Nothing Special   »   [go: up one dir, main page]

CY1124568T1 - PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY CYSTIC FIBER TRANSMEMBRANE CONDUCTANCE REGULATOR - Google Patents

PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY CYSTIC FIBER TRANSMEMBRANE CONDUCTANCE REGULATOR

Info

Publication number
CY1124568T1
CY1124568T1 CY20211100734T CY211100734T CY1124568T1 CY 1124568 T1 CY1124568 T1 CY 1124568T1 CY 20211100734 T CY20211100734 T CY 20211100734T CY 211100734 T CY211100734 T CY 211100734T CY 1124568 T1 CY1124568 T1 CY 1124568T1
Authority
CY
Cyprus
Prior art keywords
treatment
transmembrane conductance
pharmaceutical compositions
diseases mediated
conductance regulator
Prior art date
Application number
CY20211100734T
Other languages
Greek (el)
Inventor
Brian Dean Phenix
Laurent Jean-claude Bagnol
Geoffrey Glen BRODEUR
Sachin Chandran
Eleni Dokou
Lori Ann Ferris
Dragutin Knezic
Katie Lynn McCarty
Ales Medek
Sara A. Waggener
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53175129&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124568(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of CY1124568T1 publication Critical patent/CY1124568T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση αφορά συνθέσεις που περιλαμβάνουν πλήθος θεραπευτικών παραγόντων, όπου η παρουσία ενός θεραπευτικού παράγοντα ενισχύει τις ιδιότητες τουλάχιστον ενός άλλου θεραπευτικού παράγοντα. Σε μία υλοποίηση, οι θεραπευτικοί παράγοντες είναι ρυθμιστές διαμεμβρανικής αγωγιμότητας κυστικής ίνωσης (CFTR) όπως CFTR διορθωτής ή CFTR ενδυναμωτής για την αγωγή CFTR μεσολαβούμενων παθήσεων όπως κυστικής ίνωσης. Επίσης αποκαλύπτονται μέθοδοι και κιτ αυτών.The present invention relates to compositions comprising a plurality of therapeutic agents, where the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance modulators (CFTR) such as CFTR corrector or CFTR enhancer for the treatment of CFTR mediated diseases such as cystic fibrosis. Also disclosed are methods and kits thereof.

CY20211100734T 2014-04-15 2021-08-13 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY CYSTIC FIBER TRANSMEMBRANE CONDUCTANCE REGULATOR CY1124568T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461979848P 2014-04-15 2014-04-15
US201462059287P 2014-10-03 2014-10-03
EP15721912.2A EP3131582B1 (en) 2014-04-15 2015-04-14 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
PCT/US2015/025722 WO2015160787A1 (en) 2014-04-15 2015-04-14 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

Publications (1)

Publication Number Publication Date
CY1124568T1 true CY1124568T1 (en) 2022-07-22

Family

ID=53175129

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20181100866T CY1120582T1 (en) 2014-04-15 2018-08-17 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INTERMEDIATELY CYSTIC FROM REGULATORY DIAGNOSIS DISEASES
CY20211100734T CY1124568T1 (en) 2014-04-15 2021-08-13 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY CYSTIC FIBER TRANSMEMBRANE CONDUCTANCE REGULATOR

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20181100866T CY1120582T1 (en) 2014-04-15 2018-08-17 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INTERMEDIATELY CYSTIC FROM REGULATORY DIAGNOSIS DISEASES

Country Status (28)

