5-7).

This corresponds to the results of the prior art (see Rhodium catalyzed hydroformylation, ed. By PWNM van Leeuwen et C. Claver, Kluwer Academic Publishers 2006, AA Dordrecht, NL, pp. 45-46 ). ). In contrast, the unsymmetrical ligand (1a), both as a pure substance and in the mixture with the ligand (2a) (Table 6, entries 8-11, 12-15) completely surprisingly characterized by excellent service life as well as very good selectivities , Furthermore, it was possible to show that mixtures of constitutionally isomeric ligands (1a) and (2a) can be used directly from the synthesis without additional complicated purification processes and solve the technical problem.

Examples of time trials

Example L1: Hydroformylation with the non-inventive ligand (100) over 1200 h (Comparative Example 1)

The out EP2280920B1 Known non-inventive ligand of the formula (100) was used in the hydroformylation of a butene / butane mixture.

In this case, ligand (100) was stabilized with the amine of formula (Ib).

The continuously operated pilot plant consisted essentially of a 20 liter pressure reactor with a downstream condenser and phase separation vessel (gas / liquid) for the gas phase originating from the reactor and a recycle gas compressor, which returns the gas phase from the phase separation vessel back down into the reaction zone. A part of this cycle gas is driven out of the reaction system after the phase separation as exhaust gas. In order to realize an optimal gas distribution in the reactor system, a gas distributor ring with holes was installed here. About installed heating and cooling devices, the reactor could be tempered. Prior to hydroformylation, the system was purged with nitrogen free of oxygen. Subsequently, the reactor was filled with 12 liters of catalyst solution. This catalyst solution consisted of 12 kg of a eutectic mixture from biphenyl and diphenyl ether (Diphyl ^® , heat transfer oil Fa. Lanxess), 3 g of Rh (acac) (CO) ₂ , 36 g of bisphosphite ligand of formula (100), 67.5 g of amine of formula (Ib) together and was previously in mixed in a container. The eutectic mixture of biphenyl and diphenyl ether (Diphyl ^®) has been previously stripped with nitrogen to remove oxygen and water from the heat transfer oil. Subsequently, the reactor system was purged with synthesis gas free of nitrogen. After the nitrogen content had fallen below 10% by volume, the reactor system was pressurized with syngas to 1.0 MPa and then heated to 120 ° C. After reaching the operating temperature, the reactor system was brought to 1.7 MPa reaction pressure with synthesis gas. Then the addition of the starting materials was started. For this purpose, a feed mixture was run over an evaporator in order to drive it in gaseous form into the cycle gas. The feed mixture was a mixture of 35% by weight of 2-butenes and 1-butene in a concentration of about 1%. The rest was n-butane. The following throughputs were set: 0.3 kg / h feed, 75 Nl / h synthesis gas (50 vol% H ₂ and 50 vol% CO) For the daily dosage of the bisphosphite ligand (100) and amine (Ib) was a 1.4% Solution of the bisphosphite ligand (100) in n-pentanal, which was previously freed by stripping with nitrogen of residual C ₄ hydrocarbons (<3%). The amine (Ib) was used in a three-fold molar excess to the bisphosphite ligand (100). To better stabilize this solution, the amine (Ib) was added to the solution before the bisphosphite ligand (100). After about 1000 h, a stationary state was reached. The reaction products were continuously removed from the reactor via the circulating gas stream and partially condensed out in the condenser at 50 ° C. The condensed phase was continuously driven out of the phase separation vessel. To determine the sales, samples were taken from the recycle gas before and after the reactor. By daily dosing of the ligand solution described above, the conversion and regioselectivity could be kept constant.

To determine the reactor contents, samples were taken from the reactor and analyzed by liquid chromatography (HLPC). Butene conversions of around 65 to 70% were achieved under the chosen reaction conditions. The percent distribution between n-pentanal and 2-methylbutanal, or the n / iso selectivity, was 95% to 5%. In the stationary phase of the experiment, no rhodium degradation was recorded.

The yield of C ₅ -aldehydes over the experimental period is in 3 applied.

3 : Pentanal Yield to Example L1 After 1200 h, the reactor was decompressed and the catalyst solution was investigated. The reactor showed a precipitate. An analysis of this precipitate showed that this consisted of phosphorus-containing secondary products of bisphosphite ligand (100) and the amine used (Ib). There were no caking of these precipitates found in the reactor. Part of the reactor contents was, after separation of the precipitate, at 1.2 KPa abs. and 220 ° C bottom temperature is reduced to 13% based on the feed. The resulting bottoms residue was still fluid and no precipitate was detected. Rhodium analysis showed that all of the rhodium from the feed was in this bottoms residue.

