DE102014017409A1 - Single-dose powder inhaler and process for its preparation - Google Patents

Abstract

The present invention provides a single-dose powder inhaler and its method of preparation. It consists of an inhaler housing which has a housing part (1) in which at least one medicament chamber (11) for receiving a powdered medicament is formed, and wherein the inhaler housing has an outlet opening (13 ') and an outlet channel (13) which extends from the medicament chamber (11) to the outlet port (13 '). Advantageously, the outlet channel (13) in the housing part (1) is formed. Furthermore, in the housing part (1) an air inlet opening (12 ') on a side remote from the outlet opening (13') side of the medicament chamber (11) and an inlet channel (12) are formed, where at the inlet channel (13) from the air inlet opening (12). 12 ') to the medicament chamber (11).

Description

The invention relates to a single-dose powder inhaler according to the preamble of claim 1 and a method for its production.

The usual market inhalers ("inhaler") are often designed for multiple use and therefore expensive and expensive to manufacture. The use as a disposable article is often not suitable. However, the multiple application creates some major hygiene problems, since the patient does not clean the inhaler correctly, rarely or not at all after use. Another problem is that cover caps are lost. It is also unfavorable from a hygienic point of view, if the patient uses the inhaler incorrectly, exhaling into the inhaler: In known inhalers, patients do not always exhale in a predefined direction of expiration, but through the inhaler, so that the inhaler can be used in multiple applications due to the respiratory humidity Constipation tends because the powdered drug clumps and sticks in the inhaler in the air duct. These deposits and adhesions, which may also be burdened with pathological germs, can lead to dose inaccuracies and other disadvantages, such as in the nasal administration: There are nose germs to consider, for. B. if a sinusitis proves to be resistant to treatment. It is possible that the person concerned repeatedly puts himself on the inhaler (nasal, oropharyngeal).

The WO2007 / 042822 describes a single-dose powder inhaler comprising a first housing part and a second housing part made of metal, which together form an inhaler housing with outlet. The first housing part comprises a medicament chamber which contains a single dose of a powdered medicament and which is closed by a film attached to the first housing part. This film extends from the inhaler housing so that it can be gripped and withdrawn for use by a user, thereby releasing the powdered medicament from the medicament chamber. The second housing part has a collecting shaft and / or a dispersion chamber, through which an air duct formed in the inhaler housing leads to the outlet. When the medicament chamber is opened, an air flow is generated on inhalation at the outlet through the gap between the housing parts which remains after removal of the foil, which entrains the powdery medicament released from the medicament chamber from the collection well or the dispersion chamber.

Based on this prior art, it is an object of the present invention to provide a single-dose powder inhaler that is simple and inexpensive to produce, easy to use, and that improves deagglomeration of the contained powder and completeness of powder evacuation.

This object is achieved by a single-dose powder inhaler having the features of claim 1.

The object of manufacturing such an inhaler is achieved by the method having the features of independent claim 10.

Further developments of the device are set forth in the subclaims.

A single-dose powder inhaler according to the invention consists of an inhaler housing having a housing portion in which at least one medicament chamber for receiving a powdered medicament is formed, the inhaler housing having an outlet opening and an outlet channel extending from the medicament chamber to the outlet opening. According to the invention, not only the outlet channel is formed in the housing part, but also an air inlet opening on a side of the medicament chamber facing away from the outlet opening and an inlet channel extending from the air inlet opening to the medicament chamber. Thus, all relevant for the powder inhaler sections may be formed in a single housing part, which is then capped only after filling the drug chamber with a powder dose with a capping element. The powder inhaler can therefore be manufactured extremely cost-effectively and is therefore suitable for administering a powder dose (or a combination of several powder doses) in a single use with the associated hygienic benefits for the user.