Country Link
US (3) US10206877B2 (en)
EP (4) EP3131582B1 (en)
JP (1) JP6543268B2 (en)
KR (1) KR102447581B1 (en)
CN (2) CN106163517B (en)
AU (2) AU2015247850B2 (en)
BR (1) BR112016023422A8 (en)
CA (1) CA2944140C (en)
CL (2) CL2016002600A1 (en)
CY (2) CY1120582T1 (en)
DK (3) DK3131582T3 (en)
ES (3) ES2957761T3 (en)
FI (1) FI3925607T3 (en)
HR (3) HRP20230709T1 (en)
HU (3) HUE055369T2 (en)
IL (3) IL266286B2 (en)
LT (3) LT3424534T (en)
MX (2) MX2016013301A (en)
PL (3) PL3424534T3 (en)
PT (3) PT3925607T (en)
RS (3) RS64400B1 (en)
RU (1) RU2744460C2 (en)
SG (2) SG10201913575VA (en)
SI (3) SI3131582T1 (en)
TR (1) TR201809684T4 (en)
UA (1) UA124567C2 (en)
WO (1) WO2015160787A1 (en)
ZA (1) ZA201606418B (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
MX365890B (en) 2004-06-24 2019-06-19 Vertex Pharma Modulators of atp-binding cassette transporters.
SI2395002T1 (en) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition containing a heterocyclic modulator of atp-binding cassette transporters.
RS55940B1 (en) 2005-12-28 2017-09-29 Vertex Pharma Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
IN2014KN02423A (en) 2006-04-07 2015-05-01 Vertex Pharma
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
NZ583420A (en) 2007-08-24 2012-06-29 Vertex Pharma Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis
PT2217572E (en) 2007-11-16 2014-02-17 Vertex Pharma Isoquinoline modulators of atp-binding cassette transporters
MX364936B (en) 2007-12-07 2019-05-15 Vertex Pharma Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids.
NZ585880A (en) 2007-12-07 2012-08-31 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
NZ602030A (en) 2008-02-28 2014-02-28 Vertex Pharma Heteroaryl derivatives as cftr modulators
US20230210839A1 (en) * 2008-08-13 2023-07-06 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
SG174410A1 (en) 2009-03-20 2011-11-28 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
EP3150198B1 (en) 2010-04-07 2021-09-22 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
CN105130948A (en) 2010-04-22 2015-12-09 弗特克斯药品有限公司 Pharmaceutical compositions and administrations thereof
RU2692779C2 (en) 2012-02-27 2019-06-27 Вертекс Фармасьютикалз Инкорпорейтед Pharmaceutical composition and introduction thereof
AR092857A1 (en) 2012-07-16 2015-05-06 Vertex Pharma PHARMACEUTICAL COMPOSITIONS OF (R) -1- (2,2-DIFLUOROBENZO [D] [1,3] DIOXOL-5-IL) -N- (1- (2,3-DIHYDROXIPROPIL) -6-FLUORO-2- ( 1-HYDROXI-2-METHYLPROPAN-2-IL) -1H-INDOL-5-IL) CYCLOPROPANCARBOXAMIDE AND ADMINISTRATION OF THE SAME
BR112016010403A2 (en) 2013-11-12 2017-08-08 Vertex Pharma PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR-MEDIATED DISEASES
CN106163517B (en) 2014-04-15 2020-08-14 沃泰克斯药物股份有限公司 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
MY181019A (en) 2014-10-03 2020-12-16 Sanofi Sa Fused pentacyclic imidazole derivatives
CN112279808B (en) 2014-10-06 2024-03-08 弗特克斯药品有限公司 Cystic fibrosis transmembrane conductance regulator modulators
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
EP3221692B1 (en) 2014-11-18 2021-06-23 Vertex Pharmaceuticals Inc. Process of conducting high throughput testing high performance liquid chromatography
CA2981495C (en) 2015-03-31 2023-09-26 Vertex Pharmaceuticals (Europe) Limited Deuterated vx-661
PL3436446T3 (en) 2016-03-31 2023-09-11 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
HUP1600271A2 (en) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Pharmaceutical composition comprising complex formulations of ivacaftor and lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
US10383865B2 (en) 2016-04-25 2019-08-20 Druggability Technologies Ip Holdco Limited Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
US10206915B2 (en) 2016-04-25 2019-02-19 Druggability Technologies Ip Holdco Limited Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP1600270A2 (en) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Complexes of ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
PT3519401T (en) 2016-09-30 2021-12-27 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
MX2021013639A (en) 2016-12-09 2022-09-30 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator.
WO2018183367A1 (en) 2017-03-28 2018-10-04 Van Goor Fredrick F Methods of treating cystic fibrosis in patients with residual function mutations
BR112019025801A2 (en) 2017-06-08 2020-07-07 Vertex Pharmaceuticals Incorporated treatment methods for cystic fibrosis
WO2019010092A1 (en) 2017-07-01 2019-01-10 Vertex Pharmaceuticals Incorporated Compositions and methods for treatment of cystic fibrosis
AU2018304168B2 (en) 2017-07-17 2023-05-04 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2019018353A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
JP7121794B2 (en) 2017-08-02 2022-08-18 バーテックス ファーマシューティカルズ インコーポレイテッド Process for preparing pyrrolidine compounds
TWI719349B (en) 2017-10-19 2021-02-21 美商維泰克斯製藥公司 Crystalline forms and compositions of cftr modulators
US20210228489A1 (en) * 2017-12-04 2021-07-29 Vertex Pharmaceuticals Incorporated Compositions for treating cystic fibrosis
WO2019113476A2 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (en) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 Pharmaceutical compositions for treating cystic fibrosis
KR102482271B1 (en) 2018-02-15 2022-12-27 버텍스 파마슈티칼스 인코포레이티드 Macrocycles as modulators of cystic fibrosis transmembrane conductance modulators, pharmaceutical compositions thereof, uses thereof in the treatment of cystic fibrosis, and methods for their preparation
US20210139514A1 (en) 2018-04-05 2021-05-13 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN110511204A (en) * 2018-05-22 2019-11-29 上海特化医药科技有限公司 The preparation method of benzyl cyanide
CA3123578A1 (en) 2018-11-14 2020-05-20 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CA3067611A1 (en) 2019-01-15 2020-07-15 Apotex Inc. Processes for the preparation of tezacaftor and intermediates thereof
TWI848092B (en) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 Cystic fibrosis transmembrane conductance regulator modulating agents
WO2020214921A1 (en) 2019-04-17 2020-10-22 Vertex Pharmaceuticals Incorporated Solid forms of modulators of cftr
WO2020242935A1 (en) 2019-05-29 2020-12-03 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
JP2022545359A (en) 2019-08-14 2022-10-27 バーテックス ファーマシューティカルズ インコーポレイテッド cystic fibrosis transmembrane conductance regulator
TW202120517A (en) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 Process of making cftr modulators
BR112022002605A2 (en) 2019-08-14 2022-05-03 Vertex Pharma Crystalline forms of cfr modulators
TW202115092A (en) 2019-08-14 2021-04-16 美商維泰克斯製藥公司 Modulators of cystic fibrosis transmembrane conductance regulator
CR20230120A (en) 2020-08-07 2023-09-01 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
CA3188787A1 (en) 2020-08-13 2022-02-17 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
WO2022076626A1 (en) 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225748A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
PE20231951A1 (en) 2020-10-07 2023-12-06 Vertex Pharma MODULATORS OF THE REGULATOR OF TRANSMEMBRANE CONDUCTANCE OF CYSTIC FIBROSIS
EP4225750A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225446A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225737A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
KR20230107725A (en) 2020-10-07 2023-07-17 버텍스 파마슈티칼스 인코포레이티드 Modulators of Cystic Fibrosis Transmembrane Conductance Modulators
WO2022076620A1 (en) 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225762A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US20230382925A1 (en) 2020-10-07 2023-11-30 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US20220184049A1 (en) 2020-12-10 2022-06-16 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2023150237A1 (en) 2022-02-03 2023-08-10 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
IL314691A (en) 2022-02-03 2024-10-01 Vertex Pharma Methods of preparing and crystalline forms of (6a,12a)-17-amino-12-methyl-6,15-bis(trifluoromethyl)-13,19-dioxa-3,4,18-triazatricyclo[ 12.3.1.12,5]nonadeca-1(18),2,4,14,16-pentaen-6-ol
WO2023154291A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
AU2023249173A1 (en) 2022-04-06 2024-10-03 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2023224924A1 (en) 2022-05-16 2023-11-23 Vertex Pharmaceuticals Incorporated Solid forms of a macrocyclic compounds as cftr modulators and their preparation
WO2023224931A1 (en) 2022-05-16 2023-11-23 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2024031081A1 (en) 2022-08-04 2024-02-08 Vertex Pharmaceuticals Incorporated Compositions for the treatment of cftr-mediated diseases