Example L2: Hydroformylation with the Ligand (100) Not According to the Invention over 8000 h (Comparative Example 2)

The experiment was carried out in the pilot plant described in Example L1. The preparation of the experiment and the implementation took place analogously to example L1. In this example, the catalyst solution was composed of 12 kg of isononyl benzoate, 4.5 g of Rh (acac) (CO) ₂ , 55 g of bisphosphite ligand of formula (100), 67.5 g of amine of formula (Ib). The isononyl benzoate was also previously stripped with nitrogen to remove oxygen and water from the solvent. Subsequently, the reactor system was purged with synthesis gas free of nitrogen. After the nitrogen content had fallen below 10% by volume, the reactor system was pressurized with syngas to 1.0 MPa and then heated to 120 ° C. After reaching the operating temperature, the reactor system was brought to 1.7 MPa reaction pressure with synthesis gas.

Subsequently, the addition of the starting materials was started. For this purpose, a feed mixture was run over an evaporator in order to drive it in gaseous form into the cycle gas. The feed mixture was a mixture of 35% by weight of 2-butenes and 1-butene in a concentration of about 1%. The rest was n-butane. The following throughputs were set: 0.3 kg / h feed mixture, 75 Nl / h synthesis gas (50% by volume H ₂ and 50% by volume CO). For daily dosing of the bisphosphite ligand (100) and amine (Ib), a 1.4% solution of the bisphosphite ligand (100) in n-pentanal was prepared, which previously had been stripped with nitrogen from residual C ₄ -hydrocarbons (<3%). ) was freed. The amine (Ib) was used in a three-fold molar excess to the bisphosphite ligand (100). To better stabilize this solution, the amine (Ib) was added to the solution before the bisphosphite ligand (100). As in Example L1, a steady state was reached after about 1000 hours. The reaction products were continuously from the circulating gas stream removed from the reactor and partially condensed in the condenser at 50 ° C. The condensed phase was continuously driven out of the phase separation vessel. To determine the sales, samples were taken from the recycle gas before and after the reactor. By daily dosing of the ligand solution described above, the conversion and regioselectivity could be kept constant. To determine the reactor contents, samples were taken from the reactor and analyzed by liquid chromatography (HLPC). Butene conversions of around 65 to 70% were achieved under the chosen reaction conditions. The percent distribution between n-pentanal and 2-methylbutanal, or the n / iso selectivity, was 95% to 5%. In the stationary phase of the experiment, no rhodium degradation was recorded.

The yield of C ₅ -aldehydes over the experimental period is in 4 applied.

4 : Pentanal Yield to Example L2 After 1500 h, first precipitates appeared in the samples from the reactor. The analysis of these precipitates showed that, as in Example L1, it consisted of phosphorus-containing secondary products of the bisphosphite ligand (100) and the amine used (Ib). The reaction was operated for a total of 8100 hours, the rhodium losses by sampling were compensated by adding appropriate amounts of Rh (acac) (CO) ₂ in the daily ligand dosing.

In the course of about 7000 h, a decrease in activity was observed in the reaction and the reaction solution was prone to foaming. The process could not be operated and the attempt had to be stopped. After the end of the reaction, the reactor was depressurized and the reaction mixture was examined. There were large amounts of solid. 250 ml of the reaction solution were stirred for 4 h under N ₂ atomic phase at 40 ° C and then measured the viscosity of the residue. The viscosity was 300 mPas.