Preferably, the housing part can be inexpensively made of plastic and in the injection molding process or by molding, preferably by deep drawing, a pharmagerechten, preferably unmixed plastic film are made. For capping the housing part in order to delimit the air inlet channel, the medicament chamber and the outlet channel and to supplement the housing part to the inhaler housing, a capping element is provided, which is simple and inexpensive flat and substantially planar and unshaped. "Substantially planar and unshaped" is intended here to mean that the cap element can be completely flat in the simplest and preferred variant; However, it can also be provided that the capping element has a longitudinal curvature along the air inlet channel, the medicament chamber and the outlet channel on the one hand for stabilization and on the other hand for flow optimization having. The construction of a powder inhaler according to the invention thus corresponds to that of a blister pack. In this case, at least one of the two inhaler housing components housing part and capping element can be made transparent, so that the present in the drug chamber powder and its administration can be controlled by view. Preferably, the housing part may be formed of a transparent plastic film which is capped with an aluminum or plastic film so that only the air inlet and outlet openings remain open. If a plastic film is used for the lid, then this can preferably be made of the same plastic as the first housing part, so that the powder inhaler can be recycled well after use. Of course, can be used as a capping element and a composite film; but this is not preferred due to the poorer recyclability.

The cap member may also be advantageously printed to provide information about the content and use of the inhaler to the user. This information may be provided by a text or, preferably, figuratively and optionally in color, to be internationally understood. If appropriate, information can also be introduced in Braille (Braille) into the film.

But it can also be provided that the housing part is made of an opaque or colored plastic. In this way, different colored plastics can also provide information about the type and / or amount of powdered drug contained.

In order to assist or improve the deagglomeration, the uniform dispersion and / or the complete emptying of the powder in the use of the single-dose powder inhaler, in the housing part in the air inlet channel, in the medicament chamber and / or in the outlet channel, air-conduction, turbulence and / or deflecting structures to influence the flow of air into, through and out of the medicament chamber. The outlet opening may be formed as a mouth tube or connected to a nasal cannula. Further, to control the flow rate, the inlet port may taper from the air inlet port to the medicament chamber and the outlet port may expand from the medicament chamber toward the outlet port (and may rejuvenate in the presence of a nasal cannula), preferably keeping a cross section of the air inlet port on the medicament chamber smaller is as a cross section of the outlet channel on the drug chamber.

To aid deagglomeration of the powder in the drug chamber in the single-dose powder inhaler application, there may be at least one loose deagglomerator fluidized with the powder from the turbulent airflow created by the design of the air inlet channel in the drug chamber and disrupting powder agglomerates , Preferably, a deagglomerator is sized so that it remains in the drug chamber and can not penetrate into the air inlet duct or into the outlet channel. Optionally, the deagglomerator with breakthroughs, d. H. be permeable to air, so that an air flow is not blocked, even if the deagglomerator comes to rest in front of the outlet opening of the drug chamber.

According to the invention, it is provided that the medicament chamber of the single-dose powder inhaler is closed after being filled with the powder dose (and optionally also the deagglomerator), so that the filled single-dose powder inhaler can be stored until it is used. This cap is designed to be opened when the powder inhaler is to be used to inhale the contained powder. For the purpose of closure different variants are provided according to the invention.

A preferred for the user due to the ease of use includes a film element, for example made of aluminum or plastic, with a locking tab that closes the drug chamber. Further, the film member has a pull tab connected to the closure tab via a band portion and extending from one side of the medicament chamber through the opposing air inlet or outlet channel from the air inlet or outlet port. That is, either the band portion extends from the outlet side of the medicament chamber through the air inlet passage with the pull tab from the air inlet port, or preferably from the inlet side of the medicament chamber through the outlet port out of the outlet port because the channel cross section at the outlet side of the medicament chamber is larger , When tension is applied to the pull tab, the closure member is withdrawn from the medicament chamber so that the powder medicament is released and can be removed from the inhaler housing.

Alternatively, the medicament chamber may be closed by two plug members, each plug member having a plug portion disposed in a portion of the air inlet port and the outlet port adjacent to the medicament chamber. Further, the plug member has a pull tab which extends each extending out of the air inlet opening and the outlet opening. In order to make the powder inhaler ready for inhalation, the plug sections are removed from the air inlet channel and the outlet channel by pulling on the pull tabs.