Family Cites Families (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US206877A (en) * 1878-08-13 Improvement in paper-pulp washers
JPS5328173A (en) 1976-08-06 1978-03-16 Zenyaku Kogyo Kk Novel phenylmethanenitro compound and its preparation
US4138397A (en) 1978-02-27 1979-02-06 Richardson-Merrell Inc. 6-(2,3-Dihydro-5-benzofuranyl)acetamido penicillin derivatives
GB8524157D0 (en) 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
JPS61103861A (en) 1984-10-27 1986-05-22 Nitto Kasei Kk Preparation of aryl-substituted cyanoacetic acid ester
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
GB9317764D0 (en) 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
US5510379A (en) 1994-12-19 1996-04-23 Warner-Lambert Company Sulfonate ACAT inhibitors
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
JPH10213820A (en) 1997-01-31 1998-08-11 Canon Inc Liquid crystal element and liquid crystal device
WO1998047868A1 (en) 1997-04-18 1998-10-29 Smithkline Beecham Plc Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists
AU746853B2 (en) 1997-06-21 2002-05-02 Roche Diagnostics Gmbh Barbituric acid derivatives with antimetastatic and antitumor activity
PT901786E (en) 1997-08-11 2007-08-07 Pfizer Prod Inc Solid pharmaceutical dispersions with enhanced bioavailability
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
WO1999029318A1 (en) 1997-12-11 1999-06-17 Biochem Pharma Inc. Antiviral compounds
US6426331B1 (en) 1998-07-08 2002-07-30 Tularik Inc. Inhibitors of STAT function
AUPP609198A0 (en) 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
DE60014216T2 (en) 1999-02-24 2006-03-02 F. Hoffmann-La Roche Ag 4-phenylpyridine derivatives and their use as NK-1 receptor antagonists
ATE309250T1 (en) 1999-09-10 2005-11-15 Novo Nordisk As MODULATORS OF PROTEIN TYROSINE PHOSPHATASE (PTPASES)
AU6985200A (en) 1999-09-10 2001-04-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
AUPQ288499A0 (en) 1999-09-16 1999-10-07 Biota Scientific Management Pty Ltd Antiviral agents
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
IT1315267B1 (en) 1999-12-23 2003-02-03 Novuspharma Spa DERIVATIVES OF 2- (1H-INDOL-3-IL) -2-OXO-ACETAMIDES FOR ANTI-TUMOR ACTIVITY
AU2001229501A1 (en) 2000-01-24 2001-07-31 Isis Pharmaceuticals, Inc. Antisense modulation of inducible nitric oxide synthase expression
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
DE10038019A1 (en) 2000-08-04 2002-02-14 Bayer Ag Substituted triazolopyride (az) ine
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6562989B2 (en) 2000-08-07 2003-05-13 Yale University Catalyst for aromatic C—O, C—N, and C—C bond formation
TWI259180B (en) 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
AR030357A1 (en) 2000-08-18 2003-08-20 Lundbeck & Co As H DERIVATIVES 4 -, 5 -, 6 - AND 7-INDOL
AU9598601A (en) 2000-10-20 2002-04-29 Eisai Co Ltd Nitrogenous aromatic ring compounds
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
GB0102109D0 (en) 2001-01-26 2001-03-14 Syngenta Ltd Chemical process
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
AU2002258794A1 (en) 2001-04-10 2003-10-20 Transtech Pharma, Inc. Probes, systems and methods for drug discovery
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
WO2003002533A1 (en) 2001-06-28 2003-01-09 Pfizer Products Inc. Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mtp) and/or apolipoprotein b (apo b) secretion
EP1411928A1 (en) 2001-07-20 2004-04-28 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
AUPR738301A0 (en) 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
DE60225316T2 (en) 2001-11-13 2009-02-26 AXYS Pharmaceuticals, Inc., South San Francisco CYANO ALKYLAMINO DERIVATIVES AS PROTEASE INHIBITORS
KR20050044450A (en) 2001-11-14 2005-05-12 테바 파마슈티컬 인더스트리즈 리미티드 Amorphous and crystalline forms of losartan potassium and process for their preparation
KR101018318B1 (en) 2001-12-21 2011-03-04 노보 노르디스크 에이/에스 Amide derivatives as gk activators
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US20030158188A1 (en) 2002-02-20 2003-08-21 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2003093498A1 (en) 2002-04-29 2003-11-13 The Ohio State University Inhibition of protein tyrosine phosphatases and sh2 domains by a neutral phosphotyrosine mimetic
BR0312023A (en) 2002-06-27 2005-03-22 Novo Nordisk As Compound, glucose kinase activating compound, method for preventing hypoglycemia, use of a compound, and pharmaceutical composition
EP1541563A4 (en) 2002-07-10 2007-11-07 Ono Pharmaceutical Co Ccr4 antagonist and medicinal use thereof
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
US20060083784A1 (en) 2002-08-07 2006-04-20 Smithkline Beecham Corporation Amorphous pharmaceutical compositions
CN1688577A (en) 2002-09-18 2005-10-26 小野药品工业株式会社 Triazaspiro [5.5] undecane derivatives and drugs comprising the same as the active ingredient
MXPA05003366A (en) 2002-09-30 2005-10-05 Univ California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof.
JP2004131393A (en) 2002-10-08 2004-04-30 Kowa Co Readily eluting pharmaceutical preparation
CA2501547A1 (en) 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
FR2846327B1 (en) 2002-10-25 2006-03-24 Merck Sante Sas N-BENZODIOXOLYL, N-BENZODIOXANYL AND N-BENZODIOXEPINYL ARYLCARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
AU2003286757B2 (en) 2002-11-01 2009-06-04 Merck Sharp & Dohme Corp. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
DE10251019A1 (en) 2002-11-02 2004-05-19 Aventis Pharma Deutschland Gmbh New pyrimidine-4,6-dicarboxamide derivatives, are selective collagenase inhibitors useful e.g. for treating degenerative joint diseases, connective tissue disorders or cancer
ES2298621T3 (en) 2002-11-02 2008-05-16 Sanofi-Aventis Deutschland Gmbh NEW DIAMIDES OF THE PYRIMIDIN-4,6-DICARBOXILIC ACID FOR THE SELECTIVE INHIBITION OF COLAGENASES.
US20040146941A1 (en) 2002-11-04 2004-07-29 Biliang Zhang Chemical encoding technology for combinatorial synthesis
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
DE10300017A1 (en) 2003-01-03 2004-07-15 Aventis Pharma Deutschland Gmbh Selective MMP 13 inhibitors
JP5086635B2 (en) 2003-01-08 2012-11-28 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Antibacterial agent
WO2004089470A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S New amide derivatives and pharmaceutical use thereof
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2004072069A1 (en) 2003-02-14 2004-08-26 Glaxo Group Limited Carboxamide derivatives
DE10306941A1 (en) 2003-02-18 2004-08-26 Merck Patent Gmbh New indolyl-substituted benzofuranyloxy-alkylamine derivatives, are 5-hydroxytryptamine reuptake inhibitors useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents
WO2004080972A1 (en) 2003-03-12 2004-09-23 Vertex Pharmaceuticals Incorporated Pirazole modulators of atp-binding cassette transporters
NZ543366A (en) 2003-04-03 2008-11-28 Merck Patent Gmbh Carbonyl compounds
US20050164951A1 (en) 2003-04-03 2005-07-28 The Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
DE10315377A1 (en) 2003-04-03 2004-10-14 Merck Patent Gmbh New carbonyl-substituted carbocyclic or heterocyclic compounds, are factor Xa and factor VIIa inhibitors useful e.g. for treating thrombosis, myocardial infarction, arteriosclerosis, inflammation or tumors