Example L3: Hydroformylation with Inventive Catalyst System

The same pilot plant was used as in Example L3. The same feed mixture and the same synthesis gas were used. As a ligand, however, a mixture of the two bisphosphite ligands (1a) and (2a) was used. The out EP2280920B1 known ligand of formula (100) was not included in the reaction mixture. The same amine (Ib) as in Comparative Example 1 (L1) was used as the stabilizer. The solvent used was isononyl benzoate. Prior to hydroformylation, the system was purged with nitrogen free of oxygen. Subsequently, the reactor was filled with 12 liters of catalyst solution. This catalyst solution was composed of 12 kg of isononyl benzoate, 4.5 g of Rh (acac) (CO) 2, 63 g of ligand isomer mixture of formulas (1a) and (2a), 200 g of amine of formula (Ib) and was previously mixed in a container , The isononyl benzoate was previously stripped with nitrogen to remove oxygen and water from the solvent. Subsequently, the reactor system was purged with synthesis gas free of nitrogen. After the nitrogen content had fallen below 10% by volume, the reactor system was pressurized with syngas to 1.0 MPa and then heated to 120 ° C. After reaching the operating temperature, the reactor system was brought to 1.7 MPa reaction pressure with synthesis gas. Then the addition of the starting materials was started. The feed mixture was run over an evaporator in order to drive it in gaseous form into the recycle gas. The following throughputs were set: 0.3 kg / h feed mixture, 75 Nl / h synthesis gas. For daily dosing of the isomer mixture consisting of (1a) and (2a) and amine (Ib), a 1.4% solution of the ligand mixtures of the bisphosphite ligands (1a) and (2a) was prepared in n-pentanal, which previously by stripping was freed with nitrogen from residual C ₄ hydrocarbons (<3%). The amine (Ib) was used in a threefold molar excess to the ligand isomer mixture consisting of (1a) and (2a). To better stabilize this solution, the amine (Ib) was added to the solution before the bisphosphite ligand isomer mixture. The reaction products were continuously removed from the reactor via the circulating gas stream and partially condensed out in the condenser at 50 ° C. The condensed phase was continuously driven out of the phase separation vessel. To determine the yield, samples were taken from the cycle gas before and after the reactor and analyzed by means of a gas chromatograph. By daily dosing of the ligand solution described above, the conversion and regioselectivity could be kept constant. To determine the reactor contents, samples were taken from the reactor and analyzed by liquid chromatography (HLPC). Under the chosen reaction conditions, an aldehyde yield of between 80% and 90% was established at the start of the reaction. After 8000 hours of operation, the yield fell to about 65%, due to the rhodium losses from the sampling. Foaming of the reaction solution could not be determined in this case. The percentage distribution between n-pentanal and 2-methylbutanal, or the regio selectivity, was 92% to 8%. Aldehyde yield and regio selectivity are over the duration of the experiment in 5 applied.

5 : Aldehyde yield and regio selectivity for Example L3 Apart from the rhodium loss from sampling, no further rhodium degradation was observed in the stationary phase of the experiment. The rhodium concentration in the reactor over the duration of the experiment is in 6 applied.

6 Rh Concentration to Example L3 After completion of the reaction, the reactor was depressurized and the reaction mixture was examined. There was no solid. 250 ml of the reaction solution were stirred for 4 h under N ₂ atmosphere at 40 ° C and then measured the viscosity of the residue. The viscosity was 20 mPas.

Comparison of Examples L1, L2 and L3

Comparing the corresponding examples, the example L3 carried out according to the invention clearly distinguishes itself from the examples L1 and L2 by the following features, which represent the state of the art:
The inventive example L3 shows no run-in phase, that is, the system shows no decline in activity in the first 1000 h operating time and thus produces the system in the inventive example L3 in the same period significantly more product. In Comparative Example 2 (L2) solid precipitates in the course of the reaction, which can only be removed by a complicated filtration. The inventive example L3 shows no solids accumulation even after more than 8000 hours, thus the filtration can be dispensed with in this process. Comparative Example 2 (L2) shows a marked foaming of the reaction solution at the end of the experiment, so that the process can no longer be operated. Such behavior could only be prevented by expensive foam breakers. The process according to the invention does without these aids.

Inventive Results - Substrate Variation

For the subsequent experiments, a mixture of constitution isomeric bisphosphites, consisting of the ligands (1a) and (2a) ( ³¹ P-NMR specific ratio: L1a = 91% + L2a = 9%) was investigated.

example 1

4.8 g of propene were hydroformylated at 120 ° C. and 30 bar in a 100 ml autoclave from Parr Instruments. 0.005 g of Rh (acac) (CO) ₂ in 43.08 g of toluene were initially introduced as precursor. The ligand used was 0.0708 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0401 g of the compound (Ib) and 0.5033 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. 88.4 mol% of butanal, 6.48 mol% of 2-methylpropanal and 2.79 mol% of propane were formed. The regioselectivity to n-butanal is 93.2%.

Example 2

In a 100 ml autoclave from Parr Instruments, 6.7 g of cis-2-butene were hydroformylated at 120 ° C. and 20 bar. 0.0053 g of Rh (acac) (CO) ₂ in 43.48 g of toluene were initially introduced as precursor. The ligand used was 0.0671 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0381 g of the compound (Ib) and 0.5099 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. 84.6 mol% of pentanal, 5.70 mol% of 2-methylbutanal and 3.43 mol% of n-butane were formed. The regioselectivity to n-pentanal is 93.7%.