Another, technically more complex alternative to the closure of the drug chamber provides that in the housing part on both sides of the drug chamber transversely or perpendicular to the air inlet channel and the outlet channel a laterally limited locking channel is formed, which thereby gives the housing part increased stability and in which a corresponding formed fold of the capping element is sealingly closed the air inlet channel and the outlet channel. In order for these folds to be lifted out of the barrier channel in order to release the air inlet channel and the outlet channel for opening the medicament chamber, the powder inhaler has a lifting element, for which different embodiments according to the invention are again provided.

A lifting element of a powder inhaler according to the invention may have at least one predetermined and marked pressure, kink or pull point on the inhaler housing, i. H. be the capping element, so that by exerting pressure or train or buckling at certain points of the inhaler housing the folds are lifted out of the locking channels.

Alternatively, as a lifting element, a tension band may be provided which extends through the air inlet channel and the outlet channel and transversely through the locking channel between the fold of the capping member and the housing part. This drawstring may have a handle portion at both ends, so that for lifting the folds is pulled simultaneously at both ends of the tension band. Alternatively, and preferably because of the easier handling, the tension band can have a grip portion only at one end, while the other end is anchored to an anchor structure of the inhaler housing. This anchor structure can simultaneously be designed as Luftumlenk- or conductive structure in the air inlet or outlet channel.

Furthermore, the plug elements described above can also be used as lifting elements by lifting the fold when pulling out of the adjacent to the drug chamber channel sections.

Finally, it is also conceivable that a structure arranged loosely in the medicament chamber, which may preferably be the deagglomerator, can be used to lift the fold.

Although a powder inhaler according to the invention is designed for single use, in the preferred low-cost embodiment with the unmixed Kunststofftiefziehfolie for the housing part and aluminum or plastic film for the cap, the components are good for recycling. In addition, it can also be provided that the plastic used for the production may preferably be biodegradable, if it is not recycled.

To meet increased hygienic requirements, the plastic used may be an antiseptic and / or antimicrobial plastic. Alternatively, at least the air inlet channel, the medicament chamber and the outlet channel, as well as the mouth or nose piece may be provided with an antiseptic and / or antimicrobial coating.

To protect against plagiarism, the plastic may also contain a marker, which can be detected in the finished powder inhaler.

Finally, for example, when two or more active substances are to be administered simultaneously, two or more medicament chambers may be formed in the housing part, which are arranged parallel to each other, each with an air inlet channel and an outlet channel or in series, wherein the air inlet channel leads to the first medicament chamber and the outlet channel extends from the last medicament chamber and the medicament chambers are connected to each other via another channel. However, it may also be that a division of a larger single dose into several drug chambers is more favorable in terms of flow in order to achieve complete de-fermentation and emptying as well as uniform dispersion and thus inhalation of the contained powder.

An inventive method for producing a single-dose powder inhaler according to the invention can be advantageously listed in a single device. This is designed according to a blister machine for film deep drawing, filling and sealing. The method initially provides injection molding or preferably deep-drawing of the housing part made of plastic, whereupon the medicament chamber is filled with a dose of a powdered medicament. After sealing the drug chamber with a foil element, wherein the closure tab is sealed or glued to the medicament chamber and folded to the Abziehlasche band section is folded or folded, the planar, substantially planar cap member is attached to the housing part, preferably also by sealing, Gluing or through Welding (eg ultrasonic welding). As an alternative to the film element, the medicament chamber may optionally also be closed by two plug elements and / or by a fold of the cap element received in a locking channel.

This simple method enables extremely cost-effective production of the powder inhaler and is also quickly and easily adaptable to different variants, so that even patient-specific embodiments and fillings are economically possible. Furthermore, this powder inhaler, which combines cost-effective production with optimized powder release, thus also suitable for distribution or distribution in third world countries.