HUE055434T2 (en) 2003-04-11 2021-11-29 Ptc Therapeutics Inc 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease
US7696244B2 (en) 2003-05-16 2010-04-13 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
DE602004022819D1 (en) 2003-06-06 2009-10-08 Vertex Pharma TRANSPORTER OF ATP-BINDING CASSETTE
CA2530075C (en) 2003-06-27 2012-08-21 Harvey Pollard Amphiphilic pyridinium compounds, method of making and use thereof
US20050113576A1 (en) 2003-08-05 2005-05-26 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
BRPI0413584A (en) 2003-08-15 2006-10-17 Lundbeck & Co As H compound, pharmaceutical composition, use of a compound, and methods for treating disease and treating a disorder in the central nervous system
ZA200602755B (en) 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
US20050070718A1 (en) 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
JP2007509044A (en) 2003-10-08 2007-04-12 バーテックス　ファーマシューティカルズ　インコーポレイテッド Modulator of ATP binding cassette transporter containing cycloalkylpyranyl group
TW200522964A (en) 2003-10-16 2005-07-16 Sankyo Co 5-aryl-pyrimidine derivatives
US20070099938A1 (en) 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
ES2328824T3 (en) 2003-11-14 2009-11-18 Vertex Pharmaceuticals Incorporated USEFUL TIAZOLS AND OXAZOLES AS MODULATORS OF CONNECTORS OF CASETE TYPE FROM UNION TO ATP.
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8759335B2 (en) 2004-01-30 2014-06-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
BRPI0507169A (en) 2004-02-02 2007-06-26 Ambrx Inc modified human growth hormone polypeptides and their uses
WO2005094374A2 (en) 2004-03-30 2005-10-13 The Regents Of The University Of California Hydrazide-containing cftr inhibitor compounds and uses thereof
US20050222271A1 (en) 2004-03-31 2005-10-06 Le Huang Novel amorphous form of memantine hydrochloride
FR2868417B1 (en) 2004-04-02 2006-06-23 Rhodia Chimie Sa PROCESS FOR FORMING CARBON-CARBON BOND
US20080138803A1 (en) 2004-06-01 2008-06-12 Galvan-Goldman Nee Galvan Barb Method of Detecting Cystic Fibrosis Associated Mutations
WO2005120497A2 (en) 2004-06-04 2005-12-22 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-cftr and uses thereof
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
MX365890B (en) 2004-06-24 2019-06-19 Vertex Pharma Modulators of atp-binding cassette transporters.
US20140343098A1 (en) 2004-06-24 2014-11-20 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
AU2005269981A1 (en) 2004-07-02 2006-02-09 Bonck, John A Tablet for pulsed delivery
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
US8188277B2 (en) 2004-08-06 2012-05-29 Otsuka Pharmaceutical Co., Ltd. Aromatic compounds for suppressing the generation of collagen
DE102004047254A1 (en) 2004-09-29 2006-04-13 Merck Patent Gmbh carbonyl
MX2007004487A (en) 2004-10-13 2007-06-18 Ptc Therapeutics Inc Compounds for nonsense suppression, and methods for their use.
CA2584342C (en) 2004-10-20 2013-04-30 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
EP1829863A4 (en) 2004-11-26 2009-04-22 Takeda Pharmaceutical Arylalkanoic acid derivative
EP1676834A1 (en) * 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
CA2599348C (en) 2005-02-25 2013-07-23 Ono Pharmaceutical Co., Ltd. Indole compound and use thereof
EP1865949B1 (en) 2005-03-11 2012-11-14 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
MX2007011512A (en) 2005-03-18 2007-12-07 Univ California Compounds having activity in correcting mutant-cftr processing and uses thereof.
US20100120789A1 (en) 2005-03-24 2010-05-13 Nigel Vicker Compound
GB0506133D0 (en) 2005-03-24 2005-05-04 Sterix Ltd Compound
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
PT2248809E (en) 2005-03-28 2012-07-02 Toyama Chemical Co Ltd Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of azetidin-3-ol derivatives
JP2006282534A (en) 2005-03-31 2006-10-19 Fuji Photo Film Co Ltd Preparation method of amides
PT1874306E (en) 2005-04-08 2012-10-11 Ptc Therapeutics Inc Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
EP1877401A2 (en) 2005-04-15 2008-01-16 Elan Pharmaceuticals Inc. Novel compounds useful for bradykinin b1 receptor antagonism
CN101223146A (en) 2005-05-24 2008-07-16 沃泰克斯药物股份有限公司 Modulators of ATP-binding cassette transporters
AU2006279810B2 (en) 2005-08-11 2011-10-27 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN101287732A (en) 2005-08-11 2008-10-15 沃泰克斯药物股份有限公司 Modulators of cystic fibrosis transmembrane conductance regulator
ZA200801893B (en) 2005-08-29 2009-08-26 Sanofi Aventis Us Llc Amorphous solid dispersions of 7-chloro-N,N, 5-Trimethyl-4-Oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4,5-B] indole-1-acetamide
CA2624683A1 (en) 2005-10-06 2007-04-19 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US20070219192A1 (en) 2005-11-02 2007-09-20 Xiangping Qian Certain chemical entities, compositions, and methods
US20120232059A1 (en) 2005-11-08 2012-09-13 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette Transporters
SI2395002T1 (en) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition containing a heterocyclic modulator of atp-binding cassette transporters.
GB0525144D0 (en) 2005-12-09 2006-01-18 Novartis Ag Organic compounds
HUE030390T2 (en) 2005-12-21 2017-05-29 Janssen Pharmaceutica Nv Triazolopyridazines as tyrosine kinase modulators
AU2006331614A1 (en) 2005-12-24 2007-07-05 Vertex Pharmaceuticals Incorporated Quinolin- 4 - one derivatives as modulators of ABC transporters
CA2635214A1 (en) 2005-12-27 2007-07-05 Vertex Pharmaceuticals Incorporated Compounds useful in cftr assays and methods therewith
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
RS55940B1 (en) 2005-12-28 2017-09-29 Vertex Pharma Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
CA2856037C (en) 2005-12-28 2017-03-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
AR059826A1 (en) 2006-03-13 2008-04-30 Univ California UREA INHIBITORS CONFORMATIONALLY RESTRICTED OF SOLUBLE HYDROLASSE EPOXIDE
GEP20125378B (en) 2006-03-20 2012-01-10 Vertex Pharma Pharmaceutical compositions
TW200812611A (en) 2006-03-20 2008-03-16 Vertex Pharma Pharmaceutical compositions
JP2009530399A (en) 2006-03-22 2009-08-27 シンデクサ ファーマシューティカルズ コーポレーション Compounds and methods for the treatment of diseases associated with ER stress
NZ596965A (en) * 2006-03-30 2013-06-28 Ptc Therapeutics Inc Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
IN2014KN02423A (en) 2006-04-07 2015-05-01 Vertex Pharma
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US7553855B2 (en) 2006-05-12 2009-06-30 Vertex Pharmaceuticals Incorporated Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
WO2007146712A2 (en) 2006-06-09 2007-12-21 Kemia, Inc. Therapy using cytokine inhibitors
WO2008020227A2 (en) 2006-08-17 2008-02-21 Astrazeneca Ab Antibacterial pyrrolecarboxamides
WO2008029152A2 (en) 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
WO2008029168A2 (en) 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
KR101083177B1 (en) 2006-10-23 2011-11-11 에스지엑스 파마슈티컬스, 인코포레이티드 Triazolo-pyridazine protein kinase modulators
WO2008127399A2 (en) 2006-11-03 2008-10-23 Vertex Pharmaceuticals Incorporated Azaindole derivatives as cftr modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
WO2008064259A2 (en) 2006-11-21 2008-05-29 Biokey, Inc. Solid dispersion composition comprising fluvastatin