Example 3

In a 100 ml autoclave from Parr Instruments, 6.7 g of 1-butene were hydroformylated at 120 ° C. and 20 bar. 0.0052 g of Rh (acac) (CO) ₂ in 43.08 g of toluene were initially introduced as precursor. The ligand used was 0.0694 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0378 g of the compound (Ib) and 0.5052 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. 86.5 mol% of pentanal, 5.08 mol% of 2-methylbutanal and 3.23 mol% of n-butane were formed. The regioselectivity to n-pentanal is 98.9%.

Example 4

In a 100 ml autoclave from Parr Instruments, 6.7 g of isobutene were hydroformylated at 120 ° C. and 20 bar. As a precursor, 0.0051 g of Rh (acac) (CO) ₂ in 42.1 g of toluene were placed. The ligand used was 0.0678 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0369 g of the compound (Ib) and 0.4937 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. 64.0 mol% of 3-methylbutanal, 0.07 mol% of pivalaldehyde and 2.92 mol% of isobutane were formed.

Example 5

In a 100 ml autoclave from Parr Instruments, 7.4 g of a C-4 mixture having the following composition were prepared at 120 ° C. and 20 bar: 2.9 mol% isobutane, 9.9 mol% n-butane, 28.7 mol % 1-butene, 43.5 mol% isobutene, 14.6 mol% 2-butenes and 0.2 mol% 1,3-butadiene. hydroformylated. 0.0048 g of Rh (acac) (CO) ₂ in 41.49 g of toluene were initially charged as precursor. The ligand used was 0.0681 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0367 g of the compound (Ib) and 0.5027 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 32.7% 3-methylbutanal (conversion isobutene 75.2 mol%), 39.44 mol% n-pentanal and 2.18 mol% 2-methylbutanal (butene turnover 78.1 mol%, regioselectivity to n-pentanal 94.8%). 4.13 mol% of isobutane and 9.95 mol% of n-butane are found as the hydrogenation products in the discharge.

Example 6

In a 100 ml autoclave from Parr Instruments, at 120 ° C. and 20 bar, 7.0 g of a C-4 mixture having the following composition: 5.9 mol% isobutane, 15.6 mol% n-butane, 52.9 mol% 1 Butylene, 0.1 mol% isobutene, 24.8 mol% of 2-butenes and 0.5 mol% of 1,3-butadiene hydroformylated. 0.0054 g of Rh (acac) (CO) ₂ in 46.93 g of toluene were initially introduced as precursor. The ligand used was 0.0755 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0412 g of the compound (Ib) and 0.5467 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 0.17 mol% of 3-methylbutanal, 70.31 mol% of n-pentanal and 4.20 mol% of 2-methylbutanal (butene turnover 93.4 mol%, regioselectivity to n-pentanal 94.4%). The hydrogenation products found in the discharge are 5.52 mol% of isobutane and 18.1 mol% of n-butane.

Example 7

In a 100 ml autoclave from Parr Instruments 5.0 g of a C-4 mixture at 120 ° C and 20 bar with the following composition: 5.9 mol% isobutane, 22.0 mol% n-butane, 45.5 mol% 1 -Butene, 2.1 mol% isobutene, 17.1 mol% 2-butenes and 0.2 mol% 1,3-butadiene hydroformylated. 0.0044 g of Rh (acac) (CO) ₂ in 37.96 g of toluene were initially introduced as precursor. The ligand used was 0.0611 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0333 g of the compound (Ib) and 0.4422 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 1.52 mol% of 3-methylbutanal (isobutene conversion 72.1 mol%), 63.2 mol% of n-pentanal and 3.13 mol% of 2-methylbutanal (butene 95.6 mol% conversion, regioselectivity to n-pentanal 95.3%) , The hydrogenation products found in the discharge are 5.41 mol% isobutane and 23.89 mol% n-butane.