Other embodiments as well as some of the advantages associated with these and other embodiments will become apparent and better understood by the following detailed description with reference to the accompanying drawings. Items or parts thereof that are substantially the same or similar may be provided with the same reference numerals. The figures are merely a schematic representation of an embodiment of the invention.

Showing:

1 a perspective view of the housing part of a single dose powder inhaler according to the invention,

2 a plan view of the housing part 1 .

3 a longitudinal sectional view through the housing part 1 .

4 a perspective view of the housing part 1 in which the medicament chamber is closed with a foil element,

5 a perspective view of a powder inhaler according to the invention with the housing part 4 which is closed with a flat (aluminum) foil as a capping element,

6 a longitudinal sectional view through the powder inhaler according to the invention 5 .

7 a perspective view of a powder inhaler according to the invention with an outlet formed for nasal application,

8th 3 a perspective view of a housing part in which two plug elements are provided for closing the medicament chamber,

9 a perspective view of a powder inhaler according to the invention with the housing part 8th which is closed with a flat (aluminum) foil as a capping element,

10 a perspective view of a housing part, in which two locking channels are provided for closing the medicament chamber and a tension band for opening,

11 a perspective view of a powder inhaler according to the invention with the housing part 10 which is closed with a flat (aluminum) foil as a capping element, the folds of which are accommodated in the blocking channels,

12 1 is a schematic side sectional view of a powder inhaler according to the invention, in which the medicament chamber is closed by folds in the capping element in the blocking channels, which are lifted by pulling on the capping element;

13 a schematic side sectional view of a powder inhaler according to the invention, in which the medicament chamber is closed by folds in the capping element in the locking channels, which are lifted by pressure on the capping element and buckling elements.

The device according to the invention relates to a simple and inexpensive producible powder inhaler comprising two housing parts, a molded housing part and a capping element, which together form the inhaler housing. The powder inhaler according to the invention can be designed in the manner of a visual packaging or blister-like, wherein the housing part or the capping element or both are transparent and so allows an insight into the powder inhaler, in particular in the drug chamber / n. With the at least partially transparent designed inhaler, the content or the complete emptying of the content can be controlled in the application. Also, the turbulence can be tracked during use.

The housing part is designed to provide the air inlet channel, the medicament chamber and the outlet channel and can advantageously be manufactured inexpensively by a plastic thermoforming foil or optionally also be produced by plastic injection molding.

To limit the air inlet channel, the medicament chamber and the outlet channel may simply a pharmagerechte foil, which may be an aluminum, composite or (transparent) plastic film, as a capping element on the Housing be added, for example, by sealing; Welding or gluing.

1 to 3 show an example of a housing part 1 , as it is used for the preparation of a powder inhaler according to the invention. The molded here of thermoforming housing part 1 has a semi-funnel-shaped air inlet channel 12 up, extending from an air intake opening 12 ' to the cupped medicine chamber 11 extends. On the side facing away from the air inlet side, the outlet channel extends 13 from the drug chamber 11 to the outlet opening 13 ' , which has a semi-oval cross-section here in order to be well absorbed in the mouth.

In the air intake duct 12 are several air guiding structures 15 formed to torsion in the application sucked air stream before it enters the drug chamber 11 arrives. In the bottom of the drug chamber 11 are air swirling structures 16 formed, which improve the deagglomeration of the fluidized powder. A widening of the outlet channel 13 following the drug chamber 11 provides a spacer effect, whereby not only the previously increased through the funnel-shaped inlet flow rate is slowed, but also the entrained powder is evenly distributed. This effect is due to the lead structures 17 supports, in addition, the housing part 1 give increased stability in the outlet area.

After the production of the housing part 1 What is preferably done by film thermoforming, but optionally also can be done by injection molding, the drug chamber 11 with a powder dose (possibly also a loose deagglomerator) filled (not shown in the figures) and then sealed.

The closure of the drug chamber 11 can be done differently.