WO2008065732A1 (en) 2006-11-27 2008-06-05 Nippon Polyurethane Industry Co., Ltd. Process for production of modified isocyanate mixture containing allophanate bond and isocyanurate bond
US20080260820A1 (en) 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
AU2008256717B2 (en) 2007-05-25 2013-11-21 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US8557823B2 (en) 2007-06-18 2013-10-15 Advanced Cancer Therapeutics, Llc Family of PFKFB3 inhibitors with anti-neoplastic activities
WO2008156783A2 (en) 2007-06-18 2008-12-24 University Of Louisville Research Foundation, Inc. Family of pfkfb3 inhibitors with anti-neoplastic activities
WO2009012482A2 (en) 2007-07-19 2009-01-22 H.Lundbeck A/S 5-membered heterocyclic amides and related compounds
WO2009023509A2 (en) 2007-08-09 2009-02-19 Vertex Pharmaceuticals Incorporated Therapeutic combinations useful in treating cftr related diseases
NZ583420A (en) 2007-08-24 2012-06-29 Vertex Pharma Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis
RU2010114732A (en) 2007-09-14 2011-10-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) SOLID FORMS OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOCHINOLIN-3-CARBOXAMIDE
NZ583878A (en) 2007-09-14 2012-10-26 Vertex Pharma Modulators of ABC transporter and cystic fibrosis transmembrane conductance regulator (CFTR)
US8673911B2 (en) 2007-11-02 2014-03-18 Methylgene Inc. Inhibitors of histone deacetylase
PT2217572E (en) 2007-11-16 2014-02-17 Vertex Pharma Isoquinoline modulators of atp-binding cassette transporters
CN101883765B (en) 2007-11-22 2014-10-01 全药工业株式会社 Amorphous form of heterocyclic compound, solid dispersion and medicinal preparation each comprising the same, and process for production of the same
MX364936B (en) 2007-12-07 2019-05-15 Vertex Pharma Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids.
NZ585880A (en) 2007-12-07 2012-08-31 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
EA201070699A1 (en) 2007-12-07 2011-02-28 Вертекс Фармасьютикалз Инкорпорейтед COMPOSITIONS 3- (6- (1-2,2-DIFTORBENZO [D] [1,3] DIOXOL-5-IL) CYCLOPROPANKARAROXAMIDO) -3-Methylpyridine-2-il
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
JP5637859B2 (en) 2007-12-13 2014-12-10 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Modulator of cystic fibrosis membrane conductance regulator
US20090247521A1 (en) 2007-12-28 2009-10-01 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors for the treatment of endothelial dysfunction
NZ602030A (en) 2008-02-28 2014-02-28 Vertex Pharma Heteroaryl derivatives as cftr modulators
US8227615B2 (en) 2008-03-31 2012-07-24 Vertex Pharmaceutical Incorporated Pyridyl derivatives as CFTR modulators
WO2009127822A2 (en) 2008-04-16 2009-10-22 Biolipox Ab Bis-aryl compounds for use as medicaments
US20090270452A1 (en) 2008-04-18 2009-10-29 Arete Therapeutics, Inc. Use of soluble epoxide hydrolase inhibitors in the treatment of smooth muscle disorders
DK2276485T3 (en) 2008-04-24 2014-10-13 Bristol Myers Squibb Co USE OF EPOTHILON D IN TREATMENT OF TAU-ASSOCIATED DISEASES, INCLUDING ALZHEIMER'S DISEASE
US20110112193A1 (en) 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
CA2733908C (en) 2008-08-13 2017-05-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US20100256184A1 (en) 2008-08-13 2010-10-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
WO2010028159A2 (en) 2008-09-04 2010-03-11 Georgetown University Transition metal-catalyzed c-h amination using unactivated amines
TW201011009A (en) 2008-09-15 2010-03-16 Priaxon Ag Novel pyrrolidin-2-ones
AU2009296271A1 (en) 2008-09-29 2010-04-01 Vertex Pharmaceuticals Incorporated Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
PL2358680T3 (en) 2008-10-23 2013-08-30 Vertex Pharma Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
JP5645834B2 (en) 2008-10-23 2014-12-24 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Modulator of cystic fibrosis membrane conductance regulator
EA018891B1 (en) 2008-10-23 2013-11-29 Вертекс Фармасьютикалз, Инкорпорейтед Modulators of cystic fibrosis transmembrane conductance regulator
US20110257223A1 (en) 2008-10-23 2011-10-20 Vertex Pharmaceuticals Incorporated Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
DK2365972T3 (en) 2008-11-06 2015-01-19 Vertex Pharma Modulators of atp-binding cassette conveyors
UA104876C2 (en) 2008-11-06 2014-03-25 Вертекс Фармасьютікалз Інкорпорейтед Modulators of atp-binding cassette transporters
AR074231A1 (en) 2008-11-27 2010-12-29 Boehringer Ingelheim Int DERIVATIVES OF 6, 7, 8, 9-TETRAHIDRO-5H-1, 4, 7, 10A-TETRAAZA-CICLOHEPT [F] INDENO, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE IN THE 5-HT2C RECEPTOR AGONISM AND PROCESSES FOR PREPARE THEM.
WO2010065668A1 (en) 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
US8367660B2 (en) 2008-12-30 2013-02-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010104306A2 (en) 2009-03-07 2010-09-16 주식회사 메디젠텍 Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm
SG174410A1 (en) 2009-03-20 2011-11-28 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
RU2518897C2 (en) 2009-03-20 2014-06-10 Вертекс Фармасьютикалз Инкорпорейтед 3-carboxamide-4-oxoquinoline derivatives, useful as modulators of regulator of transmembrane cystic fibrosis conductivity
GB0905641D0 (en) 2009-04-01 2009-05-13 Serodus As Compounds
US8778935B2 (en) 2009-04-16 2014-07-15 Centro Nacional De Investigaciones Oncologicas (Cnio) Imidazopyrazines for use as kinase inhibitors
WO2011005355A1 (en) 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
WO2010137351A1 (en) 2009-05-29 2010-12-02 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
EP2264012A1 (en) 2009-06-03 2010-12-22 Bayer CropScience AG Heteroarylamidines and their use as fungicides
KR101256018B1 (en) 2009-08-20 2013-04-18 한국과학기술연구원 1,3,6-Substituted indole derivatives having inhibitory activity for protein kinase
AR078278A1 (en) 2009-09-09 2011-10-26 Vifor Int Ag ANTAGONISTS OF TIAZOL AND OXAZOL HEPCIDINE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF ANEMIAS AND ILLNESSES ASSOCIATED WITH IRON DEFICIENCIES.
JP5793496B2 (en) 2009-09-17 2015-10-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Process for preparing azabicyclic compounds
SG179112A1 (en) 2009-09-18 2012-04-27 Univ Nanyang Tech Process of forming an amide
CN102665715A (en) 2009-10-22 2012-09-12 沃泰克斯药物股份有限公司 Compositions for treatment of cystic fibrosis and other chronic diseases
CN102666546B (en) 2009-10-23 2015-09-09 沃泰克斯药物股份有限公司 The solid form of N-(4-(7-azabicyclo [2.2.1]-7-in heptan base)-2-(trifluoromethyl) phenyl)-4-oxo-5-(trifluoromethyl)-Isosorbide-5-Nitrae-dihydroquinoline-3-methane amide
WO2011050215A1 (en) 2009-10-23 2011-04-28 Vertex Pharmaceuticals Incorporated Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
KR20120130777A (en) 2010-03-01 2012-12-03 유니버시티 오브 테네시 리서치 파운데이션 Compounds for treatment of cancer
WO2011115892A1 (en) 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
CN103180298A (en) 2010-03-19 2013-06-26 沃泰克斯药物股份有限公司 Solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydr o-4-oxoquinoline-3-carboxamide
ES2951520T3 (en) 2010-03-25 2023-10-23 Vertex Pharma Synthesis and intermediates of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2- (1-hydroxy-2-methylpropan-2-yl)-1H-indol-5yl)-cyclopropanecarboxamide