Example 8

In a 100 ml autoclave from Parr Instruments, at 120 ° C. and 20 bar, 6.4 g of a C-4 mixture having the following composition: 3.4 mol% isobutane, 13.0 mol% n-butane, 47.3 mol% 1 -Butene, 13.9 mol% isobutene, 21.6 mol% 2-butenes and 0.4 mol% 1,3-butadiene hydroformylated. 0.0052 g of Rh (acac) (CO) ₂ in 44.95 g of toluene were initially introduced as precursor. The ligand used was 0.0704 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0387 g of the compound (Ib) and 0.5318 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 9.93 mol% of 3-methylbutanal (isobutene conversion 71.7 mol%), 62.6 mol% of n-pentanal and 2.98 mol% of 2-methylbutanal (butene 95.6 mol% conversion, regioselectivity to n-pentanal 95.5%) , The hydrogenation products found in the discharge are 3.59 mol% isobutane and 15.41 mol% n-butane.

Example 9

In a 100 ml autoclave from Parr Instruments, at 120 ° C. and 20 bar, 6.8 g of a C-4 mixture having the following composition: 0.1 mol% isobutane, 27.6 mol% n-butane, 27.9 mol% 1 Butylene, 0.1 mol% isobutene and 44.0 mol% 2-butenes hydroformylated. As precursor, 0.0051 g of Rh (acac) (CO) ₂ in 42.29 g of toluene were placed. The ligand used was 0.0681 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0371 g of the compound (Ib) and 0.4960 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 60.45 mol% of n-pentanal and 3.51 mol% of 2-methylbutanal (butene turnover 92.8 mol%, regioselectivity to n-pentanal 94.5%). As the hydrogenation products are found in the discharge 0.1 mol% of isobutane and 28.8 mol% of n-butane.

Example 10

In a 100 ml autoclave from Parr Instruments, at 120 ° C. and 20 bar, 6.8 g of a C-4 mixture having the following composition: 63.6 mol% n-butane, 1.0 mol% 1-butene and 35.8 mol% 2-butenes hydroformylated. 0.0049 g of Rh (acac) (CO) ₂ in 40.42 g of toluene were initially introduced as precursor. The ligand used was 0.0651 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0354 g of the compound (Ib) and 0.4740 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature.

During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 27.76 mol% of n-pentanal and 2.14 mol% of 2-methylbutanal (conversion butene 81.0 mol%, regioselectivity to n-pentanal 92.8%). As the hydrogenation 65.0 mol% of n-butane are found in the discharge.

Example 11

In a 100 ml autoclave from Parr Instruments, hydroformylated at 120 ° C. and 20 bar 6.8 trans-2-butene. 0.0054 g of Rh (acac) (CO) ₂ in 43.78 g of toluene were initially introduced as precursor. The ligand used was 0.0696 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0370 g of the compound (Ib) and 0.5121 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 85.4 mol% of n-pentanal and 5.95 mol% of 2-methylbutanal (regioselectivity to n-pentanal 93.4%). 3.99 mol% of n-butane are found as the hydrogenation products in the discharge.

Example 12

In a 100 ml autoclave from Parr Instruments, at 120 ° C. and 20 bar, 6.0 g of a hydrocarbon mixture of catalytically operated cracking systems having the following composition: 1.5 mol% propane, 0.8 mol% propene, 28.1 mol% isobutane, 8.1 mol% n-butane, 16.4 mol% 1-butene, 16.9 mol% Isobutene, 28.2 mol% of 2-butenes, 0.5 mol% of 1,3-butadiene and proportions of C5 olefins and hydrocarbons hydroformylated. 0.0046 g of Rh (acac) (CO) ₂ in 39.43 g of toluene were initially introduced as precursor. The ligand used was 0.0672 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0331 g of the compound (Ib) and 0.4665 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours.

The effluent contains 1.2 mol% propane, 0.68 mol% butanal, 26.9 mol% isobutane, 9.66 mol% n-butane, 12.66 mol% 3-methylbutanal (74.8% isobutene conversion), 39.5 mol% pentanal, 2.07 mol % 2-methylbutanal (conversion n-butenes 97.9%, regioselectivity to n-pentanal 95.0%).

Example 13

5.8 g of 1,3-butadiene were hydroformylated at 120 ° C. and 20 bar in a 100 ml autoclave from Parr Instruments. 0.0048 g of Rh (acac) (CO) ₂ in 41.19 g of toluene were initially introduced as precursor. The ligand used was 0.0677 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0364 g of the compound (Ib) and 0.4991 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The effluent contains 0.26 mol% of n-butane, 14.25% of n-butenes, 16.65% of aldehydes and 9.68 mol% of 4-vinylcyclohexene. The total conversion of 1-3-butadiene is 42.4%.