4 to 6 show an embodiment in which to close the medicament chamber 11 a foil element 3 is used. The foil element 3 has a closure tab 30 that is sized to fit the drug chamber 11 closes. From this flap 30 a band section extends 31 to a pull tab 32 which has riffled here for safer gripping. Here is the band section 31 at the locking tab 30 folded down, leaving the pull tab 32 on the side facing away from the folded end side of the housing part 1 protrudes. In the example shown, the band section is 31 at the inlet side of the locking tab 30 deflected and sticks out with the pull tab 32 from the outlet opening 13 ' out.

In general, it is also conceivable that such a foil element 3 may also be arranged vice versa, so that the pull tab 32 from the inlet opening 12 ' protrudes; there however the cross-section of the outlet channel 13 at the drug chamber 11 is preferably larger than the cross section of the inlet channel 12 , offers the outlet channel 13 for removing the locking tab 30 at. The locking tab 30 can with a wall portion or a circumferential shoulder of the drug chamber 11 sealed, welded or glued, the connection is indeed tight but yet releasable, so that the locking tab 30 by pulling on the pull tab 32 solve without tearing.

This in 1 to 6 The example shown represents a preferred variant of a powder inhaler according to the invention, which can be produced extremely simply and inexpensively in a single machine due to the blister-like construction and is also easy and intuitive to operate for the users.

In 7 By way of example, it is exemplified that a powder inhaler of the present invention can not be formed only with an outlet shaped for receipt in the mouth. At the (imaginary and dashed) exhaust port 13 ' may be a nasal application shaped outlet piece 14 connect, which can extend integrally away from the housing part, or on the outlet opening 13 ' can be put on.

8th and 9 show a variant of a powder inhaler according to the invention, in which the closure of the medicament chamber 11 through two plug elements 4 takes place before the capping element 2 the air inlet duct 12 , the drug chamber 11 and the outlet channel 13 deckelt. The plug elements 4 each have a plug section 40 of which there is a band section 41 to a pull tab 42 extends. The plug section 40 the respective plug element 4 is in a to the drug chamber 11 adjacent section 120 . 130 the air inlet duct 12 and the outlet channel 13 arranged and is so dimensioned and shaped that he has this section 120 . 130 closes. A material of the plug sections 40 is chosen so that a tight seal is made possible, but this by pulling the pull tabs 42 can be overcome. Alternatively, between plug portion 40 and channel section 120 . 130 an adhesive or sealant may be introduced, which is the removal of the plug sections 40 when pulling at the pull tabs 42 non-destructive allowed.

Another alternative to the closure of the drug chamber is in 10 to 13 shown. In 10 and 11 is a housing part 1 to see where in the to the drug chamber 11 adjacent sections 120 . 130 the air inlet duct 12 and the outlet channel 13 a transversely extending barrier channel 18 is formed. The substantially planar capping element 2 points to the these barrier channels 18 corresponding places molded folds 21 on that the blocking channels 18 fill in and thus the sections 120 . 130 the air inlet duct 12 and the outlet channel 13 lock and so the drug chamber 11 close. To such a closed drug chamber 11 to open and the air intake duct 12 and the outlet channel 13 release, the folds 21 from the blocking channels 18 raised, including various variants of the invention are provided.

In the in 10 and 11 example shown here is a drawstring 5 provided, the band section 51 from the outlet channel 13 across the barrier channels 18 and the drug chamber 11 up to the air inlet duct 12 extends. The drawstring 5 is with an end section 50 at an anchor structure 17 ' in the outlet channel 13 attached, which also serves as a baffle structure. At the other end of the drawstring 5 sticks out a tab 52 from the air intake duct 12 out. The band section 51 is in the arrangement of the capping element 2 with the folds 21 in the blocking channels 18 pressed. To release the air inlet duct 12 and the outlet channel 13 will pull on the tab 52 on the band section 51 exercised at the anchor structure 17 ' is held so that the band section 51 the folds 21 from the blocking channels 18 can lift. Unlike shown, such a drawstring can also be executed floating with two tabs, so that for lifting the folds 21 and to release the air intake duct 12 and the outlet channel 13 is pulled on both tabs.