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
AR081069A1 (en) 2010-04-07 2012-06-06 Vertex Pharma SOLID FORMS OF ACID 3- (6- (1- (2,2-DIFLUORBENZO [D] [1,3] DIOXOL-5-IL) CYCLOPROPANCARBOXAMIDE) -3-METHYLPIRIDIN-2-IL) BENZOIC
EP3150198B1 (en) 2010-04-07 2021-09-22 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
WO2011133956A1 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
AU2011242452A1 (en) 2010-04-22 2012-11-08 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
EP2560650A1 (en) 2010-04-22 2013-02-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
CN105130948A (en) 2010-04-22 2015-12-09 弗特克斯药品有限公司 Pharmaceutical compositions and administrations thereof
EP2386606B1 (en) 2010-04-30 2018-03-21 Total Marketing Services Use of organogelator derivatives in bituminous compositions to improve the resistance thereof to chemical attacks
PL2571506T3 (en) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Processes for preparing macrolides and ketolides and intermediates therefor
US8404849B2 (en) 2010-05-20 2013-03-26 Vertex Pharmaceuticals Processes for producing modulators of cystic fibrosis transmembrane conductance regulator
WO2011146901A1 (en) * 2010-05-20 2011-11-24 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
US20120149708A1 (en) 2010-06-17 2012-06-14 George Mason University Modulators of viral transcription, and methods and compositions therewith
UA110113C2 (en) 2010-07-29 2015-11-25 BICYCLIC AZAGETEROCYCLIC CARBOXAMIDES
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
EP2608779A2 (en) 2010-08-23 2013-07-03 Vertex Pharmaceuticals Incorporated Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof
CN103153286A (en) 2010-08-27 2013-06-12 沃泰克斯药物股份有限公司 Pharmaceutical composition and administrations thereof
WO2012049555A1 (en) 2010-10-13 2012-04-19 Lupin Limited Spirocyclic compounds as voltage-gated sodium channel modulators
US9394290B2 (en) 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
WO2012079583A1 (en) 2010-12-15 2012-06-21 Aarhus Universitet System providing controlled delivery of gaseous co for carbonylation reactions
CA2827392A1 (en) 2011-02-24 2012-08-30 Emory University Noggin blocking compositions for ossification and methods related thereto
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
CN102731492B (en) 2011-03-30 2016-06-29 江苏恒瑞医药股份有限公司 Cyclohexanes derivant, its preparation method and in application pharmaceutically
HUE047354T2 (en) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Deuterated derivatives of ivacaftor
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
CN104159890B (en) 2011-09-09 2018-04-10 蓝瑟斯医学影像公司 Composition, method and system for synthesizing and using developer
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
JP6165733B2 (en) 2011-09-16 2017-07-19 ノバルティス アーゲー N-substituted heterocyclylcarboxamides
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
WO2013067410A1 (en) 2011-11-02 2013-05-10 Vertex Pharmaceuticals Incorporated Use of (n- [2, 4 -bis (1, 1 -dimethylethyl) - 5 - hydroxyphenyl] - 1, 4 - dihydro - 4 - oxoquinoline - 3 - ca rboxamide) for treating cftr mediated diseases
MX357328B (en) 2011-11-08 2018-07-05 Vertex Pharma Modulators of atp-binding cassette transporters.
US20140127901A1 (en) 2012-11-08 2014-05-08 Taiwan Semiconductor Manufacturing Company, Ltd. Low-k damage free integration scheme for copper interconnects
WO2013086131A1 (en) 2011-12-06 2013-06-13 The Trustees Of The University Of Pennsylvania Inhibitors targeting drug-resistant influenza a
US8772541B2 (en) 2011-12-15 2014-07-08 University of Pittsburgh—of the Commonwealth System of Higher Education Cannabinoid receptor 2 (CB2) inverse agonists and therapeutic potential for multiple myeloma and osteoporosis bone diseases
EP2606726A1 (en) 2011-12-21 2013-06-26 Bayer CropScience AG N-Arylamidine-substituted trifluoroethylsulfide derivatives as acaricides and insecticides
US20130186801A1 (en) 2012-01-25 2013-07-25 Vertex Pharmaceuticals Incorporated Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
RU2692779C2 (en) 2012-02-27 2019-06-27 Вертекс Фармасьютикалз Инкорпорейтед Pharmaceutical composition and introduction thereof
WO2013151739A1 (en) 2012-04-03 2013-10-10 3M Innovative Properties Company Crosslinkable composition comprising photobase generators
US8674108B2 (en) 2012-04-20 2014-03-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US20130284054A1 (en) 2012-04-26 2013-10-31 Xerox Corporation Rapid solidifying crystalline-amorphous inks
US9528016B2 (en) 2012-04-26 2016-12-27 Xerox Corporation Phase change inks comprising crystalline amides
US8888905B2 (en) 2012-04-26 2014-11-18 Xerox Corporation Fast crystallizing crystalline-amorphous ink compositions and methods for making the same
US9228101B2 (en) 2012-04-26 2016-01-05 Xerox Corporation Rapidly crystallizing phase change inks and methods for forming the same
CA2813472A1 (en) 2012-04-26 2013-10-26 Xerox Corporation Rapid solidifying crystalline-amorphous inks
EP2861577B1 (en) 2012-05-25 2017-01-04 Boehringer Ingelheim International GmbH Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof
GB2502624A (en) 2012-06-01 2013-12-04 Univ East Anglia Phosphoramide and phosphoramide-based catalysts and their use in intermolecular aziridination
EP2858645A1 (en) 2012-06-08 2015-04-15 Vertex Pharmaceuticals Incorporated Pharmaceuticl compositions for the treatment of cftr -mediated disorders
WO2013184198A1 (en) 2012-06-08 2013-12-12 Massachusetts Institute Of Technology Phosphine-ligated palladium sulfonate palladacycles
FR2992317B1 (en) 2012-06-22 2016-05-13 Diverchim PROCESS FOR THE PREPARATION OF CHIRAL PEPTIDES
WO2014002106A1 (en) 2012-06-25 2014-01-03 Cadila Healthcare Limited Novel compounds for the treatment of dyslipidemia and related diseases
RU2663110C2 (en) 2012-07-12 2018-08-01 ПРОКЬЮЭР ТЕРАПЬЮТИКС II Би.Ви. Oligonucleotides for making change in sequence of target rna molecule present in living cell
US20150209448A1 (en) 2012-07-12 2015-07-30 Proqr Therapeutics N.V. Exon replacement with stabilized artificial rnas
AR092857A1 (en) 2012-07-16 2015-05-06 Vertex Pharma PHARMACEUTICAL COMPOSITIONS OF (R) -1- (2,2-DIFLUOROBENZO [D] [1,3] DIOXOL-5-IL) -N- (1- (2,3-DIHYDROXIPROPIL) -6-FLUORO-2- ( 1-HYDROXI-2-METHYLPROPAN-2-IL) -1H-INDOL-5-IL) CYCLOPROPANCARBOXAMIDE AND ADMINISTRATION OF THE SAME
WO2014047110A2 (en) 2012-09-20 2014-03-27 Temple University - Of The Commonwealth System Of Higher Education Substituted alkyl diaryl derivatives, methods of preparation and uses
BR102012025405A2 (en) 2012-10-05 2014-10-07 Fundação Universidade De Brasília Process of obtaining starches via catalytic aminolysis of esters and carboxylic acids in ionic liquids
KR101677866B1 (en) 2012-10-29 2016-11-18 코니카 미놀타 가부시키가이샤 Phase difference film, circularly polarizing plate, and image forming device
KR102396897B1 (en) 2012-11-02 2022-05-13 버텍스 파마슈티칼스 인코포레이티드 Pharmaceutical compositions for the treatment of cftr mediated diseases
US9757379B2 (en) 2012-11-14 2017-09-12 The Board Of Regents Of The University Of Texas System Inhibition of HIF-2α heterodimerization with HIF1β (ARNT)
JP6146990B2 (en) 2012-11-16 2017-06-14 コンサート ファーマシューティカルズ インコーポレイテッド Deuterated CFTR enhancer