Example 14

In a 100 ml autoclave from Parr Instruments, 1.8 g of ethene were hydroformylated at 120 ° C. and 50 bar. 0.0050 g of Rh (acac) (CO) ₂ in 42.68 g of toluene were initially introduced as precursor. The ligand used was 0.0668 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0363 g of the compound (Ib) and 0.5095 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. The conversion to propanal is 98.7%.

Example 15

In a 100 ml autoclave from Parr Instruments, 5.74 g of methyl oleate were hydroformylated at 120 ° C. and 20 bar. 0.0049 g of Rh (acac) (CO) ₂ in 42.00 g of toluene were initially introduced as precursor. The ligand used was 0.0665 g of the above-described ligand mixture (L1a = 91% + L2a = 9%) in the catalyst feed solution. As the organic amine, 0.0345 g of the compound (Ib) and 0.4956 g of TIPB were added as a GC standard. The educt was metered in after reaching the intended reaction temperature. During the reaction, the pressure was kept constant via a mass flow metering synthesis gas control. Samples were withdrawn from the reaction mixture after 20 hours. From ¹ H and ¹³ C NMR spectra, an aldehyde yield of 43.3 mol% was calculated. The regioselectivity to terminal Aldeyden is 22.2 mol%. The double bond content is 36.3 mol%.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

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Claims (18)

Mixture of compounds of the formulas (1a) and (2a):

 Mixture according to claim 1, wherein the content of isomers of the formula (1a) in a range of 74 to 99% by mass, the content of isomers of the formula (2a) in a range of 1 to 26% by mass. A process for the preparation of the mixture according to claim 1 or 2, comprising the steps of: i) oxidative coupling of 2,4-dimethylphenol to 3,3', 5,5'-tetramethyl-2,2'-dihydroxybiphenyl; ii) oxidative coupling of 3-tert-butyl-4-hydroxyanisole to 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl; iii) reaction of 3,3', 5,5'-tetramethyl-2,2'-dihydroxybiphenyl from i) with PCl ₃ to give a phosphorochloridite derivative under an inert gas atmosphere; iv) reaction of at least 2 equivalents of the phosphorochloridite derivative from iii) with 1 equivalent of the 5,5'-dimethoxy-3,3'-di-tert-butyl-2,2'-dihydroxybiphenyl from ii) under an inert gas atmosphere. The method of claim 3, wherein in step iv) a solvent mixture is used. Process according to claim 4, wherein the solvent mixture used in process step iv) is selected from organic nitrogen compounds, organic esters, aromatics. A method according to claim 5, characterized in that the organic nitrogen compounds are selected from: nitriles, amines, amides. Complex mixture of compounds of the formulas (1b) and (2b):

where M is in each case selected from Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt and M can form additional bonds.  A complex mixture according to claim 7, which additionally comprises at least one of the compounds (1a) or (2a) which are not bound to M.  A complex mixture according to any one of claims 7 or 8, wherein M is Rh. A complex mixture according to claim 9, which comprises compound (1ca).

A composition comprising: a complex mixture according to any one of claims 7 to 10, another component selected from bases, organic amines, epoxides, buffer solutions, ion exchangers.  The composition of claim 11, wherein the organic amine comprises at least one 2,2,6,6-tetramethylpiperidine moiety.  The composition of claim 12, wherein the organic amine is a sebacic di-4- (2,2,6,6-tetramethylpiperidinyl) ester.  Process for the hydroformylation of an unsaturated compound or a mixture of unsaturated compounds comprising the steps: a) presentation of a mixture according to claims 1 and 2 or a composition according to any one of claims 11 to 13; b) introducing a gas mixture comprising carbon monoxide and hydrogen; c) adding at least one unsaturated compound or a mixture of unsaturated compounds. The method of claim 14, wherein the unsaturated compounds and mixtures thereof are selected from: - Hydrocarbon mixtures from steam cracking plants; - Hydrocarbon mixtures from catalytically operated cracking plants; - Hydrocarbon mixtures from oligomerization processes; - Hydrocarbon mixtures comprising polyunsaturated compounds; - unsaturated carboxylic acid derivatives. A method according to claim 15, characterized in that the hydrocarbon mixtures have unsaturated compounds having 2 to 30 carbon atoms. Process according to any one of Claims 15 to 16, characterized in that the mixture comprises unsaturated compounds of 2 to 8 carbon atoms. A method according to claim 15, characterized in that the unsaturated carboxylic acid derivatives are selected from fatty acid esters.

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