Alternatively, as in 12 is indicated, the tensile force Z on the capping element 2 be exercised to raise the folds, as the double arrows indicate a. But it can also be provided that, as in 13 indicated at certain points pressure D on the capping element 2 is applied to lift the folds and / or to fold the housing at designated locations K.

Another way to enable the flow channel through the air inlet duct 12 and exhaust duct 13 and opening the drug chamber 11 consists in releasing plug elements (as described above) to raise the folds. Further, a loosely arranged in the drug chamber, and thus freely movable, preferably spherical structure, which also acts as a deagglomerator in the application, can be used by lifting to lift the folds in the locking channels.

In general, a powder inhaler according to the invention may deviate from the exemplary embodiments shown, so the invention is not limited to the numbers and shapes of the air swirling, deflecting and guiding structures shown in the figures 15 . 16 . 17 respectively. 17 ' limited; in the air intake duct 12 , in the drug chamber 11 and the outlet 13 To improve the aerodynamic, the resistance and / or the deagglomeration formed structures of the inner wall of a single dose Pulverinhalators according to the invention may differ as intraluminal flow elements of the illustrated forms and be formed, for example, as baffles, blades, screws, spirals or meanders.

Furthermore, the flow profile through the drug chamber is aerodynamically tunable to resistance, flow, and powder through variations in the bore profile in terms of size, shape, and edge design (sharp, chamfered, or rounded) at the inlet and outlet of the drug chamber. Thus, various factors affect the flow of air through the powder inhaler and, in particular, the medicament chamber, which affect the completeness of depletion and deagglomeration and dispersion in the air flow, such as the tapered cross-sectional shape in the air inlet and the flared cross-section in the outlet, where Flow channel on the inlet side of the drug chamber is preferably narrower than on the outlet side.

The housing part and the capping element of a single-dose powder inhaler according to the invention can be welded together by heat, but there are also bonding, clamping connections (wherein the edge of a housing part is bent around the edge of the other housing part), latching connections or stapling connections in question.

The powder inhaler according to the invention is intended for single use, so that the inhaler housing after opening the drug chamber and the inhalation of the powder dose can not be reused, which also serves to protect against misuse. In addition to the good recyclability or biodegradability, from the point of view of environmental protection considered to be disadvantageous increased packaging waste volume but also by the reduced use of multi-dose inhalers whose disposal is complex, since usually residual amounts of powdered medicine are included.

The single-dose powder inhaler according to the invention enables economical use for a variety of indications - for example, when only a few applications or only when necessary are required, such as As in migraine, pain, immunomodulators, biologicals or the administration of CNS-active substances. The powder inhaler according to the invention is hygienic and unwanted influences such as high humidity or contamination due to incorrect use are largely excluded.

Because of the cost-effective production, the powder inhaler according to the invention is also suitable for use in the Third World and in crisis areas.

In fact, the powder inhaler according to the invention is so inexpensive to manufacture that patient-specific blistering of the drug can be achieved in an economically justifiable framework. The composition and dosage of the powdered medicament (or several medicaments) can thus be filled individually and tailor-made for each patient in the powder inhaler according to the invention.

Exemplary embodiments of a single-dose powder inhaler according to the invention with a single medicament chamber in which a powder dose is present are shown in conjunction with the figures. However, it is also conceivable according to the invention that two or more medicament chambers are formed in the housing part, which are arranged parallel or in series in the flow channel between the air inlet and the outlet. Parallel here means that in each case at least one air inlet duct (from a common air inlet opening or separate air inlet openings) leads to each of the medicament chambers, and in each case at least one outlet duct from each medicament chamber opens into the outlet formed as a mouthpiece or nasal proboscis. In the arrangement of the medicament chambers in series, the air inlet duct extends to a first medicament chamber, from there another duct to the next medicament chamber, and the outlet duct from the last medicament chamber to the outlet port. In each drug chamber, a dose of powder may be present, which may be different agents that come into contact with each other only in the application. Thus, in principle, such a powder inhaler contains more than one powder dose, but according to the invention this powder inhaler should be understood as a "single-dose" powder inhaler, as these multiple powder doses combined are inhaled in a single application, whereupon the powder inhaler can no longer be used.