CN104884453B (en) 2012-11-20 2018-06-22 梅里亚股份有限公司 Dehelminthization compound and composition and use its method
ITMI20122065A1 (en) 2012-12-03 2014-06-04 Univ Padova USE OF CFTR CORRECTORS IN THE TREATMENT OF STRUCTURAL MUSCLE PATHOLOGIES
WO2014086934A1 (en) 2012-12-05 2014-06-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Diagnosis of cystic fibrosis
CA2894279A1 (en) 2012-12-07 2014-06-12 Paul Boucher Nasal cannula for delivery of aerosolized medicaments
US20140221424A1 (en) 2013-01-30 2014-08-07 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for use in the treatment of cystic fibrosis
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
US20140296164A1 (en) 2013-03-29 2014-10-02 Calista Therapeutics, Inc. Compositions and methods of use for cell targeted inhibitors of the Cystic Fibrosis transmembrane regulator associated ligand
CA3122383A1 (en) 2013-05-07 2014-11-13 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis.
CN105473578A (en) 2013-05-24 2016-04-06 加州生物医学研究所 Compounds for treatment of drug resistant and persistent tuberculosis
JP2014232188A (en) 2013-05-29 2014-12-11 コニカミノルタ株式会社 Cellulose acylate film, circularly polarizing plate and image display device
CA2915975A1 (en) 2013-06-26 2014-12-31 Proteostasis Therapeutics, Inc. Methods of modulating cftr activity
SI3030568T1 (en) 2013-08-08 2019-02-28 Galapagos Nv Thieno(2,3-c)pyrans as cftr modulators
WO2015036552A1 (en) 2013-09-12 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of cystic fibrosis
US10882834B2 (en) 2013-09-20 2021-01-05 University of Pittsburgh—of the Commonwealth System of Higher Education Compounds for treating prostate cancer
US9353078B2 (en) 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
US9700881B2 (en) 2013-10-09 2017-07-11 Emory University Heterocyclic coupling catalysts and methods related thereto
BR112016010403A2 (en) 2013-11-12 2017-08-08 Vertex Pharma PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR-MEDIATED DISEASES
KR20150062652A (en) 2013-11-29 2015-06-08 삼성전자주식회사 Sonosensitive liposome, a pharmaceutical composition comprising the same and a method of delivering an active agent into a subject using the same
MX2016008688A (en) 2013-12-30 2017-01-12 Lifesci Pharmaceuticals Inc Therapeutic inhibitory compounds.
CN106458856A (en) 2014-03-07 2017-02-22 约翰霍普金斯大学 Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
JP2015172005A (en) 2014-03-11 2015-10-01 国立大学法人 東京大学 Method of producing coupling compound by iron catalyst
WO2015138934A1 (en) 2014-03-13 2015-09-17 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
AU2015229188A1 (en) 2014-03-13 2016-09-29 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity
CN106163517B (en) 2014-04-15 2020-08-14 沃泰克斯药物股份有限公司 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
EP3139949B1 (en) 2014-05-08 2020-07-29 Phasebio Pharmaceuticals, Inc. Compositions comprising a vip-elp fusion protein for use in treating cystic fibrosis
DK3231444T3 (en) 2014-05-12 2020-03-16 Verona Pharma Plc New treatment
JP6764792B2 (en) 2014-05-16 2020-10-07 オラプレックス， インコーポレイテッド Keratin-treated formulations and methods
EP3145925B1 (en) 2014-05-19 2020-11-04 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds
AU2015269598B2 (en) 2014-06-05 2019-11-14 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
EP3157917B1 (en) 2014-06-19 2020-03-18 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity
EP3179870B1 (en) 2014-08-13 2023-10-04 Akeso Biomedical Inc. Antimicrobial compounds and compositions, and uses thereof
GB201415381D0 (en) 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
SG11201701598PA (en) 2014-09-10 2017-03-30 Epizyme Inc Smyd inhibitors
CN104725628B (en) 2014-10-01 2018-04-17 厦门赛诺邦格生物科技股份有限公司 A kind of single functionalization branched polyethylene glycol, preparation method and its bio-related substance containing degradable group
WO2016050208A1 (en) 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 Bio-related substance modified by multifunctionalized polyethylene glycol derivative
WO2016050209A1 (en) 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 Heterofunctionalized polyethylene glycol derivative, preparation method, and bio-related substance
WO2016050210A1 (en) 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 Multifunctionalized polyethylene glycol derivative and preparation method therefor
WO2016054560A1 (en) 2014-10-02 2016-04-07 Flatley Discovery Lab Isoxazole compounds and methods for the treatment of cystic fibrosis
CN112279808B (en) 2014-10-06 2024-03-08 弗特克斯药品有限公司 Cystic fibrosis transmembrane conductance regulator modulators
WO2016057522A1 (en) 2014-10-06 2016-04-14 Flatley Discovery Lab Triazolopyridine compounds and methods for the treatment of cystic fibrosis
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
EP3204010A1 (en) 2014-10-08 2017-08-16 Nivalis Therapeutics, Inc. Methods for the treatment of cystic fibrosis
US20160108406A1 (en) 2014-10-08 2016-04-21 University Of Iowa Research Foundation Method of regulating cftr expression and processing
GB201418892D0 (en) 2014-10-23 2014-12-10 Proqr Therapeutics B V DNA editing
WO2016066582A1 (en) 2014-10-28 2016-05-06 Bci Pharma Nucleoside kinase inhibitors
MX2017005663A (en) 2014-10-31 2018-03-01 Abbvie Sarl Substituted tetrahydropyrans and method of use.
JP6676646B2 (en) 2014-10-31 2020-04-08 アッヴィ・エス・ア・エール・エル Substitution chromans and methods of use
EP3221692B1 (en) 2014-11-18 2021-06-23 Vertex Pharmaceuticals Inc. Process of conducting high throughput testing high performance liquid chromatography
WO2016086015A1 (en) 2014-11-25 2016-06-02 University Of Rochester Myoglobin-based catalysts for carbene transfer reactions
MA41031A (en) 2014-11-26 2017-10-03 Catabasis Pharmaceuticals Inc CYSTEAMINE-FATTY ACID CONJUGATES AND THEIR USE AS AUTOPHAGIC ACTIVATORS
WO2016086136A1 (en) 2014-11-26 2016-06-02 Catabasis Pharmaceuticals, Inc. Fatty acid cysteamine conjugates of cftr modulators and their use in treating medical disorders
US10738011B2 (en) 2014-12-23 2020-08-11 Proteostasis Therapeutics, Inc. Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
CA2971850A1 (en) 2014-12-23 2016-06-30 Proteostasis Therapeutics, Inc. Derivatives of 5-phenyl- or 5-heteroarylthiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis
US10344023B2 (en) 2014-12-23 2019-07-09 Proteostasis Therapeutics, Inc. Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis
MA41253A (en) 2014-12-23 2017-10-31 Proteostasis Therapeutics Inc COMPOUNDS, COMPOSITIONS AND PROCESSES TO INCREASE THE ACTIVITY OF CFTR
PL3236983T3 (en) 2014-12-24 2019-10-31 Kither Biotech S R L Novel pi3k gamma inhibitor peptide for treatment of respiratory system diseases
EA201791500A1 (en) 2014-12-31 2018-01-31 Оспекс Фармасьютикалз, Инк. CYCLOPROPANKARCARBOXAMID MODULATORS OF THE MUCOVISCIDOUS TRANSMEMBRANE CONDUCTOR REGULATOR
WO2016107603A1 (en) 2015-01-01 2016-07-07 成都贝斯凯瑞生物科技有限公司 Substituted nitrogen-containing heterocyclic derivatives and applications thereof
US20180147187A1 (en) 2015-01-12 2018-05-31 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
CA2981495C (en) 2015-03-31 2023-09-26 Vertex Pharmaceuticals (Europe) Limited Deuterated vx-661
WO2018183367A1 (en) 2017-03-28 2018-10-04 Van Goor Fredrick F Methods of treating cystic fibrosis in patients with residual function mutations

Also Published As

Publication number Publication date
UA124567C2 (en) 2021-10-13
PL3424534T3 (en) 2021-11-22
EP3424534A1 (en) 2019-01-09
HRP20181194T1 (en) 2018-09-21
US10980746B2 (en) 2021-04-20
US20190125674A1 (en) 2019-05-02
PT3424534T (en) 2021-08-10
PT3131582T (en) 2018-10-08
IL303422A (en) 2023-08-01
HUE039062T2 (en) 2018-12-28
LT3131582T (en) 2018-10-25
AU2019250116B2 (en) 2021-09-16
KR102447581B1 (en) 2022-09-28
EP3424534B1 (en) 2021-06-02
EP4223294A1 (en) 2023-08-09
EP3925607A1 (en) 2021-12-22
PT3925607T (en) 2023-09-26
CA2944140A1 (en) 2015-10-22
IL266286A (en) 2019-06-30
LT3925607T (en) 2023-11-27
US10206877B2 (en) 2019-02-19
CN110840847B (en) 2022-07-29
LT3424534T (en) 2021-11-10
US20150320736A1 (en) 2015-11-12
IL248359A0 (en) 2016-11-30
CN110840847A (en) 2020-02-28
IL266286B2 (en) 2023-11-01
SI3424534T1 (en) 2021-08-31
DK3131582T3 (en) 2018-08-06
PL3925607T3 (en) 2023-10-30
CA2944140C (en) 2022-10-04
IL248359B (en) 2019-05-30
IL266286B1 (en) 2023-07-01
JP2017511344A (en) 2017-04-20
RS57476B1 (en) 2018-10-31
ES2885181T3 (en) 2021-12-13
SG10201913575VA (en) 2020-02-27
RU2016144479A3 (en) 2018-05-16
RU2744460C2 (en) 2021-03-09
NZ763453A (en) 2023-10-27
CN106163517A (en) 2016-11-23
US11951212B2 (en) 2024-04-09
SG11201607670XA (en) 2016-10-28
FI3925607T3 (en) 2023-08-28
EP3131582A1 (en) 2017-02-22
ES2957761T3 (en) 2024-01-25
BR112016023422A2 (en) 2017-08-15
BR112016023422A8 (en) 2021-07-20
RS62140B1 (en) 2021-08-31
HRP20230709T1 (en) 2023-10-13
MX2021013638A (en) 2022-01-06
HUE055369T2 (en) 2021-11-29
ZA201606418B (en) 2019-12-18
WO2015160787A1 (en) 2015-10-22
RS64400B1 (en) 2023-08-31
PL3131582T3 (en) 2018-10-31
CY1120582T1 (en) 2019-07-10
NZ724488A (en) 2023-10-27
JP6543268B2 (en) 2019-07-10
US20210308053A1 (en) 2021-10-07
ES2675858T3 (en) 2018-07-13
CL2016002600A1 (en) 2017-08-18
KR20160145124A (en) 2016-12-19
EP3131582B1 (en) 2018-05-23
HUE062736T2 (en) 2023-12-28
CN106163517B (en) 2020-08-14
AU2015247850B2 (en) 2019-07-18
EP3925607B1 (en) 2023-06-28
TR201809684T4 (en) 2018-07-23
DK3424534T3 (en) 2021-07-26
SI3131582T1 (en) 2018-09-28
AU2015247850A1 (en) 2016-10-06
DK3925607T3 (en) 2023-08-21
AU2019250116A1 (en) 2019-10-31
MX2016013301A (en) 2017-01-18
HRP20211012T1 (en) 2021-09-17
RU2016144479A (en) 2018-05-16
RS57476B9 (en) 2021-10-29
SI3925607T1 (en) 2023-10-30
CL2020002757A1 (en) 2021-02-26

Similar Documents

Publication Publication Date Title
CY1124568T1 (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY CYSTIC FIBER TRANSMEMBRANE CONDUCTANCE REGULATOR
CY1123487T1 (en) Modulators of cystic fiber transmembrane conductance regulator
CY1123996T1 (en) SUBSTITUTED OXOPYRIDINE DERIVATIVES
CY1124959T1 (en) LYSINE INHIBITORS OF SPECIFIC DEMETHYLATION-1
CY1124918T1 (en) CCR2 REGULATORS
CY1125436T1 (en) DNA-PK INHIBITORS
CY1120893T1 (en) METHODS FOR TREATMENT OF FILOVIRIDAE VIRUS INFECTIONS
CY1124407T1 (en) AUTOTAXIN INHIBITOR COMPOUNDS
CY1122227T1 (en) ADJUSTMENT OF SUPPLEMENT ACTIVITY
CY1124131T1 (en) ANTI-RTK7 ANTIBODY-DRUG CONJUGATS
CY1120361T1 (en) 2,3-INDOLAMINE DIAGNOSIS INHIBITORS (IDO)
CY1123354T1 (en) TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID AND A RETINOID FOR THE TREATMENT OF PSORIASIS
CY1123581T1 (en) NEW METHODS FOR THE PRODUCTION OF OLIGONUCLEOTIDES
DK3551622T3 (en) MODULATOR OF TRANSMEMBRANE CONDUCTANCE REGULATOR OF CYSTIC FIBROSE, PHARMACEUTICAL COMPOSITIONS, TREATMENT PROCEDURES AND METHOD OF MANUFACTURE OF THE MODULATOR
CY1121550T1 (en) PYRIDINE PLADIENOLIDES COMPOUNDS AND METHODS OF USE
CY1121710T1 (en) ANGIOPIETIN-BASED INTERVENTIONS FOR THE TREATMENT OF CEREBRAL MALARIA
CY1124704T1 (en) SOBETIROME PRODUCT
CY1121972T1 (en) MONO- OR DI- SUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION
CY1125150T1 (en) PHENYL-2-HYDROXY-ACETYLAMINO-2-METHYL-PHENYL COMPOUNDS
EA201790273A1 (en) FLAGELLIN COMPOSITIONS AND THEIR APPLICATION
CY1123963T1 (en) INNOVATIVE POLYMERIC HGH PRODRUGS
CY1123031T1 (en) REGULATORS OF SUPPLEMENT EFFECTIVENESS
CY1124761T1 (en) REGULATORS OF SUPPLEMENT EFFECTIVENESS
EA201991997A1 (en) COMBINED THERAPY
CY1120742T1 (en) US X RELAY RECONSTRUCTORS (LXR) FOR THE TREATMENT OF SKIN DISEASES, DISORDERS AND CONDITIONS