The plastic used to make a powder inhaler of the invention designed as a disposable article may preferably be a biodegradable plastic.

Each powder inhaler according to the invention may be provided at least partially with an antiseptic or antibacterial and / or antimicrobial coating. Thus, in particular, the air inlet channel, medicament chamber and air outlet channel may be coated in order to inhale no germs in the application of the inhalation device. Because of the simpler application but also the entire inhalation device may be coated. An example of such a coating is Perlazid ^® from Rilit, Endingen. Alternatively, an antiseptic or antibacterial and / or antimicrobial plastic may be used to manufacture the inhalation device.

A powder inhaler according to the invention can, for example, also be distributed in an outer packaging, which ensures that the powder inhaler is clean or sterile and therefore ready for use. Alternatively, it may be conceivable that the capping element has an overlap at the ends, with which the outlet (possibly also the air inlet) can be closed in the manner of a yogurt cup lid. The overlap can then be withdrawn, for example by means of a shaped tab of the orifices. In order to prevent that the film can then be removed from the housing part, a predetermined breaking point, for example a perforation may be provided at the junction of the overlap.

Furthermore, the plastic used for producing a powder inhaler according to the invention can have a marker for its recognizability in order to be able to recognize plagiarisms which do not contain the marker.

LIST OF REFERENCE NUMBERS

1

housing part

11

medication chamber

12, 120

Air inlet duct, section adjacent to the medicament chamber

13, 130

Outlet channel, section adjacent to the drug chamber

14

nosepiece

15, 16, 17

Air turbulence, deflecting, guiding structures

17 '

anchoring device

18

blocking channel

2

Capping element capping element

21

fold

3

film element

30

flap

31

band section

32

pull tab

4

plug member

40

plug section

41

band section

42

pull tab

5

tieback

50

end

51

band section

52

pull tab

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• WO 2007/042822 [0003]

Claims (10)

Single-dose powder inhaler from an inhaler housing comprising a housing part ( 1 ), in which at least one medicament chamber ( 11 ) is formed for receiving a powdered medicine, and wherein the inhaler housing an outlet opening ( 13 ' ) and an outlet channel ( 13 ) extending from the drug chamber ( 11 ) to the outlet opening ( 13 ' ), characterized in that the outlet channel ( 13 ) in the housing part ( 1 ) is formed, and that in the housing part ( 1 ) - an air inlet opening ( 12 ' ) on one of the outlet opening ( 13 ' ) facing away from the drug chamber ( 11 ) and - an inlet channel ( 12 ) are formed from the air inlet opening ( 12 ' ) to the drug chamber ( 11 ), are formed. Single-dose powder inhaler according to claim 1, characterized in that the housing part ( 1 ) is a plastic injection-molded part or molded from a pharmaceutically correct, preferably single-grade plastic film, preferably deep-drawn, wherein the inhaler housing is a capping element ( 2 ), which with the housing part ( 1 ) forms the inhaler housing forms and the capping member is formed flat and substantially planar and the inlet channel ( 12 ), the drug chamber ( 11 ) and the outlet channel ( 13 ), and / or consists of a plastic, aluminum or composite film, and / or at least one inhaler housing component housing part ( 1 ) and / or capping element ( 2 ) is transparent. Single-dose powder inhaler according to claim 1 or 2, characterized in that in the housing part ( 1 ) in the air intake duct ( 12 ), in the drug chamber ( 11 ) and / or in the outlet channel ( 13 ) Air guiding, swirling and / or deflecting structures ( 15 . 16 . 17 ) are formed, wherein the outlet opening ( 13 ' ) is formed as a mouth tube or with a nasal cannula ( 14 ), and / or that the inlet channel ( 12 ) from the air inlet opening ( 12 ' ) to the drug chamber ( 11 ) and the outlet channel ( 13 ) from the drug chamber ( 11 ) in the direction of the outlet opening ( 13 ' ), wherein a cross-section of the air inlet channel ( 12 ) at the drug chamber ( 11 ) is smaller than a cross section of the outlet channel ( 13 ) at the drug chamber ( 11 ). Single-dose powder inhaler according to at least one of claims 1 to 3, characterized in that in the medicament chamber ( 11 ) At least a loose disagglomerator is arranged. Single-dose powder inhaler according to at least one of claims 1 to 4, characterized in that - a film element ( 3 ) with a locking tab ( 30 ) the medicament chamber ( 11 ) and at least one pull tab ( 32 ) extending from one side of the medicament chamber ( 11 ) through the opposite air inlet channel or outlet channel ( 12 . 13 ) from the air inlet or outlet ( 12 ' . 13 ' ), or - the drug chamber ( 11 ) by two plug elements ( 4 ) is closed, each plug element ( 4 ) a plug portion ( 40 ), which in one to the medicament chamber ( 11 ) adjacent section ( 120 . 130 ) of the air inlet duct ( 12 ) and the outlet channel ( 13 ), and a pull tab ( 42 ), each extending from the air inlet opening ( 12 ' ) and the outlet opening ( 13 ' ), or - in the housing part ( 1 ) on both sides of the medicament chamber ( 11 ) at right angles to the air inlet duct ( 12 ) and the outlet channel ( 13 ) a blocking channel ( 18 ) is formed in which a correspondingly shaped fold ( 21 ) of the capping element ( 2 ) the air inlet duct ( 12 ) and the outlet channel ( 13 ) is sealingly occluded, wherein the powder inhaler ( 1 ) has a lifting element, by means of which the fold ( 21 ) from the blocking channel ( 18 ) is liftable. Single dose powder inhaler according to claim 5, characterized in that the lifting element - is at least a predetermined and marked pressure, bending or traction point (D, Z) on the inhaler housing, or - a drawstring ( 5 ), which extends through the air inlet duct ( 12 ) and / or the outlet channel ( 13 ) and across the barrier channel ( 18 ) between the fold ( 21 ) and the housing part ( 1 ), and the two ends a handle portion ( 52 ) or at one end a handle portion ( 52 ) and at the other end ( 50 ) at an anchor structure ( 17 ' ) of the inhaler housing is anchored, or - by the plug elements ( 4 ), or - a structure arranged loosely in the medicament chamber, which is preferably the deagglomerator. Single-dose powder inhaler according to at least one of claims 2 to 6, characterized in that the plastic - biodegradable, and / or - contains a marker. Single-dose powder inhaler according to at least one of claims 2 to 7, characterized in that the plastic is an antiseptic and / or antimicrobial plastic, or that at least the air inlet channel ( 12 ), the drug chamber ( 11 ) and the outlet channel ( 13 ) are provided with an antiseptic and / or antimicrobial coating. Single dose powder inhaler ( 1 ) according to at least one of claims 1 to 8, characterized in that in the housing part ( 1 ) two or more drug chambers ( 11 ) are formed parallel to each other, each with an air inlet channel ( 12 ) and an outlet channel ( 13 ) or in series one behind the other, wherein the air inlet duct ( 12 ) to the first drug chamber ( 11 ) and the outlet channel ( 13 ) from the last drug chamber ( 11 ) and the drug chambers ( 11 ) are connected to each other via another channel. A method of manufacturing a single-dose powder inhaler according to at least one of claims 2 to 9, comprising the steps of - manufacturing the housing part ( 1 ) by injection molding of plastic or preferably by deep-drawing a plastic film, - filling the medicament chamber ( 11 ) with a dose of a powdered medicament, - closing the medicament chamber ( 11 ) with a foil element ( 3 ), by two plug elements ( 4 ) and / or by means of a blocking channel ( 18 ) recorded fold ( 21 ) of the capping element ( 2 ), and - attaching the planar and substantially planar capping element ( 2 ) on the housing part ( 1 ), the process being performed in a single device.

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